EP0278823B1 - Instrument zur künstlichen Besamung, zur Übertragung von Embryos oder zur Entnahme von follikulären Flüssigkeiten bei Säugetieren - Google Patents

Instrument zur künstlichen Besamung, zur Übertragung von Embryos oder zur Entnahme von follikulären Flüssigkeiten bei Säugetieren Download PDF

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Publication number
EP0278823B1
EP0278823B1 EP88400142A EP88400142A EP0278823B1 EP 0278823 B1 EP0278823 B1 EP 0278823B1 EP 88400142 A EP88400142 A EP 88400142A EP 88400142 A EP88400142 A EP 88400142A EP 0278823 B1 EP0278823 B1 EP 0278823B1
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EP
European Patent Office
Prior art keywords
sheath
needle
instrument according
instrument
piston
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Expired - Lifetime
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EP88400142A
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English (en)
French (fr)
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EP0278823A1 (de
Inventor
Robert Cassou
Bertrand Cassou
Maurice Cassou
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Individual
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
    • A61D19/027—Devices for injecting semen into animals, e.g. syringes, guns, probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/04—Instruments or methods for reproduction or fertilisation for embryo transplantation

Definitions

  • the invention relates to an instrument for artificial insemination, embryo transfer or the removal of follicular fluids from mammals in general, in particular equines, pigs, sheep, goats, cattle, deer and all carnivores.
  • the invention therefore relates to an instrument which can be used for artificial insemination or the transfer of embryos by transperitoneal route, for example in goats, sheep or canines or by the natural route when the morphology of the mammal is suitable.
  • This instrument can also be applicable to the collection of follicular fluids by the cervical route.
  • a syringe comprising a pump body pivotally connected to a sheath by means of a device supported by said pump body and further comprising a ball abutting by means of a spring, against a pin determining the position of the pump body relative to the sleeve.
  • a rack piston rod is capable of sliding in said pump body, at the end of which a hypodermic needle can be provided.
  • the sheath is integral with a handling handle comprising in particular a toothed wheel controlled by a spring and capable of driving the piston rod to pump or inject a liquid.
  • syringes formed of a sheath and of a piston whose translation is precisely controlled by a thumb wheel carried by a handle coupled to the anterior end of the sheath.
  • the front end of the sheath is extended by a needle coupled to a tip, comprising a conical cavity, this tip being fixed by gluing or welding inside the front end of the sheath.
  • a piston provided with a removable sealing head, or (when the sheath contains a fine sterilized packaging straw) the simple push rod, the piston head being in this case removed and replaced by the "factory" plug usually closing the packaging straw.
  • the sheath is protected externally by a tubular end piece or rigid sheath preventing its deformation during its introduction.
  • the object of the invention is to improve these known instruments so that they can be used, in particular according to the transperitoneal technique, in the best conditions of manipulation and of dosage control, whether artificial insemination or embryo transfer.
  • Another object of the invention is to release one of the operator's hands so that he can simultaneously handle the transfer instrument and the endoscope.
  • Another object of the invention is to mask the needle during the introduction phase of the instrument so as not to bruise, injure or stress the animal.
  • the invention therefore relates to an instrument which can be used indifferently for artificial insemination, or for the transfer of embryos by transperitoneal route or by uterine route in mammals, or also for the collection of follicular fluids by the cervical route, comprising a syringe formed a sheath in which a piston slides in leaktightness, movable in translation, this sheath being protected from the outside by a rigid sheath, the sheath and the sheath being immobilized in a handling handle comprising a rotary member for translational drive of piston, this instrument being characterized in that the anterior end of the sheath is provided with a needle which can be, depending on the function, flexible or rigid, and in that the sheath protecting the sheath serves as a guide for a feeler whose length is slightly less than that of the sheath (including its needle) to be able respectively and by simple axial sliding, either to hide the needle of the syringe, during the introduction of the instrument, or to discover all or
  • the front end of the feeler comprises at least one graduated radial slot, making it possible to follow the displacements of the piston inside the sheath, which, for this purpose, is transparent.
