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Definitions

• the present invention relates to novel thiazolyl-dihydro-quinazolines of the general formula (I)
• radicals A, R 1 , R 2 , R a and R b have the meanings mentioned in the claims and the description, their tautomers, racemates, enantiomers, diastereomers and their mixtures, and optionally their pharmacologically acceptable acid addition salts, solvates and hydrates, and processes for the preparation of these thiazolyl-dihydro-quinazolines and their use as medicaments.
• Phosphatidylinositol 3-kinases are a subfamily of lipid kinases that catalyze the transfer of a phosphate moiety to the 3 'position of the inositol ring of phosphoinositides.
• PI3-kinases can be used in many tumors, such as breast cancer, ovarian or pancreatic carcinoma, tumor types such as colon, breast or lung carcinomas, but especially in autoimmune diseases such as Crohn's disease or rheumatoid arthritis, or in the cardiovascular system such for example, in the development of cardiac hypertrophy (Oudit et al., Circulation, 2003 Oct. 28; 108 (17): 2147-52).
• PI3-kinase modulators may provide a potential for anti-inflammatory therapy with relatively minor side effects (Ward and Finan, Curr Opin Pharmacol., 2003 Aug; 3 (4): 426-34).
• PI3-kinase inhibitors for the treatment of inflammatory diseases are known in the literature.
• WO 03/072557 discloses 5-phenylthiazole derivatives
• WO 04/029055 shows anellated azolpyrimidines
• WO 04/007491 azolidinone-vinyl-linked benzene derivatives.
• the two documents WO 04/052373 and WO 04/056820 disclose benzoxazine and benzoxazin-3-one derivatives.
• the object of the present invention is to provide novel compounds which, owing to their pharmaceutical activity, can be used as a PI3-kinase modulator for therapeutic use in the treatment of inflammatory or allergic diseases.
• inflammatory and allergic respiratory disorders are inflammatory and allergic respiratory disorders, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions, in which autoimmune reactions are involved or called kidney inflammations.
• compounds of the formula (I) act as inhibitors of PI3-kinase, in particular as inhibitors of PI3-kinase gamma.
• the compounds according to the invention can be used, for example, for the treatment of respiratory diseases.
• the present invention therefore relates to compounds of the general formula (I),
• A is N or CH
• R a is hydrogen or an optionally substituted radical selected from
• R b is hydrogen, OH or NH 2 or an optionally substituted radical selected from the group consisting of C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl, C 2 -C 8 -alkenyl, C 2 -C 8 -alkynyl, C 3 -C 8 -
• R 2 is hydrogen or an optionally substituted radical selected from the group consisting of C r C 8 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 8 alkenyl, C 3 -C 8 - cycloalkenyl, C r C 6 - haloalkyl, C 6 -C 4 aryl, C 6 -C 4 -alkyl- aryl-Ci-C 5, C 5 -C 0 - heteroaryl, alkyl C 3 -C 8 cycloalkyl-C 4, C 3 -C 8 cycloalkenyl-C r C 4 alkyl, C 5 -C 0 - heteroaryl-Ci-C ⁇ -alkyl, C 9 -C 3 spiro, C 3 -C 8 -heterocycloalkyl, C 3 - C 8 -
• R 1 and R 2 together form an optionally substituted five-, six- or seven-membered ring consisting of carbon atoms and optionally 1 to 2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen.
• R 1 and R 2 together form an optionally substituted nine- to thirteen-membered spirocyclic ring
• R 2 is a radical selected from the group consisting of the general
• X and Y may be linked to the same or different atoms of G, and X is a bond or an optionally substituted radical selected from the group consisting of -C 7 -alkylene, C 3 -C 7 -alkenylene and C 3 -C 7 alkynylene, or
• X together with R 1 , R 3 or R 4 can form a C 1 -C 7 -alkylene bridge
• Y is a bond or optionally substituted C 1 -C 4 -alkylene
• Q is an optionally substituted radical selected from the group consisting of C 1 -C 7 -alkylene, C 3 -C 7 -alkenylene and C 3 -C 7 -alkynylene, or Q together with R 1 , R 3 or R 4 is a C 1 -C 7 -alkylene Bridge can form;
• R 3 , R 4 , R 5 are identical or different, hydrogen or an optionally substituted
• Radical selected from the group consisting of -C 8 alkyl, C 3 -C 8 - cycloalkyl, C 2 -C 6 -haloalkyl, Ci-C 4 alkyl-C 3 -C 8 -cycloalkyl, C 3 -C 8 cycloalkyl
• R 3 , R 4 , R 5 together form an optionally substituted five-, six- or seven-membered ring consisting of carbon atoms and optionally 1-2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen;
• G is a saturated, partially saturated or unsaturated ring system of 3-10 C atoms, wherein optionally up to 6 C atoms are replaced by heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur;
• R 7, R 8, R 9 are identical or different, represent hydrogen or an optionally substituted radical selected from the group consisting of C- ⁇ -C 8 alkyl, C 3 -C 8 -
• R 7 , R 8 , R 9 together form an optionally substituted five-, six- or seven-membered ring consisting of carbon atoms and optionally 1-2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen;
• X, Y, Q and G may have the meaning given, and
• R a is hydrogen or a radical selected from the group consisting of C- ⁇ -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 8 cycloalkyl, C 3 - C 8 cycloalkenyl, C r C 6 - haloalkyl, C 6 -C 4 -Ar / !, Ce-Cu-aryl-CRCS alkyl, C 5 -C 0 heteroaryl, C 3 -C 8 - cycloalkyl-C r C alkyl 4, C 3 -C 8 cycloalkenyl-C r C 4 alkyl, C 5 -C 0 -heteroaryl-Ci-C 4 - alkyl, spiro, C 3 -C 8 -heterocycloalkyl and C C 3 -C 8 -heterocycloalkyl-C 1 -C 4 -alkyl
• R 13 to R 16 are identical or different, hydrogen or C 1 -C 6 -alkyl, or two of the substituents
• R 13 to R 16 together form an optionally substituted five-, six- or seven-membered ring consisting of carbon atoms and optionally 1-2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen;
• R 10 , R 11 , R 12 are identical or different, hydrogen or a radical selected from the group consisting of C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 - Cycloalkyl and C r C 6
• haloalkyl or in each case two of the radicals R 10 , R 11 , R 12 together form a five-, six- or seven-membered ring consisting of carbon atoms and optionally 1-2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen;
• R b is hydrogen, OH or NH 2, or an optionally substituted radical selected from the group consisting of Ci-C 8 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 8 - cycloalkenyl, C r C 6 haloalkyl, C 6 -C 4 aryl, Ce-Cu-aryl-CRCS alkyl, C 5 -C 0 - heteroaryl, C 3 -C 8 cycloalkyl C r C 4 alkyl, C 3 -C 8 cycloalkenyl alkyl-C r C 4, C 5 -C 0 - heteroaryl-Ci-C4 alkyl-, spiro, C 3 -C 8 heterocycloalkyl, CONH 2 , C 6 -C 4 -aryl-NH-, QrC ⁇ -heterocycloalkyl-NH- and
• Ci-C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, C r C 6 haloalkyl, halogen, OH, OMe, CN, NH 2, NHMe and NMe 2, may be substituted;
• R 1 is hydrogen or a radical selected from the group consisting of C 1 -C 8 -alkyl, C 3 -C 8 -cycloalkyl, C 2 -C 8 -alkenyl, C 2 -C 8 -alkynyl and C 6 -C 4 -aryl-Ci C 5 -alkyl, which may optionally have one or more of the radicals, identical or different, selected from the group consisting of halogen, COOH, NH 2 , OH, CN, C 1 -C 6 -alkyl, OMe, -NH (CO) -alkyl and - (CO) O-alkyl may be substituted,
• R 2 is hydrogen or a radical selected from the group consisting of -C 8 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 8 alkenyl, C 3 -C 8 cycloalkenyl, C r C 6 haloalkyl, C 6 - Ci 4 -aryl,
• Ce-Cu-aryl-CRCS alkyl C 5 -C, C 0 -alkyl heteroaryl C 3 -C 8 cycloalkyl-C 4, C 3 -C 8 - alkyl cycloalkenyl CrC 4, Cs -Cio-heteroaryl-Ci-C ⁇ -alkyl, C 9 -C 3 spiro, C 3 -C 8 - heterocycloalkyl, C 3 -C 8 -heterocycloalkyl-C r C 6 alkyl, and Ce-Cu-aryl C 1 -C 4 -alkyl optionally having one or more of the radicals, identical or different, selected from the group consisting of halogen, NH 2 , OH, CN, C 1 -C 6 -alkyl,
• OMe, -NH (CO) alkyl, 0, COOH and - (CO) O-alkyl may be substituted.
• R 1 and R 2 together form a five-, six- or seven-membered ring consisting of carbon atoms and optionally 1 to 2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen, optionally with one or more of the radicals, the same or different selected from the group consisting of halogen, NH 2, OH, CN, d-Ce-alkyl, OMe, -NH (CO) - C r C 4 alkyl, and - (CO) O-CrC 4 -
• Alkyl may be substituted.
