EP2140834B1 - Intrauterines Transferinstrument über den natürlichen vaginal-uterinen Weg - Google Patents

Intrauterines Transferinstrument über den natürlichen vaginal-uterinen Weg Download PDF

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Publication number
EP2140834B1
EP2140834B1 EP09290478A EP09290478A EP2140834B1 EP 2140834 B1 EP2140834 B1 EP 2140834B1 EP 09290478 A EP09290478 A EP 09290478A EP 09290478 A EP09290478 A EP 09290478A EP 2140834 B1 EP2140834 B1 EP 2140834B1
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EP
European Patent Office
Prior art keywords
transfer
instrument according
transfer head
head
tube
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP09290478A
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English (en)
French (fr)
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EP2140834A1 (de
EP2140834B8 (de
Inventor
Laurent Huet
Christophe Staub
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IMV Technologies SA
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IMV Technologies SA
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Publication of EP2140834B1 publication Critical patent/EP2140834B1/de
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
    • A61D19/027—Devices for injecting semen into animals, e.g. syringes, guns, probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/04—Instruments or methods for reproduction or fertilisation for embryo transplantation

Definitions

  • the invention relates to intrauterine transfer instruments by the natural vagino-uterine route.
  • instruments for insemination or transfer of embryos into the uterus of a female animal such as a sow.
  • These instruments generally comprise a probe-type device intended to be introduced into the vagina of the animal.
  • This probe carries at its end a mouthpiece which is intended to be positioned at the level of the neck of the uterus, either in support thereon, or by crossing it partially to fix it and serve as longitudinal reference point to the device insemination. In both cases this tip ensures the closure of the neck and prevents the return of the products that will be injected inside the uterus.
  • This probe generally contains a flexible catheter for passing through said tip to deploy in the uterus after the positioning of the tip and allow the injection of the product as close to the desired area, that is to say to the closer to the uterine horns.
  • the catheter remains locked in the probe during the introduction of the latter into the vagina to keep it clean and prevent it from being polluted in contact with the vaginal wall.
  • the length of the catheter that the operator leaves the probe is also predetermined, thanks to markings carried by the probe, which are graduated according to the age of the animal or the number of litters he has already had. .
  • the invention aims to provide a catheter whose end can penetrate and progress optimally in a uterine horn.
  • the invention proposes a transfer instrument according to claim 1.
  • the oblong character of the transfer head that is to say that it is longer than wide, while the greater width is of course smaller and relatively close to the diameter of a uterine horn, makes it possible to avoid during the progression of the head in a horn, that it crosses or that it turns, which is absolutely to avoid, since in this case the exit orifice or the channel of routing of the substance to be transferred would be clogged and / or the catheter could not progress further.
  • the fact that no portion of the transfer head is more prominent laterally than the two rounded bulges has the advantage that the contact area of the head with the uterine horns is limited to lines, one for each bulge , so that the sliding of the transfer head is greatly facilitated.
  • the latter is a solid tube pierced by said channel and by a second channel disjoint and parallel to the first, said second channel containing a reinforcing cable.
  • the catheter is provided in a particularly simple, convenient and economical manner, at the same time flexibility and resistance to folding which allows it to walk in the best conditions in the uterus and then in a uterine horn.
  • said reinforcing cable is made of a material suitable for backscattering the ultrasound.
  • said reinforcing cable has a diameter of between 1 and 1.5 mm.
