EP3019861A4 - Analytical method for detecting sulfated oligosaccharides - Google Patents
Analytical method for detecting sulfated oligosaccharides Download PDFInfo
- Publication number
- EP3019861A4 EP3019861A4 EP13888999.3A EP13888999A EP3019861A4 EP 3019861 A4 EP3019861 A4 EP 3019861A4 EP 13888999 A EP13888999 A EP 13888999A EP 3019861 A4 EP3019861 A4 EP 3019861A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- analytical method
- sulfated oligosaccharides
- detecting
- detecting sulfated
- oligosaccharides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/30—Partition chromatography
- B01D15/305—Hydrophilic interaction chromatography [HILIC]
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8836—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving saccharides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2013/050147 WO2015005928A1 (en) | 2013-07-11 | 2013-07-11 | Analytical method for detecting sulfated oligosaccharides |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3019861A1 EP3019861A1 (en) | 2016-05-18 |
EP3019861A4 true EP3019861A4 (en) | 2017-02-22 |
Family
ID=52280428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13888999.3A Withdrawn EP3019861A4 (en) | 2013-07-11 | 2013-07-11 | Analytical method for detecting sulfated oligosaccharides |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP3019861A4 (ko) |
JP (1) | JP6208866B2 (ko) |
KR (1) | KR20160030963A (ko) |
CN (1) | CN105431733B (ko) |
AU (1) | AU2013393832B2 (ko) |
CA (1) | CA2917460A1 (ko) |
IL (1) | IL243405A0 (ko) |
WO (1) | WO2015005928A1 (ko) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2016017317A (es) | 2014-06-26 | 2017-08-24 | Regeneron Pharma | Metodos y composiciones para modificaciones geneticas dirigidas y metodos de uso. |
JP6706497B2 (ja) * | 2015-12-24 | 2020-06-10 | 昭和電工株式会社 | 親水性化合物の分離分析方法 |
CN105628820A (zh) * | 2016-01-08 | 2016-06-01 | 东营天东制药有限公司 | 一种低分子肝素生产过程中游离硫酸根离子快速检测方法 |
US11166915B2 (en) | 2016-09-16 | 2021-11-09 | Leukocare Ag | Method for obtaining efficient viral vector-based compositions for vaccination or gene therapy |
EP3512496A1 (en) | 2016-09-16 | 2019-07-24 | Leukocare Ag | A novel method for producing low viscous and highly concentrated biopharmaceutical drug products in liquid formulation |
CN110709696B (zh) * | 2017-06-22 | 2022-01-04 | 昭和电工株式会社 | 寡核苷酸的混合物的分离分析方法 |
CN109254101B (zh) * | 2017-07-13 | 2021-07-09 | 中国科学院大连化学物理研究所 | 一种母乳酸性寡糖净化和分析方法 |
CN109459523B (zh) * | 2017-09-06 | 2022-11-08 | 上海绿谷制药有限公司 | 一种测定酸性糖可溶性盐重均分子量和含量的方法 |
CN112005110B (zh) * | 2018-07-24 | 2022-11-29 | 深圳市海普瑞药业集团股份有限公司 | 一种达肝素钠亚硝酸降解产物的分析方法及其应用 |
WO2020020145A1 (zh) * | 2018-07-26 | 2020-01-30 | 深圳市海普瑞药业集团股份有限公司 | 低分子肝素糖链分布的分析方法及其应用 |
CN111239311A (zh) * | 2018-11-28 | 2020-06-05 | 中国科学院大连化学物理研究所 | 一种婴幼儿排泄物中酸性糖及酸性糖衍生物的分析方法 |
CN109633003A (zh) * | 2018-12-26 | 2019-04-16 | 成都普思生物科技股份有限公司 | 一种测定远志中远志口山酮ⅲ和3,6,-二芥子酰基蔗糖含量的方法 |
CN110161147A (zh) * | 2019-06-19 | 2019-08-23 | 北京三元食品股份有限公司 | 乳中游离低聚糖的高通量定量测定方法 |
JP7487987B1 (ja) | 2023-12-21 | 2024-05-21 | 伊那食品工業株式会社 | アガロオリゴ糖の分析方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011073408A2 (en) * | 2009-12-18 | 2011-06-23 | Endotis Pharma | Pharmaceutical oral dosage form containing a synthetic oligosaccharide |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090162938A1 (en) * | 2005-11-08 | 2009-06-25 | Suomen Punainen Risti,Veripalvelu | Novel Carbohydrate Profile Compositions From Human Cells and Methods for Analysis and Modification Thereof |
US9091695B2 (en) * | 2007-06-01 | 2015-07-28 | Laboratory Corporation Of America Holdings | Methods and systems for quantification of peptides and other analytes |
US8696917B2 (en) * | 2009-02-09 | 2014-04-15 | Edwards Lifesciences Corporation | Analyte sensor and fabrication methods |
