EP2854781A4 - XYLITOL-BASED ANTI-MUCOSAL COMPOSITIONS, RELATED METHODS AND COMPOSITIONS RELATED THERETO - Google Patents
XYLITOL-BASED ANTI-MUCOSAL COMPOSITIONS, RELATED METHODS AND COMPOSITIONS RELATED THERETOInfo
- Publication number
- EP2854781A4 EP2854781A4 EP13793355.2A EP13793355A EP2854781A4 EP 2854781 A4 EP2854781 A4 EP 2854781A4 EP 13793355 A EP13793355 A EP 13793355A EP 2854781 A4 EP2854781 A4 EP 2854781A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- compositions
- xylitol
- related methods
- mucosal
- based anti
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261651741P | 2012-05-25 | 2012-05-25 | |
PCT/US2013/042925 WO2013177594A2 (en) | 2012-05-25 | 2013-05-28 | Xylitol-based anti-mucosal compositions and related methods and compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2854781A2 EP2854781A2 (en) | 2015-04-08 |
EP2854781A4 true EP2854781A4 (en) | 2016-04-13 |
Family
ID=49621806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13793355.2A Ceased EP2854781A4 (en) | 2012-05-25 | 2013-05-28 | XYLITOL-BASED ANTI-MUCOSAL COMPOSITIONS, RELATED METHODS AND COMPOSITIONS RELATED THERETO |
Country Status (13)
Country | Link |
---|---|
US (3) | US8709508B2 (he) |
EP (1) | EP2854781A4 (he) |
JP (1) | JP2015518006A (he) |
KR (1) | KR20150011807A (he) |
CN (1) | CN104334164A (he) |
AU (1) | AU2013266067B2 (he) |
BR (1) | BR112014029442A2 (he) |
CA (1) | CA2870158C (he) |
IL (1) | IL235875A (he) |
MX (1) | MX2014013998A (he) |
RU (1) | RU2607892C2 (he) |
WO (1) | WO2013177594A2 (he) |
ZA (1) | ZA201408594B (he) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
US20120225918A1 (en) | 2011-03-03 | 2012-09-06 | Voom, Llc | Compositions and Methods for Non-Surgical Treatment of Ptosis |
JP2015518006A (ja) | 2012-05-25 | 2015-06-25 | エクスクリア インコーポレイテッド | キシリトール系の抗粘膜組成物及び関連する方法並びに組成物 |
US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
EP3563849A3 (en) | 2012-10-25 | 2020-02-12 | The General Hospital Corporation | Combination therapies for the treatment of alzheimer's disease and related disorders |
BR112015023328A2 (pt) | 2013-03-13 | 2017-07-18 | Flatley Discovery Lab | compostos de piridazinona e métodos para o tratamento de fibrose cística |
US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
EP3060205A4 (en) | 2013-10-22 | 2017-06-28 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
CN106456595A (zh) | 2014-02-10 | 2017-02-22 | 帕塔拉制药有限责任公司 | 用于系统性病症的肥大细胞稳定剂治疗 |
HUE049323T2 (hu) | 2014-02-10 | 2020-09-28 | Respivant Sciences Gmbh | Hízósejt-stabilizálók tüdõbetegség kezelésére |
US10238625B2 (en) | 2015-08-07 | 2019-03-26 | Respivant Sciences Gmbh | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
US10265296B2 (en) | 2015-08-07 | 2019-04-23 | Respivant Sciences Gmbh | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
WO2018009889A1 (en) * | 2016-07-07 | 2018-01-11 | Xlear, Inc | Antibacterial nasal compositions and related methods |
JP2019528320A (ja) | 2016-08-31 | 2019-10-10 | レシュピファント サイエンシス ゲゼルシャフト ミット ベシュレンクター ハフトゥングRespivant Sciences Gmbh | 特発性肺線維症による慢性咳の治療のためのクロモリン組成物 |
CA3033079A1 (en) | 2016-08-31 | 2018-03-08 | The General Hospital Corporation | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases |
JP2019531308A (ja) | 2016-10-07 | 2019-10-31 | レシュピファント サイエンシス ゲゼルシャフト ミット ベシュレンクター ハフトゥングRespivant Sciences Gmbh | 肺線維症の治療のためのクロモリン組成物 |
WO2019017995A1 (en) | 2017-07-20 | 2019-01-24 | Aztherapies, Inc. | FORMULATIONS OF CROMOLYNE SODIUM POWDER AND IBUPROFEN |
CN113038944A (zh) | 2018-07-02 | 2021-06-25 | 通用医疗公司 | 色甘酸钠和α-乳糖的粉末化制剂 |
US10799481B1 (en) | 2019-05-06 | 2020-10-13 | Rvl Pharmaceuticals, Inc. | Compositions and methods for treating ocular disorders |
WO2021216869A1 (en) | 2020-04-24 | 2021-10-28 | Joseph Scivoletto | Nasal spray composition |
WO2022140795A2 (en) * | 2020-12-23 | 2022-06-30 | Spotlight Therapeutics | Nucleic acid binding protein formulations and uses thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040235807A1 (en) * | 2003-05-21 | 2004-11-25 | Weinrich Karl P. | Formulations including a topical decongestant and a topical corticosteroid suitable for nasal administration and method for treating obstructive sleep apnea |
WO2008070264A2 (en) * | 2006-10-10 | 2008-06-12 | Case Western Reserve University | Nasal spray composition and method for treating rhinitis, sinusitis or both |
