EP2705023A4 - Procédés pour la préparation de n-[2-(7-méthoxy-1-naphtyléthyl]acétamide - Google Patents
Procédés pour la préparation de n-[2-(7-méthoxy-1-naphtyléthyl]acétamideInfo
- Publication number
- EP2705023A4 EP2705023A4 EP11854945.0A EP11854945A EP2705023A4 EP 2705023 A4 EP2705023 A4 EP 2705023A4 EP 11854945 A EP11854945 A EP 11854945A EP 2705023 A4 EP2705023 A4 EP 2705023A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- acetamide
- naphthyl
- methoxy
- ethyl
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IN2011/000003 WO2012093402A1 (fr) | 2011-01-04 | 2011-01-04 | Procédés pour la préparation de n-[2-(7-méthoxy-1-naphtyléthyl]acétamide |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2705023A1 EP2705023A1 (fr) | 2014-03-12 |
EP2705023A4 true EP2705023A4 (fr) | 2014-11-19 |
Family
ID=46457287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11854945.0A Withdrawn EP2705023A4 (fr) | 2011-01-04 | 2011-01-04 | Procédés pour la préparation de n-[2-(7-méthoxy-1-naphtyléthyl]acétamide |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2705023A4 (fr) |
AR (1) | AR083840A1 (fr) |
WO (1) | WO2012093402A1 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102276492B (zh) * | 2010-06-08 | 2013-04-10 | 上海医药工业研究院 | 阿戈美拉汀中间体及其制备方法 |
JO3339B1 (ar) * | 2012-09-11 | 2019-03-13 | Shanghai Inst Pharmaceutical Ind | شكل مستقر غير متبلور من الأغوميلاتين وعملية تحضيره والتركيبات الدوائية التي تحتوي عليه |
WO2014040228A1 (fr) * | 2012-09-11 | 2014-03-20 | Les Laboratoires Servier | Forme amorphe stabilisée de l'agomélatine, son procédé de préparation et compositions pharmaceutiques la contenant |
FR2995896B1 (fr) * | 2012-09-26 | 2014-11-21 | Servier Lab | Forme amorphe stabilisee de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent. |
WO2014064706A1 (fr) * | 2012-10-22 | 2014-05-01 | Symed Labs Limited | Procédé pour la préparation d'agomélatine à l'aide de nouveaux intermédiaires |
CN102993040B (zh) * | 2012-11-30 | 2015-09-30 | 中国药科大学 | 一种合成阿戈美拉汀的新方法 |
CN103073441A (zh) * | 2012-12-27 | 2013-05-01 | 上海右手医药科技开发有限公司 | 合成(7-甲氧基-1-萘基)乙胺的新方法及其在合成阿戈美拉汀中的应用 |
CN103113243A (zh) * | 2013-03-08 | 2013-05-22 | 山东方明药业集团股份有限公司 | 一种2-(7-甲氧基-1-萘基)乙胺盐酸盐的合成方法 |
CN104130154A (zh) * | 2013-05-03 | 2014-11-05 | 郭炳华 | 一种制备高纯度阿戈美拉汀的方法 |
CZ2013621A3 (cs) * | 2013-08-13 | 2015-02-25 | Zentiva, K.S. | Termodynamicky stabilní tuhý roztok agomelatinu pro použití ve farmaceutické formulaci |
WO2015124496A1 (fr) | 2014-02-19 | 2015-08-27 | Synthon B.V. | Composition pharmaceutique comprenant de l'agomélatine amorphe |
WO2015189778A1 (fr) * | 2014-06-10 | 2015-12-17 | Laboratorio Chimico Internazionale S.P.A. | Adsorbats et compositions d'agomélatine en solution |
CN104262197A (zh) * | 2014-08-28 | 2015-01-07 | 太仓运通生物化工有限公司 | 一种1-环己烯基乙腈的合成方法 |
WO2016046833A2 (fr) * | 2014-09-24 | 2016-03-31 | Symed Labs Limited | Procédé amélioré de préparation de l'agomélatine à l'aide de nouveaux intermédiaires |
ES2959460T3 (es) | 2015-03-31 | 2024-02-26 | Fis Fabbrica Italiana Sintetici Spa | Forma sólida de agomelatina |
CN105601537B (zh) * | 2016-01-25 | 2018-11-06 | 江西同和药业股份有限公司 | 一种2-(7-甲氧基-1-萘基)乙腈的制备方法 |
