EP2376894A1 - Optisch aktive funktionelle fl?ssigkeitsmarker - Google Patents
Optisch aktive funktionelle fl?ssigkeitsmarkerInfo
- Publication number
- EP2376894A1 EP2376894A1 EP09768585A EP09768585A EP2376894A1 EP 2376894 A1 EP2376894 A1 EP 2376894A1 EP 09768585 A EP09768585 A EP 09768585A EP 09768585 A EP09768585 A EP 09768585A EP 2376894 A1 EP2376894 A1 EP 2376894A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- fluid
- fluids
- optically active
- marker
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 239000003550 marker Substances 0.000 claims abstract description 78
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- 150000001875 compounds Chemical class 0.000 claims description 30
- 230000005540 biological transmission Effects 0.000 claims description 17
- 239000000314 lubricant Substances 0.000 claims description 15
- 239000000446 fuel Substances 0.000 claims description 12
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 12
- 239000010705 motor oil Substances 0.000 claims description 11
- 239000003921 oil Substances 0.000 claims description 10
- XMGQYMWWDOXHJM-JTQLQIEISA-N (+)-α-limonene Chemical compound CC(=C)[C@@H]1CCC(C)=CC1 XMGQYMWWDOXHJM-JTQLQIEISA-N 0.000 claims description 9
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 9
- 238000009007 Diagnostic Kit Methods 0.000 claims description 7
- UJNOLBSYLSYIBM-WISYIIOYSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2r)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@@H](C)O UJNOLBSYLSYIBM-WISYIIOYSA-N 0.000 claims description 7
- 238000004458 analytical method Methods 0.000 claims description 7
- RUMOYJJNUMEFDD-SNVBAGLBSA-N (4s)-4-prop-1-en-2-ylcyclohexene-1-carbaldehyde Chemical compound CC(=C)[C@H]1CCC(C=O)=CC1 RUMOYJJNUMEFDD-SNVBAGLBSA-N 0.000 claims description 6
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
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- 235000002906 tartaric acid Nutrition 0.000 claims description 6
- XUGISPSHIFXEHZ-UHFFFAOYSA-N 3beta-acetoxy-cholest-5-ene Natural products C1C=C2CC(OC(C)=O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 XUGISPSHIFXEHZ-UHFFFAOYSA-N 0.000 claims description 5
- YEYCQJVCAMFWCO-UHFFFAOYSA-N 3beta-cholesteryl formate Natural products C1C=C2CC(OC=O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 YEYCQJVCAMFWCO-UHFFFAOYSA-N 0.000 claims description 5
- XUGISPSHIFXEHZ-VEVYEIKRSA-N cholesteryl acetate Chemical compound C1C=C2C[C@@H](OC(C)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 XUGISPSHIFXEHZ-VEVYEIKRSA-N 0.000 claims description 5
- 150000005690 diesters Chemical class 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
- 238000005555 metalworking Methods 0.000 claims description 4
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- 125000003118 aryl group Chemical group 0.000 claims description 2
- 239000007865 axle lubricant Substances 0.000 claims description 2
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- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims 1
- MPPPKRYCTPRNTB-UHFFFAOYSA-N 1-bromobutane Chemical compound CCCCBr MPPPKRYCTPRNTB-UHFFFAOYSA-N 0.000 claims 1
- 241000723346 Cinnamomum camphora Species 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 229930195708 Penicillin V Natural products 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- XHXUANMFYXWVNG-OIKLOGQESA-N [(5r)-5-methyl-2-propan-2-ylcyclohexyl] acetate Chemical compound CC(C)C1CC[C@@H](C)CC1OC(C)=O XHXUANMFYXWVNG-OIKLOGQESA-N 0.000 claims 1
- 229960000846 camphor Drugs 0.000 claims 1
- 229930008380 camphor Natural products 0.000 claims 1
- URQGPPCZQAUJRX-UHFFFAOYSA-N cavicularin Chemical compound C=1C(O)=CC=C(C=2C(O)=CC=C3CCC4=C(C=23)C=C(C(=C4)O)O2)C=1CCC1=CC=C2C=C1 URQGPPCZQAUJRX-UHFFFAOYSA-N 0.000 claims 1
- MCFLLKAHGNIXPF-UHFFFAOYSA-N cavicularin Natural products C=1C(O)=CC=C(C2=C(O)C=C3CCC=4C=CC(O)=C(C=4C3=C2)O2)C=1CCC1=CC=C2C=C1 MCFLLKAHGNIXPF-UHFFFAOYSA-N 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 229940107161 cholesterol Drugs 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 229940056367 penicillin v Drugs 0.000 claims 1
- RUMOYJJNUMEFDD-UHFFFAOYSA-N perillaldehyde Natural products CC(=C)C1CCC(C=O)=CC1 RUMOYJJNUMEFDD-UHFFFAOYSA-N 0.000 claims 1
- BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 229960004793 sucrose Drugs 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 40
- -1 glycol ethers Chemical class 0.000 description 33
- 239000000463 material Substances 0.000 description 17
- 238000012360 testing method Methods 0.000 description 17
- 239000002904 solvent Substances 0.000 description 15
- 239000000126 substance Substances 0.000 description 15
- 125000001424 substituent group Chemical group 0.000 description 11
- 125000004432 carbon atom Chemical group C* 0.000 description 10
- 239000000047 product Substances 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 8
- 125000004429 atom Chemical group 0.000 description 8
- 239000000654 additive Substances 0.000 description 7
- 150000001298 alcohols Chemical class 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 239000002253 acid Substances 0.000 description 6
- 150000001412 amines Chemical class 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 230000000007 visual effect Effects 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N 2-propanol Substances CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
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- IJXJGQCXFSSHNL-QMMMGPOBSA-N (R)-(-)-2-Phenylglycinol Chemical compound OC[C@H](N)C1=CC=CC=C1 IJXJGQCXFSSHNL-QMMMGPOBSA-N 0.000 description 4
