EP3019139A1 - Dispositif permettant la réunion de substances, en particulier pour la reconstitution de solutions d'injection - Google Patents

Dispositif permettant la réunion de substances, en particulier pour la reconstitution de solutions d'injection

Info

Publication number
EP3019139A1
EP3019139A1 EP14735596.0A EP14735596A EP3019139A1 EP 3019139 A1 EP3019139 A1 EP 3019139A1 EP 14735596 A EP14735596 A EP 14735596A EP 3019139 A1 EP3019139 A1 EP 3019139A1
Authority
EP
European Patent Office
Prior art keywords
housing
bag
pressure plate
syringe
spring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP14735596.0A
Other languages
German (de)
English (en)
Other versions
EP3019139B1 (fr
Inventor
Ludwig Daniel Weibel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Weibel CDS AG
Original Assignee
Weibel CDS AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Weibel CDS AG filed Critical Weibel CDS AG
Priority to EP14735596.0A priority Critical patent/EP3019139B1/fr
Publication of EP3019139A1 publication Critical patent/EP3019139A1/fr
Application granted granted Critical
Publication of EP3019139B1 publication Critical patent/EP3019139B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/0055—Containers or packages provided with a flexible bag or a deformable membrane or diaphragm for expelling the contents
    • B65D83/0077—Containers or packages provided with a flexible bag or a deformable membrane or diaphragm for expelling the contents moves by a spring-like mechanism

