EP2086597A1 - Neuartige hydrogele auf basis aliphatischer nco-prepolymere - Google Patents
Neuartige hydrogele auf basis aliphatischer nco-prepolymereInfo
- Publication number
- EP2086597A1 EP2086597A1 EP07818980A EP07818980A EP2086597A1 EP 2086597 A1 EP2086597 A1 EP 2086597A1 EP 07818980 A EP07818980 A EP 07818980A EP 07818980 A EP07818980 A EP 07818980A EP 2086597 A1 EP2086597 A1 EP 2086597A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- chx
- weight
- water
- prepolymers
- hydrogels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/08—Processes
- C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/48—Polyethers
- C08G18/4833—Polyethers containing oxyethylene units
- C08G18/4837—Polyethers containing oxyethylene units and other oxyalkylene units
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
- C08G18/72—Polyisocyanates or polyisothiocyanates
- C08G18/73—Polyisocyanates or polyisothiocyanates acyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2210/00—Compositions for preparing hydrogels
Definitions
- the invention relates to novel hydrogels obtained by reaction of aliphatic isocyanate prepolymers with tertiary nitrogen-containing polyols in water.
- Polyurethane hydrogels are usually prepared from an isocyanate component and polyethylene glycol, propylene glycol or glycerol as a polyol, partly in the presence of oligoalkylene oxides with primary amino end groups as accelerators and water for hydrolysis. Regardless of whether working with or without accelerator, the polyol component is always used in excess, so that the hydrogels thus obtained still contain excess polyol and, if appropriate, accelerator. Furthermore, the gel formation reaction times are very slow. The gel point, even in the case of the accelerator-containing variants, is not produced until more than 90 minutes. reached, followed by an after-reaction over several hours. The hydrogels are described with and without antimicrobial active substances.
- the water used in c) is used in amounts such that a satisfactory gelation is achieved. Based on the amount by weight of the compounds used in a) and b) (corresponding to one part by weight), 2 to 50 parts by weight, more preferably 4 to 19 parts by weight of water, are preferably used.
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Polyurethanes Or Polyureas (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006050793A DE102006050793A1 (de) | 2006-10-27 | 2006-10-27 | Neuartige Hydrogele auf Basis aliphatischer NCO-Prepolymere |
PCT/EP2007/008909 WO2008049527A1 (de) | 2006-10-27 | 2007-10-13 | Neuartige hydrogele auf basis aliphatischer nco-prepolymere |
Publications (1)
Publication Number | Publication Date |
---|---|
EP2086597A1 true EP2086597A1 (de) | 2009-08-12 |
Family
ID=38799639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07818980A Withdrawn EP2086597A1 (de) | 2006-10-27 | 2007-10-13 | Neuartige hydrogele auf basis aliphatischer nco-prepolymere |
Country Status (12)
Country | Link |
---|---|
US (1) | US8133509B2 (ko) |
EP (1) | EP2086597A1 (ko) |
JP (1) | JP2010507693A (ko) |
KR (1) | KR20090082371A (ko) |
CN (1) | CN101528278A (ko) |
AU (1) | AU2007308443A1 (ko) |
BR (1) | BRPI0718020A2 (ko) |
CA (1) | CA2667503A1 (ko) |
DE (1) | DE102006050793A1 (ko) |
MX (1) | MX2009004340A (ko) |
RU (1) | RU2009119723A (ko) |
WO (1) | WO2008049527A1 (ko) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20120098638A (ko) | 2009-10-21 | 2012-09-05 | 바이엘 머티리얼사이언스 아게 | 생분해성 히드로겔 |
KR100970461B1 (ko) * | 2010-02-09 | 2010-07-16 | 엘베스트지에이티 주식회사 | 유무기 하이브리드 방식 코팅제 조성물 및 그 제조방법 |
WO2012107385A1 (de) | 2011-02-09 | 2012-08-16 | Bayer Materialscience Ag | Bioabbaubare prepolymere |
PL3551241T3 (pl) | 2016-12-06 | 2023-06-05 | The Texas A&M University System | Polimery przeciwdrobnoustrojowe z pamięcią kształtu |
DE102016125579A1 (de) * | 2016-12-23 | 2018-06-28 | Paul Hartmann Ag | Wasserhaltige Hydrogelzusammensetzung, umfassend elementare Silberpartikel |
KR102479313B1 (ko) | 2017-10-25 | 2022-12-21 | 다우 글로벌 테크놀로지스 엘엘씨 | 음식 신선도를 보존하기 위한 유연성 포장 물질 |
KR101954346B1 (ko) * | 2017-12-27 | 2019-03-05 | 에스케이씨 주식회사 | 안정성 및 반응성이 개선된 이소시아네이트 조성물, 및 이를 이용한 광학 렌즈 |
DE202018004305U1 (de) | 2018-09-18 | 2018-10-30 | Covestro Deutschland Ag | PUR-Hydrogele und deren Verwendung als Wundauflage |
