EP2480322A1 - Appareil d'agitation à commande programmée et procédé permettant de faire fonctionner ledit appareil - Google Patents

Appareil d'agitation à commande programmée et procédé permettant de faire fonctionner ledit appareil

Info

Publication number
EP2480322A1
EP2480322A1 EP10760288A EP10760288A EP2480322A1 EP 2480322 A1 EP2480322 A1 EP 2480322A1 EP 10760288 A EP10760288 A EP 10760288A EP 10760288 A EP10760288 A EP 10760288A EP 2480322 A1 EP2480322 A1 EP 2480322A1
Authority
EP
European Patent Office
Prior art keywords
stirring
mixing
strokes
mixing vessel
tool
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10760288A
Other languages
German (de)
English (en)
Inventor
Matthias Konietzko
Albrecht Konietzko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gako Konietzko GmbH
Original Assignee
Gako Konietzko GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gako Konietzko GmbH filed Critical Gako Konietzko GmbH
Publication of EP2480322A1 publication Critical patent/EP2480322A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/23—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis
    • B01F27/231—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis with a variable orientation during mixing operation, e.g. with tiltable rotor axis
    • B01F27/2312—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis with a variable orientation during mixing operation, e.g. with tiltable rotor axis the position of the rotating shaft being adjustable in the interior of the receptacle, e.g. to locate the stirrer in different locations during the mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/805—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis wherein the stirrers or the receptacles are moved in order to bring them into operative position; Means for fixing the receptacle
    • B01F27/806—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis wherein the stirrers or the receptacles are moved in order to bring them into operative position; Means for fixing the receptacle with vertical displacement of the stirrer, e.g. in combination with means for pivoting the stirrer about a vertical axis in order to co-operate with different receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/2201—Control or regulation characterised by the type of control technique used
    • B01F35/2206—Use of stored recipes for controlling the computer programs, e.g. for manipulation, handling, production or composition in mixing plants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/2201—Control or regulation characterised by the type of control technique used
    • B01F35/2207—Use of data, i.e. barcodes, 3D codes or similar type of tagging information, as instruction or identification codes for controlling the computer programs, e.g. for manipulation, handling, production or compounding in mixing plants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/2201—Control or regulation characterised by the type of control technique used
    • B01F35/2209—Controlling the mixing process as a whole, i.e. involving a complete monitoring and controlling of the mixing process during the whole mixing cycle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
    • B01F35/2214—Speed during the operation
    • B01F35/22142—Speed of the mixing device during the operation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
    • B01F35/2216—Time, i.e. duration, of at least one parameter during the operation
    • B01F35/22161—Time, i.e. duration, of at least one parameter during the operation duration of the mixing process or parts of it
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/21—Mixing of ingredients for cosmetic or perfume compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions

