EP2035005A4 - Therapie mit zytokinhemmern - Google Patents
Therapie mit zytokinhemmernInfo
- Publication number
- EP2035005A4 EP2035005A4 EP07798190A EP07798190A EP2035005A4 EP 2035005 A4 EP2035005 A4 EP 2035005A4 EP 07798190 A EP07798190 A EP 07798190A EP 07798190 A EP07798190 A EP 07798190A EP 2035005 A4 EP2035005 A4 EP 2035005A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- therapy
- cytokine inhibitors
- cytokine
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81226806P | 2006-06-09 | 2006-06-09 | |
US83307806P | 2006-07-24 | 2006-07-24 | |
US83527006P | 2006-08-03 | 2006-08-03 | |
PCT/US2007/070547 WO2007146712A2 (en) | 2006-06-09 | 2007-06-06 | Therapy using cytokine inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2035005A2 EP2035005A2 (de) | 2009-03-18 |
EP2035005A4 true EP2035005A4 (de) | 2011-07-06 |
Family
ID=38832677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07798190A Withdrawn EP2035005A4 (de) | 2006-06-09 | 2007-06-06 | Therapie mit zytokinhemmern |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP2035005A4 (de) |
AR (1) | AR061273A1 (de) |
AU (1) | AU2007257959A1 (de) |
CA (1) | CA2691214A1 (de) |
CL (1) | CL2007001670A1 (de) |
PE (1) | PE20080935A1 (de) |
TW (1) | TW200814998A (de) |
WO (1) | WO2007146712A2 (de) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
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JP5376956B2 (ja) | 2006-02-10 | 2013-12-25 | スムミト コーポレーション ピーエルシー | デュシェンヌ型筋ジストロフィーの治療 |
US7989459B2 (en) | 2006-02-17 | 2011-08-02 | Pharmacopeia, Llc | Purinones and 1H-imidazopyridinones as PKC-theta inhibitors |
US7915268B2 (en) | 2006-10-04 | 2011-03-29 | Wyeth Llc | 8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression |
US7902187B2 (en) | 2006-10-04 | 2011-03-08 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
TW200831104A (en) | 2006-10-04 | 2008-08-01 | Pharmacopeia Inc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
US7902248B2 (en) | 2006-12-14 | 2011-03-08 | Hoffmann-La Roche Inc. | Oxime glucokinase activators |
JP5453258B2 (ja) * | 2007-07-13 | 2014-03-26 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | カンナビノイド受容体の複素環式モジュレーター |
EP3251694A1 (de) | 2007-08-03 | 2017-12-06 | Summit (Oxford) Limited | Wirkstoffkombinationen zur behandlung der duchenne-muskeldystrophie |
JP5627574B2 (ja) | 2008-06-03 | 2014-11-19 | インターミューン, インコーポレイテッド | 炎症性および線維性疾患を治療するための化合物および方法 |
EP2352730A4 (de) * | 2008-11-07 | 2012-04-25 | Lundbeck & Co As H | Biologisch aktive amide |
BRPI1010024A2 (pt) | 2009-06-05 | 2019-09-24 | Link Medicine Corp | derivados de aminopirrolidinona e uso dos mesmos |
US20110117055A1 (en) * | 2009-11-19 | 2011-05-19 | Macdonald James E | Methods of Treating Hepatitis C Virus with Oxoacetamide Compounds |
ES2548845T3 (es) * | 2009-12-23 | 2015-10-21 | Ratiopharm Gmbh | Forma de dosificación farmacéutica sólida de ticagrelor y ácido acetilsalicílico |
US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
NZ603156A (en) | 2010-03-30 | 2014-10-31 | Verseon Corp | Multisubstituted aromatic compounds as inhibitors of thrombin |
EP3045452A1 (de) | 2010-04-22 | 2016-07-20 | Vertex Pharmaceuticals Inc. | Verfahren zur herstellung von cycloalkylcarboxamid-indol-verbindungen |
AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
EP2560488B1 (de) | 2010-04-23 | 2015-10-28 | Cytokinetics, Inc. | Bestimmte aminopyrimidine und aminotriazine, zusammensetzungen daraus und verfahren zu ihrer verwendung |
AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
US8759380B2 (en) | 2011-04-22 | 2014-06-24 | Cytokinetics, Inc. | Certain heterocycles, compositions thereof, and methods for their use |
SG2014011670A (en) | 2011-10-21 | 2014-10-30 | Abbvie Inc | Combination treatment (eg. with abt-072 or abt -333) of daas for use in treating hcv |
US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