Definitions

  • the invention relates to a device for combining substances, in particular for the reconstitution of
  • Ingredients in mixed form are not storable, so that, for example, a lyophilized drug is mixed with a solvent only before administration and then grown in a syringe.
  • Cylinder can be arranged and connected to each other via piston movements.
  • a device having the features in claim 1.
  • a liquid which is usually a solvent.
  • a dispensing device is arranged, which is usually an injection syringe.
  • Other dispensers such as e.g. Dropper, Sprühgefässe or the like would be conceivable without further ado.
  • a transfer channel for the direct or indirect transfer of the liquid leads from the bag into the delivery device.
  • the hydraulic pressure for the transfer of the liquid is provided by at least one pressure plate pressable against the bag for squeezing the bag
  • the device is equipped with two printing plates, between which the bag is arranged.
  • the bag can be squeezed out so that it always remains approximately in the same plane, each of the two pressure plates must perform a smaller movement, as with a single pressure plate. Further advantages can be achieved if each pressure plate has two articulated sections which extend from an angled rest position to a stretched one
  • Squeezing position are movable. This is how they work
  • Pressure plates are not plane-parallel to the flexible bag, but there is squeezing out from the outer edge towards the center of the bag.
  • the two sections can be connected to each other, for example via a film hinge.
  • the printing plates may be made of plastic material and be produced for example by injection molding. It is also possible that the printing plates are structured on the side facing away from the bag and functional
  • the housing may have a connecting piece for connecting a container containing a second substance, wherein the connecting piece via a valve device with the
  • connection piece can be provided with coupling means for holding a container mouth as well as with a hollow needle for penetrating the closure element on the container. In this way, a container with an arbitrary substance can be connected to the device.
  • an additional container preferably also a flexible bag, to be arranged in the housing, which communicates with the transfer channel via a valve device. In this way it is possible to store the second substance already in the additional container within the housing.
  • the second substance could be this
  • valve device by a
  • Lifting movement can be brought into the open position.
  • An activatable by means of stroke movement valve device can be controlled very easily. Alternatively, there would be others
  • Valve functions conceivable as e.g. a flap valve or a tap.
  • a particularly advantageous function can be achieved if a mechanical energy store, in particular a spring mechanism is arranged as a drive in the housing, with which the pressure plate can be pressed against the bag.
  • a mechanical energy store in particular a spring mechanism is arranged as a drive in the housing, with which the pressure plate can be pressed against the bag.
  • Such an energy storage causes the pressure plate is almost always applied position-independent with the same force, wherein the transfer of the liquid always takes place in the same time.
  • Spring mechanism is particularly advantageous for this purpose, because it can be applied safely and lossless sufficient forces.
  • Alternative energy storage such as e.g. Compressed air storage or batteries for driving a micromotor would be conceivable.
  • a magnetic actuation of the printing plate would be possible in principle.
  • the lifting movement on the valve device and the pressure plate are activated with the same drive.
  • a spring mechanism with at least one coil spring is arranged in the housing.
  • Spring mechanism can be easily and inexpensively manufactured and depending on the design of the coil spring is sufficient energy for various functions available. Spring mechanisms of this type are also well known and common in other fields of technology.
  • the drive axle of the spring mechanism can be connected to a cam disk for forming the rotational movement into at least one linear force component.
  • the cam can do this in a relatively simple way
  • Torque of the spring mechanism can be converted into a linear force. Of course, this would also be done by means of a
  • the at least one pressure plate can be mounted linearly displaceable together with the bag in the housing and in particular relative to the cam. In this way, there is a lifting movement with which a valve device can be activated. In the case of using a cam, this can cooperate with engagement members on the pressure plate such that it initially performs a linear movement and is then pressed while maintaining the reached end position against the bag. This results in a compound
  • the housing may have a lid or a handle member, wherein the drive by the opening of the lid or through
  • Lid is in particular the removable from the housing
  • Dispenser protected and held in position. A
  • Activating the drive by means of the lid movement has the advantage that the transfer of the liquid from the flexible bag takes place automatically, without the need to activate further actuating means. Activation of the drive would of course also be conceivable via a pushbutton or the like.
  • the filling opening is picked up by actuating the piston and automatically takes place when it is removed from the syringe holder
  • Injection syringe or another type of dispenser is stored, which already contains a second substance. In this way, the reconstitution would give the
  • the flexible bag is advantageously arranged between two pressure plates, these either via a common drive or individually to the printing plates associated drives
  • each pressure plate can be associated with a spring mechanism with its own cam. These two cams can also have such differently shaped curve sections that the printing plates can be pressed in an asymmetrical movement against the bag. This will ensure that the bag is squeezed in such a way that no pockets of fluid remain.
  • At least one spring clip is mounted in such a clamped against the spring force rest position that it can be brought by a lifting movement from the rest position into a pressing position in which the pressure plate is pressed against the bag.