Definitions

  • the invention relates to a method for controlling a program-controlled stirring device for the production of pharmaceutical or cosmetic formulations. Furthermore, the invention relates to a stirring device for carrying out such a method.
  • Generic agitators include a control unit, a motor-driven stirring unit with a stirrer ⁇ tool, which engages in a mixing vessel, and a Hubein ⁇ unit .
  • the lifting unit causes an axial relative movement between the stirring tool and the mixing vessel in order to displace the stirring tool in the mixing vessel between an upper and a lower end position at a constant lifting speed.
  • program-controlled agitators also enforced in pharmacies, because they make it possible to deliver recipes with consistent top quality, even with repeated production.
  • the viscosity during the stirring process can be determined continuously.
  • a method for using a program-controlled agitator is known in which initially variable and constant data are read.
  • the variable data defines the category of the recipe to be prepared as well as the size of the mixing vessel or the amount of the recipe.
  • the constant data are specified in a data store and contain basic values for the stirring time and the Rlickge ⁇ speed for different categories of recipes and sizes of mixing vessels. From the read data will be Stirring time and stirring speed for producing the gewünsch ⁇ th amount of the recipe determined by linking the variable and constant data. With the determined data, the stirring unit is controlled accordingly and the recipe Herge ⁇ provides.
  • control parameters used are stored in a data memory for a later re-production of the same recipe in the same amount, together with identification data of the recipe produced.
  • the applied control parameters and / or identification data are output in electronic and / or printed form via data output means.
  • the object of the invention is to make individual formulations once prepared or standardized formulations reproducible in consistent quality, regardless of the quantity of formulation to be prepared or the size of the mixing vessel used.
  • a program-controlled mixer with which the fiction, modern ⁇ method is useful, includes initially in a known manner a control unit, a motor-driven Rlickein ⁇ integrated with a stirring tool, which in a mixing vessel
  • the lifting unit causes an axial relative movement between the stirring tool and the mixing vessel in order to displace the stirring tool in the mixing vessel between an upper and a lower end position with a preferably constant lifting speed.
  • a Mutrlickfrac for Farmrezeptur is ⁇ leads, said input values or default values that are used for the stirring time and the rotational speed of the stirring each stirring period. In this case, preferably up to six consecutive stirring periods can be used.
  • identification ⁇ data for the prepared first formulation.
  • This identifica ⁇ approximate data include at least the predetermined number of strokes per period of stirring and the speeds used per stirring period. It is not necessary for this, for example, that the number of strokes is included as unchanged numerical value in the identification data.
  • the specific number of strokes can be encrypted in a code or added converted and then the iden ⁇ approximate data using certain factors in a time value.
  • the size of the mixing vessel can be stored to the identification data.
  • input values for the entire stirring process are entered for the preparation of the initial formulation, wherein already during the input
  • the input is preferably carried out as follows: input of the mixing vessel size (or the quantity of the recipe to be prepared) and then the input of stirring speed (eg by specifying the speed to be applied) and stirring time per stirring period.
  • the input can also be made via an internal memory location or a so-called identification number, in which these input values are stored in encrypted form. If this Clearrezeptur now be prepared again in a different discharge amount, a Wiederholrlick mixes is performed, according to the invention determined in Warrlickrindpens stroke rate per stirring period regardless of the size of the Mixing vessel and the amount of the recipe is used. For this purpose, the previously stored identification data are used. The identification data are read in either from the internal memory or by entering an ident number.
  • the result is the quality at least as good, if not better than a smaller mixing vessel.
  • the stirring time is automatically adjusted by counting the executed strokes to the effectively used mixing vessel size. For the first time ever, a consistently high quality is ensured, even if larger mixing vessels are not completely filled and an adjustment of the stirring time determined by the operator is dispensed with.
  • the identification data are output after the first running process.
  • the output can be carried out as an encrypted number / letter combination or, for example, as a barcode or square Aztec code, which are printed on a label or output to a monitor and optionally additionally stored in a memory.
  • an output of modified identification data takes place. These can, for example, be printed out (numeric / letter combination, barcode, Aztec code) or otherwise output (USB, memory card ).
  • modified identification data are output as a so-called identification number, for example with the following information:
  • the next statement includes the speed and togehö ⁇ engined time for a period of stirring.
  • the rotational speed can thereby be output preferably stepwise 0-2400 Flip Cellphone relationships ⁇ / min in 10 stages.
  • the duration of the individual stirring periods is intended for orientation of the user of the mixer and is not relevant to the reproduction of the recipe. However, the user is habitually oriented to stirring times, so that they are easier to understand for him than information on the number of strokes.
  • the duration of the stirring periods is determined from the stored number of strokes at a known lifting speed. The measurement of the stirring time during the execution of the stirring process can thus be dispensed with.
  • the time values output to the user are calculated by the device from the specific number of strokes and stored as identification data.
  • the device preferably additionally stores the actual number of processed strokes per stirring period. Also a separate output can be made. In carrying out the Wiederholrezeptur is now the
  • the input of the identification data (Ident number) in the production of a repeating recipe can be via a
  • Keyboard or other input media (scanner, memory card o. The like.) Made
  • a scaling function is only required if certain speeds are not available due to the size of the mixing vessel. For large agitators very high speeds can not be used if unwanted forces should be avoided due to imbalances. For this reason, it is advantageous if at the beginning of a Wiederholrmileprozes ⁇ ses the mixing vessel size actually used determined (eg on the stroke length) or is entered (eg on the amount of the recipe) to the large stirring vessels required in large mixing vessels not with unacceptably high speeds to operate. It should be remembered at this point that the stirring tools of such devices are adapted to the diameter of the mixing vessels to allow rubbing operations on the wall and to achieve a complete, uniform mixing of the mix.
  • a Safe ⁇ integral function ensures the agitator that an operation is ruled out with excessive speeds. So if the maximum speed stage is set for a particular mixing ⁇ vessel size, a correction factor must increase the number of strokes accordingly if the process against the Managerrlick- a reduced speed must be used.
  • Context be described and executed by the microprocessor of the mixer. It is also possible to store a value table, which is used for scaling.
  • a warning signal can be output to alert the operator to the quality of the recipe.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Software Systems (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)

