EP2920587B1 - Assay wick with analyte fluid sufficiency indicator - Google Patents

Assay wick with analyte fluid sufficiency indicator Download PDF

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Publication number
EP2920587B1
EP2920587B1 EP13854971.2A EP13854971A EP2920587B1 EP 2920587 B1 EP2920587 B1 EP 2920587B1 EP 13854971 A EP13854971 A EP 13854971A EP 2920587 B1 EP2920587 B1 EP 2920587B1
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EP
European Patent Office
Prior art keywords
wick
indicator
primary
analyte
fluid
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EP13854971.2A
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German (de)
English (en)
French (fr)
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EP2920587A1 (en
EP2920587A4 (en
Inventor
Bennett C. Ward
Jian Xiang
Stacey TIBBS
Yelena N. Rogova
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Essentra Porous Technologies Corp
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Essentra Porous Technologies Corp
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    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/02—Forms or constructions
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F25/00—Devices used by the smoker for controlling the moisture content of, or for scenting, cigars, cigarettes or tobacco
    • A24F25/02—Moistening devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
    • B65D81/22—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient in moist conditions or immersed in liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
    • B65D85/07—Containers, packaging elements or packages, specially adapted for particular articles or materials for compressible or flexible articles
    • B65D85/08—Containers, packaging elements or packages, specially adapted for particular articles or materials for compressible or flexible articles rod-shaped or tubular
    • B65D85/10—Containers, packaging elements or packages, specially adapted for particular articles or materials for compressible or flexible articles rod-shaped or tubular for cigarettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
    • B65D85/07—Containers, packaging elements or packages, specially adapted for particular articles or materials for compressible or flexible articles
    • B65D85/08—Containers, packaging elements or packages, specially adapted for particular articles or materials for compressible or flexible articles rod-shaped or tubular
    • B65D85/10—Containers, packaging elements or packages, specially adapted for particular articles or materials for compressible or flexible articles rod-shaped or tubular for cigarettes
    • B65D85/1081—Inserts or accessories added or joined to the container, e.g. coins, pens, cards, spacers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/02—Forms or constructions
    • G09F3/0291—Labels or tickets undergoing a change under particular conditions, e.g. heat, radiation, passage of time
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/02—Forms or constructions
    • G09F3/0291—Labels or tickets undergoing a change under particular conditions, e.g. heat, radiation, passage of time
    • G09F3/0294—Labels or tickets undergoing a change under particular conditions, e.g. heat, radiation, passage of time where the change is not permanent, e.g. labels only readable under a special light, temperature indicating labels and the like
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/08—Fastening or securing by means not forming part of the material of the label itself
    • G09F3/10—Fastening or securing by means not forming part of the material of the label itself by an adhesive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B2010/0003—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements including means for analysis by an unskilled person
    • A61B2010/0006—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements including means for analysis by an unskilled person involving a colour change
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B2010/0009—Testing for drug or alcohol abuse
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/02—Forms or constructions
    • G09F2003/023—Adhesive
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09F—DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS
    • G09F3/00—Labels, tag tickets, or similar identification or indication means; Seals; Postage or like stamps
    • G09F3/02—Forms or constructions
    • G09F2003/0272—Labels for containers

Definitions

  • the invention relates generally to hygroscopic wicks and, more particularly, to fiber wicks configured for transporting analyte fluids in assay devices.
  • test devices for use in the home, office, clinic, hospital or doctor's surgery for providing an analytical result which is rapid and which requires a minimal degree of skill and involvement by the user.
  • Examples include test devices or assays for pregnancy and fertile period (ovulation determination.
  • Typical assay devices comprise a housing, a reaction medium positioned in the housing, upon which the assay chemistry occurs, and a wick for collecting the liquid to be assayed and transferring it to the reaction medium.
  • the assay device should merely require that a collection portion of the device be contacted with a sample (e.g., a urine sample for pregnancy testing), and thereafter no further user actions are required.
  • the sample is carried from the collection portion to the reaction medium by the wick.
  • Observation of changes to the reaction medium or a substrate carrying the reaction medium provide an analytical result Ideally, the analytical result should he observable within a matter of minutes following sampling.
  • the actual analytic techniques used to obtain the results typically determine the presence or absence of, and/or quantify the amount of various analytes in, tissues and fluids of organisme.
  • Most diagnostic testing is done with blood, urine, fecal material, saliva, or tissue biopsy Assay devices for collecting and reacting these materials can be used for, inter alia , pregnancy and ovulation tests, drug-of-above tests, and infections disease tests.
  • One approach to solving this problem is to provide diagnostic assay devices with a color change indicator to signal that sufficient analyte-containing liquid (e.g., urine, saliva, plasma) has been collected hy the sample collector. In wick-based devices, the color change generally indicates that the wicking component has been "wetted out" with the analyte fluid.
  • the color change indication is based on the presence of a dye or colored substance that undergoes a change when wetted with water or other aqueous liquid.