  • the instrument further comprises a probe provided at one of its ends with a tip adapted to be positioned against or in the cervix, said catheter being inserted into the central space of the probe and being able to pass through said tip to leave a retracted position where the transfer head of the catheter is retracted inside the central space of said probe and an extended position where said transfer head makes protruding out of the tip of the probe
  • the figure 1 shows an intrauterine transfer instrument, of the prior art, connected to supply means 27 for substances to be transferred and to a connecting duct 28 via a connector 11.
  • the instrument itself comprises a probe 1 provided at one of its ends with a tip 4.
  • the probe 1 is intended to be inserted by the natural vagino-uterine way in or against the uterus of a female animal, such as a sow or a laity, which one wishes to fertilize by artificial insemination for example.
  • the probe 1 comprises a hollow tube 2 carrying at its distal end, that is to say the one opposite the supply means 27, a nozzle 4.
  • This nozzle 4 has the shape substantially of a cylinder of which the The distal end is chamfered to prevent injury during its introduction and to facilitate the crossing of the cervix. It also has a circular groove in the middle, so as to remain astride the neck and thus define a longitudinal reference point for the uterine cavity.
  • the probe 1 also comprises, inserted inside the hollow tube 2, a catheter 6 able to slide between a retracted position where it is fully positioned in the central space of the tube 2, and an extended position where it projects out of the tube 2 passing through the tip 4, so as to reach the bottom of the uterine cavity and deposit the substances to be transferred to the immediate vicinity of the uterine horns.
  • This catheter has at its distal end 7 a transfer head 8 provided with an end portion 9 ball-shaped, carrying an orifice 10 for discharging the substances to be transferred.
  • the catheter 6 is seen in the retracted position, with its end portion 9 bearing against the inner wall of the distal end of the tip 4.
  • This tip has an orifice 5 through which the catheter and its transfer head pass, with a elastic deformation, to project into the uterine cavity.
  • a catheter whose transfer head 8 has the form of a peanut, that is to say an oblong shape with here two bulges, a distal bulge 31 and a proximal bulge 32, separated by a constriction 33 of smaller section.
  • the two bulges represented have equal sections, without this characteristic being imperative.
  • the head 8 is oriented in the extension of the catheter tube 6 to provide longitudinal stability to this head when pushed by the tube within the uterine horns. This oblong shape avoids a reversal of the end portion and its skew relative to the desired direction of advancement.
  • the greatest length L is more than twice greater than the largest diameter of the bulges 31 and 32, and even more preferably equal to three times the same diameter.
  • this length L is between 20 and 40 mm and preferably of the order of 30 mm.
  • the second advantage provided by this form in peanut comes from the presence of two bulges 31 and 32 which have only a circular line of contact with a cylinder which would form a tangential envelope for the head 8. This makes it possible to have as surface contact with the inner wall of the uterine horns, only two lines, one for each bulge, when introducing the catheter. The sliding of the transfer head is therefore greatly facilitated and the comfort of the animal improved accordingly.
  • the section of the constriction is between a quarter and half of the largest section of the bulges 31 and 32, and, even more preferably, equal to substantially one-third of this larger section.
  • the peanut shape given to the head 8 has two rounded ends, a distal rounded end 34 and a proximal rounded end 35.
  • the distal rounded shape 34 is intended to facilitate first the passage of the head 8 through the orifice 5 of the tip 4, and then its introduction into the uterus of the animal avoiding that it sinks into the wall of the uterus and makes to suffer the animal unnecessarily.
  • the proximal rounded shape can be a sphere section as shown on the figure 3 , or any other form of connection with the distal end of the catheter, as long as it is free of ridges that could injure the animal during removal of the probe.
  • the end portion has a symmetry of revolution about its axis and a symmetry with respect to a plane perpendicular to this axis, passing through one of the diameters of the constriction 33.
  • the material preferentially used to make this end part is a polyoxymethylene, which has the advantage of being light and smooth, which provides a low coefficient of friction with the uterine wall.
