EP3019139B1 - Dispositif d'assemblage de substances, notamment pour la reconstitution de solutions d'injection - Google Patents

Dispositif d'assemblage de substances, notamment pour la reconstitution de solutions d'injection Download PDF

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Publication number
EP3019139B1
EP3019139B1 EP14735596.0A EP14735596A EP3019139B1 EP 3019139 B1 EP3019139 B1 EP 3019139B1 EP 14735596 A EP14735596 A EP 14735596A EP 3019139 B1 EP3019139 B1 EP 3019139B1
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EP
European Patent Office
Prior art keywords
housing
bag
pressure plate
syringe
spring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP14735596.0A
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German (de)
English (en)
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EP3019139A1 (fr
Inventor
Ludwig Daniel Weibel
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Weibel CDS AG
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Weibel CDS AG
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Priority to EP14735596.0A priority Critical patent/EP3019139B1/fr
Publication of EP3019139A1 publication Critical patent/EP3019139A1/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/0055—Containers or packages provided with a flexible bag or a deformable membrane or diaphragm for expelling the contents
    • B65D83/0077—Containers or packages provided with a flexible bag or a deformable membrane or diaphragm for expelling the contents moves by a spring-like mechanism

Definitions

  • the invention relates to a device for combining substances, in particular for the reconstitution of injection solutions.
  • Such devices are needed, for example, for injection solutions whose ingredients are not storable in a mixed form, so that, for example, a lyophilized drug is mixed with a solvent before administration and then drawn into a syringe.
  • the WO2012 / 133052 also describes a reconstitution device.
  • a disadvantage of the known systems is that in some cases up to 20 working steps have to be carried out until the injection solution is drawn up in the syringe and ready for injection. It also requires a degree of care and skill, with frequent misuse. Finally, in many systems, different components must be stored separately, which increases the overall cost.
  • the handling should be as simple and safe as possible.
  • a device having the features in claim 1.
  • the arranged in a housing, flexible bag serves to receive a liquid, which is usually a solvent.
  • a dispensing device is arranged, which is usually an injection syringe.
  • Other dispensers such as e.g. Dropper, Sprühgefässe or the like would be conceivable without further ado.
  • a transfer channel for the direct or indirect transfer of the liquid leads from the bag into the delivery device.
  • the hydraulic pressure for the transfer of the liquid is applied by at least one pressable against the bag pressure plate for squeezing the bag. These at least one pressure plate is housed in the mentioned housing, so that the device forms a compact unit, which can be easily stored and transported.
  • the device is equipped with two printing plates, between which the bag is arranged.
  • the bag can be squeezed out so that it always remains approximately in the same plane, each of the two pressure plates must perform a smaller movement, as with a single pressure plate.
  • each pressure plate has two articulated sections which are movable from an angled rest position to an extended squish position.
  • the pressure plates do not act plane-parallel to the flexible bag, but there is squeezing out from the outer edge towards the center of the bag.
  • the two sections can be connected to each other, for example via a film hinge.
  • the printing plates may be made of plastic material and be produced for example by injection molding. It is also possible that the printing plates are structured on the side facing away from the bag and functional elements such. Reinforcing ribs, cams or the like.
  • the housing may have a connecting piece for connecting a container containing a second substance, wherein the connecting piece communicates via a valve device with the transfer channel and / or with the flexible bag.
  • This connection piece can be provided with coupling means for holding a container mouth as well as with a hollow needle for penetrating the closure element on the container. In this way, a container with an arbitrary substance can be connected to the device.
  • an additional container preferably also a flexible bag, to be arranged in the housing, which communicates with the transfer channel via a valve device.
  • an additional container preferably also a flexible bag
  • the housing which communicates with the transfer channel via a valve device.
  • the second substance could also be a liquid.
  • valve device for shutting off the fluid connection between the flexible bag and the dispensing device is arranged in the transfer channel, wherein the valve device can be brought into the open position by a lifting movement.
  • An activatable by means of stroke movement valve device can be controlled very easily.
  • other valve functions would be conceivable such. a flap valve or a tap.
  • a particularly advantageous function can be achieved if a mechanical energy store, in particular a spring mechanism is arranged as a drive in the housing, with which the pressure plate can be pressed against the bag.
  • a mechanical energy store in particular a spring mechanism is arranged as a drive in the housing, with which the pressure plate can be pressed against the bag.
  • Such an energy storage causes the pressure plate is almost always applied position-independent with the same force, wherein the transfer of the liquid always takes place in the same time.
  • a spring mechanism is particularly advantageous for this purpose, because it can be applied safely and lossless sufficient forces.