  • a spring clip can be easily manufactured and mounted in the rest position.
  • two spring clips can attack laterally on each side of the press plate.
  • Gripping element in the housing is displaceable and if by means of this displacement of the spring clip can be brought into the pressing position and at the same time arranged in a transfer channel valve device for shutting off the fluid connection between the flexible bag and the dispenser can be brought into the open position.
  • this is done by relaxing the spring clip by moving the pressure plate in the housing, this lifting movement is not due to the mechanical
  • the housing has a gripping element, this can be designed as a lever pivotable about a pivot lever, which secures the dispensing device in the housing in a closed position and, in an open position, the dispensing device
  • the flexible bag is arranged between two pressure plates, which are guided by complementary guide elements against each other pressed.
  • FIG. 1 shows a perspective view of a device with a partially removed housing and with the cover open, the device according to FIG. 1 before the opening of the device
  • FIG. Fig. 7 is a side view corresponding to FIG. 3 after the
  • FIG. 9 a top view of the device according to FIG. 7, FIG. 10: a perspective view of a spring mechanism prior to activation,
  • FIG. 11 shows the spring mechanism according to FIG. 10 after activation
  • FIG. 12 shows a cross section through the device according to FIG. 1 in the plane of the flexible bag
  • FIG. 13 shows the detail x according to FIG. 12,
  • FIG. 14 shows the device according to FIG. 12 after the opening of the
  • FIG. 15 the detail y according to FIG. 14, FIG.
  • FIG. 17 shows the detail y according to FIG. 16, FIG.
  • 18 is a side view of a closed housing with extended syringe plunger
  • Fig. 19 an enlarged cross section through the plane A-A
  • FIGS. 20a-20e the representation of the function of a
  • FIG. 21 A perspective view of the device according to
  • Fig. 1 with the housing removed and remote drive
  • Fig. 22 the apparatus of FIG. 21 with closed
  • FIG. 23 shows an alternative embodiment of a device with a gear drive
  • FIG. 24 a top view of the device according to FIG. 23, FIG. 25: a cross section through the device according to FIG. 23, FIG. 26: the detail x according to FIG. 25, 27a-27e: the function of the device according to FIG. 23 in five different steps,
  • FIG. 28 shows a further embodiment of the device with a second container inside the housing
  • FIG. 29 shows the device according to FIG. 28 after the flexible bag has been pressed out
  • FIG. 29 shows the device according to FIG. 28 after the flexible bag has been pressed out
  • FIG. 30 a cross section through the device according to FIG. 28, FIG. 31: the detail x according to FIG. 30,
  • FIG. 32 shows the device according to FIG. 30 after opening the
  • FIG. 33 the detail y according to FIG. 32, FIG.
  • FIG. 34 shows the device according to FIG. 32 after the filling of the
  • FIG. 35 shows the device according to FIG. 34 after mounting the
  • Fig. 36 a perspective view of an alternative
  • FIG. 37 shows the device according to FIG. 36, but with a partially cutaway housing, FIG.
  • Fig. 38 a view on the narrow side of the device according to
  • FIG. 36 in the direction of the arrow a
  • FIG. 39 a longitudinal section through the device according to FIG. 36
  • FIG. 40 a cross section through the device according to FIG. 36 in the plane of the flexible bag
  • FIG. 41 shows the detail E according to FIG. 40, FIG.
  • FIG. 42 shows the device according to FIG. 36 after the handle element has pivoted up, but shortly before the compression of the printing plates, FIG.
  • FIG. 43 a view of the device according to FIG. 42.
  • FIG. 44 is a perspective detail view of the
  • Printing plate suspension prior to compression 45 shows a plan view of the device according to FIG. 42 after the compression of the printing plates, FIG.
  • Fig. 46 A perspective view of the device according to
  • Fig. 42 after the compression of the printing plates
  • Fig. 47 a detailed perspective view of
  • FIG. 48 shows the device according to FIG. 46, but with the housing partially cut away, FIG.
  • FIG. 49 shows a cross section through the device according to FIG. 46 in the plane of the flexible bag
  • FIG. 50 the detail Q according to FIG. 49.
  • Lid 24 This is mounted on a cover joint 36 pivotally mounted on the housing. Inside the case is a
  • Syringe holder 29 is formed, which accommodates a syringe designated 5 clearance. Parallel next to the
  • Syringe holder are two congruent pressure plates
  • connection piece 9 from the housing 2, in which a container 10 can be inserted.
  • the syringe 5 has a
  • Injection syringe rests in a quiver 37, which runs approximately parallel to the connecting piece 9.
  • FIGs 3 to 6 show further structural details, according to the figures 3 and 4, the device is rotated such that the lid 24 is below and the connecting piece 9 above.
  • a flexible bag 3 is visible between the two pressure plates 7, 1 ', in which a liquid, such as a solvent is filled.
  • the two printing plates are in a starting position before the squeezing of the bag 3.
  • each of the two printing plates consists of two separate
  • FIG. 6 also shows a piercing mandrel 34 in the center of the connecting piece, with the aid of which a closure element of the container 10 can be pierced.
  • FIGS. 7 and 8 show the device according to FIGS. 3 and 4, but after the squeezing of the bag 3.
  • the coil spring 17 of a spring mechanism 16 surrounds in several turns a drive axle 18 which is formed in the present case as a hollow hub and which is mounted in the side wall of the housing.
  • the free end 39 of the coil spring is laterally supported on a spring stop 40.
  • the spring mechanism can be mounted from the outside, so that the coil spring exerts a torque on the drive axle 18.
  • a lock gear 32 ensures that a cam 19 is rotatable only in the drive direction, while they are when mounting the spring mechanism by a stop 30 is prevented from turning.
  • the cam plate 19 further has a press wedge segment 21, which is curved in the circumferential direction, as well as a lifting cam 20, which on a