CN110408189A (zh) * | 2019-07-29 | 2019-11-05 | 东南大学 | 一种提高医用聚氨酯材料血液相容性和抗菌性的方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4118354A (en) * | 1972-11-24 | 1978-10-03 | Dai-Ichi Kogyo Seiyaku Co., Ltd. | Polyurethane hydrogel and method for the production of the same |
DE3402697A1 (de) * | 1984-01-26 | 1985-08-01 | Bayer Ag, 5090 Leverkusen | Verwendung von hydrophilen, hochgefuellten polyurethanmassen zur biologischen abwasserreinigung |
CA1279741C (en) * | 1984-09-28 | 1991-01-29 | Alton J. Gasper | Grouting composition |
US5175229A (en) * | 1986-11-18 | 1992-12-29 | W. R. Grace & Co.-Conn. | Biocompatible polyurea-urethane hydrated polymers |
US5059424A (en) | 1989-11-01 | 1991-10-22 | Ndm Acquisition Corp. | Hydrogel wound dressing product |
US5112618A (en) | 1989-11-01 | 1992-05-12 | Ndm Acquisition Corp. | Hydrogel wound dressing product |
US5037879A (en) * | 1990-04-05 | 1991-08-06 | Minnesota Mining And Manufacturing Company | Polyurethane composition with reduced water to prepolymer mix ratio |
US5115801A (en) | 1990-05-02 | 1992-05-26 | Ndm Acquisition Corp. | Hydrogel burn dressing product |
US5204110A (en) | 1990-05-02 | 1993-04-20 | Ndm Acquisition Corp. | High absorbency hydrogel wound dressing |
US5102938A (en) * | 1990-06-05 | 1992-04-07 | Minnesota Mining And Manufacturing Company | Polyurethane prepolymer composition comprising a water-immiscible solvent |
AU4033893A (en) * | 1992-04-24 | 1993-11-29 | Polymer Technology Group, Inc., The | Copolymers and non-porous, semi-permeable membrane thereof and its use for permeating molecules of predetermined molecular weight range |
MX9705922A (es) * | 1995-02-01 | 1997-10-31 | Schneider Usa Inc | Procedimientos para hidrofilizar polimeros hidrofobos. |
CA2241188C (en) | 1996-10-24 | 2007-07-31 | Yeong Hua Huang | Hydrogel wound dressing and the method of making and using the same |
WO1999013923A2 (en) | 1997-09-18 | 1999-03-25 | Tyco Group S.A.R.L. | Hydrogel wound dressing and the method of making and using the same |
US6861067B2 (en) * | 1998-09-17 | 2005-03-01 | Sherwood Services Ag | Hydrogel wound dressing and the method of making and using the same |
JP4573391B2 (ja) * | 2000-03-17 | 2010-11-04 | 関西ペイント株式会社 | 含水ゲル、その製造法及びその用途 |
US6448364B1 (en) * | 2001-03-16 | 2002-09-10 | Bayer Corporation | IMR having synergistic effect with stabilizing system additives and catalyst package |
KR100350075B1 (ko) * | 2001-03-16 | 2002-08-24 | 김석만 | 미생물 혹은 의약품 담체용 폴리우레탄 수화 겔 비드의제조방법 |
-
2006
- 2006-10-27 DE DE102006050793A patent/DE102006050793A1/de not_active Withdrawn
-
2007
- 2007-10-13 MX MX2009004340A patent/MX2009004340A/es not_active Application Discontinuation
- 2007-10-13 EP EP07818980A patent/EP2086597A1/de not_active Withdrawn
- 2007-10-13 CA CA002667503A patent/CA2667503A1/en not_active Abandoned
- 2007-10-13 WO PCT/EP2007/008909 patent/WO2008049527A1/de active Application Filing
- 2007-10-13 BR BRPI0718020-9A patent/BRPI0718020A2/pt not_active IP Right Cessation
- 2007-10-13 KR KR1020097008432A patent/KR20090082371A/ko not_active Application Discontinuation
- 2007-10-13 RU RU2009119723/04A patent/RU2009119723A/ru not_active Application Discontinuation
- 2007-10-13 AU AU2007308443A patent/AU2007308443A1/en not_active Abandoned
- 2007-10-13 CN CNA2007800401433A patent/CN101528278A/zh active Pending
- 2007-10-13 JP JP2009533695A patent/JP2010507693A/ja not_active Withdrawn
- 2007-10-24 US US11/977,278 patent/US8133509B2/en not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
See references of WO2008049527A1 * |
Also Published As
Publication number | Publication date |
---|---|
MX2009004340A (es) | 2009-05-05 |
BRPI0718020A2 (pt) | 2013-11-12 |
AU2007308443A1 (en) | 2008-05-02 |
CN101528278A (zh) | 2009-09-09 |
CA2667503A1 (en) | 2008-05-02 |
DE102006050793A1 (de) | 2008-04-30 |
US20080102126A1 (en) | 2008-05-01 |
RU2009119723A (ru) | 2010-12-10 |
WO2008049527A1 (de) | 2008-05-02 |
KR20090082371A (ko) | 2009-07-30 |
US8133509B2 (en) | 2012-03-13 |
JP2010507693A (ja) | 2010-03-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20090527 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR |
|
DAX | Request for extension of the european patent (deleted) | ||
17Q | First examination report despatched |
Effective date: 20100308 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Effective date: 20120228 |