  • Alternative energy storage such as e.g. Compressed air storage or batteries for driving a micromotor would be conceivable.
  • a magnetic actuation of the printing plate would be possible in principle.
  • the lifting movement on the valve device and the pressure plate are activated with the same drive.
  • these movements can be performed sequentially.
  • the lifting movement or another movement for valve actuation is performed manually and that with the help of the drive, only the pressure plate is activated.
  • a spring mechanism with at least one coil spring is arranged in the housing.
  • Such a spring mechanism is simple and inexpensive to produce and depending on the design of the coil spring is sufficient energy for various functions available.
  • Spring mechanisms of this type are also well known and common in other fields of technology.
  • the drive axle of the spring mechanism can be connected to a cam disk for forming the rotational movement into at least one linear force component.
  • By means of the cam can be converted into a linear force in a relatively simple manner, the torque of the spring mechanism.
  • the at least one pressure plate can be mounted linearly displaceable together with the bag in the housing and in particular relative to the cam. In this way, there is a lifting movement with which a valve device can be activated. In the case of using a cam, this can cooperate with engaging members on the pressure plate such that it initially performs a linear movement and is then pressed while maintaining the reached end position against the bag. This results in a composite movement, with the help of which the valve is first actuated, in order subsequently to effect the transfer of the liquid.
  • the squeezing of the bag could also be done with other mechanical means, for example via a linkage or over against the pressure plate pressable rollers or pins or directly via a spring which presses directly against the pressure plate.
  • the housing may have a lid or a handle element, wherein the drive can be activated by opening the lid or by actuating the handle element.
  • the drive can be activated by opening the lid or by actuating the handle element.
  • the lid With the help of the lid, in particular the removable from the housing dispenser is protected and held in position.
  • Activation of the drive by means of the lid movement has the advantage that the transfer of the liquid from the flexible bag takes place automatically, without the need for activating further actuating means.
  • Activation of the drive would of course also be conceivable via a pushbutton or the like.
  • a particularly advantageous transfer of the liquid into an injection syringe with a filling opening mounted in the housing can take place in that the injection syringe has a needle holder which communicates with the transfer channel, wherein the filling opening can be closed during removal of the injection syringe from a syringe holder.
  • the piston is retracted.
  • the solution for injection is taken up via the filling opening by actuation of the piston and when removing it from the syringe holder, the filling opening closes automatically so that the solution for injection can only be dispensed via the needle.
  • Such mechanisms are already known per se and, for example, in the EP 2 559 414 described.
  • hypodermic syringe or another type of dispensing device is stored in the housing, which already contains a second substance. In this way, the reconstitution of the liquid to be dispensed would take place directly in the dispenser itself.
  • the flexible bag is advantageously arranged between two printing plates, which can be activated either via a common drive or individually assigned to the printing plates drives.
  • each pressure plate can be associated with a spring mechanism with its own cam.
  • These two cams can also have such differently shaped curve sections that the printing plates can be pressed in an asymmetrical movement against the bag. This will ensure that the bag is squeezed in such a way that no pockets of fluid remain.
  • An advantageous embodiment of the mechanical energy storage can be achieved if in the housing at least one spring clip is mounted in such a clamped against the spring force rest position that it can be brought by a lifting movement from the rest position to a pressing position in which the pressure plate against the bag can be pressed ,
  • a spring clip can be easily manufactured and mounted in the rest position.
  • two spring clips can attack laterally on each side of the press plate.
  • the pressure plate is displaceable by opening the lid or by pressing the handle member in the housing and if by means of this displacement of the spring clip can be brought into the pressing position and at the same time arranged in the transfer channel valve device for shutting off the fluid connection between the flexible Bag and the dispenser can be brought into the open position.
  • this is done by relaxing the spring clip by moving the pressure plate in the housing, wherein this lifting movement is not done by the mechanical energy storage, but manually. Since no particularly high forces must be exercised, this solution leads to a reduction of the moving components and thus to a simplification.
  • the housing has a grip element
  • this may be designed as a pivotable about a hinge lever, which secures the dispenser in the housing in a closed position and releases the dispenser in an open position.
  • the cover or the grip element can be operatively connected to the pressure plate via a lever mechanism such that a rotational movement on the cover or on the grip element can be transmitted in a linear movement on the pressure plate.
  • the flexible bag is arranged between two pressure plates, which are guided by complementary guide elements against each other pressed.