- FEWJPZIEWOKRBE-LWMBPPNESA-N levotartaric acid Chemical compound OC(=O)[C@@H](O)[C@H](O)C(O)=O FEWJPZIEWOKRBE-LWMBPPNESA-N 0.000 description 4
- BKMMTJMQCTUHRP-GSVOUGTGSA-N (2r)-2-aminopropan-1-ol Chemical compound C[C@@H](N)CO BKMMTJMQCTUHRP-GSVOUGTGSA-N 0.000 description 3
- VTQHAQXFSHDMHT-UHFFFAOYSA-N 2-amino-3-methylpentan-1-ol Chemical compound CCC(C)C(N)CO VTQHAQXFSHDMHT-UHFFFAOYSA-N 0.000 description 3
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 3
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- WXZVAROIGSFCFJ-UHFFFAOYSA-N N,N-diethyl-2-(naphthalen-1-yloxy)propanamide Chemical compound C1=CC=C2C(OC(C)C(=O)N(CC)CC)=CC=CC2=C1 WXZVAROIGSFCFJ-UHFFFAOYSA-N 0.000 description 3
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 3
- CVRALZAYCYJELZ-UHFFFAOYSA-N O-(4-bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate Chemical compound C=1C=CC=CC=1P(=S)(OC)OC1=CC(Cl)=C(Br)C=C1Cl CVRALZAYCYJELZ-UHFFFAOYSA-N 0.000 description 3
- 238000002485 combustion reaction Methods 0.000 description 3
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- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 3
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- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 3
- JLIDBLDQVAYHNE-YKALOCIXSA-N (+)-Abscisic acid Chemical compound OC(=O)/C=C(/C)\C=C\[C@@]1(O)C(C)=CC(=O)CC1(C)C JLIDBLDQVAYHNE-YKALOCIXSA-N 0.000 description 2
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- ZFYFBPCRUQZGJE-JTQLQIEISA-N methyl (2s)-2-(6-methoxynaphthalen-2-yl)propanoate Chemical group C1=C(OC)C=CC2=CC([C@H](C)C(=O)OC)=CC=C21 ZFYFBPCRUQZGJE-JTQLQIEISA-N 0.000 description 1
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- BPLDQMXXYMKQPW-BDAKNGLRSA-N tert-butyl n-[(2r,3r)-1-hydroxy-3-methylpentan-2-yl]carbamate Chemical compound CC[C@@H](C)[C@H](CO)NC(=O)OC(C)(C)C BPLDQMXXYMKQPW-BDAKNGLRSA-N 0.000 description 1
- OOQRRYDVICNJGC-MRVPVSSYSA-N tert-butyl n-[(2s)-1-hydroxy-3-methylbutan-2-yl]carbamate Chemical compound CC(C)[C@@H](CO)NC(=O)OC(C)(C)C OOQRRYDVICNJGC-MRVPVSSYSA-N 0.000 description 1
- LDKDMDVMMCXTMO-LBPRGKRZSA-N tert-butyl n-[(2s)-1-hydroxy-3-phenylpropan-2-yl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@H](CO)CC1=CC=CC=C1 LDKDMDVMMCXTMO-LBPRGKRZSA-N 0.000 description 1
- PDAFIZPRSXHMCO-LURJTMIESA-N tert-butyl n-[(2s)-1-hydroxypropan-2-yl]carbamate Chemical compound OC[C@H](C)NC(=O)OC(C)(C)C PDAFIZPRSXHMCO-LURJTMIESA-N 0.000 description 1
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- LMJSLTNSBFUCMU-UHFFFAOYSA-N trichlormethiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC(C(Cl)Cl)NS2(=O)=O LMJSLTNSBFUCMU-UHFFFAOYSA-N 0.000 description 1
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- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
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- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 1
- 229960004791 tropicamide Drugs 0.000 description 1
- 229960004799 tryptophan Drugs 0.000 description 1
- SXPSZIHEWFTLEQ-UHFFFAOYSA-N tröger's base Chemical compound C12=CC=C(C)C=C2CN2C3=CC=C(C)C=C3CN1C2 SXPSZIHEWFTLEQ-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/21—Polarisation-affecting properties
- G01N21/211—Ellipsometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/02—Food
Definitions
- the present invention relates to the determination of the identity of a fluid, such as organic fluids.
- the invention provides a convenient and reliable means for identifying the fluid before, during and/or after the fluid's use.
- the present invention also relates to a system for identifying a fluid by passing a beam of polarized light through a sample of the fluid, and measuring the amount of optical rotation caused by the sample.
- the invention further provides for the use of optically active markers to increase and/or adjust the amount of rotation that is observed from a sample. The measurement of this rotation, caused by the materials in the fluid being tested, including the optional optically active marker, allows for the identification of the fluid.
- Fluids are fluids employed in a variety of automotive, off-highway vehicles, on-highway vehicles, equipment, machines, metal working and industrial applications. It is important to know the identity of such functional fluids to prevent the improper utilization or unauthorized counterfeiting of the functional fluid. A proper functional fluid helps to insure the good condition of the device and/or equipment containing the functional fluid and may also impact warranty agreements. It is, therefore, desirable to be able to determine the identity of such functional fluids.
- Markers are sometimes employed by government agencies to ensure appropriate taxes have been paid on particular grades of fuel. Oil companies also mark their products to help assist in identifying diluted or altered products. These companies often go to great expense to make sure their branded products meet certain specifications as well as to provide their products with effective additive packages. Consumers rely upon product names and quality designations to assure that the product being purchased is the quality desired. Thus, it is important to be able to identify a marker in a petroleum product. [0006] Traditionally, the presence of a marker substance is detected and optionally quantified by extracting the fluid with an aqueous or significantly aqueous solution of an acid substance, the precise nature of which can be varied depending on the marker substance.