• R 1 and R 2 together form an optionally substituted nine- to thirteen-membered spirocyclic ring
• R 2 is a radical selected from the group consisting of the general
• R 3, R 4, R 5 are identical or different, denote hydrogen or a radical selected from the group consisting of -C 8 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 6 haloalkyl, C 4 alkyl d- -C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkyl-Ci-C 4 alkyl, NR 7 R 8 , NR 7 R 8 -C r C 4 alkyl, C r C 4 alkoxy , Ci-C 4 -alkoxy-C r C 4 alkyl, C 6 -C 4 aryl and C 5 -C 0 -
• Heteroaryl optionally substituted with one or more of the radicals, the same or different, selected from the group consisting of halogen, NH 2, OH, CN, NR 9 R 10, -NH (CO) -C r C 4 alkyl and substituted MeO can be,
• R 3 , R 4 , R 5 together form a five-, six- or seven-membered ring consisting of carbon atoms and optionally 1-2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen; which may optionally be substituted by one or more of the radicals, identically or differently, selected from the group consisting of halogen, NH 2 , OH, CN, NR 9 R 10 , -NH (CO) -dC 4 -alkyl and MeO,
• R 7, R 8, R 9 are identical or different, hydrogen or a radical selected from the group consisting of -C 8 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 6 haloalkyl, d- C4 alkyl -C 3 -C 8 cycloalkyl, C 3 -C 8 -cycloalkyl alkyl-C 3, C 6 -C 4 aryl, Ci-C 4 - alkyl-C 6 -C 4 aryl, C 6 -C 4 aryl-Ci-C 4 alkyl, C 3 -C 8 -heterocycloalkyl, C r C 5 - alkyl-CrC ⁇ -heterocycloalkyl, C 3 -C 8 -heterocycloalkyl-Ci-C 4 alkyl -, C r C 4 -
• Alkyl (CO) - and CrC 4 alkyl-O (CO) - optionally with one or more of the radicals, identical or different, selected from the group consisting of halogen, NH 2 , OH, CN, OMe, NHMe, NMe 2 dC 6 alkyl and (CO) O may be Ci-C 6 alkyl substituted
• R 7 , R 8 , R 9 together form a five, six or seven membered ring consisting of carbon atoms and optionally 1-2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen; optionally with one or more of the radicals, identically or differently, selected from the group consisting of halogen, NH 2 , OH, CN, OMe, NHMe, NMe 2 C r C 6 alkyl and (CO) OC r C 6 alkyl , may be substituted.
• R a and R 1 to R 16 may have the meaning given, and
• R b is hydrogen
• R 1 to R 16 may have the meaning given and R a C 6 -C 4 -aryl or C r C 6 -alkyl wherein R a is optionally substituted by one or more of the radicals, identical or different, selected from the group consisting of d-C ⁇ -alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, C r C 6 haloalkyl, halogen, OH, Ci-C 4 alkoxy, CN, NO 2 , NR 10 R 11 , OR 10 , COR 10 , COOR 10 , CONR 10 R 11 , NR 10 COR 11 , NR 10 (CO) NR 11 R 12 , O (CO) NR 10 R 11 , NR 10 (CO ) OR 11 , SO 2 R 10 , SOR 10 , SO 2 NR 10 R 11 , NR 10 SO 2 NR 11 R 12 and NR 10 SO 2 R 11
• R b is hydrogen
• R 1 is hydrogen, C r C 5 alkyl or C 3 -C 8 cycloalkyl
• R 2 is hydrogen, C r C 5 alkyl or C 3 -C 8 cycloalkyl, phenyl or
• R 1 and R 2 together form an optionally substituted five- or six-membered ring consisting of carbon atoms and optionally 1 to 2 nitrogen atoms, or
• R 1 and R 2 together form an optionally substituted nine- to thirteen-membered spirocyclic ring
• R 1 , R 2 are identical or different, a radical selected from the group consisting of the general formulas formulas (A1) -A (17), where
• X can form a bond or an optionally substituted C 1 -C 3 -alkylene, or X together with R 1 , R 3 or R 4 can form a C 1 -C 7 -alkylene bridge;
• Q is an optionally substituted C 1 -C 3 -alkylene,
• R 3, R 4, R 5 are identical or different, represent hydrogen or an optionally substituted radical selected from the group consisting of -C 4 -alkyl, Ci-C 4 - alkoxy, C 3 -C 6 cycloalkyl, C 3 -C 8 -heterocycloalkyl, -C r C 3 alkyl C 3 -C 6 - cycloalkyl, phenyl and C 5 -C -heteroaryl 0
• R 3 , R 4 , R 5 together form an optionally substituted five- or six-membered ring consisting of carbon atoms and optionally 1-2 heteroatoms selected from the group consisting of oxygen and nitrogen; mean.
• R 2 is hydrogen or a radical of the general formulas (A18), where
• X is a bond or an optionally substituted radical selected from the group consisting of C 1 -C 7 -alkylene, C 3 -C 7 -alkenylene and C 3 -C 7 -alkynylene, or X together with R 1 denotes a C 1 -C 7 -alkylene Bridge can form;
• Y is a bond or methylene, ethylene
• X and Y may be linked to the same or different atoms of G, and G is a saturated, partially saturated or unsaturated ring system of 3-10 C atoms, wherein optionally up to 6 C atoms are replaced by heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur;
• R 7 , R 8 , R 9 are identical or different, hydrogen or an optionally substituted radical selected from the group consisting of C 1 -C 5 -alkyl, C 1 -C 4 -alkyl, C 6 -C 4 -aryl, C 3 -C 6 - Heterocycloalkyl, C 1 -C 5 -alkyl-C 3 -C 8 -heterocycloalkyl- and C 3 -C 6 -cycloalkyl,
• R 7 , R 8 , R 9 together form an optionally substituted five- or six-membered ring consisting of carbon atoms and optionally 1-2 heteroatoms selected from the group consisting of oxygen and nitrogen;
• Another object of the invention are compounds of formula (I) for use as medicaments.
• Another object of the invention is the use of the compounds of formula (I) for the manufacture of a medicament for the treatment of diseases in whose pathology an activity of PI3-kinases is involved, in which therapeutically effective doses of the compounds of formula (I) have a therapeutic benefit can unfold.
• Another object of the invention is the use of the compounds of formula (I), for the manufacture of a medicament for the treatment of inflammatory and allergic diseases of the respiratory tract.
• Another object of the invention is the use of the compounds of formula (I) for the manufacture of a medicament for the treatment of a disease selected from the group consisting of chronic bronchitis, acute bronchitis, bronchitis due to bacterial or viral infection or fungi or helminths, allergic bronchitis, toxic bronchitis, chronic obstructive bronchitis (COPD), asthma (intrinsic or allergic), pediatric asthma, bronchiectasis, allergic alveolitis, allergic or non-allergic rhinitis, chronic sinusitis, cystic fibrosis or cystic fibrosis, alpha-1-antitrypsin Deficiency, cough, pulmonary emphysema, interstitial lung disease, alveolitis, hyperreactive airways, nasal polyps, pulmonary edema, pneumonitis due to differential causes such as radiation-induced or by aspiration or infectious, collagenoses such as lupus erythematosus
• Another object of the invention is the use of the compounds of formula (I), for the manufacture of a medicament for the treatment of inflammatory and allergic diseases of the skin.
• Another object of the invention is the use of the compounds of formula (I) for the manufacture of a medicament for the treatment of a disease selected from the group consisting of psoriasis, contact dermatitis, atopic dermatitis, alopecia areata (circular hair loss), erythema exudative multiforme (Stevens-Johnson syndrome), dermatitis herpetiformis, scleroderma, vitiligo, hives (urticaria), lupus erythematosus, follicular and areal pyoderma, endogenous and exogenous acne, acne rosacea, and other inflammatory and allergic or proliferative skin diseases.
• Another object of the invention is the use of the compounds of formula (I) for the manufacture of a medicament for the treatment of inflammation of the eye.
• Another object of the invention is the use of the compounds of formula (I) for the manufacture of a medicament for the treatment of a disease which is selected from the group consisting of conjunctivitis of various species such as fungal or bacterial infections, allergic conjunctivitis, irritable conjunctivitis, drug-induced conjunctivitis, keratitis and uveitis.
• Another object of the invention is the use of the compounds of formula (I) for the manufacture of a medicament for the treatment of diseases of the nasal mucosa.
• Another object of the invention is the use of the compounds of formula (I) for the manufacture of a medicament for the treatment of a disease selected from the group consisting of allergic rhinitis, allergic sinusitis and nasal polyps.
• Another object of the invention is the use of the compounds of formula (I), for the manufacture of a medicament for the treatment of inflammatory or allergic disease states, in which autoimmune reactions are involved.
• Another object of the invention is the use of the compounds of formula (I) for the manufacture of a medicament for the treatment of a disease selected from the group consisting of Crohn's disease, ulcerative colitis, systemic lupus erythematosus, chronic hepatitis, multiple sclerosis, rheumatoid Arthritis, psoriatic arthritis, osteoarthritis, rheumatoid spondylitis.
• a disease selected from the group consisting of Crohn's disease, ulcerative colitis, systemic lupus erythematosus, chronic hepatitis, multiple sclerosis, rheumatoid Arthritis, psoriatic arthritis, osteoarthritis, rheumatoid spondylitis.
• Another object of the invention is the use of the compounds of formula (I), for the manufacture of a medicament for the treatment of renal inflammation.
