EP2094674B1 - A salt of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one - Google Patents
A salt of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one Download PDFInfo
- Publication number
- EP2094674B1 EP2094674B1 EP07825549A EP07825549A EP2094674B1 EP 2094674 B1 EP2094674 B1 EP 2094674B1 EP 07825549 A EP07825549 A EP 07825549A EP 07825549 A EP07825549 A EP 07825549A EP 2094674 B1 EP2094674 B1 EP 2094674B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- fumarate
- fumarate salt
- medicament
- compound
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Definitions
- the present invention relates to fumarate salt of the compound of formula: in all its stereochemical configurations, a process for its preparation and its use in treating mood disorders, disorders of anxiety, depression and convulsive conditions, in the improvement of learning ability, in the reversal of amnesia, in resolving the abstinence syndrome from drugs and drugs of abuse.
- the invention concerns fumarate salt ofrel-(3R,3aS,7aS)-3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one.
- the compound BTG 1640 is prepared as a yellow oil and, in tests demonstrating the proposed activity, it is used after dilution in PEG and distilled water.
- oils are in fact hard to weight, basically less stable to temperature variations, less soluble in ordinary solvents and therefore technically harder to dose for the preparation of pharmaceutical formulations.
- the form of active ingredient is the crystalline solid one which normally shows better characteristics, specifically in terms of handling for activities of pharmaceutical formulation.
- patent application WO93/17004 cites the possibility of preparing the salt form of new psychoactive compounds of general Formula (I), by treating the free base of a compound of Formula (I) with the suitable free acid.
- document WO93/17004 describes the hydrochloride of BTG 1640 obtained in the form of white crystalline powders.
- An object of the present invention is therefore to provide a form of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one which does not require peculiar preservation and storage conditions.
- the inventors of the present invention carried out studies and researches and as a result they surprisingly found out that the fumarate salt of: shows a highly improved stability so as not to require peculiar preservation conditions, even after six months of preservation at 40°C/75%RH.
- the invention concerns fumarate salt as recited in claim 1, a new process of preparation and its use as a medicament, specifically in treating mood disorders, disorders of anxiety, depression and convulsive conditions, in the improvement of learning ability, in the reversal of amnesia, in resolving the abstinence syndrome from drugs and drugs of abuse.
- fumarate of rel-(3R,3aS,7aS)-3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one is provided, comprising the molecule in the two enantiomeric forms and as racemic mixture.
- the molecule 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one so as represented in formula I: comprises in its definition any stereochemical configuration associated to chiral centers, as well as racemic mixtures and enantiomers obtainable through separation techniques known to skilled men and any mixture of two or more stereochemical compounds.
- the invention therefore concerns the fumarate salt of molecule 3-benzyl-2-methyl-2,3,3 a,4,5,6,7,7a-octahydrobenzo [d]isoxazol-4-one.
- such salt can be obtained by treating the free base 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one with fumaric acid, or alternatively, from hydrochloride salt of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one through treatment directed to free the molecule 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one as free base and subsequent reaction with fumaric acid.
- the invention concerns a process for the preparation of fumarate salt of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one according to claim 5, comprising the following steps:
- step i) the free base 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one of step i) can be obtained in a preceding step to step i), which provides for freeing said base from correspondent hydrochloride salt.
- the hydrochloride salt of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one can be subjected to subsequent extractions in dichloromethane to obtain the molecule 3-benzyl-2-metil-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one as free base in form of a transparent oil of slightly brown colour.
- fumaric acid can be added in presence of an ice bath at about 2-8°C in form of crystals.
- Further preparation processes can be of course provided for by a synthesis organic technician.
- the salt so obtained can be furthermore optionally subjected to purification methods, if necessary.
- the fumarate salt so obtained resulted to be stable in different preservation conditions, as it will be demonstrated in examples, thus demonstrating itself more stable than hydrochloride salt.
- Fumarate salt of the compound of formula I having improved stability can be combined to suitable excipients for formulating pharmaceutical compositions according to the invention and is capable to act as pharmaceutical active substance in the treatment of mood disorders, disorders of anxiety, depression and convulsive conditions, in the improvement of learning ability, in the reversal of amnesia generated for example by Alzheimer disease or vascular dementia, in resolving the abstinence syndrome from drugs and drugs of abuse.