- the acid reacts with the marker compound to produce a readily visible, more or less intensely colored cation dissolved in the aqueous acid phase.
- This method is disclosed in US Pat. 5,145,573. Additionally, a method has been disclosed in WO 03/078551 A2 where the acidic substance has been applied to a test strip. The test strip is dipped into the oil and a diazo-type marker reacts with the acidic substance in the test strip and changes color. [0007] In many of these methods it may be necessary to make repeated, typically two or three, extractions of the fluid to recover a sufficient amount of marker in order for complete quantification.
- the extracted, separated phase is often classifiable as a hazardous waste and presents problems of safe and lawful disposal, especially when examinations are made "in the field.”
- the functional fluid being tested may be contaminated by the process, making its return to its original source undesirable, presenting additional waste disposal problems.
- the present invention provides a method to determine the identity of a functional fluid comprising: (1) adding an optional optically active marker component to the fluid; (2) obtaining a sample of the fluid before, during or after its use in an application; (3) passing a beam of polarized light through the sample; (4) measuring the rotation of the plane of the light after it passes through the sample; (5) determining the identity of the fluid by the amount of rotation observed.
- the invention further provides for the use of chiral molecules as optically active markers where the chiral molecules are at least partially soluble in the fluid.
- the optically active marker components used in the methods of the invention are non-racemic in regards to at least one set of enantiomers.
- the invention further provides a diagnostic kit for the analysis of a fluid comprising a source of polarized light, a means for directing a beam of polarized light from said source through a sample of fluid, a means for detecting the amount of rotation in the beam of polarized light after it passes through the sample, and a means of communicating the results from the analyzer to a user.
- the kit may also comprise written instruction, pictures, drawings, and/or photographs to aid the user in the identification of the fluid.
- the fluid used with such diagnostic kits may comprise an optically active marker. DETAILED DESCRIPTION OF THE INVENTION
- the invention provides for the use of measured optical rotation as a means for identifying and/or confirming the source of a fluid, including a method and a device, such as a kit, for analyzing and monitoring the identity of various fluids.
- the invention further provides optical markers which impact a fluid's ability to rotate polarized light. These markers may be used in the methods, devices and kits described here, used in identifying and/or confirming the source of a fluid and/or monitoring the identity of a fluid.
- Suitable fluids include, for example, functional fluids which come from innumerable sources, including internal combustion engines, stationary engines, turbines, transmissions, differentials, pumps, metalworking operations, cooling systems, industrial systems and the like.
- the functional fluids include automatic transmission fluids, continuously variable transmission fluids, infinitely variable transmission fluids, traction drive transmission fluids, manual transmission fluids, power steering fluids, antifreeze fluids, lubricating oils, greases, crankcase lubricants, cylinder lubricants, mineral oils, Group I, II, III or IV base oils, differential lubricants, turbine lubricants, gear lubricants, gear box lubricants, axle lubricants, farm tractor fluids, transformer fluids, compressor fluids, cooling system fluids, metal working fluids, hydraulic fluids, brake fluids, industrial fluids, fuels, infinitely variable transmission fluid, and the like.
- the functional fluid is an automatic transmission fluid.
- the functional fluid is a power steering fluid.
- the functional fluid is an internal combustion fuel such as gasoline and/or diesel.
- the functional fluid is compressor fluids such as air compressor lubricants and/or turbine lubricants.
- the functional fluid is an internal combustion engine oil.
- the functional fluid is tested after some time in use, up to and including the fluid's service life.
- the fluids are organic and are free of any aqueous materials except small amounts that are commonly caused by contamination.
- the fluid may contain less than 10 % water or less than 5 %, less than 1 % or even less than 0.5 % water.
- the fluids include both organic and aqueous fluids, and mixtures thereof.
- Non- fluid materials may also be used with the invention, where the non- fluid material is dissolved into a solvent, melted, or otherwise transferred into a fluid medium in order to be tested.
- Many fluids contain materials that will rotate the plane of polarized light. The measurement of this rotation may be used to verify the identity of the fluid, as described below. Such materials inherently contain optically active materials that may be used as markers in the methods of the invention. The invention includes methods that measure the optical rotation of such materials and uses the observed rotation as a means to identify the fluid.
- a fluid may not provide any significant rotation and/or may not rotate light any more or less than a competing, counterfeit and/or alternative product.
- the invention further provides for the use of optically active markers which may be added to the fluid in order to provide a different level of optical rotation.
- the fluid which then includes the optional marker, can then be tested by the methods of the present invention and the observed optical rotation, which has been adjusted by the use of the optical markers described herein, may be used to identify and/or verify the identify of the fluid Solvents to be used with the Markers [0019]
- the markers may be added to the fluid with which they are used as a neat component.
- the marker may be present in a mixture comprising one or more optical markers, as described herein, and further comprising one or more solvents, forming a marker concentrate or marker solution, which may then be added to the fluid.
- This mixture may further comprise additional materials, such as but not limited to, performance additives designed to impact and/or improve the performance of the resulting functional fluid.
- suitable solvents may be used with the markers, forming a marker solution. The solvent used depends on the type of functional fluid being tested, the delivery system being used and the marker being used. Combinations of solvents are also useful when the marker, depending on the application and type of analysis desired, is not soluble in the functional fluid.
- Solvents or combinations of solvents may be selected by considering desirable properties including good solvency power and miscibility with the functional fluid and the marker, low vapor pressure at ambient temperatures, high flash points and the like.