  • U.S. Patent Application No. 10/495,714 ('714 Application"), for example, describes sample collectors having wicking components (termed “bibulous members") that contain a dye that changes color as the result of a pH change.
  • wicking components termed “bibulous members”
  • a dry wick contains the acid form of a pH-sensitive dye which, upon wetting by the analyte-containing solution, experiences a pH change to more basic conditions, resulting in a color change.
  • the color change is said to be distinctly visible to the eye so as to indicate sufficient analyte solution is present to both conduct the diagnostic analysis and effect color change.
  • CoCl2 cobalt chloride
  • Anhydrous cobalt chloride is blue. When it bonds with two water molecules, (CoCl2•2H2O), it turns purple. Further hydration results in the pink hexaaquacobalt(II) chloride complex [Co(H2O)6]Cl2.
  • pH-sensitive dye molecules such as phloxine B or bromophenol blue
  • pH altering reagents ascids or bases
  • inorganic compounds use of these chemical compounds may interfere with, or otherwise after, the analyte itself or the diagnostic assay. This may reduce the sensitivity of the assay or lead to false negative or false positive results
  • Another approach to sufficiency indication is to permanently color the wicking material or provide it with a permanently colored marker and cover the wick or marker with an additional material that is substantially opaque when dry and light transmittent when wet.
  • the above-mentioned '714 Application discloses the use of such materials as sugar paste, nitrocellulose membranes, and nylon microporous membranes to cover an acetate strip affixed to the wicking material. This approach, however, may introduce additional uncertainly due to the separation of the cover material from the wicking material. It also introduces significant complexity and cost to the production of the wick.
  • the present invention provides a wick for use in determining sufficiency of an amount of analyte fluid provided to an analyte test section of an assay device.
  • the wick comprises a primary wick portion attached to the analyte test section so as to be in fluid communication therewith.
  • the primary wick portion has a receiving surface adapted for receiving the analyte fluid into a first area of the primary wick portion and is configured to draw the analyte fluid from the first area to a second area of the primary wick portion.
  • the wick further comprises an indicator portion having a contrasting visual characteristic.
  • the indicator portion is deposed so that some or all ot the indicator portion is covered by at least a portion of the primary wick portion.
  • the indicator portion is entirely non-wicking.
  • the at least a portion of the primary wick portion comprises a first wicking material that becomes more light transmissive when the first wicking material is wetted by the analyte fluid.
  • the contrasting visual characteristic is viewable through the at least a portion of the primary wick portion only when the at least a portion of the primary wick portion is suffused by a predetermined amount of the analyte fluid. All of the indicator portion is located upstream of the analyte test section.
  • the present invention provides a visual sufficiency indicator system that does not contain color changing additives or reagents that change as the result of a chemical change or reaction.
  • Embodiments of the present invention provide assay devices having wicks in which the wicking material itself is configured so that it reveals a colored or indicia-emblazoned indicator when it has absorbed a desired amount of analyte fluid. This is accomplished through the use of selected materials that tend to become more light transmittent when wetted with the particular analyte fluid and the tailoring of other physical characteristics of the wick so that the wick becomes sufficiently translucent to allow an underlying indicator layer to be viewed.
  • an assay wick has two primary components ; (1) a primary wick material that provides most or all of the wicking potential and (2) an indicator material or layer positioned underneath or embedded within the pimary wick material.
  • the primary wick material is formed from fibers that are selected so that (a) the primary wick material adequately wicks a predetermined analyte fluid and (b) visually obscures the indicator material when dry and visually reveals the indicator material when wetted by a predetermined amount of the predetermined analyte fluid type.
  • the indicator material is configured with a contrasting color or graphical indicium that is viewable through the primary wick material when the wick material is suffused with a sufficient amount of the analyte fluid.
  • analyte fluid means a fluid sample that is to be analyzed for the presence of one or more analytes m the fluid sample and/or to quantify the amount of one or more analytes present in the fluid simple.
  • the wicking materials used in the various embodiments of the present invention need to provide rapid, controlled transport of analyte fluids. This can sometimes be accomplished by using fiber or other materials that have a natural affinity for the analyte fluid of interest. In many instances, however, the materials of the wick must be treated to enhance their affinity (or eliminate their phobicity) for the analyte fluid.
  • wicking capability is not the only consideration.
  • the material must also exhibit the above-described effect in which translucency increases upon wetting with the analyte fluid. This not only limits the base material that can be used, it also restricts or eliminates the use of certain additives that would limit the inherent translucency of the material.
  • an assay wick 100 includes a primary wick layer 110 and an indicator layer 120.
  • the primary wick layer 110 has an upper or receiving surface 112, some or all of which may be printed for receiving an analyte fluid, and a lower surface 114.
  • the primary wick layer 110 may in addition or instead receive analyte fluid through an end surface 113 from an external source or from another wick element.
  • the primary wick layer 110 is configured for receiving the analyte fluid through the upper surface 112 and/or the end surface 113 and for transporting the analyte fluid from one portion of the primary wick layer 110 to another portion of the primary wick layer 110 that includes or is in fluid communication with an analyte test section 130.
