EP2140834A1 - Intrauterines Transferinstrument über den natürlichen vaginal-uterinen Weg - Google Patents

Intrauterines Transferinstrument über den natürlichen vaginal-uterinen Weg Download PDF

Info

Publication number
EP2140834A1
EP2140834A1 EP09290478A EP09290478A EP2140834A1 EP 2140834 A1 EP2140834 A1 EP 2140834A1 EP 09290478 A EP09290478 A EP 09290478A EP 09290478 A EP09290478 A EP 09290478A EP 2140834 A1 EP2140834 A1 EP 2140834A1
Authority
EP
European Patent Office
Prior art keywords
transfer
instrument according
transfer head
head
tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP09290478A
Other languages
English (en)
French (fr)
Other versions
EP2140834B8 (de
EP2140834B1 (de
Inventor
Laurent Huet
Christophe Staub
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IMV Technologies SA
Original Assignee
IMV Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IMV Technologies SA filed Critical IMV Technologies SA
Publication of EP2140834A1 publication Critical patent/EP2140834A1/de
Application granted granted Critical
Publication of EP2140834B1 publication Critical patent/EP2140834B1/de
Publication of EP2140834B8 publication Critical patent/EP2140834B8/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
    • A61D19/027—Devices for injecting semen into animals, e.g. syringes, guns, probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/04—Instruments or methods for reproduction or fertilisation for embryo transplantation