- Suitable solvents include aliphatic, unsaturated and aromatic hydrocarbons, alcohols, glycols, glycol ethers, polyols such as glycerol, lower alcohols, such as methanol, ethanol and propanol, ethers, esters, amides, amines, water and the like. Combinations of solvents may be used.
- the marker component which refers to the mixture of the marker and any optional solvents and/or additional additives that may be present, is free of any materials that would inhibit the optically active nature of the marker compounds. In other embodiments the marker component is free of any materials that would react with the optically active markers present. In other embodiments the marker component is free of any non-chiral and/or non-optically active components.
- marker and/or the term marker component when used in the application, unless otherwise indicated, can mean either the marker compound or compounds themselves with no added solvent, or the marker solution comprising a mixture of the marker compound or compounds and one or more solvents or additional additives.
- the solvent may be present in the marker solution in the range of about 1 wt. % to about 99.99 wt. %, in one embodiment about 5 wt. % to about 98 wt. % and in another embodiment about 1 wt. % to about 95.5 wt. % of the marker solution.
- the Optically Active Markers [0024]
- the marker substance is chosen to be compatible with, or not adverse to, the fluid with which it is used and/or the system in which the fluid will be used. In one embodiment, the marker is chosen to survive the application and/or service conditions the functional fluid is exposed to during its use.
- the marker substance is used to identify new and/or unused fluids. In other embodiments it is useful to validate the identity of a used fluid for, as an example, warranty claims. In this case the marker needs to survive and be detectable after experiencing the typical operating and/or use conditions of the fluid. In the case of functional fluids, this may include surviving the operation of an engine or other device in which the functional fluid is used.
- Markers suitable for use in the present invention may be described as optically active markers.
- Suitable optically active markers include: one or more compounds comprising chiral molecules; one or more compounds wherein its molecules contains at least one chiral center, axis or plane; one or more compounds wherein its molecules contains at least one tetrahedrally-bonded atom in which all four substituents on the tetrahedrally bonded atom are different; or mixtures of one or more of the compounds described above.
- the mixture of markers used must have an overall enantiomeric excess such that an optically active system exists, such that the system rotates the plane of polarized light.
- the marker of the present invention includes one more compounds represented by Formula I shown below:
- R 1 , R 2 , R 3 , and R 4 are each independently a hydrocarbyl group, an -OR 5 group where R 5 is hydrogen or a hydrocarbyl group, an aromatic group, a lone pair of electrons, a double bonded oxygen or nitrogen atom when X is P or S, with the provisos that each R group is unique and each R group may contain functional groups. That is R 1 , R 2 , R 3 , and R 4 are each a unique substituent group wherein R 1 ⁇ R 2 ⁇ R 3 ⁇ R 4 .
- the optically active marker is: soluble in the fluid being marked; exhibits a measurable optical rotation of an appropriate wavelength of light; causes no harm to the fluid being marked or to the application in which the fluid is used; is colorless in the visible spectrum and/or makes no impact on the color of the fluid being marked; is odorless and/or tasteless and/or has no impact on the odor and/or taste of the fluid being marked; or some combination thereof.
- the markers may be soluble in the fluid from 0.00001% up to 100% by weight. Appropriate wavelengths of light for which suitable markers cause rotations include ultraviolet light, visible light, infrared light, or combinations thereof.
- Sufficient optical rotation may be an amount greater than the margin of error in the measuring device used to evaluate the rotation, and in some embodiments is at least 0.1 degree of rotation, at least 0.5 degrees, at least 1 degree, or at least 5 degrees of rotation.
- Optical rotations of greater than 360 degrees are possible but for this invention molecules that rotate light greater than 360 degrees are characterized as having optical rotations of their actual rotation minus 360.
- a compound is considered to be optically active if it can rotate the plane of polarized light that passes through it.
- the amount of optical rotation is determined by the molecular structure and concentration of the optically active molecules in the fluid, the wavelength of the light passing though the fluid, the optical path length involved, and the temperature.
- the rotation caused by the optically active compounds results from the interaction of chiral materials with polarized light. Specific enantiomers of a chiral molecule absorb polarized light to differing degrees.
- Enantiomers can be named by the direction in which it rotates the plane of polarized light. If it rotates the light clockwise (as seen by a viewer towards whom the light is traveling) the enantiomer is labeled (+) or "d-"for dextrorotatory. Its mirror-image is labeled (-) or "l-”for levorotatory.
- Optically active compounds may also be labeled by identifying each isomer by the spatial configuration of its atoms using an R/S designation. The R/S system has no fixed relation to the (+)/(-)or d-/l- systems described above.
- the R/S system labels each chiral center present in a compound with an R or S according to a system in which the chiral center's substituents are assigned a priority, based on atomic number. If the chiral center is oriented such that the lowest-priority substituents is pointed away from a viewer, the viewer will then see two possibilities: if the priority of the other three substituents decreases in a clockwise direction, it is labeled R for Rectus; if the substituents' priority decrease in a counterclockwise direction, it is labeled S for Sinister.
- Optically active compounds include chiral molecules.
- the term chiral is used to describe an object that is non-superimposable on its own mirror image.
- Chiral molecules can have "point chirality" where the chirality of the molecule is centered around a single atom, usually a carbon atom, which has four different substituents. If all four substituents on the tetrahedrally bonded atom are different, the molecule is chiral. Isotopic differences are enough for chirality.
- chiral molecules is not limited to tetrahedral carbon atoms, but also includes any other type of central atom with an appropriate set of substituent groups or ligands. Examples include octahedral and other coordination geometries of appropriate substitution, including metal complexes and inorganic structures.
- a molecule may have multiple chiral centers. It is also possible for a molecule to be chiral without having point chirality. Common examples include l,l '-bi-2-naphthol (BINOL) and 1,3-dichloro-allene, which have axial chirality, and (E)-cyclooctene, which has planar chirality.
