EP3019861A4 - Analytisches verfahren zum nachweis sulfatierter oligosaccharide - Google Patents

Analytisches verfahren zum nachweis sulfatierter oligosaccharide Download PDF

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Publication number
EP3019861A4
EP3019861A4 EP13888999.3A EP13888999A EP3019861A4 EP 3019861 A4 EP3019861 A4 EP 3019861A4 EP 13888999 A EP13888999 A EP 13888999A EP 3019861 A4 EP3019861 A4 EP 3019861A4
Authority
EP
European Patent Office
Prior art keywords
analytical method
sulfated oligosaccharides
detecting
detecting sulfated
oligosaccharides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13888999.3A
Other languages
English (en)
French (fr)
Other versions
EP3019861A1 (de
Inventor
Helen CHAO
ChungYao WANG
Imin HUANG
ChiaYen WU
YungTe CHIANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scinopharm Taiwan Ltd
Original Assignee
Scinopharm Taiwan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scinopharm Taiwan Ltd filed Critical Scinopharm Taiwan Ltd
Publication of EP3019861A1 publication Critical patent/EP3019861A1/de
Publication of EP3019861A4 publication Critical patent/EP3019861A4/de
Withdrawn legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/30—Partition chromatography
    • B01D15/305—Hydrophilic interaction chromatography [HILIC]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8836—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving saccharides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Saccharide Compounds (AREA)
EP13888999.3A 2013-07-11 2013-07-11 Analytisches verfahren zum nachweis sulfatierter oligosaccharide Withdrawn EP3019861A4 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2013/050147 WO2015005928A1 (en) 2013-07-11 2013-07-11 Analytical method for detecting sulfated oligosaccharides

Publications (2)

Publication Number Publication Date
EP3019861A1 EP3019861A1 (de) 2016-05-18
EP3019861A4 true EP3019861A4 (de) 2017-02-22

Family

ID=52280428

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13888999.3A Withdrawn EP3019861A4 (de) 2013-07-11 2013-07-11 Analytisches verfahren zum nachweis sulfatierter oligosaccharide

Country Status (8)

Country Link
EP (1) EP3019861A4 (de)
JP (1) JP6208866B2 (de)
KR (1) KR20160030963A (de)
CN (1) CN105431733B (de)
AU (1) AU2013393832B2 (de)
CA (1) CA2917460A1 (de)
IL (1) IL243405A0 (de)
WO (1) WO2015005928A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE041584T2 (hu) 2014-06-26 2019-05-28 Regeneron Pharma Célzott genetikai módosítások és alkalmazási módszerek és készítmények
JP6706497B2 (ja) * 2015-12-24 2020-06-10 昭和電工株式会社 親水性化合物の分離分析方法
CN105628820A (zh) * 2016-01-08 2016-06-01 东营天东制药有限公司 一种低分子肝素生产过程中游离硫酸根离子快速检测方法
US11510871B2 (en) 2016-09-16 2022-11-29 Leukocare Ag Method for producing low viscous and highly concentrated biopharmaceutical drug products in liquid formulation
CN109952372A (zh) 2016-09-16 2019-06-28 白血球保健股份有限公司 获得有效用于疫苗接种或基因治疗的基于病毒载体的组合物的新方法
EP3644055B1 (de) 2017-06-22 2022-04-13 Showa Denko K.K. Trenn-/analyseverfahren für mischung aus oligonukleotiden
CN109254101B (zh) * 2017-07-13 2021-07-09 中国科学院大连化学物理研究所 一种母乳酸性寡糖净化和分析方法
CN109459523B (zh) * 2017-09-06 2022-11-08 上海绿谷制药有限公司 一种测定酸性糖可溶性盐重均分子量和含量的方法
CN112005110B (zh) * 2018-07-24 2022-11-29 深圳市海普瑞药业集团股份有限公司 一种达肝素钠亚硝酸降解产物的分析方法及其应用
WO2020020145A1 (zh) * 2018-07-26 2020-01-30 深圳市海普瑞药业集团股份有限公司 低分子肝素糖链分布的分析方法及其应用
CN111239311A (zh) * 2018-11-28 2020-06-05 中国科学院大连化学物理研究所 一种婴幼儿排泄物中酸性糖及酸性糖衍生物的分析方法
CN109633003A (zh) * 2018-12-26 2019-04-16 成都普思生物科技股份有限公司 一种测定远志中远志口山酮ⅲ和3,6，-二芥子酰基蔗糖含量的方法
CN110161147A (zh) * 2019-06-19 2019-08-23 北京三元食品股份有限公司 乳中游离低聚糖的高通量定量测定方法
JP7487987B1 (ja) 2023-12-21 2024-05-21 伊那食品工業株式会社 アガロオリゴ糖の分析方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011073408A2 (en) * 2009-12-18 2011-06-23 Endotis Pharma Pharmaceutical oral dosage form containing a synthetic oligosaccharide