CN105669494A (zh) * | 2016-03-11 | 2016-06-15 | 上海韬鸿化工科技有限公司 | 一种2-(7-甲氧基-1-萘基)乙氰的制备方法 |
CN107151221A (zh) * | 2017-06-19 | 2017-09-12 | 太仓卡斯特姆新材料有限公司 | 一种制备阿戈美拉汀重要中间体7‑甲氧基萘乙腈的方法 |
CN109251151A (zh) * | 2017-07-12 | 2019-01-22 | 北京广为医药科技有限公司 | N-(2-(取代-萘-1-基)乙基)取代酰胺类化合物、其制备及其用途 |
CN107353229B (zh) * | 2017-08-08 | 2019-04-30 | 许昌恒生制药有限公司 | 一种阿戈美拉汀中间体的制备方法 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0447285A1 (fr) * | 1990-02-27 | 1991-09-18 | Adir Et Compagnie | Nouveaux dérivés à structure naphtalénique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
WO2008137461A1 (fr) * | 2007-05-01 | 2008-11-13 | Concert Pharmaceuticals Inc. | Naphtyl(éthyl)acétamides |
WO2010102554A1 (fr) * | 2009-03-10 | 2010-09-16 | 上海医药工业研究院 | Nouvelle forme cristalline vi de l'agomélatine son procédé de préparation et son application |
WO2012130837A1 (fr) * | 2011-03-28 | 2012-10-04 | Ratiopharm Gmbh | Agomélatine solide sous une forme non cristalline |
CN102716493A (zh) * | 2011-03-31 | 2012-10-10 | 天津药物研究院 | 含无定型态阿戈美拉汀的共聚物、其制备方法、其药物组合物及用途 |
WO2014040228A1 (fr) * | 2012-09-11 | 2014-03-20 | Les Laboratoires Servier | Forme amorphe stabilisée de l'agomélatine, son procédé de préparation et compositions pharmaceutiques la contenant |
WO2014041015A1 (fr) * | 2012-09-11 | 2014-03-20 | Les Laboratoires Servier | Forme amorphe stabilisée d'agomélatine, procédé pour sa préparation et compositions pharmaceutiques la contenant |
WO2014095818A1 (fr) * | 2012-12-20 | 2014-06-26 | Synthon B.V. | Préparation comprenant de l'agomélatine amorphe |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2866335B1 (fr) * | 2004-02-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
FR2934856B1 (fr) * | 2008-08-05 | 2010-08-13 | Servier Lab | Nouveau procede d'obtention de la forme cristalline v de l'agomelatine |
-
2011
- 2011-01-04 EP EP11854945.0A patent/EP2705023A4/fr not_active Withdrawn
- 2011-01-04 WO PCT/IN2011/000003 patent/WO2012093402A1/fr active Application Filing
- 2011-11-11 AR ARP110104214A patent/AR083840A1/es unknown
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0447285A1 (fr) * | 1990-02-27 | 1991-09-18 | Adir Et Compagnie | Nouveaux dérivés à structure naphtalénique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
WO2008137461A1 (fr) * | 2007-05-01 | 2008-11-13 | Concert Pharmaceuticals Inc. | Naphtyl(éthyl)acétamides |
WO2010102554A1 (fr) * | 2009-03-10 | 2010-09-16 | 上海医药工业研究院 | Nouvelle forme cristalline vi de l'agomélatine son procédé de préparation et son application |
US20120004313A1 (en) * | 2009-03-10 | 2012-01-05 | Hanbin Shan | Crystalline form vi of agomelatine, preparation method and application thereof |
WO2012130837A1 (fr) * | 2011-03-28 | 2012-10-04 | Ratiopharm Gmbh | Agomélatine solide sous une forme non cristalline |
CN102716493A (zh) * | 2011-03-31 | 2012-10-10 | 天津药物研究院 | 含无定型态阿戈美拉汀的共聚物、其制备方法、其药物组合物及用途 |
WO2014040228A1 (fr) * | 2012-09-11 | 2014-03-20 | Les Laboratoires Servier | Forme amorphe stabilisée de l'agomélatine, son procédé de préparation et compositions pharmaceutiques la contenant |