  • the instrument illustrated in FIG. 1 consists, in known manner, of a syringe formed of a semi-rigid sheath 1, of transparent, flexible and deformable plastic material, in which a piston 2 movable in sealing moves alternative translation, whose stem 21 pusher can, optionally, receive a removable head, ensuring sealing with the bore of the sheath 1 or even be used alone, as in the example of FIG. 1 where a sterilized straw 3 for packaging is used of seed.
  • a syringe formed of a semi-rigid sheath 1, of transparent, flexible and deformable plastic material, in which a piston 2 movable in sealing moves alternative translation, whose stem 21 pusher can, optionally, receive a removable head, ensuring sealing with the bore of the sheath 1 or even be used alone, as in the example of FIG. 1 where a sterilized straw 3 for packaging is used of seed.
  • a syringe formed of a semi-rigid sheath 1, of transparent, flexible and deform
  • the piston head 22 is formed by a cap crimped on the front end of the push rod, that comprising a rounded face 23 connecting to an annular lip 24 greater than its diameter nominal, this lip being of a diameter slightly greater than that of the bore of the sheath 1 which deforms radially when the piston head passes. This ensures excellent sealing, without jamming, inside the sheath.
  • the push rod 21 comes to bear directly on the "factory" plug 4 of the straw which then plays itself the role of piston head.
  • the diameter of the push rod 21 is slightly less than that of the conduit of the packaging straw 3 so that said rod can, by displacement of the "factory" plug, expel the content of said straw through the needle 5 which extends the sheath 1.
  • the needle is integral with a tip 6, glued or welded inside the front part of the sheath 1, said tip having a conical cavity 7 in which can be crimped, by simple fitting, the front end of the straw 3.
  • the syringe can be used as indicated above, without straw, (in particular in the case of the use of fresh seed) and in this case, the push rod 21 is provided at its front end with a piston head. removable 22 such as that described above with reference to Figure 2a.
  • the sheath 1 is assembled with a handle or handling handle 8, for example by a needle screw 9, so that it is immobilized in translation and in rotation.
  • the push rod 21 projects beyond the rear end of the sheath 1 and passes through the handle 8 to project on its rear face 81.
  • the handle is provided with a cavity 10 in which is mounted movable in alternating rotation a thumb wheel 11 provided with at least two notches 111-112, diametrically opposite, the angular travel of 180 °, between these two notches, corresponding to a linear distance from piston 2, equal to half a dose, for insemination of a uterine horn.
  • the periphery of this wheel 11 is in contact with the push rod 21 and is advantageously mounted on an axis 12, housed in a vertical slot 13 allowing its rigorous application on the push rod.
  • sheath 1 is protected from the outside by a rigid sheath 14, intended to protect the flexible sheath 1, this sheath extending over only part of the length of said sheath and screwing into the handling handle 8, after insertion of an O-ring seal 14 joint.
  • the syringe is enclosed in a feeler 15, mounted freely sliding in the axial direction on the sheath 14 which serves as a guide.
  • the feeler is slightly shorter than the length of the sheath (including the needle 5) so that it can take at least two distinct positions, on the one hand, a position known as "inserting the syringe" ( as illustrated in dashed line, under the reference 151), and in this case the needle 5 is masked by the feeler, on the other hand a position called “operational” (as illustrated in solid line under the reference 15 ) and in this case the needle 5 projects more or less relative to the end 152 of the feeler.
  • the feeler 15 advantageously comprises a or several longitudinal graduated slots 16 located near the front part of the sheath 1, these thus making it possible, by reading through the sheath 1, to control the movement of the piston 2, under the action of the thumb wheel 11 The tip of the feeler is eroded so as not to injure the subject.
  • the feeler also has, at its rear end, a tulip shoulder 17 coming, when it is fully retracted, pressing on the front end face 81 of the handle 8. On the contrary, when the feeler is in the introduction phase (151) , this shoulder 17 is spaced from this front face 81.
  • the feeler comprises at its tulip shoulder 17 an O-ring seal 18 opposing the reflux of the gas which is generally blown between the viscera and the abdominal wall of the subject when one proceeds to a pneumo-peritoneum.
  • This O-ring 18 therefore ensures perfect tightness by obstructing the possible lamellar gap which could remain between the probe duct and the periphery of the stiffening sheath 14.
  • the handling handle 8 has a second notch 19, diametrically opposite the notched wheel 11 which receives the thumb, this notch being intended for receiving the operator's index finger.