Definitions

  • the invention relates to intrauterine transfer instruments by the natural vagino-uterine route.
  • instruments for insemination or transfer of embryos into the uterus of a female animal such as a sow.
  • These instruments generally comprise a probe-type device intended to be introduced into the vagina of the animal.
  • This probe carries at its end a mouthpiece which is intended to be positioned at the level of the neck of the uterus, either in support thereon, or by crossing it partially to fix it and serve as longitudinal reference point to the device insemination. In both cases this tip ensures the closure of the neck and prevents the return of the products that will be injected inside the uterus.
  • This probe generally contains a flexible catheter for passing through said tip to deploy in the uterus after the positioning of the tip and allow the injection of the product as close to the desired area, that is to say to the closer to the uterine horns.
  • the catheter remains locked in the probe during the introduction of the latter into the vagina to keep it clean and prevent it from being polluted in contact with the vaginal wall.
  • the length of the catheter that the operator leaves the probe is also predetermined, thanks to markings carried by the probe, which are graduated according to the age of the animal or the number of litters he has already had. .
  • the invention aims to provide a catheter whose end can penetrate and progress optimally in a uterine horn.
  • the invention provides a vaginally uterine intrauterine intrauterine transfer device, comprising a catheter comprising a tube carrying at one end a transfer head, said tube being traversed by a channel for the delivery of substances, said transfer head being provided with at least one orifice for passage of the substances to be transferred; characterized in that said transfer head has an oblong shape having a general orientation in line with that of said tube, with an evolutive cross section having at least two rounded lateral bulges distinct, no portion of said head being more prominent laterally than said two bulges.
  • the oblong character of the transfer head that is to say that it is longer than wide, while the greater width is of course smaller and relatively close to the diameter of a uterine horn, makes it possible to avoid during the progression of the head in a horn, that it crosses or that it turns, which is absolutely to avoid, since in this case the exit orifice or the channel of routing of the substance to be transferred would be clogged and / or the catheter could not progress further.
  • the fact that no portion of the transfer head is more prominent laterally than the two rounded bulges has the advantage that the contact area of the head with the uterine horns is limited to lines, one for each bulge , so that the sliding of the transfer head is greatly facilitated.
  • the latter comprises a tube pierced by said channel and a second channel disjoint and parallel to the first, said second channel containing a reinforcing cable.
  • the catheter is provided in a particularly simple, convenient and economical manner, at the same time flexibility and resistance to folding which allows it to walk in the best conditions in the uterus and then in a uterine horn.
  • said reinforcing cable is made of a material suitable for backscattering the ultrasound.
  • said reinforcing cable has a diameter of between 1 and 1.5 mm.
  • the instrument further comprises a probe provided at one of its ends with a tip adapted to be positioned against or in the cervix, said catheter being inserted into the central space of the probe and being able to pass through said tip to leave a retracted position where the transfer head of the catheter is retracted inside the central space of said probe and an extended position where said transfer head makes protruding out of the tip of the probe
  • the figure 1 shows an intrauterine transfer instrument, of the prior art, connected to supply means 27 for substances to be transferred and to a connecting duct 28 via a connector 11.
  • the instrument itself comprises a probe 1 provided at one of its ends with a tip 4.
  • the probe 1 is intended to be inserted by the natural vagino-uterine way in or against the uterus of a female animal, such as a sow or a laity, which one wishes to fertilize by artificial insemination for example.
  • the probe 1 comprises a hollow tube 2 carrying at its distal end, that is to say the one opposite the supply means 27, a nozzle 4.
  • This nozzle 4 has the shape substantially of a cylinder of which the The distal end is chamfered to prevent injury during its introduction and to facilitate the crossing of the cervix. It also has a circular groove in the middle, so as to remain astride the neck and thus define a longitudinal reference point for the uterine cavity.
  • the probe 1 also comprises, inserted inside the hollow tube 2, a catheter 6 able to slide between a retracted position where it is fully positioned in the central space of the tube 2, and an extended position where it projects out of the tube 2 passing through the tip 4, so as to reach the bottom of the uterine cavity and deposit the substances to be transferred to the immediate vicinity of the uterine horns.
  • This catheter has at its distal end 7 a transfer head 8 provided with an end portion 9 ball-shaped, carrying an orifice 10 for discharging the substances to be transferred.
  • the catheter 6 is seen in the retracted position, with its end portion 9 bearing against the inner wall of the distal end of the tip 4.
  • This tip has an orifice 5 through which the catheter and its transfer head pass, with a elastic deformation, to project into the uterine cavity.
  • a catheter whose transfer head 8 has the form of a peanut, that is to say an oblong shape with here two bulges, a distal bulge 31 and a proximal bulge 32, separated by a constriction 33 of smaller section.
  • the two bulges represented have equal sections, without this characteristic being imperative.
  • the head 8 is oriented in the extension of the catheter tube 6 to provide longitudinal stability to this head when pushed by the tube within the uterine horns. This oblong shape avoids a reversal of the end portion and its skew relative to the desired direction of advancement.
  • the greatest length L is more than twice greater than the largest diameter of the bulges 31 and 32, and even more preferably equal to three times the same diameter.
  • this length L is between 20 and 40 mm and preferably of the order of 30 mm.
  • the second advantage provided by this form in peanut comes from the presence of two bulges 31 and 32 which have only a circular line of contact with a cylinder which would form a tangential envelope for the head 8. This makes it possible to have as surface contact with the inner wall of the uterine horns, only two lines, one for each bulge, when introducing the catheter. The sliding of the transfer head is therefore greatly facilitated and the comfort of the animal improved accordingly.
  • the section of the constriction is between a quarter and half of the largest section of the bulges 31 and 32, and, even more preferably, equal to substantially one-third of this larger section.
  • the peanut shape given to the head 8 has two rounded ends, a distal rounded end 34 and a proximal rounded end 35.
  • the distal rounded shape 34 is intended to facilitate first the passage of the head 8 through the orifice 5 of the tip 4, and then its introduction into the uterus of the animal avoiding that it sinks into the wall of the uterus and makes to suffer the animal unnecessarily.
  • the proximal rounded shape can be a sphere section as shown on the figure 3 , or any other form of connection with the distal end of the catheter, as long as it is free of ridges that could injure the animal during removal of the probe.
  • the end portion has a symmetry of revolution about its axis and a symmetry with respect to a plane perpendicular to this axis, passing through one of the diameters of the constriction 33.
  • the material preferentially used to make this end part is a polyoxymethylene, which has the advantage of being light and smooth, which provides a low coefficient of friction with the uterine wall.
  • This tube made of flexible and smooth material such as low-density polyethylene, is traversed longitudinally by two parallel channels, a first channel 36 for conveying the substances to be transferred and a second channel 37 for receiving a reinforcing cable 38.
  • This second channel extends parallel to the first channel over at least the entire length of the catheter 6.
  • the second canal is provided with a reinforcing cable 38 which provides a rigidity adapted to progress inside the uterus and uterine horns.
  • This reinforcing cable is preferably made of a material suitable for backscattering the ultrasound, which allows, if necessary, to visualize its path inside the uterus and to see by ultrasound, the place where the substances will be deposited.
  • the size of the reinforcing cable is typically between 1 and 1.5 mm, and preferably equal to 1.2 mm, for a tube whose diameter is of the order of 3.5 mm.
  • the diameter of the second channel is then of the order of 1.3 mm.
  • the distal end of the catheter tube 6 is intended to receive the head 8 which, for this, has at its proximal end a cavity adapted to the male form of the tube.
  • the distal end of the tube is generally fixed in the cavity of the head 8 by gluing, as shown in FIG. figure 5 .
  • Complementary bonding modes may be superimposed on the bonding to ensure good fixation of the head 8 and prevent it from becoming detached from the tube and remaining in the uterine cavity during removal of the probe.
  • Variants relating to the fixing of the head 8 are represented on the Figures 6 to 8 .
  • the reinforcing cable 38 does not extend to the distal end of the tube, so as to leave a free space in the second channel 37 where can be slid a connecting pin 39 with the head 8.
  • the present head for this purpose a complementary channel 40 positioned so that it is located opposite the second channel 37 of the tube when it is inserted into the cavity of the head 8.
  • the pin 39 is positioned astride the second channel 37 of the tube and in the complementary channel 40 of the head 8 and held in place, for example, by gluing.
  • the connecting pin 39 has latching notches and is forced into the second channel 37 and the complementary channel 40.
  • This embodiment has the advantage of offering a large bonding surface between the catheter and the head and thus to ensure good bonding between the two parts.
  • the complementary pipe 41 is not integral with the rest of the catheter tube 6 but formed by an insert, for example by gluing, welding or force fitting.
  • the subjection between the catheter tube and the head 8 is made by overmolding the tube by the material of the head.
  • the transfer channel of the head 8 does not open through an orifice 10 located at the distal end 34, but by one or more orifices arranged differently, for example by two lateral orifices as in the prior device illustrated on the figure 2 .
  • the transfer head 8 comprises more than two bulges such as the bulges 31 and 32, for example three bulges with two neighboring bulges which are separated from each other by a constriction such as 33.
  • the catheter 6 illustrated on the Figures 4 to 10 and described above is particularly suitable for performing nonsurgical embryo transfer, but it is also suitable for other applications in the field of artificial insemination, including deep insemination, or for transferring substances other than for artificial insemination, for example drugs.
  • the catheter 6 in an intrauterine transfer instrument such as the device 1 illustrated on the Figures 1 and 2 but it should be noted that the catheter 6, because of the folding resistance which the presence of the cable 38 confers on it, can be used under certain circumstances directly as an intrauterine transfer instrument or can be used with a different applicator device , for example a sheath-shaped glove having substantially the length of the vaginal cavity and the end is torn by the head 8 when the sheath meets the cervix.
  • a sheath-shaped glove having substantially the length of the vaginal cavity and the end is torn by the head 8 when the sheath meets the cervix.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Animal Husbandry (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Particle Accelerators (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Peptides Or Proteins (AREA)
  • External Artificial Organs (AREA)
EP09290478A 2008-06-30 2009-06-23 Intrauterines Transferinstrument über den natürlichen vaginal-uterinen Weg Active EP2140834B8 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0854421A FR2932977B1 (fr) 2008-06-30 2008-06-30 Instrument de transfert intra-uterin par la voie naturelle vagino-uterine