Family Cites Families (7)

* Cited by examiner, † Cited by third party
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US20090317788A1 (en) * 2005-11-08 2009-12-24 Suomen Punainen Risti, Veripalvelu Novel Carbohydrate Profile Compositions From Human Cells and Methods for Analysis and Modification Thereof
US9091695B2 (en) * 2007-06-01 2015-07-28 Laboratory Corporation Of America Holdings Methods and systems for quantification of peptides and other analytes
US8696917B2 (en) * 2009-02-09 2014-04-15 Edwards Lifesciences Corporation Analyte sensor and fabrication methods
EP2306199A1 (de) * 2009-09-29 2011-04-06 Academisch Ziekenhuis Leiden Acting Under The Name Leiden University Medical Center Reduktive Aminierung und Analyse von Kohlenhydraten unter Verwendung von 2-Pikolinboran als Reduktionsmittel
CN102101875A (zh) * 2009-12-16 2011-06-22 中国科学院大连化学物理研究所 一种寡糖纯化分离方法
BR112012016570A2 (pt) * 2010-01-07 2016-04-05 Polymedix Inc composto, composição farmacêutica, método para antagonizar a heparina não fracionada, heparina de peso molecular baixo, ou derivado de heparina /heparina de peso molecular baixo, e, uso do composto
CN102759596B (zh) * 2012-07-09 2014-08-20 山东大学 一种低分子肝素的离子对反相色谱质谱联用检测方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011073408A2 (en) * 2009-12-18 2011-06-23 Endotis Pharma Pharmaceutical oral dosage form containing a synthetic oligosaccharide

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DAVID C. A. NEVILLE ET AL: "Development of a Single Column Method for the Separation of Lipid- and Protein-Derived Oligosaccharides", JOURNAL OF PROTEOME RESEARCH, vol. 8, no. 2, 6 February 2009 (2009-02-06), pages 681 - 687, XP055108809, ISSN: 1535-3893, DOI: 10.1021/pr800704t *
JOSÉ M. CINTRÓN ET AL: "Hydrophilic interaction chromatography with aerosol-based detectors (ELSD, CAD, NQAD) for polar compounds lacking a UV chromophore in an intravenous formulation", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 78-79, 1 May 2013 (2013-05-01), US, pages 14 - 18, XP055242173, ISSN: 0731-7085, DOI: 10.1016/j.jpba.2013.01.022 *
R.REID TOWNSEND ET AL: "Multimode High-Performance Liquid Chromatography of Fluorescently Labeled Oligosaccharides from Glycoproteins", ANALYTICAL BIOCHEMISTRY, vol. 239, no. 2, 1 August 1996 (1996-08-01), pages 200 - 207, XP055108618, ISSN: 0003-2697, DOI: 10.1006/abio.1996.0315 *
See also references of WO2015005928A1 *

Also Published As

Publication number Publication date
AU2013393832A1 (en) 2016-02-04
WO2015005928A1 (en) 2015-01-15
CA2917460A1 (en) 2015-01-15
CN105431733B (zh) 2019-01-22
JP2016524166A (ja) 2016-08-12
KR20160030963A (ko) 2016-03-21
JP6208866B2 (ja) 2017-10-04
CN105431733A (zh) 2016-03-23
AU2013393832B2 (en) 2017-11-30
EP3019861A1 (de) 2016-05-18
IL243405A0 (en) 2016-02-29

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Inventor name: CHAO, HELEN

Inventor name: WANG, CHUNGYAO

Inventor name: WU, CHIAYEN

Inventor name: CHIANG, YUNGTE

Inventor name: HUANG, IMIN

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