  • the rod 21 of the piston 2 may have on its rear end one or more visual cues 20 allowing, here again, to control its linear travel.
  • this instrument is used by the transperitoneal route, two fine incisions are made in the abdominal wall of the animal, one receiving the sleeve of a trocar in the lumen of which an endoscope will be introduced, the other receiving a second trocar intended to serve as a guide for the syringe according to the invention.
  • the diameter of the bore of this second trocar corresponds substantially to that of the feeler 15 but its length is less than the latter so that the graduated viewing windows 16, which make it possible to control the stroke of the piston 2, and consequently the precise metering of the seed or medium does not are not hidden.
  • the operator axially slides the palpator backwards so that its shoulder 17 or not abuts on the front face 81 of the handle 8. In this position the needle 5 does more or less protruding from the front end of the feeler 15. All that remains is to prick the uterine horn and then inject the semen, or transfer the embryos, by simply rotating the thumb wheel 11 which causes the linear displacement of the piston 2 in the sheath 1 or in the conditioning straw 3.
  • the stroke of the piston is controlled either by means of the mark or marks 20 provided on its rear end, or by reading through the windows graduated display 16, this reading being facilitated by the lighting of the endoscope.
  • the needle 5 is intended to pierce the uterine horn. It is therefore metallic, tapered and bevelled (three-sided) to be able, with a simple small impulse, to pass through the wall of the uterine horn or membrane of the follicle.
  • the syringes illustrated in Figures 2a to 2d are more specifically intended for artificial insemination, embryo transfer and the removal of follicular fluids by the natural route, that is to say by the cervical route, faster, easier, less stressful and less expensive than laparoscopic procedures.
  • the sheath illustrated in Figure 2a comprises, as in Figure 1, a tip 6 and a metal needle 5, this tip being housed in the front part of the sheath 1 and fixed by gluing or ultrasound.
  • This needle 5 is protected from the outside, during transport, by a protective skirt 21 in the form of a section of coaxial tube and outside the needle 5. It is observed that the end piece 6 internally carries a conical cavity 7 for the possible reception of a packaging straw, this cavity connecting to the channel 51 of the needle without sharp angles to avoid possibly bruising the embryo.
  • the piston consists, in the example illustrated in Figure 2a only, of the push rod 21 whose front end is covered with the piston head 22, in the form of a cap whose front face 23 is rounded, the latter being connected with the nominal diameter of the cap 22 by an annular lip 24 ensuring the seal with the bore of the sheath 1.
  • the sheath is deliberately made of a flexible and deformable material so that the annular lip 24 slightly deforms it during its passage.
  • the front edge 11 of the sheath 1 connecting to the metal needle 5 is masked by a rod 22 molded with the end piece and avoiding any sharp angle of the sheath so as not to injure the animal during the introduction of the instrument.
  • the metal needle 5 is extended by a second coaxial and external needle 23 resembling a trunk and fixed by gluing or ultrasound on the front edge 11 of the sheath.
  • the metal needle 5 serves as an armature and a guide for the trunk 23 whose insertion end 231 is eroded in order to avoid any injury.
  • the channel of the metal needle 5 is connected to the frustoconical cavity 7 of the nozzle 6, without sharp angles, in order to avoid any attack on the embryos.
  • a rod 24 coming from molding conceals the sharp angle of the front end of the sheath.
  • This second needle 23 can be made of rigid plastic or metal and be bent on demand, that is to say at the time of use, to adapt the instrument to the morphology of the animal.
  • This type of syringe is used in particular for the transfer of embryos by the cervical route, or for artificial insemination under laparoscopy. It is also perfectly suited to women.
  • FIG. 2c is in all respects comparable to FIG. 2b except that the metal needle 5 has been removed and that the tube 25 is directly fixed in the end piece 6.
  • This tube 25 can be made in delrine or in metal and will again be curved on demand depending on the species to be treated. Still with the aim of avoiding injuring the animal, the front end of the proboscis is eroded and the sharp angle of the front section of the sheath is masked by a rod 26 molded with the end piece 6.
  • the needle particularly intended for artificial insemination by the cervical route of goats and deer consists of a monobloc tip 27 of slightly decreasing shape whose operational end 271 is substantially hemispherical.
  • This needle 27 comprises an annular groove 28 intended for fixing the sheath 1.