Publications (3)

Publication Number Publication Date
EP2140834A1 true EP2140834A1 (de) 2010-01-06
EP2140834B1 EP2140834B1 (de) 2010-12-29
EP2140834B8 EP2140834B8 (de) 2011-04-20

Family

ID=40351681

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09290478A Active EP2140834B8 (de) 2008-06-30 2009-06-23 Intrauterines Transferinstrument über den natürlichen vaginal-uterinen Weg

Country Status (9)

Country Link
US (1) US20090326317A1 (de)
EP (1) EP2140834B8 (de)
JP (1) JP2010012247A (de)
AT (1) ATE493090T1 (de)
CA (1) CA2669573A1 (de)
DE (1) DE602009000485D1 (de)
DK (1) DK2140834T3 (de)
ES (1) ES2356870T3 (de)
FR (1) FR2932977B1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6218165B2 (ja) 2012-05-22 2017-10-25 株式会社ヤマネテック 受精卵・精子注入器
CN102743240A (zh) * 2012-08-08 2012-10-24 贵州省畜牧兽医研究所 一种牛的人工授精操作方法及装置
CN107205363A (zh) * 2016-01-05 2017-09-26 常识授精产品有限责任公司 子宫内输精导管

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0071538A1 (de) * 1981-07-31 1983-02-09 Bertrand Cassou Gerät für die Verpflanzung von Elementen für die Tierfortpflanzung, wie Embrios
EP0189702A1 (de) 1984-12-21 1986-08-06 Robert Cassou Gynäkologisches Instrument, insbesondere für künstliche Befruchtung oder tierärztliche Behandlung, wie z.B. für Ferkel
EP1250897A1 (de) 2000-01-03 2002-10-23 Iberica de Reproduccion Asistida, S.L. Vorrichtung zur künstlichen befruchtung von schweinen
WO2003065925A1 (fr) 2002-02-05 2003-08-14 Imv Technologies Raccord poru un instrument gynecologique