- the daily dose required to reach the effect in the treatment of the indicated pathology varies with the subject, by depending by age, body weight and health general state, but it can be provided for a dosage suitable for the oral or topic administration in the range from 1 to 100 mg, once or more times a day, and a dosage suitable for parenteral administration in the range from 0.1 to 100 mg, once or more times a day.
- the fumarate salt of compound of formula I will be added to a pharmaceutically acceptable carrier and, optionally, to other excipients in order to obtain pharmaceutical compositions to be parenterally, orally or topically administered.
- pharmaceutically acceptable carrier it is meant to include solvents, supporting agents, diluents and the like, which are used as additives in order to provide a carrier suitable to the administration of the salt of the invention.
- compositions of the present invention suitable for oral administration will be conveniently in the form of discrete units such as tablets, capsules, cachets, powders, or granules, or still as suspensions in a liquid.
- composition of the invention for the oral administration will be in form of tablets.
- the tablet according to the invention comprises preferably an amount from 1 to 100 mg, preferably from 1 to 50 mg, of fumarate salt of a compound of formula I per tablet unit.
- the tablet comprises also suitable excipients, such as pre-gel starch, microcrystalline cellulose, sodium starch glycolate, talc, lactose, magnesium stearate, sucrose, stearic acid and mannitol.
- the tablet comprises from 1.9% to 41.4% by weight of fumarate of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one, more preferably from 2.2% to 36% by weight with respect of the total weight of the tablet.
- composition for oral administration preferably will comprise from 1 to 100 mg of fumarate salt of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d] isoxazol-4-one.
- compositions for the parenteral administration will comprise conveniently sterile aqueous preparations.
- compositions for parenteral administration preferably will comprise from 0.1 to 100 mg of fumarate salt of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one.
- compositions for topical administration will be conveniently in form of creams, oils, ointments, emulsions, gels, aqueous solutions, spray solutions and plasters.
- compositions for topical administration preferably will comprise from 1 to 100 mg of fumarate of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one.
- dichloromethane phase was separated, which was added to the Erlenmeyer flask, the extraction with further 20 ml of dichloromethane was repeated. Three aliquots of dichloromethane were then anhydrified with sodium solphate, filtered on paper filter and evaporated at rotavapor at a temperature below 35°C. The residue obtained as a slightly brown coloured oil corresponded to the free base of BTG 1640.
- Table 5 Comparison of stabilities of different salts of BTG 1640 Purity data % of various salts of BTG 1640 at temperature of 5°C Time Methanesulphonate Maleate Succinate Hydrochloride Fumarate 0 99.6 99.8 99.2 99.3 99.5 3 99.5 100.0 98.0 100.1 100.0 6 99.3 100.0 98.1 100.3 100.0 9 99.1 99.8 96.8 99.6 99.9 Purity data % of various salts of BTG 1640 at temperature of 25°C and relative humidity of 60% Time Methanesulphonate Maleate Succinate Hydrochloride Fumarate 0 99.6 99.8 99.2 99.7 99.5 3 98.2 99.8 92.7 100.9 100.0 6 97.1 100.0 87.0 101.5 100.0 9 95.0 99.7 90.5 99.3 99.
- the methanesulphonate salt begins to degrade already after three months of stability in the cited conditions b)-d), in amount of course higher as the conditions become severer, i.e. from a) to d).
- Maleate salt shows an acceptable profile in conditions a) and b), while it shows considerable degradation if subjected to conditions c) already at sixth month and degrades in unacceptable way in condition d).
- fumarate showed a different and improved stability with respect to known hydrochloride and other prepared acid addition salts, thus turning out to be the best ingredient for formulating pharmaceutical compositions, which does not require peculiar preservation conditions.
- the present invention succeeded in solving the technical problem of obtaining a form of stable BTG 1640 through identification of the fumarate salt.
- the two salts were dispersed in an aqueous suspension of arabic gum at 5% thus obtaining two formulations, each one orally administered through oesophageous gavage at dose of 10 mg/kg (expressed as free base of BTG 1640) to five rats Sprague Dawley.