• Another object of the invention is the use of the compounds of formula (I) for the manufacture of a medicament for the treatment of a disease selected from the group consisting of glomerulonephritis, interstitial nephritis and idiopathic nephrotic syndrome.
• an orally administrable pharmaceutical formulation comprising a compound of the formula (I).
• Alkyl groups and alkyl groups which are part of other groups are branched and unbranched alkyl groups having 1 to 10 carbon atoms, preferably 1 6, more preferably 1 to 4 carbon atoms, for example methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl and decyl. Unless otherwise stated, of the above designations, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl and decyl include all of the possible isomeric forms.
• propyl includes the two isomeric radicals n-propyl and iso-propyl, the term butyl n-butyl, iso-butyl, sec. Butyl and tert. Butyl, called pentyl, iso-pentyl, neopentyl, etc.
• one or more hydrogen atoms in the abovementioned alkyl groups may optionally be replaced by other radicals.
• these alkyl groups may be substituted by the halogen atoms fluorine, chlorine, bromine or iodine.
• the substituents are preferably fluorine or chlorine.
• all hydrogen atoms of the alkyl group may also be replaced.
• the alkyl bridge used is branched and unbranched 2-membered alkyl groups having 4 to 7 carbon atoms, for example, n-butylene, isobutylene, sec. Butylene and tert-butylene, pentylene, isopentylene, neopentylene, etc Designates bridges. Particularly preferred are n-butylene or n-pentylene bridges. In the abovementioned alkyl bridges, optionally 1 to 2 C atoms may be replaced by one or more heteroatoms selected from the group consisting of oxygen or sulfur.
• C 1-6 -alkylene (including those which are part of other radicals) are to be understood as meaning branched and unbranched alkylene groups having 1 to 6 carbon atoms and branched and unbranched alkylene groups having 1 to 10 by the term “C 1-4 -alkylene” 4 carbon atoms understood.
• alkylene groups having 1 to 4 carbon atoms For example: methylene, ethylene, propylene, 1-methylethylene, butylene, 1-methylpropylene, 1, 1-dimethylethylene, 1, 2-dimethylethylene, pentylene, 1, 1-dimethylpropylene, 2,2, -dimethylpropylene, 1, 2-dimethylpropylene, 1, 3
• propylene, butylene, pentylene and hexylene include all conceivable isomeric forms of the respective radicals of the same carbon number.
• propyl also includes 1-methylethylene and butylene includes 1-methylpropylene, 1, 1-dimethylethylene, 1, 2-dimethylethylene.
• Alkenyl groups are branched and unbranched alkenyl groups having 2 to 10 carbon atoms, preferably 2 to 6 carbon atoms. considered lenstoffatomen, more preferably 2-3 carbon atoms, as far as they have at least one double bond. Examples which may be mentioned are: ethenyl, propenyl, butenyl, pentenyl, etc. Unless stated otherwise, all the possible isomeric forms are included in the abovementioned designations propenyl, butenyl, etc.
• the term butylene includes n-butenyl, 1-methylpropenyl, 2-methylpropenyl, 1,1-dimethylethenyl, 1,2-dimethylethenyl, etc.
• one or more hydrogen atoms in the abovementioned alkenyl groups may optionally be replaced by other radicals.
• these alkenyl groups may be substituted by the halogen atoms fluorine, chlorine, bromine or iodine.
• the substituents are fluorine and chlorine. If appropriate, all hydrogen atoms of the alkenyl group may also be replaced.
• C 2 - 6 alkenylene (including those which are part of other groups) are meant branched and unbranched alkenylene groups with 2 to 6 carbon atoms understood and the term “C 2-4 alkenylene” refers to branched and unbranched alkylene understood len phenomenon having 2 to 4 carbon atoms. Alkenylene groups having 2 to 4 carbon atoms are preferred.
• Examples include: ethenylene, propenylene, 1-methylethenylene, butenylene, 1-methylpropenylene, 1, 1-dimethylethenylene, 1, 2-dimethylethenylene, pentenylene, 1, 1-dimethylpropenylene, 2,2-dimethylpropenylene, 1, 2-dimethylpropenylene, 1, 3-dimethylpropenylene or hexenylene.
• propenylene, butenylene, pentenylene and hexenylene include all conceivable isomeric forms of the respective radicals of equal carbon number.
• propenyl also includes 1-methylethenylene and butenylene includes 1-methylpropenylene, 1, 1-dimethylethenylene, 1, 2-dimethylethenylene.
• Alkynyl groups are branched and unbranched alkynyl groups having 2 to 10 carbon atoms, provided they have at least one triple bond, for example ethynyl, propargyl, butynyl, pentynyl, hexynyl etc., preferably ethynyl or propynyl.
• alkynyl groups having 2 to 4 carbon atoms examples include: ethynyl, propynyl, butynyl, pentynyl, or hexynyl.
• propynyl includes 1-propynyl and 2-propynyl
• butynyl includes 1-, 2- and 3-butynyl, 1-methyl-1-propynyl, 1-methyl-2-propynyl, etc.
• one or more hydrogen atoms in the abovementioned alkynyl groups may optionally be replaced by other radicals.
• these alkyl groups may be substituted by the halogen atoms fluorine, chlorine, bromine or iodine.
• the substituents are fluorine and chlorine.
• all hydrogen atoms of the alkynyl group may also be replaced.
• C 2 - 6 alkynylene (including those which are part of other groups) advertising the branched and unbranched alkynylene groups with 2 to 6 carbon atoms and by the term “C 2-4 alkynylene” are meant branched and unbranched Alkylengrup- understood pen with 2 to 4 carbon atoms. Alkynylene groups having 2 to 4 carbon atoms are preferred.
• Examples include: ethynylene, propynylene, 1-methylethynylene, butynylene, 1-methylpropynylene, 1, 1-dimethylethynylene, 1, 2-dimethylethynylene, pentynylene, 1, 1-dimethylpropynylene, 2,2-dimethylpropynylene, 1, 2 Dimethylpropynylene, 1, 3-dimethylpropynylene or hexynylene.
• the definitions propynylene, butynylene, pentynylene and hexynylene include all conceivable isomeric forms of the respective radicals of the same carbon number.
• propynyl also includes 1-methylethynylene and butynylene includes 1-methylpropynylene, 1, 1-dimethylethynylene, 1, 2-dimethylethynylene.
• Cycloalkyl radicals are saturated cycloalkyl radicals having 3-8 carbon atoms, for example cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl or cyclooctyl, preferably cyclopropyl, cyclopentyl or cyclohexyl, where each the cycloalkyl radicals mentioned above may optionally bear one or more substituents or may be fused to a benzene ring.
• the cycloalkyl radicals can form, in addition to monocyclic, bicyclic, bridged or spirocyclic ring systems.
• Cycloalkenyl are cyclic alkyl groups having 5 to 8, preferably 5 or 6, carbon atoms which contain one or two double bonds.
• the cycloalkenyl radicals can form, in addition to monocyclic radicals, bicyclic, bridged or spirocyclic ring systems.
• cycloalkynyl (including those which are part of other radicals) are meant cyclic alkyl groups having 5 to 8, preferably 5 or 6, carbon atoms which contain one or two triple bonds. Examples include: cyclopentynyl, cyclopentadinyl, cyclohexynyl, cyclohexadinyl, cycloheptinyl, cycloheptadiynyl, cyclooctynyl or cyclooctadinyl.
• the cycloalkynyl radicals can also form bicyclic, bridged or spirocyclic ring systems in addition to monocyclic compounds.
• haloalkyl including those which are part of other radicals
• haloalkyl are branched and unbranched alkyl groups having 1 to 6 carbon atoms, in which one or more hydrogen atoms by a halogen atom selected from the group fluorine, chlorine or bromine, preferably fluorine and chlorine, are exchanged.
• C 1-4 -haloalkyl means correspondingly branched and unbranched alkyl groups having 1 to 4 carbon atoms, in which one or more hydrogen atoms have been exchanged analogously as described above.
• Ci is preferred -4 -haloalkyl. For example: CH 2 F, CHF 2 , CF 3 .
• aryl represents an aromatic ring system having 6 to 14 carbon atoms, preferably 6 or 10 carbon atoms, for example phenyl or naphthyl, preferably phenyl, which, unless otherwise specified, may carry, for example, one or more substituents. Further, any of the above-mentioned aryl systems may be optionally fused to a heterocycloalkyl group or a cycloalkyl group. Examples are: 2,3-dihydro-benzo [1,4] dioxin, benzo [1,3] dioxole, 1,2,3,4-tetrahydro-naphthalene and 3,4-dihydro-1H-quinoline. 2-one.
• heterocycloalkyl radicals are, unless otherwise described in the definitions, 5-, 6- or 7-membered, saturated or unsaturated, mono- or bicyclic heterocycles in which up to four carbon atoms by one or more hetero atoms selected from the group oxygen .
• Nitrogen or sulfur may be substituted, for example tetrahydrofuran, tetrahydrofuranone, ⁇ -butylrolactone, ⁇ -pyran, ⁇ -pyran, dioxolane, tetrahydropyran, dioxane, dihydrothiophene, thiolane, dithiolane, pyrroline, pyrrolidine, pyrazoline, pyrazolidine, Imidazoline, imidazolidine, tetrazole, piperidine, pyridazine, pyrimidine, razin, piperazine, triazine, tetrazine, morpholine, thiomorpholine, diazepane
• a heterocyclic ring may be provided with a keto group. As an example for this are called.