- the stereogenic center of a chiral molecule need not to be located on a specific atom.
- adamantane derivatives with suitable substituents may also be chiral. In these structures an entire group, as opposed to a single atom, holds four substituents in a spatial arrangement making the compound non-superimposable on its mirror image.
- chirality of molecules results from hindered rotation of groups or spatial arrangements of chemical moieties, a few examples of which include 1,2,3,4-tetramethyl-cyclooctatetraene, 2,5-dimethyl- bicyclo-2,2,2-oct-2,5,7-triene, and perchloro-triphenylamine.
- catenanes and molecular knots made up from achiral molecules may be chiral.
- a chiral substance is considered enantiopure or homochiral when only one of two possible enantiomers is present.
- a mixture of equal amounts of the two enantiomers is said to be a racemic mixture.
- a chiral substance is enantioenriched or heterochiral when an excess of one enantiomer is present but not to the exclusion of the other. Enantiomeric excess is a measure for how much of one enantiomer is present compared to the other.
- a non-racemic chiral mixture may also be called scalemic.
- the present invention uses one or more optically active markers where the marker component and/or mixture is not a racemic mixture. That is, the marker component is scalemic and has an enantiomeric excess, or has less than 100% optical purity.
- the present invention requires the mixture of optically active markers to contain at least a 5 percent by weight excess of one enantiomer for each optically active marker present. In still other embodiments the excess must be 20 percent by weight, 50 percent by weight or even 75 percent by weight.
- the markers of the present invention may include one or more of the following: Abscisic Acid, sulfoximes, sulfonamides, sultams, 1-Acetoxychavicol Acetate, Acenaphthenol, Alfuzosin, Alprenolol, Althiazide, 1-Aminoindan, Amlodipine, Anisoin, 9-anthrylethanol, 9-anthryl trifluoromethyl carbinol, Arginine, Atenolol, Atropine, Azelastine, Bambuterol, Bendroflumethiazide, Benzoin, l-(4-
- Additional examples of chiral compounds include: 3-Methyl-5- phenylhydantoin, Metolachlor, Metolazone, Metoprolol, Mianserin, Modafinil,
- Pantoprazole Pazufloxacin, Permethrin, Pheniramine, Phenyl cyclohexyl Carbinol, 2-Phenylcyclopropane Carboxylate, Phenyl ethyl carbinol, Phenyl Isopropyl Carbinol, Phenyl Methyl Carbinol, l-[(4-Phenyl) phenyl] Ethanol, Phenyl phenylethyl Carbinol, l-Phenyl-2-propanol, Phenyl propyl carbinol, Phenyl tribromomethyl carbinol, Phenylalanine, Phenylbutyric acid, Phenylethylene Glycol,
- Phenylglycine 1-Phenylpentanol, Phenylsuccinic Acid, Pindolol, Pindolol- 1, Pirprofen, PPO Inhibitor, Practolol, Praziquantel, Prilocaine, Proglumide, Proline, Pronethalol, Propafenone, Propiconazole, Tilt, Propranolol, Quizalofop-ethyl, Ranolazine, Rebamipide, Resmethrin, SC 41930, Serine, Sethoxydim, Sotalol, Stilbene Oxide, Styrene Oxide, Sulconazole, Sulfinpyrazone, Sulindac, Sulpiride,
- Trityl-2-naphthalene propionic acid Troger's Base, Troglitazone, Trolox, Trolox-1, Trolox-methylether, Tropicamide, Tryptophan, Tulobuterol HCl, Tyrosine, U- 100057, U-94863, trans-U-50488H, Valine, Vanilmandelic Acid, Vapol, Verapamil, Verapamil, Viloxazine, Warfarin (normal phase), Warfarin (reverse phase), Warfarin (on ULMO CSP), Zopiclone.
- Still other examples of chiral compounds include: D-Alaninol, L- Alaninol, L-(+)-Isoleucinol, L-(+)-Isoleucinol, L-(+)-Leucinol, D-Methioninol, L- Methioninol, D-(+)-Phenylalaninol, L-(-)-Phenylalaninol, D-(-)-alpha- Phenylglycinol, L-(+)-alpha-Phenylglycinol, D-(-)-Prolinol, L-(+)-Prolinol, D- Tryptophanol, L-Tryptophanol, D-Valinol, L-Valinol, R-(-)-2-Amino-2- Phenylethanol, BOC-D-Alaninol, BOC-L-Alaninol, CBZ-D-Alanin
- FMOC-L-alpha-Phenylglycinol BOC-D-Prolinol, BOC-L-Prolinol, CBZ-D- Prolinol, FMOC-D-Prolinol, FMOC-L-Prolinol, BOC-D-Valinol, BOC-L-Valinol, FMOC-L-Valinol.
- Still further examples of chiral compounds include: S-2- methylpiperazine, R-2-methylpiperazine, S-l-Boc-2-methylpiperazine, R-l-Boc-2- methylpiperazine, S-Piperazine-2-carboxylic acid, R-Piperazine-2-carboxylic acid, S-4-Boc-Piperazine-3-carboxylic acid, R-4-Boc-Piperazine-3-carboxylic acid, S-4- Boc-2 -methylpiperazine, R-4 ⁇ Boc-2-methylpiperazine, S-4-Boc-Piperazine-2- carboxyl-t-Butylamide, R-4-Boc-Piperazine-2-carboxyl-t-Butylamide, L-Malic Acid, D-Malic Acid, Diethyl L-(+)-Tartrate, Diethyl D-(-)-Tartrate, S
- Methoxy-2-phenylethanol [0042] Tartrates, tartrimides, and similar materials, including esters, amides and imides derived from carboxylic acids such as tartaric acid, citric acid, and the like, and the acids themselves may, also be chiral, and so may also be suitable markers for use in the present invention.