WO2014041015A1 (fr) * | 2012-09-11 | 2014-03-20 | Les Laboratoires Servier | Forme amorphe stabilisée d'agomélatine, procédé pour sa préparation et compositions pharmaceutiques la contenant |
WO2014095818A1 (fr) * | 2012-12-20 | 2014-06-26 | Synthon B.V. | Préparation comprenant de l'agomélatine amorphe |
Non-Patent Citations (1)
Title |
---|
See also references of WO2012093402A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP2705023A1 (fr) | 2014-03-12 |
WO2012093402A1 (fr) | 2012-07-12 |
AR083840A1 (es) | 2013-03-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2705023A4 (fr) | Procédés pour la préparation de n-[2-(7-méthoxy-1-naphtyléthyl]acétamide | |
IL246265B (en) | A method for the production of intermediates for the preparation of 5-fluoro-h1-pyrazolopyridines and such compounds | |
HK1191354A1 (en) | Process for the preparation of nitrile rubbers | |
PL2517700T3 (pl) | Farmaceutyczne dopuszczalne kokryształy n-[2-(7-metoksy-1-naftylo]acetamidu i sposoby ich wytwarzania | |
EP2526099A4 (fr) | Procédé amélioré pour la préparation d'intermédiaires amides et leur utilisation | |
PT2723714T (pt) | Novos processos para a preparação de amidas de prostaglandina | |
EP2630143A4 (fr) | Procédés de préparation de rivaroxaban et ses intermédiaires | |
HK1198584A1 (en) | Process for the preparation of travoprost | |
HK1194733A1 (zh) | 製備 -酰基- -苯基磺酰基脯氨酰胺衍生物的方法及中間體 | |
ZA201306212B (en) | An improved process for the preparation of voriconazole and intermediates thereof | |
HK1189571A1 (en) | Process and intermediates for synthesizing agomelatine | |
IL232036A0 (en) | A new process for the preparation of acylguanidines and acylthioureas | |
EP2909166A4 (fr) | Procédé pour la préparation d'agomélatine à l'aide de nouveaux intermédiaires | |
PT2603319E (pt) | Processo para a preparação de uretanos | |
EP2680846A4 (fr) | Utilisation de n-(4-méthoxyphényl)-1-phényl-1h-pyrazol-3-amine et composés associés | |
PL2702045T3 (pl) | Nowy sposób sporządzania Etrawiryny | |
EP2555616A4 (fr) | Procédé de préparation d'hydrochlorure de mémantine | |
HRP20160767T1 (hr) | Postupak za pripremu kristalnog oblika i agomelatina | |
HK1214585A1 (zh) | -二甲基氨基-丙烯酰基 -氟-苯基 -甲基-乙酰胺的製備方法 | |
PL390177A1 (pl) | Sposób wytwarzania soli α-(N-acyloamino) alkilotrifenylofosfoniowych | |
AP3399A (en) | New process for the synthesis of agomelatine | |
HUP1100291A2 (en) | Process for the preparation of prostaglandin amides |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
TPAC | Observations filed by third parties |
Free format text: ORIGINAL CODE: EPIDOSNTIPA |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20131120 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20141017 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07C 253/30 20060101ALI20141013BHEP Ipc: C07C 213/02 20060101AFI20141013BHEP Ipc: C07C 231/12 20060101ALI20141013BHEP Ipc: C07C 233/18 20060101ALI20141013BHEP Ipc: A61P 25/24 20060101ALI20141013BHEP Ipc: C07C 231/02 20060101ALI20141013BHEP Ipc: A61K 31/165 20060101ALI20141013BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20150514 |