  • the indicator layer 120 is adhered or otherwise attached to the bottom surface 114 of the primary wick layer 110.
  • the primary wick layer 110 is formed from a material that exhibits increased light transmittance when wetted by a particular analyte fluid.
  • the indicator layer 120 may be formed from a material having a contrasting visual characteristic (i.e., a distinct color or other appearance variation such as a pattern or indicium) relative to the visual appearance of the primary wick layer 110 and/or the analyte fluid Alternatively or in addition, the indicator layer 120 may include or have applied to at least a portion of its upper surface an indicia layer 122.
  • a contrasting visual characteristic i.e., a distinct color or other appearance variation such as a pattern or indicium
  • the indicia layer 122 may be formed with a contrasting color selected to distinguish the indicia layer 122 from the primary wick layer 110 and the analyte fluid when the primary wick layer 110 is wetted with the analyte fluid Further, some or all ot the indicia layer 122 may be provided with a graphical indicium formed using a color contrasting from the primary wick layer 110 and the analyte fluid when the primary wick layer 110 is wetted with the analyte fluid.
  • the graphical indicium may be any suitable graphic such as a logo, text, pattern, symbol or sign.
  • the indicium may include one or more instructions relating to the use of the wick and/or the assay device in which the wick is incorporated.
  • the indicator portion 120 may be a monolithic body or may be a layered or comprite structure in which the uppermost layer has or carries the distinguishing color or indicia.
  • the indication portion 120 may be formed from materials that, like the material of the primary wick portion 110, exhibit increased light transittance when wetted with the analyte fluid.
  • the indicator portion 120 may be loaded with a colored particulate or other material that provides the contrasting visual characteristic when the indicator portion 120 is wetted.
  • the indicator portion is entirely non-wicking.
  • an assay wick 200 includes a primary wick portion 210 having an upper wick layer 216 and a lower wick layer 218.
  • An indicator layer 220 is disposed intermediate the upper and lower wick layers 216, 218.
  • the upper wick layer 216 has an upper or receiving surface 212, some or all of which may he presented for receiving an analyte fluid, and a lower surface 214.
  • the primary wick layer 210 may in addition or instead receive analyte fluid through an end surface 213 from an external source or from another wick element.
  • the upper wick layer 216 is configured for receiving the analyte fluid through the upper surface 212 and/or the end surface 213 and for transporting the analyte fluid to another portion of the primary wick layer 210 that includes or is in fluid communication with an analyte test section 230.
  • the indicator layer 220 is adhered or otherwise attached to the bottom surface 214 of the primary wick layer 210.
  • the lower wick layer 218 may be adhered to the indicator layer 220 or, in some embodiments, may be adhered or otherwise attached to the upper wick layer 216 through or around the indicator layer 220. Alternatively, one or both of the indicator layer 220 and the lower wick layer 218 may be held in contact with the upper wick layer 216 and with one another by mechanical means such as fasteners or a casing.
  • the indicator layer 220 may be formed from a material having a contrasting visual characteristic relative to the visual appearance of the upper wick layer 216 and/or the analyte fluid.
  • the indicator layer 220 may include or have applied to at least a portion of its upper surface an indicia layer 222. Some or all of the indicia layer 222 may be formed with a contrasting color selected to distinguish the indicia layer 222 from the upper wick layer 216 and the analyte fluid when the upper wick layer 216 is wetted with the analyte fluid.
  • the indicia layer 222 may be provided with a graphical inducium formed using a color contrasting from the upper wick layer 216 and the analyte fluid when the upper wick layer 216 is wetted with the analyte fluid.
  • the indicator portion 220 may be a monolithic body or may be a layered or composite structure in which the uppermost layer has or carries the distinguishing color or indicia.
  • the indicator portion 220 may be formed from materials that, like the material of the primary wick portion 210, exhibit increased light transmittance when wetted with the analyte fluid.
  • the indicator portion 220 may be loaded with a colored particulate or other material that provides the contrasting visual characteristic when the indicator portion 220 is wetted.
  • an assay wick 300 includes a primary wick layer 310 and an indicator layer 320.
  • the primary wick layer 310 has an upper or receiving surface 312, some or all of which may be presented for receiving an analyte fluid, and a lower surface 314.
  • the primary wick layer 310 may in addition or instead receive analyte fluid through an end surface 313 from an external source or from another wick element.
  • the primary wick layer 310 is configured for receiving the analyte fluid through the upper surface 312 and/or the end surface 313 and for transporting the analyte fluid from one portion of the primary wick layer 310 to another portion of the primary wick layer 310 that includes or is in fluid communication with an analyte test section 330.
  • the indicator layer 320 is embodded or encased entirely within the primary wick layer 310.
  • the indicator layer 320 may be formed from a material having a contrasting visual characteristic relative to the visual appearance of the primary wick layer 310 and/or the analyte fluid.
  • the indicator layer 320 may include or have applied to at least a portion of its upper surface an indicia layer 322.
