EP2859114A2 - Proteine zur bindung antagonistischer antigene mit zwei rezeptoren und verwendungen davon - Google Patents
Proteine zur bindung antagonistischer antigene mit zwei rezeptoren und verwendungen davonInfo
- Publication number
- EP2859114A2 EP2859114A2 EP13804428.4A EP13804428A EP2859114A2 EP 2859114 A2 EP2859114 A2 EP 2859114A2 EP 13804428 A EP13804428 A EP 13804428A EP 2859114 A2 EP2859114 A2 EP 2859114A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- antigen
- binding protein
- antibody
- seq
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (2)
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EP19169804.2A EP3540070A1 (de) | 2012-06-11 | 2013-06-11 | Proteine zur bindung antagonistischer antigene mit zwei rezeptoren und verwendungen davon |
EP18203126.0A EP3498857A1 (de) | 2012-06-11 | 2013-06-11 | Proteine zur bindung antagonistischer antigene mit zwei rezeptoren und verwendungen davon |
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US201261658237P | 2012-06-11 | 2012-06-11 | |
PCT/US2013/045245 WO2013188448A2 (en) | 2012-06-11 | 2013-06-11 | Dual receptor antagonistic antigen-binding proteins and uses thereof |
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EP18203126.0A Division EP3498857A1 (de) | 2012-06-11 | 2013-06-11 | Proteine zur bindung antagonistischer antigene mit zwei rezeptoren und verwendungen davon |
EP18203126.0A Division-Into EP3498857A1 (de) | 2012-06-11 | 2013-06-11 | Proteine zur bindung antagonistischer antigene mit zwei rezeptoren und verwendungen davon |
EP19169804.2A Division EP3540070A1 (de) | 2012-06-11 | 2013-06-11 | Proteine zur bindung antagonistischer antigene mit zwei rezeptoren und verwendungen davon |
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EP2859114A2 true EP2859114A2 (de) | 2015-04-15 |
EP2859114A4 EP2859114A4 (de) | 2016-08-03 |
EP2859114B1 EP2859114B1 (de) | 2019-05-15 |
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EP13804428.4A Active EP2859114B1 (de) | 2012-06-11 | 2013-06-11 | Proteine zur bindung antagonistischer antigene mit zwei rezeptoren und verwendungen davon |
EP18203126.0A Pending EP3498857A1 (de) | 2012-06-11 | 2013-06-11 | Proteine zur bindung antagonistischer antigene mit zwei rezeptoren und verwendungen davon |
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EP19169804.2A Pending EP3540070A1 (de) | 2012-06-11 | 2013-06-11 | Proteine zur bindung antagonistischer antigene mit zwei rezeptoren und verwendungen davon |
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EP18203126.0A Pending EP3498857A1 (de) | 2012-06-11 | 2013-06-11 | Proteine zur bindung antagonistischer antigene mit zwei rezeptoren und verwendungen davon |
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US (4) | US9453080B2 (de) |
EP (3) | EP3540070A1 (de) |
JP (1) | JP2015525230A (de) |
KR (1) | KR20150030706A (de) |
CN (1) | CN104540961A (de) |
AU (1) | AU2013274347B2 (de) |
BR (1) | BR112014031028A2 (de) |
CA (1) | CA2877669A1 (de) |
CL (1) | CL2014003372A1 (de) |
CO (1) | CO7240399A2 (de) |
EA (1) | EA201492282A1 (de) |
HK (1) | HK1208499A1 (de) |
IL (1) | IL236133A0 (de) |
MA (1) | MA37761A1 (de) |
MX (1) | MX2014015195A (de) |
NZ (1) | NZ703724A (de) |
PE (1) | PE20150642A1 (de) |
PH (1) | PH12014502754A1 (de) |
SG (2) | SG10201610356YA (de) |
TN (2) | TN2015000448A1 (de) |
WO (1) | WO2013188448A2 (de) |
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JP2015525230A (ja) | 2012-06-11 | 2015-09-03 | アムジエン・インコーポレーテツド | デュアル受容体アンタゴニスト性抗原結合タンパク質およびその使用 |
CN104768969B (zh) | 2012-09-13 | 2021-04-16 | 百时美施贵宝公司 | 结合至肌生成抑制素的基于纤连蛋白的支架结构域蛋白 |
MX2017007519A (es) * | 2014-12-08 | 2017-08-22 | Novartis Ag | Antagonistas de miostatina o activina para el tratamiento de sarcopenia. |
GB201500464D0 (en) * | 2015-01-12 | 2015-02-25 | Crescendo Biolog Ltd | Method of producing optimised therapeutic molecules |
AU2017222526A1 (en) * | 2016-02-22 | 2018-08-23 | Acceleron Pharma Inc. | ActRII antagonists for use in increasing immune activity |
JP6987072B2 (ja) * | 2016-03-10 | 2021-12-22 | アクセレロン ファーマ インコーポレーテッド | アクチビン2型受容体結合タンパク質及びその使用 |
US11013785B2 (en) | 2016-11-10 | 2021-05-25 | Keros Therapeutics, Inc. | Activin receptor type IIA variants and methods of use thereof |
JOP20190152A1 (ar) * | 2016-12-21 | 2019-06-20 | Novartis Ag | مضادات الميوستاتين، الآكتيفين أو مستقبلات الآكتيفين للاستخدام في علاج السمنة والحالات ذات الصلة |
EP3593144A1 (de) * | 2017-03-10 | 2020-01-15 | UCL Business Ltd | Verfahren im zusammenhang mit der hemmung des myostatin-signalwegs |
WO2018183376A1 (en) * | 2017-03-28 | 2018-10-04 | Rigel Pharmaceuticals, Inc. | Acvr2a-specific antibody and method of use thereof |
WO2019094751A1 (en) | 2017-11-09 | 2019-05-16 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
JP2021518745A (ja) | 2018-01-12 | 2021-08-05 | ケロス セラピューティクス インコーポレイテッドKeros Therapeutics,Inc. | アクチビンiib型受容体変異体およびそれらの使用方法 |
JP2022534966A (ja) * | 2019-05-30 | 2022-08-04 | アクセレロン ファーマ インコーポレーテッド | Actrii結合性タンパク質及びその使用 |
WO2021189006A1 (en) * | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Methods of using activin receptor type iia variants |
EP4121088A1 (de) * | 2020-03-20 | 2023-01-25 | Keros Therapeutics, Inc. | Verfahren zur verwendung von activinrezeptor-typ-iib-varianten |
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2013
- 2013-06-11 JP JP2015517364A patent/JP2015525230A/ja not_active Withdrawn
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