  • This tube made of flexible and smooth material such as low-density polyethylene, is traversed longitudinally by two parallel channels, a first channel 36 for conveying the substances to be transferred and a second channel 37 for receiving a reinforcing cable 38.
  • This second channel extends parallel to the first channel over at least the entire length of the catheter 6.
  • the second canal is provided with a reinforcing cable 38 which provides a rigidity adapted to progress inside the uterus and uterine horns.
  • This reinforcing cable is preferably made of a material suitable for backscattering the ultrasound, which allows, if necessary, to visualize its path inside the uterus and to see by ultrasound, the place where the substances will be deposited.
  • the size of the reinforcing cable is typically between 1 and 1.5 mm, and preferably equal to 1.2 mm, for a tube whose diameter is of the order of 3.5 mm.
  • the diameter of the second channel is then of the order of 1.3 mm.
  • the distal end of the catheter tube 6 is intended to receive the head 8 which, for this, has at its proximal end a cavity adapted to the male form of the tube.
  • the distal end of the tube is generally fixed in the cavity of the head 8 by gluing, as shown in FIG. figure 5 .
  • Complementary bonding modes may be superimposed on the bonding to ensure good fixation of the head 8 and prevent it from becoming detached from the tube and remaining in the uterine cavity during removal of the probe.
  • Variants relating to the fixing of the head 8 are represented on the Figures 6 to 8 .
  • the reinforcing cable 38 does not extend to the distal end of the tube, so as to leave a free space in the second channel 37 where can be slid a connecting pin 39 with the head 8.
  • the present head for this purpose a complementary channel 40 positioned so that it is located opposite the second channel 37 of the tube when it is inserted into the cavity of the head 8.
  • the pin 39 is positioned astride the second channel 37 of the tube and in the complementary channel 40 of the head 8 and held in place, for example, by gluing.
  • the connecting pin 39 has latching notches and is forced into the second channel 37 and the complementary channel 40.
  • This embodiment has the advantage of offering a large bonding surface between the catheter and the head and thus to ensure good bonding between the two parts.
  • the complementary pipe 41 is not integral with the rest of the catheter tube 6 but formed by an insert, for example by gluing, welding or force fitting.
  • the subjection between the catheter tube and the head 8 is made by overmolding the tube by the material of the head.
  • the transfer channel of the head 8 does not open through an orifice 10 located at the distal end 34, but by one or more orifices arranged differently, for example by two lateral orifices as in the prior device illustrated on the figure 2 .
  • the transfer head 8 comprises more than two bulges such as the bulges 31 and 32, for example three bulges with two neighboring bulges which are separated from each other by a constriction such as 33.
  • the catheter 6 illustrated on the Figures 4 to 10 and described above is particularly suitable for performing nonsurgical embryo transfer, but it is also suitable for other applications in the field of artificial insemination, including deep insemination, or for transferring substances other than for artificial insemination, for example drugs.
  • the catheter 6 in an intrauterine transfer instrument such as the device 1 illustrated on the Figures 1 and 2 but it should be noted that the catheter 6, because of the folding resistance which the presence of the cable 38 confers on it, can be used under certain circumstances directly as an intrauterine transfer instrument or can be used with a different applicator device , for example a sheath-shaped glove having substantially the length of the vaginal cavity and the end is torn by the head 8 when the sheath meets the cervix.
  • a sheath-shaped glove having substantially the length of the vaginal cavity and the end is torn by the head 8 when the sheath meets the cervix.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Husbandry (AREA)
  • Transplantation (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Particle Accelerators (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Peptides Or Proteins (AREA)
  • External Artificial Organs (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Claims (21)