• Examples of 5-10-membered bicyclic heterorings are pyrrolizine, indole, indolizine, isoindole, indazole, purine, quinoline, isoquinoline, benzimidazole, benzofuran, benzopyran, benzothiazole, benzothiazole, benzoisothiazole, pyridopyrimidine, pteridine, pyrimidopyridine,
• heteroaryl 5-10-membered mono- or bicyclic heteroaryl rings in which up to three carbon atoms may be replaced by one or more hetero atoms selected from the group oxygen, nitrogen or sulfur, which contain so many conjugated double bonds, that an aromatic system is formed.
• Each of the above heterocycles may optionally be further fused to a benzene ring.
• fused heteroaryl radicals are: benzimidazole, indole and pyrimidopyrimidine.
• each of the above-mentioned heterocycles may be optionally fused to a heterocycloalkyl group or a cycloalkyl group.
• heteroaryl rings may, for example, carry one or more substituents, preferably halogen or methyl.
• the ring may be linked to the molecule via a carbon atom or, if present, via a nitrogen atom.
• substituents preferably halogen or methyl.
• the ring may be linked to the molecule via a carbon atom or, if present, via a nitrogen atom.
• five- or six-membered heterocyclic aromatic compounds there are mentioned:
• Examples of 5-10 membered bicyclic heteroaryl rings include pyrrolizine, indole, indolizine, isoindole, indazole, purine, quinoline, isoquinoline, benzimidazole, benzofuran, benzopyran, benzothiazole, benzothiazole, benzoisothiazole, pyridopyrimidine, pteridine, pyrimidopyrimidine.
• heterocyclic spiro rings is understood to mean 5-10-membered, spirocyclic rings which may optionally contain one, two or three heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen, in which case the ring can be attached via a carbon atom or if present, be linked to the molecule via a nitrogen atom. Unless otherwise stated, a spirocyclic ring may be provided with a keto group. As examples are mentioned:
• the term "optionally substituted” in the context of the invention means the named group which is optionally substituted by a lower-molecular radical.
• Low-molecular radicals are understood to be chemically meaningful groups consisting of 1-200 atoms. Preferably, such groups have no negative effect on the pharmacological activity of the compounds.
• the groups may include:
• Aromatic or non-aromatic ring systems consisting of carbon atoms and optionally heteroatoms, which in turn may be substituted with functional groups.
• a plurality of aromatic or nonaromatic ring systems consisting of carbon atoms and optionally heteroatoms, which may be linked by one or more carbon chains, optionally interrupted by heteroatoms, optionally substituted by heteroatoms or other common functional groups.
• the halogen is generally fluorine, chlorine, bromine or iodine.
• the compounds according to the invention may be in the form of the individual optical isomers, mixtures of the individual enantiomers, diastereomers or racemates, in the form of tautomers and in the form of the free bases or the corresponding acid addition salts with pharmacologically acceptable acids - for example acid addition salts with hydrohalic acids, for example or hydrobromic acid, or organic acids such as oxalic, fumaric, diglycolic or methanesulfonic acid.
• the substituent R a may be hydrogen or an optionally substituted radical selected from the group consisting of -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 8 - cycloalkyl, C 3 -C C 8 -C 10 -cycloalkenyl, C 1 -C 6 -haloalkyl, C 6 -C 4 -ar / C 1 -C 6 -acyl-C 1 -C 6 -alkyl-, C 5 -C 10 -heteroaryl, C 3 -C 8 -cycloalkyl-C 1 -C 4 - alkyl-, C 3 -C 8 alkyl cycloalkenyl-Ci-C 4, C 5 -C 0 - alkyl- heteroaryl Ci-C 4, spiro, C 3 -C 8 -heterocycloalkyl and C 3 -C 8 Heterocyclo
• R a represents phenyl substituted by one or more of the radicals selected from the group consisting of CF 3 , F, Cl, Br and CONHCH 3 . Also particularly preferably, R a is butyl.
• the substituents R 10 , R 11 , R 12, identical or different, may be hydrogen or a radical selected from the group consisting of the group consisting of C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl , C 3 -C 8 cycloalkyl and C r C 6 haloalkyl; or in each case two of the radicals
• R 10 , R 11 , R 12 together form a five-, six- or seven-membered ring consisting of carbon atoms and optionally 1-2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen.
• the substituent R b may be hydrogen, OH or NH 2, or an optionally substituted radical selected from the group consisting of Ci-C 8 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 8 alkenyl, C 2 -C 8 -alkynyl, C 3 -C 8 cycloalkenyl, C r C 6 - haloalkyl, C 6 -C 4 aryl, C 6 -C 4 aryl-Ci-C 5 alkyl, C 5 -C 0 -heteroaryl, C 3 -C 8 -cycloalkyl-C r C 4 -alkyl-, C 3 -C 8 -cycloalkenyl-C r C 4 -alkyl-, C 5 -C 10 -heteroaryl-C 1 -C 4 -alkyl-, spiro, C 3 -C 8 - Heterocycloalkyl, CONH 2, C
• R b is hydrogen OH or NH 2 or a radical selected from the group consisting of C r C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 8 cycloalkyl, C 6 -C 4 -aryl, haloalkyl, C 5 -C 10 -heteroaryl and C 6 -C 4 -aryl-NH- which is optionally substituted by one or more of the radicals, identical or different, selected from the group consisting of d-ce Alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, C r C 6 haloalkyl, halo, OH, OMe, CN, NH 2 , NHMe, NMe 2 can.
• R b is hydrogen.
• the substituent R 1 may represent hydrogen or an optionally substituted radical selected from the group consisting of -C 8 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 8 alkenyl, C 2 -C 8 - alkynyl, and C ⁇ -C M -Aryl-Ci-Cs-alkyl- mean.
• R 1 is hydrogen, C 1 -C 5 -alkyl or C 3 -C 8 -cycloalkyl.
• the substituent R 1 is hydrogen or a radical selected from the group consisting of methyl, ethyl, propyl, cyclopropyl, cyclobutyl and piperidine, particularly preferably R 1 is hydrogen or methyl.
• the substituent R 1 may preferably be substituted by one or more of the radicals, identically or differently, selected from the group consisting of halogen, COOH, NH 2 , OH, CN, C 1 -C 6 -alkyl, OMe, -NH (CO) alkyl and (CO) OC r C 4 alkyl substituted.
• the substituent R 2 may represent hydrogen or an optionally substituted radical selected from the group consisting of -C 8 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 8 alkenyl, C 3 -C 8 cycloalkenyl, C r C 6 - haloalkyl, C 6 -C 4 aryl, Ce-Cu-aryl-Ci-Cs-alkyl, C 5 -C 0 - alkyl heteroaryl, C 3 -C 8 cycloalkyl-C r C 4, C 3 - C 8 cycloalkenyl-C r C 4 alkyl, C 5 -C 0 - heteroaryl-Ci-C 6 alkyl, C 3 -C 9 spiro, C 3 -C 8 -heterocycloalkyl, C 3 -C 8 -heterocycloalkyl-d- C 6 alkyl and C Ce-M aryl-Ci-C ⁇
• R 2 is hydrogen or a radical selected from the group consisting of C 1 -C 5 -alkyl, C 3 -C 8 -cycloalkyl-C 1 -C 4 -alkyl, C 6 -C 4 -aryl-C 1 -C 5 -alkyl, C 3 -C 8 -heterocycloalkyl-Ci-C 6 alkyl and C 5 -C 0 - heteroaryl-CrC 6 alkyl.
• R 2 is hydrogen or a radical selected from the group consisting of methyl, ethyl, propyl, butyl, pentyl, C 3 -Ce- cycloalkyl and phenyl, particularly preferably hydrogen or methyl.
• the substituent R 2 may preferably be substituted by one or more of the radicals, identical or different, selected from the group consisting of halogen, NH 2 , OH, CN, C 1 -C 6 -alkyl, OMe, -NH (CO) alkyl and (CO) OC r C 4 alkyl substituted.
• the substituents R 1 and R 2 may together form an optionally substituted, five-, six- or seven-membered ring consisting of carbon atoms and optionally 1 to 2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen, preferably nitrogen.
• the group NR 1 R 2 particularly preferably represents an optionally substituted pyrrolidinyl or morpholine radical.
• the ring formed from the substituents R 1 and R 2 may preferably with one or more of the radicals, the same or different, selected from the group consisting of heterocycloalkyl, halogen, NH 2, OH, CN, C r C 6 alkyl, OMe, -NH (CO) alkyl and - (CO) O-C 1 -C 4 -alkyl.
• the substituents R 1 and R 2 may together form an optionally substituted nine- to thirteen-membered spirocyclic ring, preferably
• the substituent R may further be a group selected from the group consisting of the general formulas (A1) to (A18)
• X and Y may be linked to the same or different G atoms.
• X can be a bond or an optionally substituted radical selected from the group consisting of -C 7 -alkylene, C 3 -C 7 -alkenylene and C 3 -C 7 -alkynylene, preferably a bond, methylene and ethylene radical.
• X may together with R 1 , R 3 or R 4 form a C 1 -C 7 -alkylene bridge, preferably a 5- or ⁇ -membered heterocycle with R 1 , R 3 or R 4 , more preferably a piperidinone or pyrrolidines - Ring with R 3 or R 4 may optionally be substituted.