WO2012031979A1 (de) * | 2010-09-07 | 2012-03-15 | Krewel Meuselbach Gmbh | Nasenspray |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01172324A (ja) * | 1987-12-15 | 1989-07-07 | Armour Internatl Co | コレスチラミン組成物及びその製造法 |
JP2824863B2 (ja) * | 1989-07-12 | 1998-11-18 | エーザイ株式会社 | α▲下1▼―ブロッカー点眼剤 |
CN1253508A (zh) * | 1997-04-30 | 2000-05-17 | 沃尼尔-朗伯公司 | 局部鼻用抗炎组合物 |
US6054143A (en) * | 1998-03-24 | 2000-04-25 | Jones; Alonzo H. | Xylitol delivery |
US6599883B1 (en) | 1998-10-30 | 2003-07-29 | Nastech Pharmaceutical Company, Inc. | Nasal delivery of xylitol |
DE19947234A1 (de) * | 1999-09-30 | 2001-04-05 | Asta Medica Ag | Neue Kombination von Loteprednol und Antihistaminika |
MXPA06001776A (es) * | 2003-08-15 | 2007-09-07 | Qlt Usa Inc | Sistema de suministro de farmaco transmucosal biocorrosivo, adhesivo. |
US20060034947A1 (en) | 2004-06-02 | 2006-02-16 | Burr James B | Erythritol compositions for nasopharynx cleansing |
EP2486942B1 (en) * | 2004-11-24 | 2018-10-10 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
US20060275223A1 (en) | 2005-06-02 | 2006-12-07 | Burr James B | Erythritol compositions for teeth and gums |
US20070286813A1 (en) * | 2006-06-09 | 2007-12-13 | Toutounghi Camille | Nasal formulation |
US20070286812A1 (en) * | 2006-06-09 | 2007-12-13 | Toutounghi Camille | Nasal formulation |
JP2015518006A (ja) | 2012-05-25 | 2015-06-25 | エクスクリア インコーポレイテッド | キシリトール系の抗粘膜組成物及び関連する方法並びに組成物 |
-
2013
- 2013-05-28 JP JP2015514242A patent/JP2015518006A/ja active Pending
- 2013-05-28 CN CN201380027507.XA patent/CN104334164A/zh active Pending
- 2013-05-28 CA CA2870158A patent/CA2870158C/en active Active
- 2013-05-28 MX MX2014013998A patent/MX2014013998A/es not_active Application Discontinuation
- 2013-05-28 KR KR20147031835A patent/KR20150011807A/ko not_active Application Discontinuation
- 2013-05-28 EP EP13793355.2A patent/EP2854781A4/en not_active Ceased
- 2013-05-28 WO PCT/US2013/042925 patent/WO2013177594A2/en active Application Filing
- 2013-05-28 BR BR112014029442A patent/BR112014029442A2/pt not_active Application Discontinuation
- 2013-05-28 RU RU2014147090A patent/RU2607892C2/ru active
- 2013-05-28 US US13/903,860 patent/US8709508B2/en active Active
- 2013-05-28 AU AU2013266067A patent/AU2013266067B2/en active Active
-
2014
- 2014-04-22 US US14/258,993 patent/US9011941B2/en active Active
- 2014-11-21 ZA ZA2014/08594A patent/ZA201408594B/en unknown
- 2014-11-24 IL IL235875A patent/IL235875A/he active IP Right Grant
-
2015
- 2015-01-27 US US14/606,888 patent/US20150140137A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040235807A1 (en) * | 2003-05-21 | 2004-11-25 | Weinrich Karl P. | Formulations including a topical decongestant and a topical corticosteroid suitable for nasal administration and method for treating obstructive sleep apnea |
WO2008070264A2 (en) * | 2006-10-10 | 2008-06-12 | Case Western Reserve University | Nasal spray composition and method for treating rhinitis, sinusitis or both |
WO2012031979A1 (de) * | 2010-09-07 | 2012-03-15 | Krewel Meuselbach Gmbh | Nasenspray |
Non-Patent Citations (1)
Title |
---|
ZABNER J ET AL: "THE OSMOLYTE XYLITOL REDUCES THE SALT CONCENTRATION OF AIRWAY SURFACE LIQUID AND MAY ENHANCE BACTERIAL KILLING", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 97, no. 21, 10 October 2000 (2000-10-10), pages 11614 - 11619, XP001197352, ISSN: 0027-8424, DOI: 10.1073/PNAS.97.21.11614 * |
Also Published As
Publication number | Publication date |
---|---|
JP2015518006A (ja) | 2015-06-25 |
ZA201408594B (en) | 2015-12-23 |
WO2013177594A2 (en) | 2013-11-28 |
RU2014147090A (ru) | 2016-07-20 |
US20150140137A1 (en) | 2015-05-21 |
WO2013177594A3 (en) | 2014-01-16 |
US20140228304A1 (en) | 2014-08-14 |
AU2013266067A1 (en) | 2014-10-23 |
US8709508B2 (en) | 2014-04-29 |
CN104334164A (zh) | 2015-02-04 |
AU2013266067B2 (en) | 2016-10-06 |
US9011941B2 (en) | 2015-04-21 |
US20130316026A1 (en) | 2013-11-28 |
CA2870158A1 (en) | 2013-11-28 |
EP2854781A2 (en) | 2015-04-08 |
RU2607892C2 (ru) | 2017-01-11 |
IL235875A (he) | 2017-10-31 |
CA2870158C (en) | 2017-10-24 |
KR20150011807A (ko) | 2015-02-02 |
BR112014029442A2 (pt) | 2017-06-27 |
IL235875A0 (he) | 2015-01-29 |
MX2014013998A (es) | 2015-07-06 |
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