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4822370Y1 (de) * 1969-09-19 1973-06-29
US4067656A (en) * 1975-10-20 1978-01-10 Dennis Edward F Joint member
JPH0350892Y2 (de) * 1987-04-10 1991-10-30
US5263928A (en) * 1991-06-14 1993-11-23 Baxter International Inc. Catheter and endoscope assembly and method of use
US5423882A (en) * 1991-12-26 1995-06-13 Cordis-Webster, Inc. Catheter having electrode with annular recess and method of using same
JPH084013Y2 (ja) * 1992-07-03 1996-02-07 岩手県 家畜用受精卵移植器
EP0868925B1 (de) * 1997-03-31 2008-04-30 Terumo Kabushiki Kaisha Führungsdraht
US6527703B2 (en) * 2001-06-14 2003-03-04 Minitube Of America, Inc. Device for sow-intra-uterine insemination and embryo transfer
JP3829318B2 (ja) * 2001-10-29 2006-10-04 ニプロ株式会社 組織採取針
AU2003203950C1 (en) * 2002-05-15 2009-01-22 Nipro Corporation Catheter for artificial insemination
JP2005211190A (ja) * 2004-01-28 2005-08-11 Nitta Moore Co 家畜の人工授精用カテーテル
US20080319387A1 (en) * 2005-02-14 2008-12-25 Shai Amisar Method and Apparatus for Inserting a Catheter Device
US8104483B2 (en) * 2006-12-26 2012-01-31 The Spectranetics Corporation Multi-port light delivery catheter and methods for the use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0071538A1 (de) * 1981-07-31 1983-02-09 Bertrand Cassou Gerät für die Verpflanzung von Elementen für die Tierfortpflanzung, wie Embrios
EP0189702A1 (de) 1984-12-21 1986-08-06 Robert Cassou Gynäkologisches Instrument, insbesondere für künstliche Befruchtung oder tierärztliche Behandlung, wie z.B. für Ferkel
EP1250897A1 (de) 2000-01-03 2002-10-23 Iberica de Reproduccion Asistida, S.L. Vorrichtung zur künstlichen befruchtung von schweinen
WO2003065925A1 (fr) 2002-02-05 2003-08-14 Imv Technologies Raccord poru un instrument gynecologique

Also Published As

Publication number Publication date
FR2932977B1 (fr) 2012-02-10
JP2010012247A (ja) 2010-01-21
EP2140834B8 (de) 2011-04-20
CA2669573A1 (fr) 2009-12-30
ES2356870T3 (es) 2011-04-13
ATE493090T1 (de) 2011-01-15
EP2140834B1 (de) 2010-12-29
FR2932977A1 (fr) 2010-01-01
DE602009000485D1 (de) 2011-02-10
DK2140834T3 (da) 2011-03-14
US20090326317A1 (en) 2009-12-31