  • a designated 1 device essentially of a housing 2, with a lid 24. This is mounted on a cover joint 36 pivotally mounted on the housing.
  • a syringe holder 29 is formed, which receives a syringe designated 5 play.
  • Parallel to the syringe holder two congruent pressure plates are arranged, of which only the one pressure plate 7 is visible here.
  • a spring mechanism 16 is fixedly mounted in the housing, whose function will be described in more detail below.
  • Below the two pressure plates protrudes a connection piece 9 from the housing 2, in which a container 10 can be inserted.
  • the syringe 5 has a piston 25, which, however, in the starting position according to FIG. 2 retracted.
  • the needle of the injection syringe which is not visible here, rests in a quiver 37, which runs approximately parallel to the connecting piece 9.
  • FIGS. 3 to 6 show further structural details, according to the FIGS. 3 and 4 the device is rotated such that the cover 24 is below and the connecting piece 9 above.
  • FIG. 4 is visible between the two pressure plates 7, 7 'a flexible bag 3, in which a liquid, such as a solvent is filled.
  • the two printing plates are in a starting position before the squeezing of the bag 3.
  • each of the two pressure plates consists of two separate sections 8a, 8b, which are hinged together along a film hinge 38.
  • Each pressure plate 7 and 7 ' is assigned its own spring mechanism 16 and 16', wherein each spring mechanism has a spiral spring 17.
  • FIG. 6 is still a piercing mandrel 34 visible in the center of the connecting piece, with the aid of a closure element of the container 10 can be pierced.
  • FIGS. 7 and 8 show the device according to the FIGS. 3 and 4 However, after the squeezing of the bag 3. This is now flat between the two pressure plates 7 and 7 ', which are moved together plane-parallel under the action of the two spring mechanisms 16 and 16'. The originally slightly angled plate sections 8a, 8b, are now stretched flat.
  • the coil spring 17 of a spring mechanism 16 surrounds in several turns a drive axle 18 which is formed in the present case as a hollow hub and which is mounted in the side wall of the housing.
  • the free end 39 of the coil spring is laterally supported on a spring stop 40.
  • the spring mechanism can be mounted from the outside, so that the coil spring exerts a torque on the drive axle 18.
  • a lock gear 32 ensures that a cam 19 is rotatable only in the drive direction, while they are when mounting the spring mechanism by a stop 30 is prevented from turning.
  • the cam 19 further has a press wedge segment 21, which is curved in the circumferential direction, as well as a lifting cam 20 which bears against a stroke stop 22 of the pressure plate 7.
  • the pressure plate further has a support shoulder 33 with a curvature corresponding to the press wedge segment 21.
  • a similar spring mechanism is arranged, which is also associated with a press wedge segment 21 '.
  • the latter has a somewhat flatter wedge inclination, so that the two pressure plates are acted upon by force unbalanced.
  • the two pressure plates with the flexible bag arranged therebetween are linearly displaceable relative to the two spring mechanisms, wherein they can cover a stroke of, for example, about 2 to 3 mm.
  • FIG. 11 shows the situation after activation of the spring mechanism and thus after the squeezing of the bag.
  • the lifting cam 20 ( FIG. 10 ) has the stroke stop 22 in the course of the rotational movement of the cam 19 is shifted upward, so that the entire unit consisting of the two pressure plates 7, 7 'and the flexible bag has made a lifting movement.
  • the press wedge segment 21 engages under the support shoulder 33, so that reversing of the lifting movement is no longer possible.
  • the locking gear 32 continues to rotate when relaxing the coil spring 17, the cam 19, wherein the press wedge segment 21 exerts a pressing force on the pressure plate 7. Exactly the same process takes place on the opposite side. Over the stroke h returned by the linear displacement of the press plates, the flexible bag is short-circuited to the transfer channel.
  • FIGS. 12 to 15 The valve functions and the fluid connections are in the FIGS. 12 to 15 shown.
  • the device is in the starting position in which the bag 3 is shut off with respect to a fluid channel 6 via the valve device 12.
  • This shut-off relates both to the connection to the piercing spike 34 on the connecting piece 9 and to a filling opening 28 on a needle holder 27 of the injection syringe 5.
  • the injection needle 26 is held by the needle holder 27.
  • FIG. 12 is also apparent that the lid 24, a hold-down element 41 is arranged, with which the pressure plate assembly is held with the bag 3 in the starting position.
  • the filling of the liquid in the flexible bag 3 is carried out in the fully assembled state via a filling channel 44. This is then inextricably closed by means of a plug 46.
  • FIGS. 14 and 15 show the state after opening the lid, for reasons of clarity, no container is shown in the connection piece 9.
  • the spring mechanism relaxes and this arrangement sets the stroke h ( FIG. 11 ) back.
  • the valve device 12 is opened and the pressure plates press the flexible bag 3 together, wherein the contents of which are emptied into the container connected to the connecting piece 9, so that the injection liquid is processed.
  • the dashed line F1 the fluid flow through the discharge channel 45 from the flexible bag through the open valve device 12 and through the connecting stems 9 in the connected container shown.
  • the transfer channel 6 and the filling opening 28 are open in this process, so that the liquid can also expand against the syringe, as far as the piston 25 and the compressed air below it permits.