  • Some or all of the indicia layer 322 may be formed with a contrasting color selected to distinguish the indicia layer 322 from the primary wick layer 310 and the analyte fluid when the primary wick layer 310 is wetted with the analyte fluid.
  • the indicia layer 322 may be provided with a graphical indicium formed using a color contracting from the primary wick layer 310 and the analyte fluid when the primary wick layer 310 is wetted with the analyte fluid.
  • the indicator portion 320 may be a monolithic body or may he a layered or composite structure in which the uppermost layer has or carries the distinguishing color or indicia.
  • the indicator portion 320 may be formed from materials that, like the material of the primary wick portion 310, exhibit increased light transmittance when wetted with the analyte fluid.
  • the indicator portion 320 may be loaded with a colored particulate or other material that provides the contrasting visual characteristic when the indicator portion 320 is wetted.
  • an assay wick 400 includes a cylindrical primary wick portion 410 surrounding an indicator portion 420.
  • the primary wick portion 410 has an outer or receiving surface 412, some or all of which may be presented for receiving an analyte fluid, and an inner surface 414.
  • the primary wick portion 410 may in addition or instead receive analyte fluid through an end surface 413 from an external source or from another wick element.
  • the primary wick portion 410 is configured for receiving the analyte fluid through the outer surface 412 and/or the end surface 413 and for transporting the analyte fluid from one portion of the primary wick portion 410 to another portion of the primary wick portion 410 that includes or is in fluid communication with an analyte test section 430.
  • the indicator portion 420 may be formed as a circular cylinder, but may also be a prism or other shape, The outer surface 422 of the indicator portion 420 is in contact with the inner surface 414 of the primary wick portion 410.
  • the indicator portion 420 may be formed from a material having a contrasting visual characteristic relative to the visual appearance of the primary wick portion 410 and/or the analyte fluid.
  • the indicator portion 420 may include or have applied to at least a portion of its outer surface an indicia portion 422 Some or all of the indicia portion 422 may be formed with a contrasting color selected to distinguish the indicia portion 422 from the primary wick portion 410 and the analyte fluid when the primary wick portion 410 is wetted with the analyte fluid. Further, some or all of the indicia portion 422 may he provided with a graphical indicium formed using a color contrasting from the primary wick portion 410 and the analyte fluid when the primary wick portion 410 is wetted with the analyte fluid.
  • the indicator portion 420 may be a monolithic body or may be a layered or compose structure in which the radially outermost layer has or carries the distinguishing color or indicia.
  • the indicator portion 420 may be formed from materials that, like the material of the primary wick portion 410, exhibit increased light transmittance when wetted with the analyte fluid
  • the indicator portion 420 may be loaded with a colored particulate or other material that provides the contrasting visual characteristic when the indicator portion 420 is wetted.
  • an assay wick 500 includes a cylindrical primary wick portion 510 having an outer wick portion 516 surrounding an indicator portion 520.
  • the indicator portion 520 may be an annular cylinder or tube or may be a thin band or strip. In either case, the indicator portion surrounds an inner wick portion 518.
  • the primary wick portion 510 has an outer or receiving surface 512, some or all of which may be presented for receiving an analyte fluid, and an inner surface 514.
  • the primary wick portion 510 may in addition or instead receive analyte fluid through an end surface 513 from an external source or from another wick element.
  • the primary wick portion 510 is configured tor receiving the analyte fluid through the outer surface 512 and/or the end surface 513 and for transporting the analyte fluid from one portion of the primary wick portion 510 to another portion of the primary wick portion 510 that includes or is in fluid communication with an analyle test section 530.
  • the indicator portion 520 has an outer surface 522 that is in contact with the inner surface 514 of the primary wick portion 510.
  • the indicator portion 520 may be formed from a material having a distinct color or other appearance variation relative to that of the primary wick portion 510 and/or the analyte fluid Alternatively or in addition, the indicator portion 520 may include or have applied to at least a portion of its outer surface an indicia portion 522. Some or all of the indicia portion 522 may be formed with a contrasting color selected to distinguish the indicia portion 522 from the primary wick portion 510 and the analyte fluid when the primary wick portion 510 is wetted with the analyte fluid.
  • indicia portion 522 may be provided with a graphical indicium formed using a color contrasting from the primary wick portion 510 and the analyte fluid when the primary wick portion 510 is wetted with the analyte fluid.
  • an assay wick 1000 has a fluid receiving portion 1040 configured for receiving an analyte fluid through a receiving surface 1042 and transporting the analyte fluid to an analyte test section 1030.
  • the analyte test section 1030 may have reagents disposed therein that react with the analyte fluid and provide a visual indication of a reaction result.
  • the analyte test section 1030 is also configured to transport at least a portion of the analyte fluid to a sufficiency indicator 1100.
  • the sufficiency indicator 1100 has a primary wick layer 1110 and an indicator layer 1120 that are similar in configuration and operation to the primary wick layer 110 and indicator layer 120 of wick 100 in figure 1 . It will be understood, however, that the wick/indicator combinations of any of the preceding embodiments could be used.