Similar Documents

Publication Publication Date Title
EP0278823B1 (de) Instrument zur künstlichen Besamung, zur Übertragung von Embryos oder zur Entnahme von follikulären Flüssigkeiten bei Säugetieren
EP0093630B1 (de) Schutzhülle gegen interne Kontamination für eine gynäkologische Pistole, insbesondere für Rinder
FR2556596A1 (fr) Instruments d'action gynecologique, notamment de transfert d'embryons
EP0071538B1 (de) Gerät für die Verpflanzung von Elementen für die Tierfortpflanzung, wie Embrios
FR2900327A1 (fr) Gaine pour pistolet d'insemination artificielle, procede de fabrication d'une telle gaine, et procede d'insemination artificielle
EP0189702A1 (de) Gynäkologisches Instrument, insbesondere für künstliche Befruchtung oder tierärztliche Behandlung, wie z.B. für Ferkel
FR2647668A1 (fr) Pipette de transfert pour embryons
EP2086479A2 (de) Monocanaliculonasale und/oder monocanaliculare intubationsanordnung für nasolakrimale imperforation
EP2140834B1 (de) Intrauterines Transferinstrument über den natürlichen vaginal-uterinen Weg
FR2477006A1 (fr) Appareil de transfert d'elements de reproduction animale, notamment d'embryons
EP2043532B1 (de) Entnehmbares intrauterines system
FR2638363A1 (fr) Instrument chirurgical pour tracheotomie, et dispositif comprenant un tel instrument
WO2010139912A1 (fr) Sonde pour insémination artificielle, notamment de porcins
FR2667783A1 (fr) Prothese pour voies urinaires.
FR2557460A1 (fr) Drain uretral et equipement pour le pontage des obstructions dans l'uretre comprenant un tel drain
FR2605211A1 (fr) Dispositif d'injection pour injecter un produit notamment pour l'insemination artificielle ou la transmission d'embryons, notamment destine aux animaux
FR2611486A1 (fr) Prothese uretrale
EP1006946B1 (de) Dreidimensionales positioniersystem für endoluminal eingebrachtes material
FR3021861A1 (fr) Dispositif perfectionne de transfert atraumatique de materiel ou substance a but reproductif, therapeutique ou diagnostique dans des mammiferes femelles
EP1263361B1 (de) Vorrichtung zum einführen einer t-förmigen intrauterinen vorrichtung
CA2687798A1 (fr) Dispositif pour le traitement du larmoiement de l'oeil
WO2003065925A1 (fr) Raccord poru un instrument gynecologique
FR3079740A1 (fr) Dispositif de nettoyage d'un implant phonatoire
FR2727617A1 (fr) Dispositif d'eveinage pour realiser l'ablation d'une veine par invagination
EP2925255A1 (de) Hygienemantel für eine besamungsspritze zur befruchtung mittels eines strohhalms und herstellungsverfahren dafür

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

17P Request for examination filed

Effective date: 20100203

17Q First examination report despatched

Effective date: 20100223

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

RIC1 Information provided on ipc code assigned before grant

Ipc: A61D 19/04 20060101ALI20100707BHEP

Ipc: A61D 19/02 20060101AFI20100707BHEP

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: IMV TECHNOLOGIES

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: FRENCH

REF Corresponds to:

Ref document number: 602009000485

Country of ref document: DE

Date of ref document: 20110210

Kind code of ref document: P

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602009000485

Country of ref document: DE

Effective date: 20110210

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

RAP2 Party data changed (patent owner data changed or rights of a patent transferred)

Owner name: IMV TECHNOLOGIES

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2356870

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20110413

REG Reference to a national code

Ref country code: NL

Ref legal event code: T3

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101229

REG Reference to a national code

Ref country code: NO

Ref legal event code: T2

Effective date: 20101229

LTIE Lt: invalidation of european patent or patent extension

Effective date: 20101229

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101229

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101229

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101229

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110329

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101229

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101229

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101229

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101229

REG Reference to a national code

Ref country code: GB

Ref legal event code: S117

Free format text: REQUEST FILED; REQUEST FOR CORRECTION UNDER SECTION 117 FILED ON 28 FEBRUARY 2011

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101229

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110429

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110330

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110429

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101229

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101229

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101229

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101229

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20110930

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101229

REG Reference to a national code

Ref country code: GB

Ref legal event code: S117

Free format text: CORRECTIONS ALLOWED; REQUEST FOR CORRECTION UNDER SECTION 117 FILED ON 28 FEBRUARY 2011 ALLOWED ON 17 AUGUST 2011

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602009000485

Country of ref document: DE

Effective date: 20110930

REG Reference to a national code

Ref country code: DE

Ref legal event code: R082

Ref document number: 602009000485

Country of ref document: DE

Representative=s name: VON ROHR PATENTANWAELTE PARTNERSCHAFT MBB, DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101229

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20110630

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20110623

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NO

Payment date: 20130524

Year of fee payment: 5

Ref country code: IE

Payment date: 20130607

Year of fee payment: 5

Ref country code: DK

Payment date: 20130606

Year of fee payment: 5

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20130530

Year of fee payment: 5

Ref country code: IT

Payment date: 20130619

Year of fee payment: 5

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101229

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101229

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20130624

Year of fee payment: 5

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130630

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130630

REG Reference to a national code

Ref country code: DK

Ref legal event code: EBP

Effective date: 20140630

REG Reference to a national code

Ref country code: NL

Ref legal event code: V1

Effective date: 20150101

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150101

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NO

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140630

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140623

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140623

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140630

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20150608

Year of fee payment: 7

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 8

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20160623

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20160623

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 9

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140630

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20210601

Year of fee payment: 13

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20210720

Year of fee payment: 13

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 602009000485

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230103

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20230628

Year of fee payment: 15

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20230801

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220624