• the substituent R1 and X together preferably form a pyrrolidine or piperidine radical.
• Y may be a bond or optionally substituted C 1 -C 4 -alkylene, preferably a bond, methylene or ethylene.
• Q is an optionally substituted radical selected from the group consisting of -C 7 -alkylene, C 3 -C 7 -alkenylene and C 3 -C 7 alkynylene; preferably optionally substituted CrC 3 alkylene, particularly preferably ethyl and propyl mean.
• Q may together with R 1 , R 3 or R 4 form a C 1 -C 7 -alkylene bridge.
• R1 and Q preferably form a pyrrolidine or piperidine radical.
• the substituents R 3 , R 4 , R 5 may be identical or different, hydrogen or an optionally substituted radical selected from the group consisting of Ci-C ⁇ -alkyl, C 3 - Cs-cycloalkyl, C 2 -C 6 haloalkyl, Ci C 4 alkyl C 3 C 8 cycloalkyl, C 3 C 8 cycloalkyl C r C 4 alkyl, NR 7 R 8 , NR 7 R 8 C r C 4 alkyl, C r C 4 alkoxy, Ci-C 4 -alkoxy-C r C 4 alkyl, C 6 -C 4 aryl and C 5 -Cio-heteroaryl; preferably hydrogen or an optionally substituted radical selected from the group consisting of dC 4 alkyl, dC 4 alkoxy and C 3 -C 6 - cycloalkyl, more preferably hydrogen, methyl, methoxy, ethoxy, propyloxy, butylene l
• substituents R 3 , R 4 , R 5 may together form an optionally substituted five-, six- or seven-membered ring, preferably 5- or 6-membered ring, consisting of carbon atoms and optionally 1-2 heteroatoms, selected from the group consisting of oxygen, sulfur and nitrogen; preferably from oxygen or nitrogen.
• the radical NR 3 R 4 preferably denotes pyrrolidine, piperidine or morpholine.
• the substituents R 3 , R 4 , R 5 or the ring formed therefrom can preferably be reacted with one or more of the radicals, identical or different, selected from the group be standing of halogen, NH 2, OH, CN, NR 9 R 10, -NH (CO) -C r C 4 alkyl and MeO.
• A may be N or CH, preferably N.
• G may be a saturated, partially saturated or unsaturated ring system of 3-10 C atoms, wherein optionally up to 4 C atoms are replaced by heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur; mean.
• G may preferably be a saturated, partially saturated or unsaturated ring system of 3-8 C atoms, more preferably of 5-6 C atoms, wherein optionally up to 6 C atoms, more preferably up to 4 C atoms are selected by heteroatoms from the group consisting of nitrogen, oxygen and sulfur, mean.
• G is preferably a ring system consisting of one or two 5-6 membered rings, more preferably selected from the group consisting of furan, cyclohexyl, cyclopropyl, phenyl, pyrrolidine, piperidine, tetrahydroquinoline, tetrahydroisoquinoline, indole, dihydroisoindole, piperazine, pyrrole , Pyrazole, pyridine, imidazolidine, imidazole, thiophene, thiazole, triazole, oxazole, oxadiazole, tetrazole, morpholine, benzimidazole, benzopyrrole, benzodioxole, and dihydrobenzo [1, 4] dioxines, particularly preferably furan, cyclohexyl, Cyclopropyl, phenyl, pyrrolidine, piperidine, tetrahydroquinoline, tetrahydro
• the substituent R 6 may be the same or different, is hydrogen or an optionally substituted radical selected from the group consisting of, -C 8 alkyl, C 2 -C 6 - alkenyl, C 3 -C 8 cycloalkyl, C 2 -C 6 haloalkyl, C 6 -C 4 aryl, C 5 -C 0 heteroaryl, C 3 -C 8 -
• Heterocycloalkyl preferably hydrogen or an optionally substituted radical selected from the group consisting of dC 4 alkyl, C 3 -C 6 cycloalkyl, C 6 -C 4 aryl, C 5 - C 6 heterocycloalkyl, and C 5 -C 6 heteroaryl, more preferably hydrogen or an optionally substituted radical selected from the group consisting of CrC 4 alkyl, C 3 -C 6 cycloalkyl, C 5 -C 6 heterocycloalkyl, C 5 -C 6 heteroaryl and phenyl.
• the substituent R 6 can preferably have one or more of the radicals, identical or different, selected from the group consisting of 0O, NH 2 , NHMe, NMe 2 OH, OMe, CN, -Ci-C 3 -alkyl-C 6 -C 4 -aryl, -NH-CO-N HC r C 3 alkyl and - (CO) OC r C 4 alkyl substituted.
• n is 1, 2 or 3, preferably 1 or 2, more preferably 1.
• the substituents R 7 , R 8 , R 9 may be identical or different, hydrogen or an optionally substituted radical selected from the group consisting of C 1 -C 8 -alkyl, C 3 -C 6 -cycloalkyl, C r C 6 haloalkyl, Ci-C 4 alkyl-C 3 -C 8 -cycloalkyl, C 3 -C 8 cycloalkyl-C r C 3 - alkyl, C 6 -C 4 aryl, Ci-C 4 alkyl C 6 -C 4 -aryl, C 6 -C 4 -aryl-C 1 -C 4 -alkyl, C 3 -C 8 -heterocycloalkyl, C 1 -C 5 -alkyl-C 3 -C 8 -heterocycloalkyl, C 3 - C 8 heterocycloalkyl-CrC 4 alkyl, C r C 4 alkyl (CO) - and C r
• the compounds of the general formula (I) can be prepared by the following synthesis schemes (Schemes 1-5), where the substituents of the general formula (I) have the abovementioned meanings. These methods are to be understood as an explanation of the invention without limiting the same to their subject matter.
• Rz is a suitable leaving group selected, for example, but not limited to the group halogen, S-alkyl, S-aryl, O-alkylsulfonyl, O-arylsulfonyl, O-alkyl, imizazole, O-hetaryl, O-acyl, O-aryl where O-aryl may optionally be substituted by suitable electron-withdrawing groups (eg nitro).
• a suitable amidine (VII) or one of its salts the intermediate (VIII) is obtained.
• Ra has the meanings given above.
• the compound thus obtained is then removed by cleavage of the acetyl group (eg by acidic or basic Saponification or reaction with hydrazine hydrate) into the free aminothiazole (IX).
• the conversion to the ureas of the general formula (I) or (Ia) is then carried out using one of the following methods: Direct reaction with a suitable isocyanate (XIII) leads directly to compounds of the formula (Ia).
• Reaction with a suitable reagent (XIV) leads to compounds of the formula (I) where Rx is a suitable leaving group selected, for example, but not limited to the group halogen, S-alkyl, S-aryl, O-alkylsulfonyl, O-arylsulfonyl, O-alkyl, imizazole, O-hetaryl, O-acyl, O-aryl, where O-aryl may optionally be substituted by suitable electron-withdrawing groups (eg nitro).
• Rx is a suitable leaving group selected, for example, but not limited to the group halogen, S-alkyl, S-aryl, O-alkylsulfonyl, O-arylsulfonyl, O-alkyl, imizazole, O-hetaryl, O-acyl, O-aryl, where O-aryl may optionally be substituted by suitable electron-withdrawing groups (eg nitro).
• Another possibility is the reaction of the
• Rx and Ry are the same or suitable leaving groups selected, for example, but not limited to the group halogen, S-alkyl, S-aryl, O-alkylsulfonyl, O-arylsulfonyl, O-alkyl, imizazole, O-hetaryl, O-acyl , O-aryl, where O-aryl may optionally be substituted by suitable electron-withdrawing groups (eg nitro).
• the intermediate (XI) may be in equilibrium with the isocyanate (XII) which may be formed by elimination of the leaving group Ry (XI).
• the further reaction of the intermediate compound (XI), (XII) or a mixture of both with suitable amines of the general formula (XV) leads to the desired compounds of the general formula (I).
• R 1 and R 2 have the meanings given above.
• the intermediate compound (XVII) is obtained.
• PG1 is a suitable nitrogen protecting group selected, for example, but not limited to the group alkyl carbonyl (carbamates), phthalic acid, benzyl (optionally substituted, for example, p-methoxybenzyl).
• the reagent (XVI) can be used as one of the two possible enantiomers or as a racemate. After cleavage of the protective group PG1, the intermediate compound (XVIII) can be obtained.
• Rx and Rv are suitable leaving groups selected, for example, but not limited to the group halogen, S-alkyl, S-aryl, O-alkylsulfonyl, O-arylsulfonyl, O-alkyl, imizazole, O-hetaryl, O-acyl, O- Aryl, where O-aryl may optionally be substituted by suitable electron-withdrawing groups (eg nitro).
• the compounds of general formula (Ig) can be prepared analogously to the procedure described in Scheme 1 by reacting intermediate compound (XVIII) with the previously described, reagent of formula (X) and subsequent reaction of the resulting intermediate (XXV) with suitable amines of the formula (XXV).
• R 3 and R 4 also have the meanings described above.
• PG1 is a suitable nitrogen protecting group selected, for example, but not limited to the group alkylcarbonyl (carbamates), phthalic acid, benzyl (optionally substituted eg p-). Methoxybenzyl).