Abstract

L'invention concerne un appareil d'agitation à commande programmée pour la préparation de formulations pharmaceutiques ou cosmétiques, ainsi qu'un procédé de commande dudit appareil. Cet appareil d'agitation comprend une unité de commande, une unité d'agitation entraînée de façon motorisée et pourvue d'un instrument d'agitation qui plonge dans un récipient de mélange, et une unité de va-et-vient. L'unité de va-et-vient provoque un mouvement relatif axial entre l'instrument d'agitation et le récipient de mélange pour déplacer l'instrument d'agitation dans le récipient de mélange entre une position terminale supérieure et une position terminale inférieure avec une vitesse de course constante. Le procédé de commande comprend également le comptage des mouvements de va-et-vient, par période d'agitation, effectués par l'unité de va-et-vient pendant un premier processus d'agitation ainsi que l'utilisation, pendant un processus d'agitation répété, d'au moins les données d'identification déterminées dans le premier processus d'agitation, les données d'identification correspondant à la formulation étant lues et le nombre de mouvements de va-et-vient déterminé dans le premier processus d'agitation, par période d'agitation, étant utilisé de manière inchangée ou graduellement adapté pour l'exécution de la période d'agitation correspondante du processus d'agitation répété.
EP10760288A 2009-09-23 2010-09-17 Appareil d'agitation à commande programmée et procédé permettant de faire fonctionner ledit appareil Withdrawn EP2480322A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102009044077A DE102009044077A1 (de) 2009-09-23 2009-09-23 Programmgesteuertes Rührgerät und Verfahren zu seiner Steuerung
PCT/EP2010/063676 WO2011036098A1 (fr) 2009-09-23 2010-09-17 Appareil d'agitation à commande programmée et procédé permettant de faire fonctionner ledit appareil

Publications (1)

Publication Number Publication Date
EP2480322A1 true EP2480322A1 (fr) 2012-08-01

Family

ID=43371026

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10760288A Withdrawn EP2480322A1 (fr) 2009-09-23 2010-09-17 Appareil d'agitation à commande programmée et procédé permettant de faire fonctionner ledit appareil

Country Status (7)

Country Link
US (1) US20120269029A1 (fr)
EP (1) EP2480322A1 (fr)
JP (1) JP5536217B2 (fr)
BR (1) BR112012006580A2 (fr)
DE (1) DE102009044077A1 (fr)
RU (1) RU2570452C2 (fr)
WO (1) WO2011036098A1 (fr)

Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
US10471242B2 (en) 2011-02-15 2019-11-12 Biosrx, Inc. Applicator and system for administering and dispensing flowable pharmaceutical preparations
DE102014105989A1 (de) 2014-04-29 2015-10-29 Gako International Gmbh Apotheken-Rezepturherstellungssystem und Apotheken-Rezepturherstellungsverfahren zum Herstellen von pharmazeutischen Individualrezepturen
CA3062126C (fr) 2016-11-10 2021-04-27 Medisca Pharmaceutique Inc. Ensemble recipient et son adaptateur
US11040181B2 (en) 2017-01-04 2021-06-22 Reflex Medical Corp. Metered dose topical applicator
USD848611S1 (en) 2018-01-24 2019-05-14 Reflex Medical Corp. Metered dose topical applicator
CN108568269A (zh) * 2018-04-20 2018-09-25 佛山市长郡科技有限公司 一种智能混合器
BR112020026295A2 (pt) * 2018-06-19 2021-03-30 Medisca Pharmaceutique Inc. Métodos e sistemas para portal de composição farmacêutica
US11697124B2 (en) * 2020-12-13 2023-07-11 Purepressure, Llc Relocating cannabis trichome separator
DE102021131517A1 (de) 2021-12-01 2023-06-01 Dr. Herfeld Gmbh & Co. Kg Industrielle Mischmaschine
WO2023115200A1 (fr) * 2021-12-20 2023-06-29 Medisca Pharmaceutique Inc. Système modulaire pour applications de mélange automatisées

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JP2003112027A (ja) * 2001-10-04 2003-04-15 Matsushita Refrig Co Ltd 撹拌装置
JP3920632B2 (ja) * 2001-11-26 2007-05-30 三洋電機株式会社 飲料製造装置
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Also Published As

Publication number Publication date
RU2570452C2 (ru) 2015-12-10
JP2013505126A (ja) 2013-02-14
DE102009044077A1 (de) 2011-04-07
WO2011036098A1 (fr) 2011-03-31
RU2012115916A (ru) 2013-10-27
JP5536217B2 (ja) 2014-07-02
US20120269029A1 (en) 2012-10-25
BR112012006580A2 (pt) 2016-04-26

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