EP2750673B1 - Transdermales therapeutisches system für 5-aminolävulinsäurehydrochlorid - Google Patents

Transdermales therapeutisches system für 5-aminolävulinsäurehydrochlorid Download PDF

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Publication number
EP2750673B1
EP2750673B1 EP12750597.2A EP12750597A EP2750673B1 EP 2750673 B1 EP2750673 B1 EP 2750673B1 EP 12750597 A EP12750597 A EP 12750597A EP 2750673 B1 EP2750673 B1 EP 2750673B1
Authority
EP
European Patent Office
Prior art keywords
transdermal therapeutic
therapeutic system
polyacrylate
aminolevulinic acid
acid hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP12750597.2A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2750673A1 (de
Inventor
Tobias Jung
Michael Horstmann
Gerd Hoffmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Photonamic GmbH and Co KG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Priority to PL12750597T priority Critical patent/PL2750673T3/pl
Publication of EP2750673A1 publication Critical patent/EP2750673A1/de
Application granted granted Critical
Publication of EP2750673B1 publication Critical patent/EP2750673B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Definitions

  • the active substance-impermeable backing layer is preferably inert and as flexible as possible, so that the transdermal therapeutic system can also be applied to uneven skin areas.
  • any suitable material such as polyethylene terephthalate, polyethylene, polybutylene, polyurethane, polyester, etc. may be used.
  • the active substance-impermeable backing layer is preferably an optionally aluminized polyester film, particularly preferably a laminate of pigmented polyethylene and aluminum vapor-coated polyester, which protects against light radiation and thus prevent photosensitization before the actual photodynamic therapy.
  • the crystals or particles of the crystalline 5-aminolevulinic acid hydrochloride are greater than the layer thickness of the polymer matrix.
  • the active ingredient protrudes from the matrix, so to speak, which has the advantage that, upon contact with the skin, especially with sweat, the protruding crystals dissolve very quickly and can therefore be absorbed easily and quickly transdermally.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
EP12750597.2A 2011-08-31 2012-08-24 Transdermales therapeutisches system für 5-aminolävulinsäurehydrochlorid Active EP2750673B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL12750597T PL2750673T3 (pl) 2011-08-31 2012-08-24 Transdermalny system terapeutyczny dla chlorowodorku kwasu 5-aminolewulinowego

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011111865A DE102011111865A1 (de) 2011-08-31 2011-08-31 Transdermales therapeutisches System für 5-Aminolävulinsäurehydrochlorid
PCT/EP2012/066541 WO2013030129A1 (de) 2011-08-31 2012-08-24 Transdermales therapeutisches system für 5-aminolävulinsäurehydrochlorid

Publications (2)

Publication Number Publication Date
EP2750673A1 EP2750673A1 (de) 2014-07-09
EP2750673B1 true EP2750673B1 (de) 2017-08-09

Family

ID=46724447

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12750597.2A Active EP2750673B1 (de) 2011-08-31 2012-08-24 Transdermales therapeutisches system für 5-aminolävulinsäurehydrochlorid

Country Status (17)

Country Link
US (2) US10307382B2 (pt)
EP (1) EP2750673B1 (pt)
JP (2) JP6035335B2 (pt)
KR (1) KR101933610B1 (pt)
CN (1) CN103764135B (pt)
AU (1) AU2012301042B2 (pt)
BR (1) BR112014004635B1 (pt)
CA (1) CA2844288C (pt)
DE (1) DE102011111865A1 (pt)
DK (1) DK2750673T3 (pt)
ES (1) ES2646737T3 (pt)
MX (1) MX351514B (pt)
NO (1) NO2750673T3 (pt)
PL (1) PL2750673T3 (pt)
PT (1) PT2750673T (pt)
RU (1) RU2607657C2 (pt)
WO (1) WO2013030129A1 (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11850025B2 (en) 2011-11-28 2023-12-26 Aranz Healthcare Limited Handheld skin measuring or monitoring device

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ307444B6 (cs) * 2015-04-22 2018-08-29 Jakub Rak Mukoadhezivní polymerní film pro fotosenzitivní terapii v ústní dutině s obsahem fotosenzitizérů
US10013527B2 (en) 2016-05-02 2018-07-03 Aranz Healthcare Limited Automatically assessing an anatomical surface feature and securely managing information related to the same
US11116407B2 (en) 2016-11-17 2021-09-14 Aranz Healthcare Limited Anatomical surface assessment methods, devices and systems
US11903723B2 (en) 2017-04-04 2024-02-20 Aranz Healthcare Limited Anatomical surface assessment methods, devices and systems
KR102171200B1 (ko) 2018-11-20 2020-10-28 제너럴바이오(주) 5-아미노레불린산 수화염화물과 그 유도체를 유효성분으로 함유하는 여드름성 피부염 개선 또는 그의 조성물
CN111517973B (zh) * 2019-02-02 2023-08-04 中国科学院天津工业生物技术研究所 一种从发酵液中制备5-氨基乙酰丙酸盐酸盐的生产工艺及其应用