  1. Instrument zur intrauterinen Übertragung auf dem natürlichen Vaginouterin-Weg, mit einem Katheter (6), der ein Rohr aufweist, das an einem Ende einen Übertragungskopf (8) trägt, wobei durch das Rohr ein Kanal (36) für den Transport von Substanzen verläuft, wobei der Übertragungskopf (8) mit wenigstens einer Mündung (10) für den Durchgang der zu übertragenden Substanzen versehen ist, wobei der Übertragungskopf (8) eine längliche Form aufweist, die eine allgemeine Orientierung in der Verlängerung dieses Rohrs hat, wobei ein evolutiver Querschnitt wenigstens zwei verschiedene abgerundete seitliche Verdickungen (31, 32) aufweist, wobei kein Teil des Kopfes (8) seitlich um mehr als die zwei Verdickungen (31, 32) vorsteht; dadurch gekennzeichnet, dass die zwei Enden (34, 35) des Übertragungskopfes (8) eine abgerundete Form haben.
  2. Übertragungsinstrument nach Anspruch 1, wobei die zwei Verdickungen (31, 32) gleiche Querschnitte haben.
  3. Übertragungsinstrument nach einem der Ansprüche 1 oder 2, wobei der Übertragungskopf eine Rotationssymmetrie um seine Achse aufweist.
  4. Übertragungsinstrument nach einem der Ansprüche 1 bis 3, wobei die größte Länge (L) des Übertragungskopfes wenigstens zweimal größer als der größte Durchmesser der Verdickungen (31, 32) ist.
  5. Übertragungsinstrument nach Anspruch 4, wobei die größte Länge (L) des Übertragungskopfes (8) im Wesentlichen gleich dem dreifachen größten Durchmesser der Verdickungen (31, 32) ist.
  6. Übertragungsinstrument nach einem der Ansprüche 1 bis 5, wobei die größte Länge des Übertragungskopfes (8) im Bereich von 20 bis 40 mm liegt.
  7. Übertragungsinstrument nach Anspruch 6, wobei die größte Länge des Übertragungskopfes (8) im Wesentlichen gleich 30 mm ist.
  8. Übertragungsinstrument nach einem der Ansprüche 1 bis 7, wobei der Querschnitt einer Einschnürung (33), die die zwei Verdickungen (33, 34) trennt, im Bereich von einem Viertel bis zur Hälfte des größten Querschnitts der Verdickungen (31, 32) liegt.
  9. Übertragungsinstrument nach einem der Ansprüche 1 bis 8, wobei der Übertragungskopf (8) eine Symmetrie in Bezug auf eine Ebene aufweist, die zu seiner Achse senkrecht ist und durch die ein Durchmesser einer die zwei Verdickungen (31, 32) trennenden Einschnürung (33) verläuft.
  10. Übertragungsinstrument nach einem der Ansprüche 1 bis 9, wobei der Übertragungskopf aus Polyoxymethylen hergestellt ist.
  11. Übertragungsinstrument nach einem der Ansprüche 1 bis 10, dadurch gekennzeichnet, dass der Katheter (6) ein Rohr enthält, durch das der Kanal (36) und ein zweiter Kanal (37), der vom ersten getrennt und hierzu parallel ist, verlaufen, wobei der zweite Kanal ein Verstärkungskabel (38) enthält.
  12. Übertragungsinstrument nach Anspruch 11, wobei das Verstärkungskabel (38) aus einem Material hergestellt ist, das Ultraschall zurückschicken kann.
  13. Übertragungsinstrument nach Anspruch 11 oder 12, wobei das Verstärkungskabel (38) einen Durchmesser im Bereich von 1 bis 1,5 mm hat.
  14. Übertragungsinstrument nach einem der Ansprüche 1 bis 13, wobei der Übertragungskopf (8) an dem Rohr durch Kleben befestigt ist.
  15. Übertragungsinstrument nach Anspruch 14, wobei der Übertragungskopf (8) an dem Rohr durch Kleben und durch einen Zapfen (39), der einerseits in das Ende des zweiten Kanals (37) und andererseits in einen angepassten Aufnahmesitz (40), den der Übertragungskopf (8) trägt, eingesetzt ist, befestigt ist.
  16. Übertragungsinstrument nach Anspruch 15, wobei der Zapfen (39) ein gerippter Zapfen ist.
  17. Übertragungsinstrument nach Anspruch 14, wobei der Übertragungskopf (8) an dem Rohr durch Kleben und durch einen Stift (43), der sowohl in den Katheter (6) als auch in den Übertragungskopf (8) längs einer zu dessen Achse senkrechter Achse eindringt, befestigt ist.
  18. Übertragungsinstrument nach einem der Ansprüche 1 bis 17, wobei das Ende des Rohrs, das den Übertragungskopf (8) trägt, durch eine komplementäre Leitung (41) mit einem geringeren Durchmesser, durch das der einzige Kanal (36) verläuft, verlängert ist.
  19. Übertragungsinstrument nach Anspruch 18, wobei der Übertragungskopf (8) einen Durchgangshohlraum (42) aufweist, der die komplementäre Leitung (41) aufnimmt.
  20. Übertragungsinstrument nach Anspruch 19, wobei die komplementäre Leitung (41) in den Durchgangshohlraum (42) so weit verlängert ist, bis sie in das Ende des Übertragungskopfes (8) mündet.
  21. Übertragungsinstrument nach einem der Ansprüche 1 bis 20, das außer dem Katheter (6) eine Sonde (1) umfasst, die an einem ihrer Enden mit einem Anschluss (4) versehen ist, der sich an oder in dem Gebärmutterhals positionieren kann, wobei der Katheter (6) in den Mittelraum der Sonde (1) eingesetzt ist und durch den Anschluss (4) verlaufen kann, um eine zurückgezogene Position, in der der Übertragungskopf (8) des Katheters (6) in den Mittelraum der Sonde zurückgezogen ist, in eine ausgefahrene Position, in der der Übertragungskopf (8) von dem Anschluss (4) der Sonde (1) vorsteht, zu verlassen.
EP09290478A 2008-06-30 2009-06-23 Intrauterines Transferinstrument über den natürlichen vaginal-uterinen Weg Active EP2140834B8 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0854421A FR2932977B1 (fr) 2008-06-30 2008-06-30 Instrument de transfert intra-uterin par la voie naturelle vagino-uterine