• the intermediate compound (XXX) can be obtained.
• Compounds of the general formula (Ii) and (Ij) can be obtained by reacting the intermediate compound (XXX) with the previously described reagents of the formula (XXIII) or (XXIV).
• the compounds of the general formula (Ij) can also be reacted analogously to the procedure described in Scheme 1 by reacting the intermediate compound (XXX) with the previously described reagent of the formula (X) and then reacting the resulting intermediate compound (XXXI) suitable amines of the formula (XXV).
• R 3 and R 4 also have the meanings described above.
• R 5 and R 6 have the meanings described above.
• reaction mixture is stirred for 1, 5 hours at -70 ° C, then allowed to come slowly to room temperature. It is diluted with dichloromethane and washed with 1 molar hydrochloric acid, sat. Sodium carbonate solution, water and sat. Washed sodium chloride solution. The organic phase is dried and evaporated to dryness. Yield: 30.80 g (96% of theory)
• Butoxycarbonylamino-propionic acid methyl ester added in 20 ml of dimethylformamide.
• reaction mixture is stirred for 3 hours at 50.degree. After cooling, 15 ml
• the intermediates (VIII.2) to (VIII.6) can be obtained by reacting the intermediate (VI.1) with the appropriate amidines (VII.2 - VII.6).
• the intermediates (IX.2) to (IX.6) can be obtained by saponification of the intermediates (VIII.2) to (VIII.6).
• Method A XTerra® column, MS Ci 8 2.5 ⁇ m, 4.6 mm x 30 mm.
• Method B Merck Chromolith TM SpeedROD RP-18e column, 4.6 mm x 50 mm.
• Example 17 70 mg (0.156 mmol of the intermediate compound (XI.1), 40.82 mg (0.172 mmol) of 2- (4-ethylthiazol-2-yl) -ethylamine hydrobromide and 0.10 ml (0.721 mmol) of triethylamine are dissolved in 1 ml of ethanol was stirred for 16 hours at 80 ° C. The reaction mixture was concentrated by evaporation, the residue was purified by chromatography and corresponding fractions were lyophilised. Yield: 73.7 mg (87% of theory)
• Examples 1, 6-16, 18-153 and 264 can also be obtained by reacting the appropriate intermediates (XM) - (XI-6) with the appropriate amines (either known from the literature or described under "Synthesis of the Reagents") ,
• Examples 155-223 can also be obtained by reacting the appropriate intermediates (XM) - (Xl.6) with the appropriate amines (either known from the literature or described under "Synthesis of the Reagents").
• Examples 224, and 226-237 can also be obtained by reacting the intermediate (XVIII.1) with the respectively suitable carboxylic acid chlorides, sulfonyl chlorides, carbamoyl chlorides, sulfamoyl chlorides or chloroformates. Furthermore, analogously to Examples 279 and 280, starting from intermediate compound (XXX.1).
• Example 239 can be obtained by reacting the intermediate (XVIII.1) with the appropriate carboxylic acid.
• Examples 240 and 242-249 can likewise be obtained by reacting the intermediate compound (XVIII.2) with the respectively suitable carboxylic acid chlorides, sulfonyl chlorides, carbamoyl chlorides, sulfamoyl chlorides or chloroformates. Synthesis of Example 250:
• Example 251 can be obtained by reacting the intermediate compound (XVIII.2) with the appropriate carboxylic acid.
• Examples 253-259 can be obtained by reacting the intermediate compound (XXVII.1) with the appropriate amines.
• Examples 261-263 and 265 can also be obtained by reacting the intermediate compound (XXV.1) with the appropriate amines.
• the examples 267-273 can be obtained by reacting the intermediate of the intermediate (XVIII.1) with the respectively suitable carboxylic acids.
• the examples 275-278 can be obtained by reacting the intermediate compound (XXX.1) with the respectively suitable carboxylic acids.
• the examples 282-293 can also be obtained by reacting the intermediate compound (XXXIII.1) with the appropriate amines.
• Examples 295-299 can also be obtained by reacting the intermediate compound (XXXI.1) with the appropriate amines. Synthesis of Example 3
• example compound 133 20 mg (0.032 mmol) of example compound 133 are stirred for 16 hours at room temperature in 20 ml of ethereal hydrochloric acid. The precipitate is then filtered off with suction and dried.
• examples 2 and 4 can be obtained from example compounds 132 and 135, respectively.
• the exemplified compounds of formula (I) are characterized by an affinity for PI3 kinase, ie in the test by an IC 50 value of less than 800 nmol / liter.
• lipid vesicles PIP 2 (0.7 ⁇ g / well), phosphatidylethanolamine (7.5 ⁇ g / well), phosphatidylserine (7.5 ⁇ g / well ), Sphingomyelin (0.7 ⁇ g / well) and phosphatidylcholine (3.2 ⁇ g / well)
• PIP 2 lipid vesicles
• phosphatidylethanolamine 7.5 ⁇ g / well
• phosphatidylserine 7.5 ⁇ g / well
• Sphingomyelin 0.7 ⁇ g / well
• phosphatidylcholine 3.2 ⁇ g / well
• reaction buffer 40 mM Hepes, pH 7.5, 100 mM NaCl, 1 mM EGTA, 1 mM ⁇ -glycerophosphate, 1 mM DTT, 7 mM MgCl 2 and 0.1% BSA, 1 ⁇ M ATP and 0.2 ⁇ Ci [ ⁇ - 33 P] -ATP
• reaction buffer 40 mM Hepes, pH 7.5, 100 mM NaCl, 1 mM EGTA, 1 mM ⁇ -glycerophosphate, 1 mM DTT, 7 mM MgCl 2 and 0.1% BSA, 1 ⁇ M ATP and 0.2 ⁇ Ci [ ⁇ - 33 P] -ATP
• the compounds of formula (I) are characterized by a variety of therapeutic applications. Particularly noteworthy are those applications for which the compounds of the formula (I) according to the invention can preferably be used as PI3-kinase modulator due to their pharmaceutical activity.
• inflammatory and allergic respiratory diseases inflammatory diseases of the gastrointestinal tract, inflammatory diseases of the musculoskeletal system, inflammatory and allergic skin diseases, inflammatory ocular diseases, diseases of the nasal mucosa, inflammatory or allergic disease states in which autoimmune reactions are involved or called kidney inflammations.
• the treatment can be symptomatic, adaptive, curative or preventive.
• Preferred respiratory diseases mentioned here would be chronic and / or obstructive respiratory diseases.
• the compounds of the formula (I) according to the invention can, on the basis of their pharmacological properties, a reduction in the
• the compounds according to the invention are particularly preferred for the preparation of a medicament for the treatment of chronic bronchitis, acute bronchitis, Bronchitis due to bacterial or viral infection or fungi or helminths, allergic bronchitis, toxic bronchitis, chronic obstructive pulmonary disease (COPD), asthma (intrinsic or allergic), pediatric asthma, bronchiectasis, allergic alveolitis, allergic or non-allergic rhinitis, chronic sinusitis, cystic Fibrosis or cystic fibrosis, alpha-1-antitrypsin deficiency, cough, pulmonary emphysema, interstitial lung diseases such as pulmonary fibrosis, asbestosis and silicosis and alveolitis; hyperreactive airways, nasal polyps, pulmonary edema such as toxic pulmonary edema and ARDS / IRDS, pneumonitis due to different causes such as
• skin diseases e.g. Psoriasis, contact dermatitis, atopic dermatitis, alopecia areaa (circular hair loss), erythema multiforme (Stevens-Johnson syndrome), dermatitis herpetiformis, scleroderma, vitiligo, hives (urticaria), lupus erythemat
• the compounds of formula (I) are useful for therapeutic use in inflammatory or allergic conditions involving autoimmune reactions, e.g. inflammatory bowel disease, e.g. Crohn's disease or ulcerative colitis; Diseases of the arthritis type, such as rheumatoid or psoriatic arthritis, osteoarthritis, rheumatoid spondylitis and other arthritic conditions or multiple sclerosis.
• autoimmune reactions e.g. inflammatory bowel disease, e.g. Crohn's disease or ulcerative colitis
• Diseases of the arthritis type such as rheumatoid or psoriatic arthritis, osteoarthritis, rheumatoid spondylitis and other arthritic conditions or multiple sclerosis.
• Conjunctivitis conjunctivitis of various types, e.g. due to infections with fungi or bacteria, allergic conjunctivitis,
• diseases of the nasal mucosa such as allergic rhinitis / sinusitis or nasal polyps • Inflammatory or allergic conditions, such as systemic lupus erythematosus, chronic hepatitis, nephritis, such as glomerulonephritis, interstitial nephritis or idiopathic nephrotic syndrome.
• the compounds of the formula (I) can be used alone or in combination with other active compounds of the formula (I).
• the compounds of formula (I) may also be used in combination with W, wherein W represents a pharmacologically active agent and is, for example, selected from the group consisting of betamimetics, anticholinergics, corticosteroids, PDE4 inhibitors, LTD4 antagonists, EGFR Inhibitors, dopamine agonists, H1 antihistamines, PAF
• Antagonists and PI3 kinase inhibitors preferably PI3- ⁇ kinase inhibitors.