EP2306199A1 (en) * | 2009-09-29 | 2011-04-06 | Academisch Ziekenhuis Leiden Acting Under The Name Leiden University Medical Center | Reductive amination and analysis of carbohydrates using 2-picoline borane as reducing agent |
CN102101875A (zh) * | 2009-12-16 | 2011-06-22 | 中国科学院大连化学物理研究所 | 一种寡糖纯化分离方法 |
MX2012007662A (es) * | 2010-01-07 | 2012-08-23 | Polymedix Inc | Compuestos anti-heparina. |
CN102759596B (zh) * | 2012-07-09 | 2014-08-20 | 山东大学 | 一种低分子肝素的离子对反相色谱质谱联用检测方法 |
-
2013
- 2013-07-11 WO PCT/US2013/050147 patent/WO2015005928A1/en active Application Filing
- 2013-07-11 KR KR1020167003059A patent/KR20160030963A/ko not_active Application Discontinuation
- 2013-07-11 EP EP13888999.3A patent/EP3019861A4/en not_active Withdrawn
- 2013-07-11 CA CA2917460A patent/CA2917460A1/en not_active Abandoned
- 2013-07-11 JP JP2016525337A patent/JP6208866B2/ja not_active Expired - Fee Related
- 2013-07-11 CN CN201380078160.1A patent/CN105431733B/zh not_active Expired - Fee Related
- 2013-07-11 AU AU2013393832A patent/AU2013393832B2/en not_active Expired - Fee Related
-
2015
- 2015-12-30 IL IL243405A patent/IL243405A0/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011073408A2 (en) * | 2009-12-18 | 2011-06-23 | Endotis Pharma | Pharmaceutical oral dosage form containing a synthetic oligosaccharide |
Non-Patent Citations (4)
Title |
---|
DAVID C. A. NEVILLE ET AL: "Development of a Single Column Method for the Separation of Lipid- and Protein-Derived Oligosaccharides", JOURNAL OF PROTEOME RESEARCH, vol. 8, no. 2, 6 February 2009 (2009-02-06), pages 681 - 687, XP055108809, ISSN: 1535-3893, DOI: 10.1021/pr800704t * |
JOSÉ M. CINTRÓN ET AL: "Hydrophilic interaction chromatography with aerosol-based detectors (ELSD, CAD, NQAD) for polar compounds lacking a UV chromophore in an intravenous formulation", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 78-79, 1 May 2013 (2013-05-01), US, pages 14 - 18, XP055242173, ISSN: 0731-7085, DOI: 10.1016/j.jpba.2013.01.022 * |
R.REID TOWNSEND ET AL: "Multimode High-Performance Liquid Chromatography of Fluorescently Labeled Oligosaccharides from Glycoproteins", ANALYTICAL BIOCHEMISTRY, vol. 239, no. 2, 1 August 1996 (1996-08-01), pages 200 - 207, XP055108618, ISSN: 0003-2697, DOI: 10.1006/abio.1996.0315 * |
See also references of WO2015005928A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU2013393832B2 (en) | 2017-11-30 |
KR20160030963A (ko) | 2016-03-21 |
EP3019861A1 (en) | 2016-05-18 |
CA2917460A1 (en) | 2015-01-15 |
JP6208866B2 (ja) | 2017-10-04 |
WO2015005928A1 (en) | 2015-01-15 |
CN105431733A (zh) | 2016-03-23 |
JP2016524166A (ja) | 2016-08-12 |
CN105431733B (zh) | 2019-01-22 |
AU2013393832A1 (en) | 2016-02-04 |
IL243405A0 (en) | 2016-02-29 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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17P | Request for examination filed |
Effective date: 20160203 |
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Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
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AX | Request for extension of the european patent |
Extension state: BA ME |
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RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: CHAO, HELEN Inventor name: WANG, CHUNGYAO Inventor name: WU, CHIAYEN Inventor name: CHIANG, YUNGTE Inventor name: HUANG, IMIN |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20170125 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: C08B 37/00 20060101ALN20170119BHEP Ipc: G01N 30/72 20060101ALN20170119BHEP Ipc: B01D 15/30 20060101ALI20170119BHEP Ipc: G01N 30/88 20060101AFI20170119BHEP |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
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18W | Application withdrawn |
Effective date: 20191122 |