  • the needle / sheath assembly can be produced either by a reserve of glue 29 introduced into the annular groove 28, or by shaping the front end 30 of the sheath in the form of a clip of the hairpin type.
  • the portion of the needle 27 introduced into the sheath 1 is slightly undercut as visible at 27 so as to favor the passage of the sheath.
  • this portion of the needle which is similar to the tip 6 of FIGS. 2a to 2c comprises a frustoconical cavity 31 capable of receiving a packaging straw 3.
  • this tip is flared at 273 so to favor the introduction of the glitter.
  • the portion of needle located downstream of the sheath is slightly tulip-shaped to connect to the diameter of said sheath and consequently avoid any salient angle which could injure or stress the animal.
  • these tubes 23, 25 and 27 insofar as they are made of plastic material use non-toxic materials having a certain rigidity but which can nevertheless be curved to adapt to the morphology of the animal.
  • the needle 5 is semi-rigid and is produced in the form of an extruded capillary conduit 32, extending the anterior end of the sheath 1.
  • This capillary conduit also extends inside sheath 1 of a length substantially equal to that extending said sheath.
  • the end of the sheath has a constriction 33 to adapt to the diameter of the capillary duct 32 which is glued or sealed at 34 inside this constriction 33.
  • This needle 32 has at its front end a blister 35 forming a kind of warhead having at least two functions, on the one hand blunting the end of the needle in order to prevent it from injuring or stressing the animal, on the other hand, opposing a phenomenon aspiration of the embryo.
  • this type of needle is more specifically intended for the transfer of embryos, because the capillary is particularly well adapted, because of its fineness and its length, to oppose the loss of embryos.
  • the embryo is generally trapped between two air bubbles from its "environment", the use of a capillary further enhances security.
  • the capillary used here is of small diameter (of the order of a few tenths of a millimeter) and its length of approximately 10 to 15 cm is precisely sufficient to avoid loss of the embryo.
  • this capillary 32 is made of non-toxic plastic material, of the crystal type, which allows good visual control of the embryo before and after transfer.
  • This needle is used using the instrument described in Figure 1 and is of course, during its introduction through the lumen of the trocar, masked by the feeler 15.
  • the only difference is that due to its non-tapered nature, it is necessary, to allow its introduction into the uterine horn, to make with another trocar, a fine incision in the wall of the horn so as to be able to insert the warhead 35 therein.
  • the external length of the capillary duct is such that one can easily deposit the embryo (s) several centimeters beyond the incision, which generates better implantation of the embryo.
  • the warhead 35 tends to close the small incision in the horn and therefore oppose a suction effect from the embryo.
  • this instrument cannot be used with a packaging straw because of the portion of capillary conduit projecting inside the sheath 1.
  • the embryo (s) are consequently removed by the suction of the piston 2, fitted with its 22 sealing head, in a petri dish to be transferred under the conditions described above.
  • this semi-rigid needle 32 allows a deep deposition of the embryo in the uterine horns, without surgical intervention, beyond the incision (5 cm).
  • the instrument as described and represented under the various embodiments has many advantages since it can be used not only for artificial insemination, embryo transfer or follicular fluid sampling, but that it allows moreover, completely freeing one of the operator's hands, which can both operate the notched wheel 11 with the thumb, hold the handle by the cavity 19 and operate the feeler by its shoulder 19, caught between the and ring finger.
  • the free hand can then, in the case of laparoscopic intervention, orient the endoscopy in order to allow proper positioning of the needle on the uterine horn to be treated.
  • the feeler 15 sliding in the lumen of the trocar is perfectly guided, which allows great precision in the positioning of the instrument.
  • This palpator finally makes it possible to inspect the viscera, to control the number and the quality of the follicles on each ovary, to position the uterine horns (artificial insemination), then to prick, inseminate, transfer or take the follicular fluid to recover the oocytes, under precise control.
  • the graduated viewing slots 16 make it possible to constantly follow the piston 2 and consequently to exercise a permanent look at the dosage of the semen or the expulsion of the embryos.
  • the needle can of course, for hygienic reasons, be covered with a protective cap.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Husbandry (AREA)
  • Transplantation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Surgical Instruments (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Claims (22)