- the markers of the present invention may include an additive represented by Formula I below:
- X is independently -Z-O-Z'-, >CH 2 , >CHR 4 , >CR 4 R 5 ,
- m is 0 or 1;
- R 1 is independently hydrogen or a hydrocarbyl group, typically containing 1 to 150, 4 to
- R 1 is hydrogen, m is 0, and n is more than or equal to 1
- R 2 is a hydrocarbyl group, typically containing 1 to 150, 4 to 30, or 6 to 20, or 10 to 20, or 11 to 18, or 8 to 10 carbon atoms
- R 3 , R 4 and R 5 are independently hydrocarbyl groups, hydroxyl- containing groups, or carboxyl-containing groups
- R 6 is hydrogen or a hydrocarbyl group, typically containing 1 to 150, or 4 to 30 carbon atoms.
- the hydrocarbyl groups used for R 1 and R 2 contain at least some portion of branched hydrocarbyl groups.
- this type of marker is a condensation product of (i), a material represented by formula II and (ii), a mixture comprising a branched alcohol or branched amine having 1 to about 150 carbon atoms, or combinations thereof;
- each X is independently -Z-O-Z-, >CH 2 , >CR 1 R 2 , >C(OH)(CO 2 R 2 ), or >CHOR 2 ; and wherein each Z is independently >CH 2 , >CR J R 2 , >C(OH)(CO 2 R 2 ), or >CHOR 2 ;
- m is 0 or 1;
- component (i) is tartaric acid, citric acid, derivatives of either acid, or combinations thereof.
- component (ii) comprises a mixture of one or more branched alcohols or amines. In one embodiment, the mixture contains one or more branched alcohols containing 6 to 16 carbon atoms. In another embodiment, the mixture contains branched amines containing 6 to 16 carbon atoms.
- component (ii) is made up of a mixture of one or more branched alcohols or amines where the overall mixture is at least 25 percent by weight branched, in that at least 25 percent by weight of the alcohols and/or amines making up the mixture have a branched structure.
- the marker may be represented by the following formulas, or similar versions thereof:
- Formula III Formula IV where the chiral centers of the molecules are identified by the asterisk (*). There may be more than one chiral center in these molecules, and both carbon atoms located between the -COOH groups in Formula III and Formula IV above may be considered chiral centers.
- each of the -OH groups in Formulas III and IV may independently also be an -OR group where R is a hydrocarbyl group.
- Markers that fit these categories include tartaric acid derived diesters.
- the diesters may be derived from tartaric acid and an alcohol and/or a mixture of alcohols (such as AlfolTM 810).
- D-tartaric acid/AlfolTM 810 diester examples include D-tartaric acid/AlfolTM 810 diester, L-tartaric acid/AlfolTM 810 diester, D- tartaric acid/Alfol TM 1214 tridecyl alcohol diester, L-tartaric acid/Alfol TM 1214 tridecyl alcohol diester, and mixtures thereof, as long as the mixture is non-racemic, that is, contains an excess of at least one enantiomer.
- the markers used in the methods of the invention are selected from the group consisting of tartaric acid and derivatives thereof, glucose and derivatives thereof, 2-bromobutane, D-alaninol, D-ananinol, L-alaninol, L-(+)-isoleucinol, D-leucinol, L-(+)-leucinol, D-methioninol, L-methioninol, D-(+)- phenylalaninol, L-(-)-phenylalaninol, D-(-)-alpha-phenylglycinol, L-(+)-alpha- phenylglycinol, D-(-)-prolinol, L-(+)-prolinol, D-tryptophanol, L-tryptophanol, D- valinol, L-valinol, R-(-)-2-amino-2-pheny
- the markers used in the methods of the invention are selected from the group consisting of cholesteryl acetate, D-tartaric acid/Alfol 810 diester, L-tartaric acid/Alfol 810 diester, L-menthyl lactate, S-(-)- perillaldehyde, lR-(-)-menthyl acetate, R-(+)-limonene, L-tartaric acid/Alfol 1214 tridecyl alcohol diester, and combinations thereof with the proviso that the mixture used is non-racemic in regards to at least one marker.
- the marker may be cholesteryl acetate, L-menthyl lactate, S-(-)- perillaldehyde, lR-(-)-menthyl acetate, R-(+)-limonene, and combinations thereof;
- the fluid is a heavy duty diesel engine oil, the marker may be S-(-)- perillaldehyde, lR-(-)-menthyl acetate, R-(+)-limonene and combinations thereof;
- the fluid is a automatic transmission fluid, the marker may be cholesteryl acetate, S-(-)-perillaldehyde, lR-(-)-menthyl acetate, R-(+)-limonene, and combinations thereof;
- the fluid is a gear oil, the marker may be L-menthyl lactate, lR-(-)-menthyl acetate, R-
- the markers of the present invention provide a measurable impact on the optical rotation caused by the fluid in which it is used. In some embodiments this impact is more than the margin of error of the testing method used. In other embodiments the marker causes the optical rotation caused by the fluid to change by at least 5%, at least 50% or at least 100%.
- the amount of marker present in the fluid is not overly limited as long as there is enough marker to allow for positive identification and so long as there is not so much marker that it interferes with the performance and/or desired characteristics of the fluid.
- the markers may be present in the fluid at concentrations of 10 to 10,000 ppm or 10 to 1,000 ppm. In another embodiment the makers are present in the fluid at 20 to 500 ppm; 25 to 350 ppm, 30 to 130 ppm; or 30 to 100 ppm. In other embodiments the markers are present in the fluid at concentrations from 0.05 to 10 % wt, or from 0.1 to 10% wt, or from 0.5 to 10% wt. In still other embodiments the markers are present at more than 0.05 % wt, or more than 0.1 % wt.