• two- or three-fold combinations of W with the compounds of formula (I) can be combined. Exemplary combinations of W would be:
• W represents a betamimetic, combined with an active ingredient selected from the group consisting of anticholinergics, corticosteroids, PDE4 inhibitors, EGFR
• W represents an anticholinergic agent combined with an active ingredient selected from the group consisting of betamimetics, corticosteroids, PDE4 inhibitors, EGFR inhibitors and LTD4 antagonists
• -W represents a corticosteroid combined with an active agent selected from the group consisting of a PDE4 inhibitor, EGFR inhibitors and LTD4 antagonists
• W represents a PDE4 inhibitor combined with an active agent selected from the group consisting of an EGFR inhibitor and LTD4 antagonist W represents an EGFR inhibitor combined with a LTD4 antagonist.
• Preferred betamimetics for this purpose are compounds selected from the group consisting of albuterol, arformoterol, bambuterol, bitolertrol, broxaterol, carbuterol, clenbuterol, fenoterol, formoterol, hexoprenaline, ibuterol, isoetharines, isoprenaline, levosalbutamol, mabuterol, meluadrine , Metaproterenol, orciprenaline, pirbuterol, procaterol, reproterol, rimiterol, ritodrine, salmefamol, salmetrol, soterenol, sulphonterol, terbutaline, tiaramide, toluubuterol, zinterol, CHF-1035, HOKU-81, KUL-1248 and (4- ⁇ 6- [2-Hydroxy-2- (4-hydroxy-3-hydroxymethyl-phenyl) -eth
• the acid addition salts of the betamimetics are selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate ,
• Preferred anticholinergic compounds are compounds which are selected from the group consisting of tiotropium salts, preferably the bromide salt, oxitropium salts, preferably the bromide salt, flutropium salts, preferably the bromide salt, ipratropium salts, preferably the bromide salt, glycopyrronium salts, preferably the bromide salt Trospium salts, preferably the chloride salt, tolterodine.
• the cations are the pharmacologically active ingredients.
• the aforementioned salts may preferably contain chloride, bromide, iodide, sulfate, phosphate, methanesulfonate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalate, succinate , Benzoate or p-toluenesulfonate, with chloride, bromide, iodide, sulfate, methanesulfonate or p-toluenesulfonate being preferred as counterions.
• the chlorides, bromides, iodide and methanesulfonate are particularly preferred. Further named compounds are:
• corticosteroids are compounds which are selected from the group consisting of prednisolone, prednisone, butixocortepionate, flunisolide, beclomethasone, triamcinolone, budesonide, fluticasone, mometasone, cronoside, rofleponide, dexamethasone, betamethasone, deflazacort, RPR -106541, NS-126, ST-26 and
• Examples of possible salts and derivatives of the steroids may be: alkali metal salts, such as, for example, sodium or potassium salts, suberobenzoates, phosphates, isonicotinates, acetates, propionates, dihydrogen phosphates, palmates, pivalates or even furoates.
• alkali metal salts such as, for example, sodium or potassium salts, suberobenzoates, phosphates, isonicotinates, acetates, propionates, dihydrogen phosphates, palmates, pivalates or even furoates.
• Preferred PDE4 inhibitors here are compounds selected from the group consisting of enprofylline, theophylline, roflumilast, A-riflo (cilomilast), tofimilast, pumafentrin, lirimilast, arofylline, atizoram, D-4418, bay 198004, BY343, CP-325,366, D-4396 (Sch-351591), AWD-12-281 (GW-842470), NCS-613, CDP-840, D-4418, PD-168787, T-440, T-2585, V-1 1294A, CI-1018, CDC-801, CDC-3052, D-22888, YM-58997, Z-15370, and - N- (3,5-dichloro-1-oxopyridine) -yl-difluoromethoxy -S-cyclopropylmethoxybenzamide - (-) p - [(4aR * , 10bS
• the acid addition salts of the betamimetics are selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate ,
• Preferred LTD4 antagonists here are compounds selected from the group consisting of montelukast, pranlukast, zafirlukast, MCC-847 (ZD-3523), MN-001, MEN-91507 (LM-1507), VUF-5078 , VUF-K-8707, L-733321 and
• the acid addition salts of the betamimetics are selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate ,
• Examples of salts or derivatives which the LTD4-antagonists are capable of forming include: alkali metal salts, such as, for example, sodium or potassium salts, alkaline earth salts, sulfobenzoates, phosphates, isocyanate, acetates, propionates, dihydrogen phosphates, palmitates, pivalates or also FUROATE.
• the EGFR inhibitors used are preferably compounds selected from the group consisting of cetuximab, trastuzumab, ABX-EGF, Mab ICR-62 and - 4 - [(3-chloro-4-fluorophenyl) amino] -6- ⁇ [4- (morpholin-4-yl) -1-oxo-2-buten-1-yl] amino] -7-cyclopropylmethoxy-quinazoline
• the acid addition salts of the betamimetics are selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate ,
• Preferred dopamine agonists are compounds selected from the group consisting of bromocriptine, cabergoline, alpha-dihydroergocryptine, lisuride, pergolide, pramipexole, roxindole, ropinirole, talipexole, terguride and viozane, optionally in the form of their racemates, enantiomers , Diastereomers and optionally in the form of their pharmacologically acceptable acid addition salts, solvates or hydrates.
• the acid addition salts of the betamimetics are selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate.
• H1 -Antihistaminika here are preferably compounds used, which are selected from the group consisting of epinastine, cetirizine, azelastine, fexofenadine, levocabastine, loratadine, mizolastine, ketotifen, emedastine, dimetindene, clemastine, bamipine, Cexchlorpheniramin, pheniramine, doxylamine , Chlorphenoxamine, dimenhydrinate, diphenhydramine, promethazine, ebastine, desloratidine and meclocine, optionally in the form of their racemates, enantiomers, diastereomers and optionally in the form of their pharmacologically acceptable acid addition salts, solvates or hydrates.
• the acid addition salts of the betamimetics are selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofluorate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p - Toluenesulfonate.
• PAF antagonists are compounds which are selected from the group consisting of: 4- (2-chlorophenyl) -9-methyl-2- [3 (4-morpholinyl) -3-propanone-1-yl] -6H-thieno [3,2-f] -
• the acid addition salts of the betamimetics are selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate ,
• PI3-kinase- ⁇ -inhibitors preferably compounds are used, which are selected from the group consisting of:
• the compounds according to the invention can be administered orally, transdermally, by inhalation, parenterally or sublingually.
• the compounds of the invention are present as active ingredients in conventional dosage forms, for example in compositions consisting essentially of an inert pharmaceutical carrier and an effective dose of the active ingredient, such as tablets, dragees, capsules, wafers, powders, solutions, suspensions , Emulsions, syrups, suppositories, transdermal systems etc.
• An effective dose of the compounds of the invention is from 0.1 to 5000, preferably from 1 to 500, more preferably from 5 to 300 mg / dose when administered orally, intravenously, subcutaneously or intramuscularly Application between 0.001 and 50, preferably between 0.1 and 10 mg / dose.
• Suitable inhalable dosage forms are inhalable powders, propellant-containing metered dose inhalers or propellant-free inhalable solutions.
• propellant-free inhalable solutions also includes concentrates or sterile, ready-to-use inhalable solutions.
• suitable solutions for inhalation are those which contain from 0.01 to 1.0, preferably from 0.1 to 0.5% of active ingredient. It is likewise possible to use the compounds according to the invention as infusion solution, preferably in a physiological saline solution or nutrient salt solution.
• the compounds according to the invention can be used alone or in combination with other active compounds according to the invention, if appropriate also in combination with other pharmacologically active substances.
• Suitable application forms are, for example, tablets, capsules, suppositories, solutions, juices, emulsions or dispersible powders.
• Corresponding tablets may, for example, be prepared by mixing the active substance (s) with known excipients, for example inert diluents such as calcium carbonate, calcium phosphate or lactose, disintegrants such as corn starch or alginic acid, binders such as starch or gelatin, lubricants such as magnesium stearate or talc, and / or agents for obtaining the depot effect, such as carboxymethyl cellulose, cellulose acetate phthalate, or polyvinyl acetate.
• excipients for example inert diluents such as calcium carbonate, calcium phosphate or lactose, disintegrants such as corn starch or alginic acid, binders such as starch or gelatin, lubricants such as magnesium stearate or talc, and / or agents for obtaining the depot effect, such as carboxymethyl cellulose, cellulose acetate phthalate, or polyvinyl acetate.
• the tablets can also consist of
• Coated tablets can accordingly be prepared by coating cores produced analogously to the tablets with agents customarily used in tablet coatings, for example, koillite or shellac, gum arabic, talc, titanium dioxide or sugar.
• the core can also consist of several layers.
• the dragee sheath to achieve a depot effect of several layers may consist of the above mentioned in the tablets excipients can be used.
• Juices of the active compounds or active compound combinations according to the invention may additionally contain a sweetener, such as saccharin, cyclamate, glycerol or sugar, as well as a taste-improving agent, e.g. Flavorings such as vanillin or orange extract. They may also contain suspending aids or thickening agents, such as sodium carboxymethylcellulose, wetting agents, for example condensation products of fatty alcohols with ethylene oxide, or protective agents, such as p-hydroxybenzoates.