1. Instrument zur künstlichen Besamung oder zum Embryotransfer durch das Bauchfell und/oder den Muttermund, oder die Entnahme von Liquor folliculi bei Säugetieren, besonders bei Pferden, Schweinen, Schafen, Ziegen, Hirschen und Karnivoren, bestehend aus einer Spritze mit einem Rohr (1), in dem sich ein abgedichteter Kolben (2) bewegt, und das von einer äusseren Schutzhülle (14) umgeben ist, wobei das Rohr und die Schutzhülle in einem Griff (8) befestigt sind, in dem eine drehbare Vorrichtung (11) zur Bewegung des Kolbens vorgesehen ist, dadurch gekennzeichnet, dass das vordere Ende des Rohres (1₁) mit einer Nadel (5, 23, 25, 27) versehen ist, und dass die Schutzhülle (14) des Rohres mit einer Tasthülse (15) überzogen ist, der sie auch als Führung dient, und die vom Griff (8) aus gemessen länger als die Schutzhülle aber kürzer als das Rohr einschliesslich der Nadel ist, so dass die Tasthülse (15) die Nadel der Spritze durch axiale Verschiebung ganz oder teilweise verdecken kann.
2. Instrument nach Anspruch 1, dadurch gekennzeichnet, dass das vordere Ende der Tasthülse (15) erodiert und mit mindestens einer radialen Öffnung (16) versehen ist, die als Fenster abgestuft zur Beobachtung der Kolbenbewegungen (2) im Rohr (1) dient.
3. Instrument nach einem der Ansprüche 1 oder 2, dadurch gekennzeichnet, dass das hintere Ende der Tasthülse (15) mit einem nasenförmigen Ansatz (17) zur ihrer Betätigung versehen ist, der bei voll zurückgezogener Tasthülse an der Vorderseite (8₁) des Griffes (8) anschlägt.
4. Instrument nach Anspruch 1, dadurch gekennzeichnet, dass der Griff (8) mit einer Vertiefung (19) für den Zeigefinger des Anwenders versehen ist, die dem mit Einschnitten versehenen Rändelknopf (11) genau gegenüberliegt.
5. Instrument nach Anspruch 1, dadurch gekennzeichnet, dass die Tasthülse (15) an ihrem hinteren Ende mit einer Runddichtung (18) versehen ist, durch die sie gegenüber der das Rohr (1) umgebenden Schutzhülle (14) abgedichtet wird.
6. Instrument nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, dass die Kolbenstange (2) aus dem Griff (8) herausragt und an ihrem hinteren freien Ende eine oder mehrere Stellmarken (20) zur Überwachung der Längsbewegung des Kolbens trägt.
7. Instrument nach Anspruch 1, dadurch gekennzeichnet, dass das Rohr (1) aus einem weichen, verformbaren, durchsichtigen, ungiftigen Kunststoff besteht.
8. Instrument nach einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, dass die Nadel (5) am vorderen Ende des Rohres in einem geklebten oder geschweissten Mundstück (6) befestigt ist.
9. Instrument nach Anspruch 8, dadurch gekennzeichnet, dass das Mundstück (6) eine dem Rohr (1) zugewandte konische Vertiefung (7) zur Aufnahme einer der Aufbereitung des Sperma oder von Embryonen dienenden sterilisierten Paillette (3) aufweist.
10. Instrument nach einem der Ansprüche 1 bis 9, dadurch gekennzeichnet, dass die Nadel (5) aus einem Metall besteht und z.B. dreiseitig abgeschrägt ist.
11. Instrument nach Anspruch 10, dadurch gekennzeichnet, dass die Nadel (5) während des Transportes durch eine abnehmbare Tülle (21) geschützt wird.
