EP2705023A4 - Procédés pour la préparation de n-[2-(7-méthoxy-1-naphtyléthyl]acétamide - Google Patents

Procédés pour la préparation de n-[2-(7-méthoxy-1-naphtyléthyl]acétamide

Info

Publication number
EP2705023A4
EP2705023A4 EP11854945.0A EP11854945A EP2705023A4 EP 2705023 A4 EP2705023 A4 EP 2705023A4 EP 11854945 A EP11854945 A EP 11854945A EP 2705023 A4 EP2705023 A4 EP 2705023A4
Authority
EP
European Patent Office
Prior art keywords
acetamide
naphthyl
methoxy
ethyl
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP11854945.0A
Other languages
German (de)
English (en)
Other versions
EP2705023A1 (fr
Inventor
Rao Dodda Mohan
Reddy Pingili Krishna
Reddy Ambati Anna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Symed Labs Ltd
Original Assignee
Symed Labs Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symed Labs Ltd filed Critical Symed Labs Ltd
Publication of EP2705023A1 publication Critical patent/EP2705023A1/fr
Publication of EP2705023A4 publication Critical patent/EP2705023A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP11854945.0A 2011-01-04 2011-01-04 Procédés pour la préparation de n-[2-(7-méthoxy-1-naphtyléthyl]acétamide Withdrawn EP2705023A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2011/000003 WO2012093402A1 (fr) 2011-01-04 2011-01-04 Procédés pour la préparation de n-[2-(7-méthoxy-1-naphtyléthyl]acétamide

Publications (2)

Publication Number Publication Date
EP2705023A1 EP2705023A1 (fr) 2014-03-12
EP2705023A4 true EP2705023A4 (fr) 2014-11-19

Family

ID=46457287

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11854945.0A Withdrawn EP2705023A4 (fr) 2011-01-04 2011-01-04 Procédés pour la préparation de n-[2-(7-méthoxy-1-naphtyléthyl]acétamide

Country Status (3)