  • the piston 25 of the syringe can be pulled out, so that via the transfer channel 6 and the filling opening 28, the contents of the container is sucked into the syringe.
  • a ventilation opening 42 ensures that no vacuum builds up in the container.
  • FIGS. 16 and 17 is shown in an alternative sectional view, the connection between the bag 3 and the connecting piece 9, wherein the position 35 shows the bag connection. Since the cutting plane is not in the central axis of the connecting piece 9, this is shown only as a sub-segment.
  • FIG. 18 shows the outside of a device (without lid) with inserted container 10 and drawn-out piston 25 of the syringe.
  • the lateral housing walls have a bearing opening 43, in which the hollow drive axle 18 of the spring mechanism 16 is mounted. This storage is in FIG. 19 shown. Through the opening 43, the spring mechanism is mounted after assembly of the device and after closing the lid.
  • FIGS. 21 and 22 show by way of illustration again the positions of the pressure plate sections 8a and 8b and 8a 'and 8b' before pressing ( FIG. 21 ) and after pressing ( FIG. 22 ).
  • Well visible here are the pressing tracks 23a, 23b, against which the press wedge segments of the cam press in the course of the rotational movement.
  • the outside of the Press plate sections are also provided with reinforcing ribs.
  • FIGS. 23 to 26 an alternative embodiment is shown, in which the Auspressmechanismus differs from that of the aforementioned embodiment.
  • a common spring mechanism 50 with a locking gear 51 serves to activate both printing plates.
  • a first gear segment 52 is driven via the locking gear, which meshes with a second gear segment 53.
  • the axes of rotation of the two gear segments lie on both sides of the pressure plate assembly.
  • the gear segments move in opposite directions and they are provided with pressing elements 55 which are pressed against the pressure plates 54 ( FIG. 25 ).
  • the opposite movement of the two gear segments 52 and 53 causes a squeezing of the bag 3.
  • FIG. 27 Analogous to FIG. 20 shows FIG. 27 the flow of liquid transfer in the alternative embodiment.
  • the container 10 is first connected to the connecting piece 9 and then the Lid 24 opened.
  • the spring mechanism is activated (c) after which the squeezing process begins.
  • FIGS. 28 to 35 show a further embodiment in which no connection piece 9 is provided for connecting a container.
  • an additional container 13 is arranged in the form of another bag within the housing and approximately at right angles to the first bag between the two pressure plates 7.
  • the function of the pressure plate assembly after the release of the spring mechanism is the same as in the first embodiment, ie the pressure plate assembly with the first bag first returns a lifting movement, so that the lift valve 15 ( FIG. 31 and 33 ) is opened.
  • the liquid passes via the transfer channel 6 and via a valve device 14 first into the additional tank 13. This is likewise a lifting valve analogous to the lifting valve 15 on the first bag.
  • the treated injection liquid enters the injection syringe 5 as described above.
  • the additional container 13 may be associated with a second substance, which may be either solid or liquid.
  • the device generally designated 1 has a housing 2 with a laterally disposed syringe holder 29 and with a connecting piece 9 for connecting a not here illustrated container.
  • the quiver 37 is visible for receiving the syringe needle ( FIG. 36 ).
  • Recesses 64 are arranged laterally in the housing so that the two pressure plates 63, 63 '(FIGS. FIG. 37 ) are visible from the outside.
  • An angled handle member 61 is pivotally mounted about pivot pin 62, wherein the pivot pin engage in corresponding openings in the housing 2.
  • the grip element secures the syringe mounted in the syringe holder 29.
  • two spring clips 60 are provided, of which in the FIGS. 36, 37 and 38 only one is visible.
  • the ends of these spring clips rest in angled spring bearings 65, which are arranged laterally on the pressure plates 63 and 63 '.
  • These spring bearings 65 are in turn supported on abutments 66 on the housing 2, these abutments are open to the top.
  • the pressure plates 63 and 63 ' remain in this way in their clamped position, in which they do not touch the flexible bag 3 ( Figures 38 and 39 ).
  • the two pressure plates are suspended laterally displaceable at its upper end, as seen from FIG. 40 is apparent.
  • the grip element 61 is provided with a continuous eccentric bar 67 which extends between the two pivot pins 62. At this eccentric the two pressure plates 63, 63 'are suspended on a hook-like suspension 68.
  • the flexible bag 3 is provided at its lower end with a bag end 69, which is part of a valve device 12, as shown FIG. 41 evident.
  • a bag end 69 which is part of a valve device 12, as shown FIG. 41 evident.
  • the operating state according to FIG. 41 thus essentially corresponds to that according to FIG. 13 , It is therefore not necessary to describe all the details again.
  • FIG. 47 It can be seen how the two pressure plates are guided on their suspension or on the eccentric 67.
  • the connecting piece 9 facing the end of the two printing plates are guided in a transverse guide 70 with transverse groove.
  • the printing plates on the bottom have a guide extension 71 which engages in the transverse groove.
  • the transverse guide 70 is connected to the bag connection 69, so that it is evidently lifted together with the printing plates.
  • FIG. 49 is again the raised position can be seen, the eccentric 67 engages under the pivoting movement about the pivot pin 62, the suspension 68 and raises.
  • FIG. 50 is brought by the lifting movement of the bag connection 69, the valve device 12 in an open position, so that the contents of the flexible bag 3 can be pressed into the container at the connecting piece 9.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (20)

