EP2001430B1 - Systeme de preparation et de fourniture d'un fluide versable forme par melange d'une substance seche et d'un fluide - Google Patents

Systeme de preparation et de fourniture d'un fluide versable forme par melange d'une substance seche et d'un fluide Download PDF

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Publication number
EP2001430B1
EP2001430B1 EP06841083A EP06841083A EP2001430B1 EP 2001430 B1 EP2001430 B1 EP 2001430B1 EP 06841083 A EP06841083 A EP 06841083A EP 06841083 A EP06841083 A EP 06841083A EP 2001430 B1 EP2001430 B1 EP 2001430B1
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EP
European Patent Office
Prior art keywords
container
transfer device
connection
head part
catch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP06841083A
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German (de)
English (en)
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EP2001430A1 (fr
Inventor
Bernd Hansen
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Individual
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Individual
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Priority to PL06841083T priority Critical patent/PL2001430T3/pl
Publication of EP2001430A1 publication Critical patent/EP2001430A1/fr
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Publication of EP2001430B1 publication Critical patent/EP2001430B1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/067—Flexible ampoules, the contents of which are expelled by squeezing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • B01F23/51—Methods thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B01F33/50111—Small portable bottles, flasks, vials, e.g. with means for mixing ingredients or for homogenizing their content, e.g. by hand shaking
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7161—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected coaxially before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7163—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected in a mouth-to-mouth, end-to-end disposition, i.e. the openings are juxtaposed before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71795—Squeezing a flexible container
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held