- Plasma concentration of molecule BTG 1640 was determined at different time points.
- Table 7 Concentration of fumarate and hydrochloride in Plasma Time (minutes) BTG 1640 free base ( ⁇ g/mL) with Fumarate Salt Administration BTG 1640 free base ( ⁇ g/mL) with Hydrochloride Salt Administration 2 1.06728 0.7402 5 2.35406 1.4242 30 0.83756 0.2354 90 0 0.1184 300 0 0
- the two salts were dispersed in an aqueous suspension, thus obtaining two formulations, each one orally administered through oesophageous gavage at dose of 2000 mg/kg bw (expressed as free base of BTG 1640) to one of two groups comprising three female CD-1 mice per group.
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT002102A ITMI20062102A1 (it) | 2006-11-02 | 2006-11-02 | Nuovui sali di 3-benzil-2-metil-2,3,3a,4,5,6,7,7a-ottaidrobenzo-d-isossazol-4-one |
PCT/IB2007/003291 WO2008053325A1 (en) | 2006-11-02 | 2007-10-31 | A salt of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2094674A1 EP2094674A1 (en) | 2009-09-02 |
EP2094674B1 true EP2094674B1 (en) | 2011-03-16 |
Family
ID=39145485
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07825549A Not-in-force EP2094674B1 (en) | 2006-11-02 | 2007-10-31 | A salt of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one |
EP07825550A Not-in-force EP2094675B1 (en) | 2006-11-02 | 2007-10-31 | A salt of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07825550A Not-in-force EP2094675B1 (en) | 2006-11-02 | 2007-10-31 | A salt of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one |
Country Status (20)
Country | Link |
---|---|
US (2) | US20100069451A1 (ja) |
EP (2) | EP2094674B1 (ja) |
JP (2) | JP2010509309A (ja) |
KR (2) | KR20090082452A (ja) |
CN (2) | CN101535282A (ja) |
AT (2) | ATE502021T1 (ja) |
AU (2) | AU2007315832A1 (ja) |
BR (2) | BRPI0718392A2 (ja) |
CA (2) | CA2667513A1 (ja) |
DE (2) | DE602007013278D1 (ja) |
HR (2) | HRP20090470A2 (ja) |
IL (2) | IL198443A0 (ja) |
IT (1) | ITMI20062102A1 (ja) |
MX (2) | MX2009004293A (ja) |
NO (2) | NO20092115L (ja) |
NZ (2) | NZ577978A (ja) |
RS (2) | RS20090389A (ja) |
RU (2) | RU2009120667A (ja) |
WO (2) | WO2008053325A1 (ja) |
ZA (2) | ZA200903618B (ja) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2112142A1 (en) * | 2008-04-24 | 2009-10-28 | Abiogen Pharma S.p.A. | Process for preparing a crystalline form compound of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one |
ITMI20080768A1 (it) * | 2008-04-24 | 2009-10-25 | Abiogen Pharma Spa | Procedimento per la preparazione di un composto in forma cristallina di 3-benzil-2-metil-2,3,3a,4,5,6,7,7a-ottaidro-benzo[d]isossazol-4-one |
EP2218721A1 (en) * | 2009-02-11 | 2010-08-18 | LEK Pharmaceuticals d.d. | Novel salts of sitagliptin |
WO2011010332A1 (en) * | 2009-07-23 | 2011-01-27 | Abiogen Pharma S.P.A. | Process for preparing rel-(3r*,3as*,7as*)-3-benzyl-2-methyl-2,3, 3a,4,5,6,7,7a- octahydrobenzo[d]isoxazoi-4-one or a salt thereof |
US10131642B1 (en) * | 2015-01-30 | 2018-11-20 | Boehringer Ingelheim International Gmbh | Aldosterone synthase inhibitors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4161595A (en) * | 1978-10-02 | 1979-07-17 | Bristol-Myers Company | Levulinic acid salt |
US4419358A (en) * | 1981-11-12 | 1983-12-06 | Mead Johnson & Company | Isethionic acid salt of 9-cyclohexyl-2-propoxy-9H-purine-6-amine and compositions containing an effective bronchodilating concentration of it |