Country Link
EP (1) EP2705023A4 (fr)
AR (1) AR083840A1 (fr)
WO (1) WO2012093402A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102276492B (zh) * 2010-06-08 2013-04-10 上海医药工业研究院 阿戈美拉汀中间体及其制备方法
JO3339B1 (ar) * 2012-09-11 2019-03-13 Shanghai Inst Pharmaceutical Ind شكل مستقر غير متبلور من الأغوميلاتين وعملية تحضيره والتركيبات الدوائية التي تحتوي عليه
WO2014040228A1 (fr) * 2012-09-11 2014-03-20 Les Laboratoires Servier Forme amorphe stabilisée de l'agomélatine, son procédé de préparation et compositions pharmaceutiques la contenant
FR2995896B1 (fr) * 2012-09-26 2014-11-21 Servier Lab Forme amorphe stabilisee de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent.
WO2014064706A1 (fr) * 2012-10-22 2014-05-01 Symed Labs Limited Procédé pour la préparation d'agomélatine à l'aide de nouveaux intermédiaires
CN102993040B (zh) * 2012-11-30 2015-09-30 中国药科大学 一种合成阿戈美拉汀的新方法
CN103073441A (zh) * 2012-12-27 2013-05-01 上海右手医药科技开发有限公司 合成（7-甲氧基-1-萘基）乙胺的新方法及其在合成阿戈美拉汀中的应用
CN103113243A (zh) * 2013-03-08 2013-05-22 山东方明药业集团股份有限公司 一种2-（7-甲氧基-1-萘基）乙胺盐酸盐的合成方法
CN104130154A (zh) * 2013-05-03 2014-11-05 郭炳华 一种制备高纯度阿戈美拉汀的方法
CZ2013621A3 (cs) * 2013-08-13 2015-02-25 Zentiva, K.S. Termodynamicky stabilní tuhý roztok agomelatinu pro použití ve farmaceutické formulaci
WO2015124496A1 (fr) 2014-02-19 2015-08-27 Synthon B.V. Composition pharmaceutique comprenant de l'agomélatine amorphe
WO2015189778A1 (fr) * 2014-06-10 2015-12-17 Laboratorio Chimico Internazionale S.P.A. Adsorbats et compositions d'agomélatine en solution
CN104262197A (zh) * 2014-08-28 2015-01-07 太仓运通生物化工有限公司 一种1-环己烯基乙腈的合成方法
WO2016046833A2 (fr) * 2014-09-24 2016-03-31 Symed Labs Limited Procédé amélioré de préparation de l'agomélatine à l'aide de nouveaux intermédiaires
ES2959460T3 (es) 2015-03-31 2024-02-26 Fis Fabbrica Italiana Sintetici Spa Forma sólida de agomelatina
CN105601537B (zh) * 2016-01-25 2018-11-06 江西同和药业股份有限公司 一种2-(7-甲氧基-1-萘基)乙腈的制备方法
CN105669494A (zh) * 2016-03-11 2016-06-15 上海韬鸿化工科技有限公司 一种2-(7-甲氧基-1-萘基)乙氰的制备方法
CN107151221A (zh) * 2017-06-19 2017-09-12 太仓卡斯特姆新材料有限公司 一种制备阿戈美拉汀重要中间体7‑甲氧基萘乙腈的方法
CN109251151A (zh) * 2017-07-12 2019-01-22 北京广为医药科技有限公司 N-(2-(取代-萘-1-基)乙基)取代酰胺类化合物、其制备及其用途
CN107353229B (zh) * 2017-08-08 2019-04-30 许昌恒生制药有限公司 一种阿戈美拉汀中间体的制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0447285A1 (fr) * 1990-02-27 1991-09-18 Adir Et Compagnie Nouveaux dérivés à structure naphtalénique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
WO2008137461A1 (fr) * 2007-05-01 2008-11-13 Concert Pharmaceuticals Inc. Naphtyl(éthyl)acétamides
WO2010102554A1 (fr) * 2009-03-10 2010-09-16 上海医药工业研究院 Nouvelle forme cristalline vi de l'agomélatine son procédé de préparation et son application
WO2012130837A1 (fr) * 2011-03-28 2012-10-04 Ratiopharm Gmbh Agomélatine solide sous une forme non cristalline
CN102716493A (zh) * 2011-03-31 2012-10-10 天津药物研究院 含无定型态阿戈美拉汀的共聚物、其制备方法、其药物组合物及用途
WO2014040228A1 (fr) * 2012-09-11 2014-03-20 Les Laboratoires Servier Forme amorphe stabilisée de l'agomélatine, son procédé de préparation et compositions pharmaceutiques la contenant
WO2014041015A1 (fr) * 2012-09-11 2014-03-20 Les Laboratoires Servier Forme amorphe stabilisée d'agomélatine, procédé pour sa préparation et compositions pharmaceutiques la contenant
WO2014095818A1 (fr) * 2012-12-20 2014-06-26 Synthon B.V. Préparation comprenant de l'agomélatine amorphe

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2866335B1 (fr) * 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'agomelatine
FR2934856B1 (fr) * 2008-08-05 2010-08-13 Servier Lab Nouveau procede d'obtention de la forme cristalline v de l'agomelatine

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0447285A1 (fr) * 1990-02-27 1991-09-18 Adir Et Compagnie Nouveaux dérivés à structure naphtalénique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
WO2008137461A1 (fr) * 2007-05-01 2008-11-13 Concert Pharmaceuticals Inc. Naphtyl(éthyl)acétamides
WO2010102554A1 (fr) * 2009-03-10 2010-09-16 上海医药工业研究院 Nouvelle forme cristalline vi de l'agomélatine son procédé de préparation et son application
US20120004313A1 (en) * 2009-03-10 2012-01-05 Hanbin Shan Crystalline form vi of agomelatine, preparation method and application thereof
WO2012130837A1 (fr) * 2011-03-28 2012-10-04 Ratiopharm Gmbh Agomélatine solide sous une forme non cristalline
CN102716493A (zh) * 2011-03-31 2012-10-10 天津药物研究院 含无定型态阿戈美拉汀的共聚物、其制备方法、其药物组合物及用途
WO2014040228A1 (fr) * 2012-09-11 2014-03-20 Les Laboratoires Servier Forme amorphe stabilisée de l'agomélatine, son procédé de préparation et compositions pharmaceutiques la contenant
WO2014041015A1 (fr) * 2012-09-11 2014-03-20 Les Laboratoires Servier Forme amorphe stabilisée d'agomélatine, procédé pour sa préparation et compositions pharmaceutiques la contenant
WO2014095818A1 (fr) * 2012-12-20 2014-06-26 Synthon B.V. Préparation comprenant de l'agomélatine amorphe