CN103826627B (zh) | 2011-10-21 | 2016-02-24 | 艾伯维公司 | 包含至少两种直接抗病毒剂和利巴韦林的组合物在制备治疗hcv的药物中的用途 |
US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
BR112015022340A2 (pt) | 2013-03-15 | 2017-07-18 | Verseon Corp | método para tratamento ou prevenção de uma doença ou distúrbio relacionado à calicreína em um sujeito, composto, e, composição farmacêutica |
RU2692485C2 (ru) | 2014-04-02 | 2019-06-25 | Интермьюн, Инк. | Противофиброзные пиридиноны |
HUE062736T2 (hu) | 2014-04-15 | 2023-12-28 | Vertex Pharma | Gyógyszerészeti készítmények cisztás fibrózis transzmembrán konduktancia regulátor által mediált betegségek kezelésére |
AU2015317522A1 (en) | 2014-09-17 | 2017-03-23 | Verseon Corporation | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
EP3230279A1 (de) | 2014-12-10 | 2017-10-18 | Massachusetts Institute of Technology | Kondensierte 1,3-azol-derivate zur behandlung von proliferativen erkrankungen |
MX2017011000A (es) | 2015-02-27 | 2017-10-20 | Verseon Corp | Compuestos de pirazol sustituidos como inhibidores de serina proteasa. |
CN107921046B (zh) | 2015-06-12 | 2022-10-14 | 格林威治大学 | 作为干扰素-γ抑制剂的三嗪衍生物 |
US20170107216A1 (en) | 2015-10-19 | 2017-04-20 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
PL3377488T3 (pl) | 2015-11-19 | 2022-12-19 | Incyte Corporation | Związki heterocykliczne jako immunomodulatory |
WO2017102784A1 (en) | 2015-12-15 | 2017-06-22 | Astrazeneca Ab | Isoindole compounds |
ES2844374T3 (es) | 2015-12-22 | 2021-07-22 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
BR112018016133A2 (pt) | 2016-02-16 | 2019-01-02 | Massachusetts Inst Technology | aglutinantes de max como moduladores de myc e usos dos mesmos |
EA201892448A1 (ru) | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения |
TW201808950A (zh) | 2016-05-06 | 2018-03-16 | 英塞特公司 | 作為免疫調節劑之雜環化合物 |
EP3464279B1 (de) | 2016-05-26 | 2021-11-24 | Incyte Corporation | Heterocyclische verbindungen als immunmodulatoren |
CA3023392C (en) * | 2016-06-08 | 2024-02-06 | Support-Venture Gmbh | Combination of ppar agonist and p38 kinase inhibitor for treating cancer |
IL263825B (en) | 2016-06-20 | 2022-08-01 | Incyte Corp | Heterocyclic compounds as immunomodulators |
WO2018013789A1 (en) | 2016-07-14 | 2018-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
MA46045A (fr) | 2016-08-29 | 2021-04-28 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
CR20190301A (es) | 2016-12-20 | 2019-09-04 | Astrazeneca Ab | Compuestos de amino-triazolopiridina y su uso en el tratamiento del cáncer |
EP3558989B1 (de) | 2016-12-22 | 2021-04-14 | Incyte Corporation | Triazolo[1,5-a]pyridin-derivate als immunmodulatoren |
CA3047986A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Benzooxazole derivatives as immunomodulators |
MA47120A (fr) | 2016-12-22 | 2021-04-28 | Incyte Corp | Dérivés pyridine utilisés en tant qu'immunomodulateurs |
PE20200005A1 (es) | 2016-12-22 | 2020-01-06 | Incyte Corp | Derivados de tetrahidro imidazo[4,5-c]piridina como inductores de internalizacion pd-l1 |
US11242327B2 (en) * | 2017-05-15 | 2022-02-08 | Recurium Ip Holdings, Llc | Analgesic compounds |
US11034654B2 (en) | 2017-06-14 | 2021-06-15 | Astrazeneca Ab | 2,3-dihydroisoindole-1-carboxamides useful as ROR-gamma modulators |
CN107474043A (zh) * | 2017-09-13 | 2017-12-15 | 厦门稀土材料研究所 | 烟酸衍生物及其制备方法与用途 |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
WO2019071144A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | USE OF P38 INHIBITORS TO REDUCE DUX4 EXPRESSION |
CN112020500A (zh) | 2017-12-22 | 2020-12-01 | 拉文纳制药公司 | 作为磷脂酰肌醇磷酸激酶抑制剂的氨基吡啶衍生物 |
IL313101A (en) | 2018-03-30 | 2024-07-01 | Incyte Corp | Heterocyclic compounds as immunomodulators |
FI3790877T3 (fi) | 2018-05-11 | 2023-05-09 | Incyte Corp | Tetrahydroimidatso[4,5-c]pyridiinijohdannaisia pd-l1-immunomodulaattoreina |
US20220079911A1 (en) * | 2018-09-13 | 2022-03-17 | Eirion Therapeutics, Inc. | Uses of plasminogen activator inhibitor 1 (pai-1) inhibitors |