- the marker compound itself may be soluble in water, substantially soluble in water, substantially insoluble in water or insoluble in water.
- the marker compound is soluble in organic liquids, such as oil, substantially soluble in organic liquids, substantially insoluble in organic liquids or insoluble in organic liquids.
- the marker compound should be substantially soluble and/or soluble in the fluid with which it is used, or substantially soluble and/or soluble in at least one of the components present in the fluid with which it is used.
- the optical markers of the present invention may be used in combination with other markers including non-optically active markers such as markers that react with reagents to provide positive identification of a fluid. The use of multiple types of markers allows for additional levels of protection and accuracy when verifying the identity and/or source of the fluid being tested.
- the marker compound is added to a functional fluid where the marker is in the form of a concentrate containing a mixture of the marker compound and a polymeric compound.
- This polymeric compound may be one or more conventional additives for functional fluids.
- the polymeric compounds that may be in the concentrate include dispersants, detergents, antiwear agents, friction modifiers, metal deactivators, corrosion inhibitors, seal swell agents, viscosity modifiers, pour point depressants, thickeners, and antioxidants, either alone or in combinations with one another.
- Optional Components may be added to the marker solutions or the fluids.
- the optional component may be used in the range of about 0% to about
- the present invention includes a method to determine the identity of a fluid comprising: (1) adding an optional marker component to a fluid; (2) obtaining a sample of the fluid before, during or after the fluid's use; (3) passing a beam of polarized light through the sample; (4) analyze the results by measuring the rotation of the plane of polarized light after it passes through the sample; (5) determining and/or verifying the identity of the fluid.
- the optical rotation observed is that caused by the fluid itself without the addition of the optional optical markers described herein.
- one or more of the optically active markers described above are added to the fluid, which causes at least some of the rotation observed in the fluid.
- the fluid is used in an application and the marker survives the conditions of the use such that it still allows for the identification of the fluid after such use.
- a functional fluid such as a lubricant
- a device such as an engine
- the sample It is not necessary that the sample be taken during actual operation of the engine or other device or machinery in order to obtain a representative sample of the fluid.
- the sample of fluid may be taken at any time before, during and/or after operation of the engine or equipment or device.
- the fluid sample can be new, used or combinations thereof.
- the fluid test is especially useful during and/or after operation for some period of time. Diagnostic Kit
- the diagnostic kit includes a means to generate a polarized beam of light and to direct that light beam through a sample of fluid.
- the kit further includes a means for measuring the rotation of the beam and/or plane of polarized light after it passes through the sample of fluid, compared to the beam before it passes through the sample. The measurement of the amount of rotation the plane of the polarized light beam experiences, is the means for identifying the fluid being tested.
- the present invention excludes the use of reactive markers or reactive reagents where a marker-containing sample of fluid is reacted with a reagent in order to produce an observable response used to identify the fluid.
- the present invention excludes identification by observing a compound removed from the function fluid by a water extraction.
- a water extraction includes where a compound, such as a dye, in a functional fluid is removed from the functional fluid and drawn into an aqueous solution, due to the compound's miscibility in water. The observance of the compound, without any reaction taking place, in the water solution is the only indicator provided.
- the functional fluid is an engine oil.
- the engine oil sample, or other functional fluid to be tested may be obtained using a dipstick provided as a part of the engine, transmission or other equipment under lubrication.
- the user will withdraw an amount of oil along with the dipstick or other device, which may then be transferred to a sample container where the sample container is glass or some other material that allows light to pass through it.
- the amount of fluid necessary for testing depends on the polarimeter used, and is some embodiments may be as small as a single drop, or as large as a several milliliters, or even several hundred milliliters.
- the beam of polarized light may be aimed through the sample and the measurement of the rotation of the light beam may be observed.
- the user may refer to a guide and/or visual indicia to help interpret the observed rotation and make a determination as the fluid's identity, condition and/or source.
- the marking/identification of a fluid is desirable because counterfeiting and adulteration/dilution of genuine fluids is a large concern of fluid suppliers as counterfeiting and adulteration results in a loss of profits, customer complaints, and harm to brand name and reputation.
- a simple, easy to use marker system is beneficial since different fluids can be indistinguishable based on casual inspection.
- Chemical analyses or physical properties can tell various fluids apart but these analyses require expensive laboratory test equipment and often take too long to be a practical end user identification test.
- the disclosed methods enable end users to exclude a counterfeit or adulterated product based on optical rotation, in an efficient and convenient way.
- the visual indicia may include an artistic rendering, a reproduction of a photograph of one or more functional fluids in various conditions with and without the reagent.
- the visual indicia generally include one representation, two representations or more than two representations of one or more functional fluids and/or a diagram showing the expected light beam, rotation for a fluid of a given source, a given identity, and/or a given condition.
- the preferred visual indicia is one or more representations showing a positive identification result and one or more representations showing a negative identification result.
- a descriptive text corresponding to each of these examples may be provided. It is to be understood that a different number of indicia may be provided.
- Example 1 Four fully formulated, commercially available engine oils are treated with several optically active markers and tested using a polarimeter. The results are summarized in the table below.
- Oil A is unused ValvolineTM motor oil.
- Oil B is unused Mobil 1TM motor oil.
- Oil C is used ValvolineTM motor oil which was drained from a car engine after 3700 miles.
- Oil D is a RotellaTM heavey duty engine oil.
- the marker is a mixture of the D and L enantiomers with a small excess of one enantiomer.
- Example 2 Four fully formulated, commercially available functional fluids are treated with several optically active markers and tested using a polarimeter. The results are summarized in the table below.
- Fluid A is an unused automatic transmission fluid.