  • the advantage of placing a sufficiency indicator dowmstream of the analyte test section is that it can be used to assure that a sufficient amount of analyte fluid reached the analyte test section.
  • Each of the fluid receiving portion 1040, analyte test section 1030, and at least the wick portion of the indicator 1100 may be or include a wicking material
  • the wicking material of any of these three sections of the wick 1000 may be the same or different from the other sections. All three of the fluid receiving potion 1040, the analyte test section 1030, and the wick portion of the sufficiency indicator 1100 comprise the same wicking material. All three are formed as a single integral wick element.
  • the wicking materials used in the various embodiments ot the invention may he or include any material that can sufficiently adsorb and wick an analyte fluid of interest.
  • the wicking material in sufficiency indicator portions must also exhibit enhanced translucency when wetted by the analyte fluid of interest.
  • materials formed from certain natural fibers such as cellulose and cotton exhibit the required enhanced translucency when wetted with water-based analyte fluids.
  • Such materials can also be used to form wicks according to the invention. It has been found, however, that materials formed from synthetic polymers may be preferable in many applications.
  • Fiber-based materials used in wicks of the invention may be woven or non-woven materials.
  • the wicks of the invention may be bonded fiber structures comprising interconnecting networks of highly dispersed continuous and/or staple fibers bonded to each other at paced apart points of contact.
  • bonded fiber strutctutes may be formed using a wide variety of fiber types and manufacturing methods.
  • structures made from fiber webs that are formed into substantially self-sustaining, three-dimensional porous components The dispersed bonded fibers of these structures define tortuous passages through the structure that can provide very high surface areas and porosity, and may be formed in a variety of sizes and shapes.
  • polystyrene resin polystyrene resin
  • polyesters polyesters
  • pulyurethanes polyamides
  • copolymers thereof include polyethylene, low density polyethylene, polypropylene, polyethylene terephthalate, polybutylene terephthalate and nylon.
  • the ideal fiber for use in sufficiency indicators of the invention is one that is formed, at least in part, from a polymer material that naturally has a refraction index close to that of the analyte fluid of interest and that can be used to form a bonded fiber structure having the desired fluid transport characteristics.
  • Monocomponent fibers bicomponent (or other multicomponent) fibers or combinations of both may be used. In bicomponent fibers, at least one ot the two fiber components (and preferably both) would have a refractive index close to that of the analyte fluid.
  • wick materials may be formed from sheath/core bicomponent fibers in which at least the sheath component and preferably both the sheath and the core components are formed from polymer materials exhibiting a retractive index close to that of the analyte fluid,
  • a sufficiency indicator according to the invention must incorporate a wick material that has an affinity for water and that exhibits increased translucency when wetted with water.
  • polyolefin fibers generally, and fibers comprising polyethylene (PE) and polypropylene (PP), in particular, exhibit suitable enhanced translucency in water.
  • Fibers formed from other polymers such as polyethylene terephthalate (PET), polybutylene terephthalate (PBT), and polyamides may also be unable
  • Bonsded fiber structures having both the desired wicking capability and translucency behavior can be formed from PE monocomponent fibers.
  • a particularly suitable bonded fiber structure may be formed from sheath/core bicomponent fibers having a PE sheath and a PP core.
  • the surface energy and water compatibility is provided by the PE sheach (typically treated with additives or hydrophillic finishes), and the PP core enhances the fiber's structural capability. Both components exhibit the requisite translucency behavior.
  • the primary wick layer/portion and the indicator layer/portion of an assay wick sufficiency indicator may both be bonded fiber structures.
  • the primary wick layer/portion may be formed from fibers (e.g., polyolefin fibers that exhibit the required translucency behavior.
  • the indicator layer/portion may use the same fiber materials, but it may, however, may be formed from other fiber materials that provide the desired flow characteristics.
  • the bonded fiber indicator layer/portion may be dyed or otherwise treated to be a contrasting color that would become visible only upon sufficient wetting of the primary wick layer/portion by the appropriate analyte fluid.
  • some embodiments may have an indicator layer/portion (e.g., a bonded fiber structure) that is configured to exhibit increased translucency upon wetting and that is loaded with a colored particulate or other contrasting material that is revealed upon wetting of the indicator layer/portion.
  • an indicator layer/portion e.g., a bonded fiber structure
  • the increased translucency of both the primary wick layer and the indicator layer upon wetting by the analyte fluid allows the contrasting material to be viewed.
  • Similar contrasting materials could be added to some or all of the primary wick layer, which, could eliminate the need for a separate indicator layer.
  • the indicator layers are entirely non-wicking.
  • the indicator layers ot the invention are formed entirely from non-wicking materials including, but not limited to, metal, foam (open or closed cell), films, molded plastic, composites, and particulates. These materials may have a contrasting color throughout their structure or on a single surface or they may be formed with contrasting topographical features.