  1. Dispositif (1) pour l'assemblage de substances, en particulier pour la reconstitution de solutions d'injection, comprenant:
    - un boîtier (2),
    - un sac flexible (3) disposé dans le boîtier, destiné à contenir un liquide (4),
    - un dispositif de délivrance disposé dans le boîtier et pouvant être retiré hors du boîtier, en particulier une seringue d'injection (5),
    - un canal de transfert (6) pour le transfert direct ou indirect du liquide du sac au dispositif de délivrance,
    caractérisé par au moins une plaque de pression (7) applicable contre le sac (3) pour vider le sac par pression.
  2. Dispositif selon la revendication 1, caractérisé en ce qu'il présente deux plaques de pression (7, 7'), entre lesquelles le sac (3) est disposé.
  3. Dispositif selon la revendication 1 ou 2, caractérisé en ce que la plaque de pression (7) présente deux parties (8a, 8b) reliées l'une à l'autre de façon articulée, qui sont mobiles d'une position de repos angulaire à une position d'écrasement tendue.
  4. Dispositif selon l'une quelconque des revendications 1 à 3, caractérisé en ce que le boîtier (2) présente un embout de raccordement (9) pour le raccordement d'un réservoir (10) contenant une deuxième substance (11), dans lequel l'embout de raccordement communique par un dispositif de soupape (12) avec le canal de transfert (6) et/ou avec le sac flexible (3).
  5. Dispositif selon l'une quelconque des revendications 1 à 4, caractérisé en ce qu'un récipient supplémentaire (15), de préférence également un sac flexible, est disposé dans le boîtier (2), et communique par un dispositif de soupape (14) avec le canal de transfert (6).
  6. Dispositif selon l'une quelconque des revendications 1 à 5, caractérisé en ce qu'un dispositif de soupape (15) est disposé dans le canal de transfert (6) pour la fermeture de la liaison fluidique entre le sac flexible (3) et le dispositif de délivrance, dans lequel le dispositif de soupape peut être amené dans la position ouverte par un mouvement de levée.
  7. Dispositif selon l'une quelconque des revendications 1 à 6, caractérisé en ce qu'un accumulateur d'énergie mécanique, en particulier un système de ressort (16), est disposé dans le boîtier (2) en tant qu'entraînement, avec lequel la plaque de pression (7) peut être pressée contre le sac (3).
  8. Dispositif selon la revendication 6 et la revendication 7, caractérisé en ce que le mouvement de levée au dispositif de soupape (15) et la plaque de pression (7) peuvent être activés avec le même entraînement.
  9. Dispositif selon la revendication 7 ou 8, caractérisé en ce qu'un système de ressort (16) avec au moins un ressort hélicoïdal (17) est disposé dans le boîtier (2), dans lequel l'axe d'entraînement (18) du système de ressort est relié à un disque de came (19) pour la conversion du mouvement de rotation en au moins une composante de force linéaire.
  10. Dispositif selon la revendication 9, caractérisé en ce que la plaque de pression (7) est montée de façon déplaçable de concert avec le sac (3) dans le boîtier (2) et linéairement par rapport au disque de came et en ce que le disque de came (19) coopère avec des organes d'engagement (20, 21) sur la plaque de pression (7), de telle manière que celle-ci effectue d'abord un mouvement linéaire et soit ensuite pressée contre le sac (3) en conservant la position finale atteinte.
  11. Dispositif selon l'une quelconque des revendications 7 à 10, caractérisé en ce que le boîtier (2) présente un couvercle (24) et un élément de prise et en ce que l'entraînement peut être activé par l'ouverture du couvercle ou par l'actionnement de l'élément de prise.