- Fluid B is a used automatic transmission fluid drain after 155, 000 miles.
- Fluid C is a gear oil.
- Fluid D is a hydraulic fluid.
- Example 3 The marker is a mixture of the D and L enantiomers with a small excess of one enantiomer.
- Example 3 Two commercially available fuels are treated with several optically active markers and tested using a polarimeter. The results are summarized in the table below.
- Fuel A is a commercially available dieselfuel.
- Fuel B is a commercially available gasoline.
- the marker is a mixture of the D and L enantiomers with a small excess of one enantiomer.
- the results show that some fluids provide a measurable amount of optical rotation that may be used in the methods of the invention as a means of identifying and/or verifying the identity of the fluid.
- the results also show that the optically active markers defined above may be used in such fluids to adjust, impact, and/or change the amount of optical rotation caused by the fluid, which may make it easier to identify a fluid.
- the markers may also be used to achieve an amount of rotation that would not otherwise be present in such a fluid, thus providing a convenient means of identifying and/or verifying the identity of a fluid.
- each chemical or composition referred to herein should be interpreted as being a commercial grade material which may contain the isomers, by-products, derivatives, and other such materials which are normally understood to be present in the commercial grade.
- the amount of each chemical component is presented exclusive of any solvent or diluent oil, which may be customarily present in the commercial material, unless otherwise indicated.
- all percentage values are percents by weight. It is to be understood that the upper and lower amounts, ranges, and ratio limits set forth herein may be independently combined. Similarly, the ranges and amounts for each element of the invention can be used together with ranges or amounts for any of the other elements.
- the expression "consisting essentially of permits the inclusion of substances that do not materially affect the basic and novel characteristics of the composition under consideration.
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PCT/US2009/067421 WO2010077754A1 (en) | 2008-12-17 | 2009-12-10 | Optically active functional fluid markers |
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JPS59193323A (ja) * | 1983-04-19 | 1984-11-01 | Japan Spectroscopic Co | 旋光計 |
JPH03130646A (ja) * | 1989-10-17 | 1991-06-04 | Nippon Soda Co Ltd | 螢光分析装置 |
DE4001662A1 (de) | 1990-01-22 | 1991-07-25 | Basf Ag | Markierte mineraloele sowie verfahren zum markieren von mineraloelen mittels basischer farbstoffe |
US5331958A (en) * | 1992-03-31 | 1994-07-26 | University Of Manitoba | Spectrophotometric blood analysis |
US5956144A (en) * | 1992-09-03 | 1999-09-21 | Micro Research, Inc. | Method and apparatus for use of polarized light vectors in identifying and evaluating constituent compounds in a specimen |
JP3072040B2 (ja) * | 1995-11-29 | 2000-07-31 | 松下電器産業株式会社 | 旋光度測定方法、旋光計、尿検査方法及び尿検査装置 |
US5942444A (en) * | 1997-01-27 | 1999-08-24 | Biocode, Inc. | Marking of products to establish identity, source and fate |
JP2000206007A (ja) * | 1999-01-07 | 2000-07-28 | Sony Corp | 材料識別方法 |
NO20004341L (no) * | 2000-09-01 | 2002-03-04 | Forinnova As | Fremgangsmåte og anordning for å måle optisk rotasjon av planpolarisert lys |
EP1436594A1 (de) * | 2001-10-01 | 2004-07-14 | Georgia Tech Research Corporation | Hoch-durchsatz chiral-detektor und verfahren zu deren verwendung |
AR038945A1 (es) | 2002-03-15 | 2005-02-02 | Shell Int Research | Composicion de aceite y metodo para detectar un marcador en una composicion de aceite |
DE10244306A1 (de) * | 2002-09-23 | 2004-04-01 | Henkel Kgaa | Verfahren zur Markierung und Identifizierung von Produkten |
JP3958247B2 (ja) * | 2003-04-24 | 2007-08-15 | 独立行政法人科学技術振興機構 | 不斉分子識別材料及び不斉分子の識別方法 |
US8129190B2 (en) * | 2006-11-17 | 2012-03-06 | Applied Nanotech Holdings, Inc. | Tagged petroleum products and methods of detecting same |
EP2373977A1 (de) * | 2008-12-17 | 2011-10-12 | The Lubrizol Corporation | Optisch aktive funktionelle flüssigkeitsmarker |
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2009
- 2009-12-10 EP EP09768585A patent/EP2376894A1/de not_active Withdrawn
- 2009-12-10 CN CN200980156748.8A patent/CN102317757B/zh not_active Expired - Fee Related
- 2009-12-10 JP JP2011542257A patent/JP2012512416A/ja active Pending
- 2009-12-10 WO PCT/US2009/067421 patent/WO2010077754A1/en active Application Filing
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2014
- 2014-08-01 JP JP2014157504A patent/JP2014206548A/ja active Pending
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Title |
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DALE L LAWLOR ET AL: "THE USE OF OPTICAL ACTIVITY MEASUREMENTS I N OIL SHALE PROCESSING", AM CHEM SOC DIV FUEL CHEM PREPR, 17 March 1978 (1978-03-17), ANAHEIM, CA, USA, pages 1 - 8, XP055405644, Retrieved from the Internet <URL:https://web.anl.gov/PCS/acsfuel/preprint archive/Files/23_2_ANAHEIM_03-78_0001.pdf> [retrieved on 20170912] * |
See also references of WO2010077754A1 * |
Also Published As
Publication number | Publication date |
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JP2012512416A (ja) | 2012-05-31 |
CN102317757B (zh) | 2015-02-18 |
WO2010077754A1 (en) | 2010-07-08 |
JP2014206548A (ja) | 2014-10-30 |
CN102317757A (zh) | 2012-01-11 |
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