GB2264299B (en) * | 1992-02-19 | 1995-07-26 | British Tech Group | Iso-oxazolidine derivatives |
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2006
- 2006-11-02 IT IT002102A patent/ITMI20062102A1/it unknown
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2007
- 2007-10-31 BR BRPI0718392-5A patent/BRPI0718392A2/pt not_active IP Right Cessation
- 2007-10-31 JP JP2009535824A patent/JP2010509309A/ja active Pending
- 2007-10-31 WO PCT/IB2007/003291 patent/WO2008053325A1/en active Application Filing
- 2007-10-31 WO PCT/IB2007/003292 patent/WO2008053326A1/en active Application Filing
- 2007-10-31 CN CNA2007800406691A patent/CN101535282A/zh active Pending
- 2007-10-31 CA CA002667513A patent/CA2667513A1/en not_active Abandoned
- 2007-10-31 NZ NZ577978A patent/NZ577978A/en unknown
- 2007-10-31 US US12/513,352 patent/US20100069451A1/en not_active Abandoned
- 2007-10-31 AT AT07825549T patent/ATE502021T1/de not_active IP Right Cessation
- 2007-10-31 RU RU2009120667/04A patent/RU2009120667A/ru not_active Application Discontinuation
- 2007-10-31 CN CNA2007800406598A patent/CN101535281A/zh active Pending
- 2007-10-31 JP JP2009535825A patent/JP2010509310A/ja active Pending
- 2007-10-31 RS RSP-2009/0389A patent/RS20090389A/sr unknown
- 2007-10-31 KR KR1020097011322A patent/KR20090082452A/ko not_active Application Discontinuation
- 2007-10-31 MX MX2009004293A patent/MX2009004293A/es not_active Application Discontinuation
- 2007-10-31 KR KR1020097011287A patent/KR20090077014A/ko not_active Application Discontinuation
- 2007-10-31 AU AU2007315832A patent/AU2007315832A1/en not_active Abandoned
- 2007-10-31 EP EP07825549A patent/EP2094674B1/en not_active Not-in-force
- 2007-10-31 CA CA002667515A patent/CA2667515A1/en not_active Abandoned
- 2007-10-31 DE DE602007013278T patent/DE602007013278D1/de active Active
- 2007-10-31 AU AU2007315833A patent/AU2007315833A1/en not_active Abandoned
- 2007-10-31 MX MX2009004294A patent/MX2009004294A/es not_active Application Discontinuation
- 2007-10-31 EP EP07825550A patent/EP2094675B1/en not_active Not-in-force
- 2007-10-31 BR BRPI0718391-7A patent/BRPI0718391A2/pt not_active IP Right Cessation
- 2007-10-31 RS RSP-2009/0388A patent/RS20090388A/sr unknown
- 2007-10-31 AT AT07825550T patent/ATE504578T1/de not_active IP Right Cessation
- 2007-10-31 DE DE602007013801T patent/DE602007013801D1/de active Active
- 2007-10-31 RU RU2009120724/04A patent/RU2009120724A/ru not_active Application Discontinuation
- 2007-10-31 NZ NZ577311A patent/NZ577311A/en unknown
- 2007-10-31 US US12/513,351 patent/US20100069450A1/en not_active Abandoned
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2009
- 2009-04-28 IL IL198443A patent/IL198443A0/en unknown
- 2009-04-28 IL IL198444A patent/IL198444A0/en unknown
- 2009-05-25 ZA ZA200903618A patent/ZA200903618B/xx unknown
- 2009-05-29 NO NO20092115A patent/NO20092115L/no not_active Application Discontinuation
- 2009-05-29 NO NO20092114A patent/NO20092114L/no not_active Application Discontinuation
- 2009-06-01 ZA ZA200903810A patent/ZA200903810B/xx unknown
- 2009-09-03 HR HR20090470A patent/HRP20090470A2/hr not_active Application Discontinuation
- 2009-09-08 HR HR20090477A patent/HRP20090477A2/hr not_active Application Discontinuation
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