  • the wick structures used in the invention can be tailored to provide desired fluid characteristics. For fiber structures, this can be accomplished by a combination of fiber material selection, fiber diameter, and porosity of the wick structure. It will further be understood that the thickness of the wick structure (or the depth of the indicator layer/material, depending on the embodiment) in the sufficiency indicator portions of the assay wicks of the invention will be dependent on the degree of translucency of the material when wetted by the analyte fluid. This, in turn, way be dependent on the density ot the wick structure and the relative difference in retractive index between the wick material and the analyte fluid. Thus, it can be seen that the various wick material characteristics can be tailored so as to optimize fluid flow characteristics and translucency for a given indicator depth.
  • any or all of these characteristics can be adjusted to assure that the indicator layer/portion becomes visible only when an amount of analyte fluid sufficient to assure a desired reaction with the reagents of the analyte test section is present.
  • the wick structure and indicator depth could then be tailored so that the indicia only become readable upon wetting by a sufficient amount of analyte fluid.
  • any or all of the assay wicks of the invention may be housed in a standard assay device casing.
  • a standard assay device casing allow for selective exposure of the wick receiving surface and one or more windows for viewing a visual indication from the analyte reaction portion of the wick.
  • a window may also he provided to view the sufficiency indicator portion of the wick.
  • any ot the assay wicks of the invention is straight forward.
  • an appropriate analyte fluid is introduced to the receiving surface of the wick, it is transported through the receiving portion of the wick toward the analyte test section.
  • the sufficiency indicator is upstream of the analyte test section
  • the analyte fluid is passed through the wicking portion(s) of the sufficiency indicator to the analyte test section.
  • the sufficiency indicator portion of the wick is downstream of the analyte test section, the analyte fluid is passed through the analyte test section and into the wicking portion(s) of the sufficiency indicator section.
  • the primary wicking layer/portion of the sufficiency indicator As the primary wicking layer/portion of the sufficiency indicator is wetted by the analyte fluid, it will become more light transmitted (i.e., more translucent). Prior to introduction of the analyte fluid, the primary wicking layer/portion is essentially white or colorless. If the amount of analyte fluid is sufficient to fully infuse the primary wicking layer/portion of the sufficiency indicator, the primary wicking layer/portion will become sufficiently translucent that the contrasting color or indicia of the indicator layer/portion can be observed.
  • the wicks of the invention have a wide applicability and may be used in conjunction with virtually any analyte fluid, including biological analyte fluids such as urine, plasma, serum, sweat, lachrymal fluid (tears), and saliva.
  • the wicks of the invention may be used in assay devices for detecting one or more analytes including, but not limited to, hormones such as human chorionic gonadotropin (hCG) frequently used as a marker for pregnancy, antigens, enzymes, antibodies to HIV, antibodies to HTLV, antibodies to Helicobacter pylori, antibodies to hepatitis, antibodies to measles, hepatitis antigens, antibodies to terponemes, antibodies to host or infections ugents, cellular markers of pathology including, but not limited to, cardiolipin, lecithin, cholesterol, lipopolysaccaride and sialic acid, antibodies to mumps, antibodies to rubella, cotinine, cocaine, benzoyleegonine
  • an assay device 1200 has a housing 1250 in which is disposed an analyte test section 1230 that is viewable through a window 1252 in the housing 1250.
  • the analyte test section 1230 is in fluid communication with a sufficiency indicator section 1201 comprising a primary wick portion 1210 and an indicator portion 1220, which may be configured according to any of the embodiments disclosed above.
  • the primary wick portion is also in fluid communication with an analyte receiving section 1240 having a receiving surface 1242.
  • Analyte fluid received by the receiving section 1240 is wicked by the primary wick portion to the analyte test section 1230 where it can be reacted with agents disposed there.
  • the reaction may be viewed through the window 1252,
  • the indicator section 1201 is configured so that the indicator portion 1220 is concealed by the primary wick portion 1210 unless or until the primary wick portion 1210 has been wetted by a sufficient amount of analyte fluid, When sufficiently suffused with analyte fluid the contrasting characteristic of the indicator portion 1220 can be viewed through the primary wick portion 1210.
  • some of the primary wick portion 1210 is disposed inside the housing 1250 and some is exposed outside the housing along with at least some of the indicator portion 1220 so that the indicator portion 1220 can be viewed when the primary wick portion is wetted.
  • the entire indicator section 1201 may be disposed inside the housing 1250, but positioned to be viewed through the window 1252 or through an additional window (not shown).
  • the receiving surface 1242 may be a surface of the primary wick portion 1210 or may be on a separate wick portion attached to or integrally formed with the primary wick portion 1210
  • an assay device 1300 has a housing 1350 in which is disposed an analyte test section 1330 that is viewable through a window 1352 in the housing 1350.
  • a sufficiency indicator section 1301 is disposed within the housing 1350 and in downstream fluid communication with the analyte test section 1330.
  • the indicator section 1301 comprises a primary wick portion 1310 and an indicator portion 1320.
  • the analyte test section 1330 is in fluid communication with an analyte receiving section 1340 having a receiving surface 1342. Analyte fluid received by the receiving section 1340 is wicked to die analyte test section 1330 where it can be reacted with agents disposed there. The reaction may be viewed through the window 1352.