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WO1996006602A1 (en) 1993-08-27 1996-03-07 Noven Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR THE ADMINISTRATION OF δ-AMINOLEVULINIC ACID AND PHARMACEUTICAL EQUIVALENTS THEREOF
HU0200901D0 (pt) * 1996-06-20 2002-08-28 Lavipharm Sa
GR1002807B (el) 1996-06-20 1997-11-13 Lavipharm A.E. Συστημα για την τοπικη θεραπεια της ακμης και μεθοδος παραγωγης του
US5856566A (en) * 1997-09-02 1999-01-05 Dusa Pharmaceuticals, Inc. Sterilized 5-aminolevulinic acid
DE60017831T3 (de) * 1999-01-14 2009-12-17 Noven Pharmaceuticals, Inc., Miami Dermale zusammensetzungen
DE10034673C1 (de) * 2000-07-17 2002-04-25 Medac Klinische Spezialpraep Dermales Applikationssystem für Aminolävulinsäure und seine Verwendung
CA2422865C (en) 2000-08-16 2012-10-16 The General Hospital Corporation D/B/A Massachusetts General Hospital Aminolevulinic acid photodynamic therapy for treating sebaceous gland disorders
KR100846912B1 (ko) 2001-01-12 2008-07-17 페데랄노에고수다르스트벤노에유니타르노에프레드프리야티에고수다르스트벤니나우쉬니티센트르나우쉬노이슬레도바텔스키인스티튜트오르가니쉐스키크흐포루프로두크토브아이크르아시텔에이에프지업지엔트스니오피크 광에너지 요법 및 그 요법을 수행하기 위한 도포기
JP4394444B2 (ja) * 2001-10-24 2010-01-06 パワー ペーパー リミティド 活性物質の制御された皮膚内デリバリーのためのデバイス及び方法
DE10200578A1 (de) 2002-01-09 2003-07-10 Roehm Gmbh Haft- und Bindemittel für dermale oder transdermale Therapiesysteme
DE10202487A1 (de) 2002-01-23 2003-07-31 Photonamic Gmbh & Co Kg Dermales Applikationssystem für Aminolävulinsäure-Derivate
DE10344334A1 (de) 2003-09-24 2005-04-28 Johann Berger Gewebtes Gurtband
EP1847264B1 (en) 2005-01-31 2017-05-03 Hisamitsu Pharmaceutical Co., Inc. Bisoprolol patch
US20060182790A1 (en) * 2005-02-17 2006-08-17 Flor Mayoral Dermal medicaments application enhancer
US20100087768A1 (en) * 2008-10-02 2010-04-08 Forlano Paula Transdermal drug delivery system for liquid active ingredient

Non-Patent Citations (1)

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Title
None *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11850025B2 (en) 2011-11-28 2023-12-26 Aranz Healthcare Limited Handheld skin measuring or monitoring device

Also Published As

Publication number Publication date
EP2750673A1 (de) 2014-07-09
DE102011111865A1 (de) 2013-02-28
KR20140056370A (ko) 2014-05-09
WO2013030129A1 (de) 2013-03-07
US20190240166A1 (en) 2019-08-08
US10307382B2 (en) 2019-06-04
CN103764135B (zh) 2018-06-22
ES2646737T3 (es) 2017-12-15
MX2014002215A (es) 2014-04-30
CA2844288C (en) 2019-08-20
MX351514B (es) 2017-10-17
JP2014527537A (ja) 2014-10-16
AU2012301042A1 (en) 2014-03-20
AU2012301042B2 (en) 2017-07-13
US20140323994A1 (en) 2014-10-30
CN103764135A (zh) 2014-04-30
RU2607657C2 (ru) 2017-01-10
JP2017061489A (ja) 2017-03-30
BR112014004635A2 (pt) 2017-03-14
CA2844288A1 (en) 2013-03-07
PL2750673T3 (pl) 2018-11-30
NO2750673T3 (pt) 2018-01-06
DK2750673T3 (da) 2017-11-20
BR112014004635B1 (pt) 2022-09-13
RU2014111255A (ru) 2015-10-10
PT2750673T (pt) 2017-11-15
KR101933610B1 (ko) 2018-12-28
JP6203364B2 (ja) 2017-09-27
JP6035335B2 (ja) 2016-11-30

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