  • the pressure plate further has a support shoulder 33 with a for
  • Press wedge segment 21 ' is assigned.
  • the latter has a somewhat flatter wedge inclination, so that the two pressure plates are acted upon by force unbalanced.
  • flexible bags are linearly displaceable relative to the two spring mechanisms, where they can cover a stroke of, for example, about 2 - 3 mm.
  • FIG 11 shows the situation after the activation of the spring mechanism and thus after the squeezing of the bag.
  • the lifting cam 20 (FIG. 10) has displaced the lifting stop 22 upwards in the course of the rotational movement of the cam disk 19, with the result that the entire unit consisting of the two pressure plates 7, 7 'and the flexible bag has made a lifting movement.
  • the press wedge segment 21 engages under the support shoulder 33, so that reversing of the lifting movement is no longer possible.
  • the lock gear 32 rotates when
  • Figures 12 to 15 shown. According to Figures 12 and 13, the device is in the starting position, in which the bag 3 with respect to a fluid channel 6 on the
  • Valve device 12 is shut off. This barrier concerns both the connection to the piercing spike 34 on the connecting piece 9, as well as to a filling opening 28 on a needle holder 27 of the injection syringe 5.
  • the injection needle 26 is through the
  • FIGS 14 and 15 show the state after opening the lid, for reasons of clarity, no container is shown in the connection piece 9.
  • Hold-down 41 relaxes the spring mechanism and this arrangement sets the stroke h ( Figure 11) back.
  • the valve device 12 is opened and the pressure plates press the flexible bag 3 together, wherein the contents of which are emptied into the container connected to the connecting piece 9, so that the injection liquid is processed.
  • Dashed line Fl is the fluid flow through the discharge channel 45 from the flexible bag through the opened one
  • the transfer channel 6 and the filling opening 28 are open in this process, so that the liquid can also expand against the syringe, as far as the piston 25 and the compressed air below it permits.
  • the piston 25 of the syringe can be pulled out, so that via the transfer channel 6 and the filling opening 28, the contents of the container is sucked into the syringe.
  • a ventilation opening 42 ensures that no vacuum builds up in the container.
  • FIG. 18 shows the outside view of a device (without cover) with inserted container 10 and drawn-out piston 25 of the injection syringe.
  • the side housing walls have a
  • Bearing opening 43 in which the hollow drive shaft 18 of the spring mechanism 16 is mounted. This storage is in FIG. 19 shown. Through the opening 43, the spring mechanism is mounted after assembly of the device and after closing the lid.
  • Injection syringe 5 are transferred in any position, but preferably in one
  • the injection syringe is then removed from the housing 2, wherein the empty syringe after application for safety reasons, in turn, can be pushed back into the housing. Subsequently, the entire unit can be disposed of.
  • FIGS. 21 and 22 again show the positions of the pressure plate sections 8a and 8b and 8a 'and 8b' before being pressed out (FIG. 21) and after being pressed out (FIG. 22). Well visible here are the pressing tracks 23a, 23b, against which the press wedge segments of the cam press in the course of the rotational movement. The outside of the Press plate sections are also provided with reinforcing ribs.
  • a common spring mechanism 50 with a locking gear 51 serves to activate both printing plates.
  • a first gear segment 52 is driven via the locking gear, which meshes with a second gear segment 53.
  • Gear segments lie on both sides of the
  • Valve device 56 ( Figure 26) is through the two
  • Control cam 57 which act on a stop 58 and thus cause a linear displacement.
  • FIG. 27 shows the sequence of the FIG.
  • the container 10 is first connected to the connecting piece 9 and then the Lid 24 opened.
  • the spring mechanism is activated (c) after which the squeezing process begins.
  • Figures 28 to 35 show a further embodiment in which no connection piece 9 is provided for connecting a container. This is within the housing a
  • Additional reservoir 13 is arranged in the form of another bag and approximately at right angles to the first bag between the two pressure plates 7.
  • the function of the pressure plate assembly after the release of the spring mechanism is the same as in the first embodiment, i. the pressure plate assembly with the first bag first returns a lifting motion, so that the lift valve 15 (FIGS. 31 and 33) is opened.
  • Liquid then passes via the transfer channel 6 and via a valve device 14 first into the additional container 13. This is likewise a lifting valve analogous to the lifting valve 15 on the first bag. After filling the additional container, as shown in Figure 34, the processed passes
  • the additional container 13 may be associated with a second substance, which may be either solid or liquid.
  • the device generally designated 1 has a housing 2 with a laterally disposed syringe holder 29 and with a connecting piece 9 for connecting a not here illustrated container.
  • a connecting piece 9 for connecting a not here illustrated container In addition to the connecting piece of the quiver 37 for receiving the syringe needle is visible ( Figure 36).
  • Laterally in the housing recesses 64 are arranged so that the two pressure plates 63, 63 ⁇ ( Figure 37) from the outside is visible.
  • An angled handle member 61 is about pivot pin 62nd
  • the two pressure plates are suspended laterally displaceable at its upper end, as shown in FIG. 40.
  • the grip element 61 is provided with a continuous eccentric 67, which extends between the two
  • Pivot pin 62 extends. At this cam plate, the two pressure plates 63, 63 ⁇ suspended from a hook-like suspension 68.
  • the flexible bag 3 is at its lower end with a
  • Beutelab Press 69 provided, which is part of a
  • Valve device 12 is, as shown in Figure 41.
  • the operating state according to FIG. 41 thus essentially corresponds to that according to FIG. 13. It is therefore not necessary to describe all the details again.
  • Transverse guide 70 is connected to the bag connection 69 so that it can be seen together with the printing plates