  • the analyte fluid is also passed to the indicator section 1301.
  • the indicator section 1301 is configured so that the indicator portion 1320 is concealed by the primary wick portion 1310 unless or until die primary wick portion 1310 has been wetted by a sufficient amount of analyte fluid.
  • the contrasting characteristic of the indicator portion 1320 can be viewed through the primary wick portion 1310 and the window 1354.
  • the preceding disclosure has focused on the use of the indicator wick sections of the invention as fluid sufficiency indicators.
  • the wetted translucency behavior of the wick materials might be useful as indicators of a dry condition.
  • they might be useful as end-of-life indicators for air freshener devices such as those disclosed in U.S. App. No. 12/099,942, filed April 9, 2008 .
  • the indicator section would be incorporated into the air freshener wick with the characteristics of the primary wick portion being tailored to the air freshener fluid (the "analyte fluids").
  • the wicking material of the primary wick portion would be substantially transparent of translucent as long as the indicator section remained immersed in the air freshener fluid. Once that fluid runs out, however, the primary wick portion begins to dry out. As it does, it will become less and less light transmittent (i.e., more opaque) until, the indicator portion/layer is obscured. This effect can be used, for example, to make the wick appear the color of the indicator portion until the fragrance fluid is gone, at which time the wick turns colorless or white.

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EP13854971.2A 2012-11-16 2013-11-14 Assay wick with analyte fluid sufficiency indicator Active EP2920587B1 (en)

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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10634597B2 (en) 2015-03-31 2020-04-28 Halliburton Energy Services, Inc. Method and apparatus for selecting surfactants
GB2552813A (en) 2016-08-10 2018-02-14 Univ Oxford Innovation Ltd Wet surface indication
DE202017101007U1 (de) * 2017-02-23 2018-05-24 Brand Gmbh + Co Kg Austauschbare Kolben-Zylinder-Einheit für einen Dispenser, Dispenser und System zum Aufnehmen und Abgeben von Fluidvolumina
CN107967866A (zh) * 2017-12-25 2018-04-27 东莞市长赢胶带有限公司 一种遇水指示标签及其制备方法
CN110890015A (zh) * 2018-09-09 2020-03-17 迈博高分子材料（宁波）有限公司 一种吸液指示部件和液体检测装置
CN110882008A (zh) * 2018-09-09 2020-03-17 迈博高分子材料（宁波）有限公司 液体采集装置
US11858715B2 (en) 2019-01-21 2024-01-02 Tracy Hosac Collectable absorber canisters
US20230256428A1 (en) 2020-06-10 2023-08-17 Salignostics Ltd. Saliva treatment devices
KR102513604B1 (ko) * 2020-06-12 2023-03-23 주식회사 케이티앤지 에어로졸 발생 장치 및 그의 전력 제어 방법
CN112414503B (zh) * 2020-11-03 2022-07-05 睿科集团(厦门)股份有限公司 一种光纤测定溶剂体积的方法
WO2023278425A1 (en) 2021-07-01 2023-01-05 Porex Corporation Squeezable sample preparation device
TWI804341B (zh) * 2022-06-10 2023-06-01 國立高雄科技大學 食物賞味期時效貼片

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1552877A (en) * 1923-01-25 1925-09-08 Ralph S Phillipps Container for tobacco and other products
BR8303428A (pt) 1982-06-28 1984-02-07 Penick Corp Composicao pesticida e metodo para preparar uma composicao pesticida
JPS60151578A (ja) * 1984-01-18 1985-08-09 Toppan Printing Co Ltd 時間経過表示体
DE8530190U1 (de) * 1985-10-25 1986-01-09 Förster, Martin, 7410 Reutlingen Anordnung zum Feuchthalten des Inhaltes einer Tabakdose
US5037459A (en) * 1988-10-07 1991-08-06 Philip Morris Management Corp. Device for controlling relative humidity within a substantially sealed container
DE68926085T2 (de) * 1988-10-07 1996-10-10 Philip Morris Prod Vorrichtung zur Kontrolle der relativen Feuchtigkeit in einem im wesentlichen geschlossenen Behälter
GB9002856D0 (en) 1990-02-08 1990-04-04 Alcan Int Ltd Fluid detection device
JPH073430Y2 (ja) * 1990-11-28 1995-01-30 呉羽化学工業株式会社 表示器
DK0567529T4 (da) * 1991-01-07 2010-04-12 Multisorb Tech Inc Oxygenabsorberende etiket
US5686161A (en) * 1991-01-07 1997-11-11 Multisorb Technologies, Inc. Moisture-sensitive label