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2012093402A1 *

Also Published As

Publication number Publication date
EP2705023A1 (fr) 2014-03-12
WO2012093402A1 (fr) 2012-07-12
AR083840A1 (es) 2013-03-27

Similar Documents

Publication Publication Date Title
EP2705023A4 (fr) Procédés pour la préparation de n-[2-(7-méthoxy-1-naphtyléthyl]acétamide
IL246265B (en) A method for the production of intermediates for the preparation of 5-fluoro-h1-pyrazolopyridines and such compounds
HK1191354A1 (en) Process for the preparation of nitrile rubbers
PL2517700T3 (pl) Farmaceutyczne dopuszczalne kokryształy n-[2-(7-metoksy-1-naftylo]acetamidu i sposoby ich wytwarzania
EP2526099A4 (fr) Procédé amélioré pour la préparation d'intermédiaires amides et leur utilisation
PT2723714T (pt) Novos processos para a preparação de amidas de prostaglandina
EP2630143A4 (fr) Procédés de préparation de rivaroxaban et ses intermédiaires
HK1198584A1 (en) Process for the preparation of travoprost
HK1194733A1 (zh) 製備 -酰基- -苯基磺酰基脯氨酰胺衍生物的方法及中間體
ZA201306212B (en) An improved process for the preparation of voriconazole and intermediates thereof
HK1189571A1 (en) Process and intermediates for synthesizing agomelatine
IL232036A0 (en) A new process for the preparation of acylguanidines and acylthioureas
EP2909166A4 (fr) Procédé pour la préparation d'agomélatine à l'aide de nouveaux intermédiaires
PT2603319E (pt) Processo para a preparação de uretanos
EP2680846A4 (fr) Utilisation de n-(4-méthoxyphényl)-1-phényl-1h-pyrazol-3-amine et composés associés
PL2702045T3 (pl) Nowy sposób sporządzania Etrawiryny
EP2555616A4 (fr) Procédé de préparation d'hydrochlorure de mémantine
HRP20160767T1 (hr) Postupak za pripremu kristalnog oblika i agomelatina
HK1214585A1 (zh) -二甲基氨基-丙烯酰基 -氟-苯基 -甲基-乙酰胺的製備方法
PL390177A1 (pl) Sposób wytwarzania soli α-(N-acyloamino) alkilotrifenylofosfoniowych
AP3399A (en) New process for the synthesis of agomelatine
HUP1100291A2 (en) Process for the preparation of prostaglandin amides

Legal Events

Date Code Title Description
TPAC Observations filed by third parties

Free format text: ORIGINAL CODE: EPIDOSNTIPA

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20131120

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

A4 Supplementary search report drawn up and despatched

Effective date: 20141017

RIC1 Information provided on ipc code assigned before grant

Ipc: C07C 253/30 20060101ALI20141013BHEP

Ipc: C07C 213/02 20060101AFI20141013BHEP

Ipc: C07C 231/12 20060101ALI20141013BHEP

Ipc: C07C 233/18 20060101ALI20141013BHEP

Ipc: A61P 25/24 20060101ALI20141013BHEP

Ipc: C07C 231/02 20060101ALI20141013BHEP

Ipc: A61K 31/165 20060101ALI20141013BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20150514