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif (1) présentant un boîtier (2) et un sachet flexible disposé dans le boîtier et destiné à loger un liquide. Par ailleurs, un dispositif de distribution, en particulier une seringue (5), est disposé dans le boîtier de telle manière qu'il peut être prélevé du boîtier. Un canal de transfert (6) sert au transfert direct ou indirect du liquide du sachet dans le dispositif de distribution. Par ailleurs, au moins une plaque de pression (17) pouvant être pressée contre le sachet est destinée à exprimer l'intérieur du sachet. La plaque de pression est de préférence activée par l'intermédiaire d'un entraînement par ressort (16), lequel sert d'accumulateur d'énergie. Le dispositif selon l'invention permet de préparer un liquide d'injection en quelques manipulations et de l'amener à la seringue, la réunion des substances se déroulant en grande partie de manière automatisée.
EP14735596.0A 2013-07-11 2014-07-07 Dispositif d'assemblage de substances, notamment pour la reconstitution de solutions d'injection Active EP3019139B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP14735596.0A EP3019139B1 (fr) 2013-07-11 2014-07-07 Dispositif d'assemblage de substances, notamment pour la reconstitution de solutions d'injection

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13176031.6A EP2823798A1 (fr) 2013-07-11 2013-07-11 Dispositif d'assemblage de substances, notamment pour la reconstitution de solutions d'injection
PCT/EP2014/064441 WO2015004056A1 (fr) 2013-07-11 2014-07-07 Dispositif permettant la réunion de substances, en particulier pour la reconstitution de solutions d'injection
EP14735596.0A EP3019139B1 (fr) 2013-07-11 2014-07-07 Dispositif d'assemblage de substances, notamment pour la reconstitution de solutions d'injection

Publications (2)

Publication Number Publication Date
EP3019139A1 true EP3019139A1 (fr) 2016-05-18
EP3019139B1 EP3019139B1 (fr) 2017-04-19

Family

ID=48808162

Family Applications (2)

Application Number Title Priority Date Filing Date
EP13176031.6A Withdrawn EP2823798A1 (fr) 2013-07-11 2013-07-11 Dispositif d'assemblage de substances, notamment pour la reconstitution de solutions d'injection
EP14735596.0A Active EP3019139B1 (fr) 2013-07-11 2014-07-07 Dispositif d'assemblage de substances, notamment pour la reconstitution de solutions d'injection

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP13176031.6A Withdrawn EP2823798A1 (fr) 2013-07-11 2013-07-11 Dispositif d'assemblage de substances, notamment pour la reconstitution de solutions d'injection

Country Status (4)

Country Link
US (1) US9801789B2 (fr)
EP (2) EP2823798A1 (fr)
CN (1) CN105407856B (fr)
WO (1) WO2015004056A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106176223A (zh) * 2016-08-30 2016-12-07 无锡兰桂医疗股份有限公司 一种新型自动配药装置
US11752070B2 (en) * 2017-11-21 2023-09-12 Sanofi Mixing and/or reconstitution system

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6056157A (en) * 1994-03-14 2000-05-02 Gehl's Guernsey Farms, Inc. Device for dispensing flowable material from a flexible package
US8292848B2 (en) * 2006-07-31 2012-10-23 Bio Quiddity, Inc. Fluid dispensing device with additive
US8225824B2 (en) * 2007-11-16 2012-07-24 Intelligent Hospital Systems, Ltd. Method and apparatus for automated fluid transfer operations
EP2627604A4 (fr) * 2010-10-12 2016-01-13 Tripp Middleton Systèmes de distribution de liquide
KR101559219B1 (ko) 2011-03-25 2015-10-12 가부시키가이샤 유야마 세이사쿠쇼 혼합 주사 장치
CA2745320A1 (fr) 2011-07-06 2013-01-06 Duoject Medical Systems Inc. Dispositif de reconstitution
EP2559414A1 (fr) 2011-08-18 2013-02-20 Weibel CDS AG Adaptateur pour un dispositif de transfert pour un fluide et dispositif de transfert

Also Published As

Publication number Publication date
CN105407856B (zh) 2019-01-04
US20160136053A1 (en) 2016-05-19
CN105407856A (zh) 2016-03-16
EP3019139B1 (fr) 2017-04-19
EP2823798A1 (fr) 2015-01-14
US9801789B2 (en) 2017-10-31
WO2015004056A1 (fr) 2015-01-15

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