• a sweetener such as saccharin, cyclamate, glycerol or sugar
• a taste-improving agent e.g. Flavorings such as vanillin or orange extract.
• suspending aids or thickening agents such as sodium carboxymethylcellulose, wetting agents, for example condensation products of fatty alcohols with ethylene oxide, or protective agents, such as p-hydroxybenzoates.
• Injection solutions are prepared in the usual manner, e.g. with the addition of preservatives, such as p-hydroxybenzoates, or stabilizers, such as alkali metal salts of ethylenediaminetetraacetic acid prepared and filled into injection bottles or ampoules.
• preservatives such as p-hydroxybenzoates, or stabilizers, such as alkali metal salts of ethylenediaminetetraacetic acid prepared and filled into injection bottles or ampoules.
• the capsules containing one or more active ingredients or combinations of active substances can be prepared, for example, by mixing the active ingredients with inert carriers, such as lactose or sorbitol, and encapsulating them in gelatine capsules.
• suitable suppositories can be prepared, for example, by mixing with suitable carriers, such as neutral fats or polyethylene glycol or its derivatives.
• Inhalable powders which can be used according to the invention may contain the active substance according to the invention either alone or in admixture with suitable physiologically acceptable excipients. If the active compounds according to the invention are mixed with physiologically acceptable excipients, the following physiologically acceptable excipients can be used to prepare these inhalable powders according to the invention: monosaccharides (eg glucose or arabinose), disaccharides (eg lactose, sucrose, maltose), oligosaccharides and polysaccharides ( eg dextranes), polyalcohols (eg sorbitol, mannitol, xylitol), salts (eg sodium chloride, calcium carbonate) or mixtures of these auxiliaries with one another.
• monosaccharides eg glucose or arabinose
• disaccharides eg lactose, sucrose, maltose
• oligosaccharides and polysaccharides eg dextranes
• the auxiliaries have a maximum average particle size of up to 250 ⁇ m, preferably between 10 and 150 ⁇ m, particularly preferably between 15 and 80 ⁇ m. If appropriate, it may seem appropriate to add finer excipient fractions having a mean particle size of 1 to 9 .mu.m to the abovementioned excipients.
• micronized active compounds according to the invention preferably having an average particle size of 0.5 to 10 .mu.m, more preferably from 1 to 5 .mu.m, mixed with the excipient mixture.
• the inhalable powders according to the invention can be applied by means of inhalers known from the prior art.
• Propellant gas-containing inhalation aerosols according to the invention can dissolve active compounds according to the invention in propellant gas or contain them in dispersed form.
• the propellant gases which can be used for the preparation of the inhalation aerosols are known from the prior art. Suitable propellant gases are selected from the group consisting of hydrocarbons such as n-propane, n-butane or isobutane and halohydrocarbons such as fluorinated derivatives of methane, ethane, propane, butane, cyclopropane or cyclobutane.
• the abovementioned propellant gases can be used alone or in mixtures thereof.
• Particularly preferred propellants are halogenated alkane derivatives selected from TG134a and TG227 and mixtures thereof.
• the propellant-containing inhalation aerosols may also contain other ingredients such as cosolvents, stabilizers, surfactants, antioxidants, lubricants, and pH adjusters. All of these ingredients are known in the art.
• Suitable solvents for this purpose are aqueous or alcoholic, preferably ethanolic solutions.
• the solvent may be water only or it may be a mixture of water and ethanol.
• the relative proportion of ethanol to water is not limited, but the maximum limit is preferably up to 70% by volume, in particular up to 60% by volume and more preferably up to 30% by volume.
• the remaining volume percentages are filled up with water.
• the solutions or suspensions containing the active compound according to the invention are adjusted to a pH of from 2 to 7, preferably from 2 to 5, with suitable acids. To adjust this pH, acids selected from inorganic or organic acids can be used. Examples of particularly suitable inorganic acids are hydrochloric acid,
• Bromic acid, nitric acid, sulfuric acid and / or phosphoric acid examples of particularly suitable organic acids are: ascorbic acid, citric acid, malic acid, tartaric acid, maleic acid, succinic acid, fumaric acid, acetic acid, formic acid and / or propionic acid and others.
• Preferred inorganic acids are hydrochloric acid and sulfuric acid. It is also possible to use the acids already with one of the Active ingredients form an acid addition salt.
• ascorbic acid, fumaric acid and citric acid are preferred.
• mixtures of the abovementioned acids in particular in the case of acids which, in addition to their acidification properties, also possess other properties, for example as flavorings, antioxidants or complexing agents, for example citric acid or ascorbic acid.
• Hydrochloric acid is particularly preferably used according to the invention for adjusting the pH.
• the addition of editic acid (EDTA) or one of the known salts thereof, sodium edetate, as stabilizer or complexing agent may optionally be dispensed with.
• Other embodiments include this compound (s).
• the content based on sodium edetate is below 100 mg / 100 ml, preferably below 50 mg / 100 ml, particularly preferably below 20 mg / 100 ml.
• those inhalation solutions are preferred in which the content of sodium edetate is 0 to 10 mg / 100 ml.
• Co-solvents and / or other auxiliaries can be added to the propellant-free inhalable solutions.
• Preferred co-solvents are those which contain hydroxyl groups or other polar groups, for example alcohols - in particular isopropyl alcohol, glycols - in particular propylene glycol, polyethylene glycol, polypropylene glycol, glycol ethers, glycerol, polyoxyethylene alcohols and polyoxyethylene fatty acid esters.
• auxiliaries and additives is meant in this context any pharmacologically acceptable substance which is not an active ingredient but which can be formulated together with the active ingredient (s) in the pharmacologically suitable solvent in order to improve the qualitative properties of the active ingredient formulation.
• These substances preferably do not develop any appreciable or at least no undesirable pharmacological effect in the context of the intended therapy.
• the auxiliaries and additives include, for example, surfactants such as soybean lecithin, oleic acid, sorbitan esters such as polysorbates, polyvinylpyrrolidone other stabilizers, complexing agents, antioxidants and / or preservatives that ensure or prolong the useful life of the finished drug formulation, flavorings, vitamins and / or other additives known in the art.
• the additives also include pharmacologically acceptable salts such as sodium chloride as isotonants.
• Preferred excipients include antioxidants, such as ascorbic acid, if not already used to adjust the pH, vitamin A, vitamin E, tocopherols, and similar vitamins or provitamins found in the human organism.
• Preservatives may be used to protect the formulation from contamination by germs. Suitable preservatives are those known in the art, in particular cetylpyridinium chloride, benzalkonium chloride or benzoic acid or benzoates such as sodium benzoate in the concentration known from the prior art. The abovementioned preservatives are preferably present in concentrations of up to 50 mg / 100 ml, more preferably between 5 and 20 mg / 100 ml.
• preferred formulations contain water and the active ingredient according to the invention only benzalkonium chloride and sodium edetate. In another preferred embodiment, sodium edetate is dispensed with.
• a therapeutically effective daily dose is between 1 and 2000 mg, preferably 10-500 mg per adult
• the finely ground active substance, lactose and part of the corn starch are mixed together.
• the mixture is screened, then moistened with a solution of polyvinylpyrrolidone in water, kneaded, wet granulated and dried.
• the granules, the remainder of the corn starch and the magnesium stearate are sieved and mixed together.
• the mixture is compressed into tablets of suitable shape and size.
• the finely ground active ingredient, a portion of the corn starch, lactose, microcrystalline cellulose and polyvinylpyrrolidone are mixed together, the mixture is sieved and processed with the remainder of the corn starch and water to a granulate which is dried and sieved. To this is added the sodium carboxymethyl starch and the magnesium stearate, mixed and pressed the mixture into tablets of suitable size.
• the active ingredient, corn starch, lactose and polyvinylpyrrolidone are mixed well and moistened with water.
• the moist mass is forced through a sieve of 1 mm mesh size, dried at about 45 ° C. and then the granules are passed through the same sieve.
• curved tablet cores having a diameter of 6 mm are pressed on a tableting machine.
• the coated dragee cores are coated in a known manner with a layer consisting essentially of sugar and talc. The finished dragees are polished with wax.
• Substance and cornstarch are mixed and moistened with water.
• the wet mass is sieved and dried.
• the dry granules are sieved and mixed with magnesium stearate.
• the final mixture is filled into hard gelatine capsules size 1.
• the active ingredient is dissolved at its own pH or optionally at pH 5.5 to 6.5 in water and treated with sodium chloride as isotonic.
• the resulting solution is filtered pyrogen-free and the filtrate filled under aseptic conditions in ampoules, which are then sterilized and sealed.
• the vials contain 5 mg, 25 mg and 50 mg active ingredient.
• the hard fat is melted.
• the ground active substance is dispersed homogeneously. It is cooled to 38 ° C and poured into slightly pre-cooled suppository molds G) oral suspension
• Distilled water is heated to 70 ° C. Herein dissolved hydroxyethyl-cellulose with stirring. After addition of sorbitol solution and glycerol is cooled to room temperature. At room temperature, sorbic acid, flavor and substance are added. To vent the suspension is evacuated with stirring. and 50 mg of active ingredient.
• the suspension is filled in a conventional aerosol container with metering valve. Per actuation preferably 50 ul suspension are delivered. If desired, the active ingredient can also be metered in higher
• the preparation of the inhalable powder is carried out in the usual manner by mixing the individual components.

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