  12. Dispositif selon l'une quelconque des revendications 1 à 11, caractérisé en ce qu'une seringue d'injection (5) avec un piston rentré (25) est montée dans un support de seringue (29) dans le boîtier, et en ce que la seringue d'injection présente un support d'aiguille (27) avec une ouverture de remplissage (28), qui communique avec le canal de transfert (6), dans lequel l'ouverture de remplissage peut être fermée lors du prélèvement de la seringue d'injection hors du support de seringue.
  13. Dispositif selon l'une quelconque des revendications 1 à 12, caractérisé en ce qu'une seringue d'injection (5), qui contient une deuxième substance, est montée dans le boîtier (2).
  14. Dispositif selon la revendication 9 ou 10, caractérisé en ce que le sac (3) est disposé entre deux plaques de pression (7, 7') et en ce qu'un système de ressort (16, 16') avec un disque de came est associé à chaque plaque de pression.
  15. Dispositif selon la revendication 14, caractérisé en ce que les deux disques de came présentent des parties de came de formes différentes, de telle manière que les plaques de pression (7, 7') puissent être pressées en un mouvement non symétrique contre le sac.
  16. Dispositif selon la revendication 7, caractérisé en ce qu'au moins un étrier élastique (60) est monté dans le boîtier (2) dans une position de repos serrée contre la force élastique, de telle manière qu'il puisse être amené, par un mouvement de levée à partir de la position de repos, dans une position de pressage, dans laquelle la plaque de pression peut être pressée contre le sac (3).
  17. Dispositif selon la revendication 11 et la revendication 16, caractérisé en ce que la plaque de pression peut être déplacée dans le boîtier par l'ouverture du couvercle ou par l'actionnement de l'élément de prise et en ce qu'au moyen de ce déplacement l'étrier élastique (60) peut être amené dans la position de pressage et en même temps un dispositif de soupape (12) disposé dans le canal de transfert pour fermer la liaison fluidique entre le sac flexible (3) et le dispositif de délivrance peut être amené dans la position ouverte.
  18. Dispositif selon la revendication 11 ou 17, comprennent un élément de prise, caractérisé en ce que l'élément de prise est réalisé sous la forme d'un levier pivotant autour d'une rotule, qui dans une position de fermeture bloque le dispositif de délivrance dans le boîtier et dans une position d'ouverture libère le dispositif de délivrance.
  19. Dispositif selon la revendication 17 ou 18, caractérisé en ce que le couvercle ou l'élément de prise est en liaison active avec la plaque de pression au moyen d'un mécanisme à leviers, de telle manière qu'un mouvement de rotation au couvercle ou à l'élément de prise puisse être transmis sous forme de mouvement linéaire à la plaque de pression.
  20. Dispositif selon la revendication 2, et l'une quelconque des revendications 16 à 19, caractérisé en ce que les deux plaques de pression peuvent être pressées l'une contre l'autre en étant guidées par des éléments de guidage complémentaires.
EP14735596.0A 2013-07-11 2014-07-07 Dispositif d'assemblage de substances, notamment pour la reconstitution de solutions d'injection Active EP3019139B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP14735596.0A EP3019139B1 (fr) 2013-07-11 2014-07-07 Dispositif d'assemblage de substances, notamment pour la reconstitution de solutions d'injection