EP3886853A4 (de) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Diarylhydantoiverbindungen und verfahren zur verwendung davon |
CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
CN111825605B (zh) * | 2019-04-19 | 2023-03-31 | 中国科学院上海药物研究所 | 芳基酮酰胺类化合物及其制备方法和用途 |
TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
WO2021030162A1 (en) | 2019-08-09 | 2021-02-18 | Incyte Corporation | Salts of a pd-1/pd-l1 inhibitor |
KR20220075382A (ko) | 2019-09-30 | 2022-06-08 | 인사이트 코포레이션 | 면역조절제로서의 피리도[3,2-d]피리미딘 화합물 |
AU2020380395A1 (en) * | 2019-11-05 | 2022-05-26 | Dermira, Inc. | MrgprX2 antagonists for the treatment of inflammatory disorders |
WO2021096849A1 (en) | 2019-11-11 | 2021-05-20 | Incyte Corporation | Salts and crystalline forms of a pd-1/pd-l1 inhibitor |
WO2021113627A1 (en) | 2019-12-06 | 2021-06-10 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofurans as modulators of sodium channels |
TW202233615A (zh) | 2020-11-06 | 2022-09-01 | 美商英塞特公司 | Pd—1/pd—l1抑制劑之結晶形式 |
CR20230230A (es) | 2020-11-06 | 2023-07-27 | Incyte Corp | Proceso para hacer un inhibidor de pd-1/pdl1 y sales y formas cristalinas del mismo |
WO2022099018A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process of preparing a pd-1/pd-l1 inhibitor |
CN113209112B (zh) * | 2021-02-06 | 2021-12-24 | 广州市朝利良生物科技有限公司 | 基于ace2与s蛋白结合靶点的抗新型冠状病毒药物及其应用 |
JP2024522292A (ja) | 2021-06-04 | 2024-06-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | ナトリウムチャネルのモジュレーターとしてのn-(ヒドロキシアルキル(ヘテロ)アリール)テトラヒドロフランカルボキサミド |
WO2024059220A2 (en) * | 2022-09-15 | 2024-03-21 | Vanderbilt University | 6,5 southwestern core compounds as mglu5 negative allosteric modulators and methods of making and using the same |
CN118496159B (zh) * | 2024-07-18 | 2024-09-24 | 广州医科大学附属市八医院 | 一种化合物在制备具有预防和/或治疗肝纤维化作用的药物中的应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030008868A1 (en) * | 2001-05-16 | 2003-01-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as anti-inflammatory agents |
WO2005023761A2 (en) * | 2003-09-11 | 2005-03-17 | Kemia, Inc. | Cytokine inhibitors |
-
2007
- 2007-06-06 WO PCT/US2007/070547 patent/WO2007146712A2/en active Application Filing
- 2007-06-06 CA CA2691214A patent/CA2691214A1/en not_active Abandoned
- 2007-06-06 EP EP07798190A patent/EP2035005A4/de not_active Withdrawn
- 2007-06-06 AU AU2007257959A patent/AU2007257959A1/en not_active Abandoned
- 2007-06-08 PE PE2007000714A patent/PE20080935A1/es not_active Application Discontinuation
- 2007-06-08 TW TW096120764A patent/TW200814998A/zh unknown
- 2007-06-08 AR ARP070102483A patent/AR061273A1/es unknown
- 2007-06-08 CL CL2007001670A patent/CL2007001670A1/es unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030008868A1 (en) * | 2001-05-16 | 2003-01-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as anti-inflammatory agents |
WO2005023761A2 (en) * | 2003-09-11 | 2005-03-17 | Kemia, Inc. | Cytokine inhibitors |
US20100273797A1 (en) * | 2003-09-11 | 2010-10-28 | Itherx Pharmaceuticals, Inc. | Alpha-ketoamides and derivatives thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2007146712A3 (en) | 2008-11-27 |
CL2007001670A1 (es) | 2008-01-18 |
TW200814998A (en) | 2008-04-01 |
CA2691214A1 (en) | 2007-12-21 |
AU2007257959A1 (en) | 2007-12-21 |
WO2007146712A2 (en) | 2007-12-21 |
AR061273A1 (es) | 2008-08-13 |
PE20080935A1 (es) | 2008-08-02 |
EP2035005A2 (de) | 2009-03-18 |
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RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: SHUSTER, LEWIS, J. Inventor name: PRYOR, KENT Inventor name: MILLER, STEPHEN Inventor name: LARSON, CHRISTOPHER, J. Inventor name: KING, BERNARD Inventor name: HEPBURN, BONNIE Inventor name: GROVE, CARRIE, GAIL Inventor name: ERNST, JUSTIN Inventor name: DELAET, NANCY G., J. Inventor name: CROWLEY, CONSTANCE, A. |
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