12. Instrument nach einem der Ansprüche 1 bis 10, dadurch gekennzeichnet, dass die Nadel (5) mit einer Verlängerung (23) versehen ist, deren Ende erodiert ist.
13. Instrument nach einem der Ansprüche 1 bis 10, dadurch gekennzeichnet, dass die Nadel (25) aus einem mittelfesten Material besteht und entsprechend der Morphologie des Tieres gebogen ist.
14. Instrument nach einem der Ansprüche 1 bis 8, dadurch gekennzeichnet, dass die Nadel (27) mit dem Mundstück fest verbunden ist und eine Ringnut (28) zur Befestigung des Rohres (1) aufweist, wobei der vor dieser Ringnut liegende Teil der Nadel entsprechend dem Durchmesser des Rohres aufgeweitet ist.
15. Instrument nach Anspruch 14, dadurch gekennzeichnet, dass das Rohr (1) mit der Nadel (27) verklebt oder mittels Ultraschall verbunden ist.
16. Instrument nach Anspruche 14, dadurch gekennzeichnet, dass das vordere Ende des Rohres (1) mit einem Umschlag (30) in Form einer Haarnadel versehen ist, die in die Ringnut (28) der Nadel (27) eingreift.
17. Instrument nach Anspruch 14, dadurch gekennzeichnet, dass der hintere Teil der Nadel (27) innerhalb des Rohres leicht hinterschliffen ist und eine kegelstumpfförmige Öffnung (31) aufweist, die sich ohne scharfkantigen Übergang an die Bohrung der Nadel (27) anschliesst.
18. Instrument nach Anspruch 1, dadurch gekennzeichnet, dass der Kolben (2) aus einem Stössel (2₁) besteht, dessen vorderes Ende einen abnehmbaren Dichtkopf (2₂) mit gewölbter Vorderseite (2₃) und ringförmiger Dichtlippe (2₄) trägt, durch die der Durchmesser des verformbaren Rohres während der Kolbenbewegung etwas verändert wird.
19. Instrument nach einem der Ansprüche 1 bis 8, dadurch gekennzeichnet, dass das Mundstück (6) eine angegossene Verdickung (22-26) zur Überdeckung der scharfen Kante am vorderen Ende (1₁) des Rohres (1) aufweist.
20. Instrument nach Anspruch 1 speziell für den Embryotransfer, dadurch gekennzeichnet, dass die ungiftige Nadel aus einer biegsamen, das Rohr (1) verlängernden Kapillare (32) besteht, die auf eine gewisse Länge in das Rohr hineinreicht, wobei das vordere Ende dieser Kapillare mit einem wulstförmigen Vorsprung (35) versehen ist.
21. Instrument nach Anspruch 20, dadurch gekennzeichnet, dass das vordere Ende des Rohres (1) mit einer Einschnürung (34) versehen ist, in die die Kapillare (32) geklebt oder eingeschweisst ist.
22. Instrument nach Anspruch 1, dadurch gekennzeichnet, dass der Rändelknopf (11) zwei sich diametral gegenüberliegende Einschnitte (11₁-11₂) aufweist, und dass eine Drehung des Knopfes um 180° der Einspritzung einer halben Spermadosis entspricht.
EP88400142A 1987-01-22 1988-01-22 Instrument zur künstlichen Besamung, zur Übertragung von Embryos oder zur Entnahme von follikulären Flüssigkeiten bei Säugetieren Expired - Lifetime EP0278823B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8700711A FR2609885B1 (fr) 1987-01-22 1987-01-22 Instrument pour l'insemination artificielle, le transfert d'embryons ou le prelevement de liquides folliculaires chez les mammiferes
FR8700711 1987-01-22