JPH0619816U (ja) * 1992-08-11 1994-03-15 エステー化学株式会社 吸湿具
US5607766A (en) 1993-03-30 1997-03-04 American Filtrona Corporation Polyethylene terephthalate sheath/thermoplastic polymer core bicomponent fibers, method of making same and products formed therefrom
US5629186A (en) 1994-04-28 1997-05-13 Lockheed Martin Corporation Porous matrix and method of its production
US6156272A (en) * 1997-06-06 2000-12-05 All Technologies Corporation Method and apparatus for urine self-test intended for use in a toilet
US5934773A (en) * 1997-07-03 1999-08-10 Ferrell; Joseph C. Humidifier device
FR2773905B1 (fr) * 1998-01-21 2001-10-05 Oreal Etiquette, notamment pour conditionnement de produit cosmetique
US6330883B1 (en) 1999-02-17 2001-12-18 Filtrona Richmond, Inc. Heat and moisture exchanger comprising hydrophilic nylon and methods of using same
US6103181A (en) 1999-02-17 2000-08-15 Filtrona International Limited Method and apparatus for spinning a web of mixed fibers, and products produced therefrom
JP2000274922A (ja) * 1999-03-26 2000-10-06 Sharp Corp 庫内環境表示機能付き冷蔵庫
DE19913761B4 (de) * 1999-03-26 2005-02-10 Lts Lohmann Therapie-Systeme Ag Trocknungsvorrichtung und Verfahren zu ihrer Herstellung sowie ihre Verwendung
US6815207B2 (en) * 2000-09-21 2004-11-09 Fuji Photo Film Co., Ltd. Moisture/wetness detecting method, moisture/wetness detecting label, articles with moisture/wetness detecting function, and detecting material and method
US7105225B2 (en) * 2001-10-05 2006-09-12 3M Innovative Properties Company Water contract indicator
JP4608213B2 (ja) 2002-01-09 2011-01-12 アレル・スウイツツアーランド・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 液体試料分析デバイス
WO2003087445A1 (en) 2002-04-10 2003-10-23 Filtrona Richmond, Inc. Method and apparatus for making nibs and ink reserviors for writing and marking instruments and the resultant products
EP1376131A1 (en) * 2002-06-27 2004-01-02 Inverness Medical Switzerland GmbH Assay device for liquid sample
JP2004037902A (ja) * 2002-07-04 2004-02-05 Toppan Printing Co Ltd 耐久性のあるｉｃタグ付き建築用・住宅用部材、及びこれらを用いることによる各種履歴確認方法。
JP4426754B2 (ja) * 2002-12-27 2010-03-03 ユニ・チャーム株式会社 体液吸収性物品のインジケータ
WO2005053821A1 (ja) * 2003-12-03 2005-06-16 Kyodo Printing Co., Ltd. インジケータ機能付き吸湿材、湿度インジケータ及び包装袋
US7290668B2 (en) * 2004-03-01 2007-11-06 Filtrona Richmond, Inc. Bicomponent fiber wick
FR2867362B1 (fr) * 2004-03-15 2007-09-21 Oreal Article d'application adhesif
JP2005313934A (ja) * 2004-04-28 2005-11-10 Asahi Kasei Life & Living Corp 包装体内環境の検知または検知・調整方法。
EP1861706B1 (en) * 2005-03-03 2016-03-02 Alere Switzerland GmbH Devices and methods for analyte assays with built-in result reporting using recognizable symbols
JP2008126172A (ja) * 2006-11-22 2008-06-05 Mitsubishi Gas Chem Co Inc 自力反応ラベル型脱酸素剤
US20080251599A1 (en) 2007-04-11 2008-10-16 Ward Bennett C Vapor Emitting Device
WO2010014505A1 (en) 2008-07-28 2010-02-04 Sensors For Medicine & Science, Inc. Systems and methods for optical measurement of analyte concentration
FR2941713B1 (fr) * 2009-02-03 2011-04-01 Arjowiggins Security Procede de securisation d'un objet opaque colore.
GB2468683A (en) 2009-03-18 2010-09-22 Cozart Bioscience Ltd Oral fluid collection device
EP2683546A4 (en) * 2011-03-11 2014-10-15 Upm Raflatac Oy LAMINATED FILM
KR20120124586A (ko) * 2011-05-04 2012-11-14 주식회사 보스팩 수분 흡착 필름을 이용한 스티커

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

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US9330580B2 (en) 2016-05-03
BR112015011130A2 (pt) 2017-08-22
GB201300225D0 (en) 2013-02-20
AU2013346513A1 (en) 2015-05-28
AU2013346513B2 (en) 2017-06-29
JP2016505869A (ja) 2016-02-25
CA2891766A1 (en) 2014-05-22
JP6374875B2 (ja) 2018-08-15
CN104956422A (zh) 2015-09-30
WO2014078534A1 (en) 2014-05-22
US20140137792A1 (en) 2014-05-22
EP2920780B1 (en) 2023-04-05
EP2920780A1 (en) 2015-09-23
EP2920587A1 (en) 2015-09-23
US20150287346A1 (en) 2015-10-08
PL2920780T3 (pl) 2023-07-24
ES2947515T3 (es) 2023-08-10
WO2014076488A1 (en) 2014-05-22
GB2509338A (en) 2014-07-02
GB2509338B (en) 2017-09-27
EP2920587A4 (en) 2016-06-08

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