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13176031.6A EP2823798A1 (fr) 2013-07-11 2013-07-11 Dispositif d'assemblage de substances, notamment pour la reconstitution de solutions d'injection
EP14735596.0A EP3019139B1 (fr) 2013-07-11 2014-07-07 Dispositif d'assemblage de substances, notamment pour la reconstitution de solutions d'injection
PCT/EP2014/064441 WO2015004056A1 (fr) 2013-07-11 2014-07-07 Dispositif permettant la réunion de substances, en particulier pour la reconstitution de solutions d'injection

Publications (2)

Publication Number Publication Date
EP3019139A1 EP3019139A1 (fr) 2016-05-18
EP3019139B1 true EP3019139B1 (fr) 2017-04-19

Family

ID=48808162

Family Applications (2)

Application Number Title Priority Date Filing Date
EP13176031.6A Withdrawn EP2823798A1 (fr) 2013-07-11 2013-07-11 Dispositif d'assemblage de substances, notamment pour la reconstitution de solutions d'injection
EP14735596.0A Active EP3019139B1 (fr) 2013-07-11 2014-07-07 Dispositif d'assemblage de substances, notamment pour la reconstitution de solutions d'injection

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP13176031.6A Withdrawn EP2823798A1 (fr) 2013-07-11 2013-07-11 Dispositif d'assemblage de substances, notamment pour la reconstitution de solutions d'injection

Country Status (4)

Country Link
US (1) US9801789B2 (fr)
EP (2) EP2823798A1 (fr)
CN (1) CN105407856B (fr)
WO (1) WO2015004056A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106176223A (zh) * 2016-08-30 2016-12-07 无锡兰桂医疗股份有限公司 一种新型自动配药装置
US11752070B2 (en) * 2017-11-21 2023-09-12 Sanofi Mixing and/or reconstitution system

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6056157A (en) * 1994-03-14 2000-05-02 Gehl's Guernsey Farms, Inc. Device for dispensing flowable material from a flexible package
US8292848B2 (en) * 2006-07-31 2012-10-23 Bio Quiddity, Inc. Fluid dispensing device with additive
US8225824B2 (en) * 2007-11-16 2012-07-24 Intelligent Hospital Systems, Ltd. Method and apparatus for automated fluid transfer operations
CN103261084A (zh) * 2010-10-12 2013-08-21 特里普·米德尔顿 液体分配系统
WO2012133052A1 (fr) * 2011-03-25 2012-10-04 株式会社湯山製作所 Dispositif de co-perfusion
CA2745320A1 (fr) 2011-07-06 2013-01-06 Duoject Medical Systems Inc. Dispositif de reconstitution
EP2559414A1 (fr) 2011-08-18 2013-02-20 Weibel CDS AG Adaptateur pour un dispositif de transfert pour un fluide et dispositif de transfert

Also Published As

Publication number Publication date
US9801789B2 (en) 2017-10-31
EP3019139A1 (fr) 2016-05-18
CN105407856B (zh) 2019-01-04
CN105407856A (zh) 2016-03-16
EP2823798A1 (fr) 2015-01-14
US20160136053A1 (en) 2016-05-19
WO2015004056A1 (fr) 2015-01-15

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