Publications (2)

Publication Number Publication Date
EP0278823A1 EP0278823A1 (de) 1988-08-17
EP0278823B1 true EP0278823B1 (de) 1991-07-31

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EP88400142A Expired - Lifetime EP0278823B1 (de) 1987-01-22 1988-01-22 Instrument zur künstlichen Besamung, zur Übertragung von Embryos oder zur Entnahme von follikulären Flüssigkeiten bei Säugetieren

Country Status (8)

Country Link
US (1) US4846785A (de)
EP (1) EP0278823B1 (de)
AU (1) AU583999B2 (de)
FI (1) FI880267A (de)
FR (1) FR2609885B1 (de)
NO (1) NO173853C (de)
NZ (1) NZ223231A (de)
ZA (1) ZA88407B (de)

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FR2705880A1 (fr) * 1993-06-04 1994-12-09 Kwahak International Co Ltd Dispositif d'insémination artificielle et de transfert d'embryon.
US6305585B1 (en) 1997-01-31 2001-10-23 Instruments De Medecine Veterinaire Filler nozzle for packaging for biological liquids, in particular for artificial insemination

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US5295974A (en) * 1991-01-07 1994-03-22 Laughlin D Michael O Shielded hypodermic needle with I.V. cannula
US5151088A (en) * 1991-07-31 1992-09-29 The Board Of Trustees Of The Leland Stanford Junior University Safety needle and syringe assembly
US5389100A (en) * 1991-11-06 1995-02-14 Imagyn Medical, Inc. Controller for manipulation of instruments within a catheter
US5346498A (en) * 1991-11-06 1994-09-13 Imagyn Medical, Inc. Controller for manipulation of instruments within a catheter
AU651745B2 (en) * 1991-12-13 1994-07-28 Covidien Ag Locking pneumoneedle
DE4235506A1 (de) * 1992-10-21 1994-04-28 Bavaria Med Tech Katheter zur Injektion von Arzneimitteln
US5360389A (en) * 1993-05-25 1994-11-01 Chenette Philip E Methods for endometrial implantation of embryos
US5460611A (en) * 1994-09-06 1995-10-24 Medisys Technologies, Inc. Safety syringe
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ZA88407B (en) 1988-07-05
AU583999B2 (en) 1989-05-11
NO173853B (no) 1993-11-08
NO880236L (no) 1988-07-25
US4846785A (en) 1989-07-11
FR2609885B1 (fr) 1989-04-14
NO880236D0 (no) 1988-01-21
AU1068188A (en) 1988-07-28
NO173853C (no) 1994-02-16
FI880267A (fi) 1988-07-23
FR2609885A1 (fr) 1988-07-29
FI880267A0 (fi) 1988-01-21
EP0278823A1 (de) 1988-08-17
NZ223231A (en) 1989-11-28

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