Publications (3)

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EP2140834A1 EP2140834A1 (de) 2010-01-06
EP2140834B1 true EP2140834B1 (de) 2010-12-29
EP2140834B8 EP2140834B8 (de) 2011-04-20

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EP09290478A Active EP2140834B8 (de) 2008-06-30 2009-06-23 Intrauterines Transferinstrument über den natürlichen vaginal-uterinen Weg

Country Status (9)

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US (1) US20090326317A1 (de)
EP (1) EP2140834B8 (de)
JP (1) JP2010012247A (de)
AT (1) ATE493090T1 (de)
CA (1) CA2669573A1 (de)
DE (1) DE602009000485D1 (de)
DK (1) DK2140834T3 (de)
ES (1) ES2356870T3 (de)
FR (1) FR2932977B1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6218165B2 (ja) 2012-05-22 2017-10-25 株式会社ヤマネテック 受精卵・精子注入器
CN102743240A (zh) * 2012-08-08 2012-10-24 贵州省畜牧兽医研究所 一种牛的人工授精操作方法及装置
WO2017120162A1 (en) * 2016-01-05 2017-07-13 Common Sense Insemination Products Co., Llc. Post cervical artificial insemination catheter

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Publication number Priority date Publication date Assignee Title
JPS4822370Y1 (de) * 1969-09-19 1973-06-29
US4067656A (en) * 1975-10-20 1978-01-10 Dennis Edward F Joint member
FR2510393A1 (fr) * 1981-07-31 1983-02-04 Bertrand Cassou Appareil de transfert d'elements de reproduction animale, tels que des embryons
FR2575063B1 (fr) 1984-12-21 1988-07-01 Cassou Robert Sonde gynecologique pour insemination artificielle, notamment pour porcins
JPH0350892Y2 (de) * 1987-04-10 1991-10-30
US5263928A (en) * 1991-06-14 1993-11-23 Baxter International Inc. Catheter and endoscope assembly and method of use
US5522873A (en) * 1991-12-26 1996-06-04 Webster Laboratories, Inc. Catheter having electrode with annular recess and method of using same
JPH084013Y2 (ja) * 1992-07-03 1996-02-07 岩手県 家畜用受精卵移植器
EP0868925B1 (de) * 1997-03-31 2008-04-30 Terumo Kabushiki Kaisha Führungsdraht
DK1250897T3 (da) * 2000-01-03 2005-01-24 Iberica De Reproduccion Asisti Indretning til kunstig befrugtning af grise
US6527703B2 (en) * 2001-06-14 2003-03-04 Minitube Of America, Inc. Device for sow-intra-uterine insemination and embryo transfer
JP3829318B2 (ja) * 2001-10-29 2006-10-04 ニプロ株式会社 組織採取針
FR2835422B1 (fr) 2002-02-05 2004-10-15 Imv Technologies Raccord pour un instrument gynecologique a usage veterinaire
AU2003203950C1 (en) * 2002-05-15 2009-01-22 Nipro Corporation Catheter for artificial insemination
JP2005211190A (ja) * 2004-01-28 2005-08-11 Nitta Moore Co 家畜の人工授精用カテーテル
WO2006085331A2 (en) * 2005-02-14 2006-08-17 Flexicath Ltd. Method and apparatus for inserting a catheter device
US8104483B2 (en) * 2006-12-26 2012-01-31 The Spectranetics Corporation Multi-port light delivery catheter and methods for the use thereof

Also Published As

Publication number Publication date
DE602009000485D1 (de) 2011-02-10
CA2669573A1 (fr) 2009-12-30
US20090326317A1 (en) 2009-12-31
EP2140834A1 (de) 2010-01-06
ATE493090T1 (de) 2011-01-15
FR2932977B1 (fr) 2012-02-10
ES2356870T3 (es) 2011-04-13
DK2140834T3 (da) 2011-03-14
EP2140834B8 (de) 2011-04-20
JP2010012247A (ja) 2010-01-21
FR2932977A1 (fr) 2010-01-01

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