Definitions

  • the invention relates to a system for preparing and providing a flowable medium formed by mixing a dry substance with a fluid, in particular a medium for therapeutic purposes, with the system components: a first, the fluid receiving container with a deformable volume change against a restoring force wall part ; a second, the dry substance receiving container; and a transfer device for establishing a fluid connection between the first and second containers; wherein the first container for its connection to the transfer device has at one end a head part on which first latching means are provided for forming a latching with second latching means provided on an associated connection device of the transfer device, and wherein the head part has a central, projecting spigot whose end is normally closed by a removable closure member.
  • Such a system is off DE 31 52 033 A1 known.
  • the known system comprises a container for the sterile storage of medicaments or the like in a particular designed as a bellows Applicator, wherein the container has a pierceable from Applizier réelle Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea Sea, or the mouthpiece tube.
  • liquid media which are provided for example for therapeutic purposes or for other purposes, must be freshly prepared in time proximity to the actual use case, because only the components forming the medium are sufficiently stable and / or storable for themselves, but not the ready-made Medium. In practice, therefore, there is often the need to keep a dry substance and a fluid separately from each other until the application of the medium formed from a mixture of dry matter and fluid is pending.
  • the procedure is such that the fluid, for example a solvent, is taken up by means of an injection syringe and injected into a container containing the dry substance. Thereafter, the resulting solution is removed with a new syringe to be applied or administered in the desired manner, which can be done in therapeutic applications such as by injecting, the introduction as an additive in an infusion container or the like.
  • the fluid for example a solvent
  • the object of the invention is to provide a system for preparing and providing a flowable medium formed by mixing a dry substance with a fluid, which is distinguished by improved handling safety.
  • the first latching means of the head part are integrally formed with this, forming a gap along the outer side of the nozzle extending arms, at the free end portions locking bodies are formed, which protrude in the direction of the nozzle.
  • the fluid exchange between the participating containers required for the preparation and the provision of the medium takes place in a closed functional sequence, ie without a separate handling of the individual containers per se and the mounting of a syringe from the container a container and the injection of the drawn up fluid in the other container would be required.
  • the fact that the fluid receiving the first container has a wall portion which is deformable against a restoring force, the fluid from the first container via the transfer device in which the dry substance receiving Press second container into it, so that takes place in this container mixing the dry matter with the fluid.
  • the deformable wall part of the first container is released, so that its volume increases again due to the effective force on the first container and thus the prepared medium is sucked into the first container via the transfer device, in which now the finished prepared medium is ready for use.
  • the system according to the invention not only allows safe handling without risk of injury, but also offers due to the closed functional sequence and a special protection against contamination.
  • the deformable against restoring force wall portion of the first container is formed by a an inherent restoring force against deformation having bellows, wherein the head part is preferably integrally formed on the bellows.
  • a container is preferably an ampoule-like plastic container which is produced by the known bottelpack ® molding method, and filled with the respective fluid and provide the wall with folds and is such bellows designed that it can be compressed in axial direction to the expressing contained fluid.
  • a bellows made of suitable plastic material returns to its original shape after removal of the compressive force acting on it, in which the volume of the container is returned to its original size.
  • the arrangement may advantageously be such that the head part has a Luer connection in its end region assigned to the connection piece. Further, it is advantageous if a closure piece integral with the neck is provided as a closure part.
  • the head part and the locking means of the first container associated with this container connection device of the transfer device may have a hollow connecting pin, which has an end extension as a seat for receiving the nozzle to form a plug connection with the neck of the first container itself extends with its outer wall surface in the space between the locking means of the head forming arms.
  • the first locking means of the head part may have recessed notches on the locking bodies.
  • locking lugs may be provided which are integrally formed on the outer wall surface of the connecting pin and with the notches interact with the arms of the headboard and secure the formed connector.
  • the transfer device in extension of the connecting pin on a through-channel, the end portion is formed as part of the provided for the second container connection means of the transfer device by a projecting cannula, on the same time the fluid connection with the dry substance containing second container is produced, if this has a penetrable by the cannula closure.
  • Such containers preferably in the form of small-volume glass bottles, are commercially available.
  • an auxiliary device may be provided as an additional system component, which facilitates and simplifies the merging of the transfer device and the second container in the positional relationship provided for the penetration of the closure through the cannula.
  • a sleeve body may be provided which is open at one end and at the other end an end plate having a central passage opening for the cannula of the transfer device, wherein the sleeve body is designed so that it forms a guide for the second container, which in the Sleeve body from the open end in the direction of the cannula is inserted.
  • the second container for example in the form of a small-volume glass bottle of commercial nature, only needs to be inserted into the sleeve body, after the transfer device has been previously inserted through the central passage opening of the end plate in the sleeve body. This ensures that when inserting the container into the sleeve body, the cannula the central area, ie penetrates the penetrable area, the closure of the second container.
  • this simultaneously forms a protective coating of the inserted cannula.
  • a cannula in contrast to conventional hypodermic needles, does not constitute a serious risk of injury, the sheathing results in an additional improvement in handling safety.
  • the invention also provides a container which is provided for use in the system according to the invention and characterized by the features specified in claim 12.
  • another object of the present invention relates to the use of a system according to any one of claims 1 to 11 and a container according to any one of claims 12 to 15 for preparing and providing a flowable medium.
  • Fig. 1 shows a designated as a whole with 1 bellows ampoule in the closed state, which forms the first container part of the system according to the invention to be described here.
  • the ampoule 1 is together with the bellows forming its actual receiving space 3, an adjoining as a final part thereto head part 5 and with its outlet opening 9 (FIG. Fig. 3 )
  • Closing twist knob 7 made in one piece by the known bottelpack ® method of plastic and filled with a fluid.
  • the plastic material used for the production has a certain elasticity property, so that when the twisting knob 7 is removed, the bellows 3 can be compressed in the axial direction, so that by the corresponding reduction of the volume of the contained fluid from the opening 9 (FIG. Fig. 3 ) can be expressed at the nozzle 11. If the bellows 3 is released, it returns through the given due to its elasticity restoring force in the Fig. 1 shown back home shape, the interior of the bellows 3 again has the initial volume.
  • Fig. 3 shows the outer shape of the neck 11 of the head part 5, wherein it can be seen that there is a Luer connection 13 at the end region located at the opening 9.
  • 11 arms 15 are formed on the head part 5 on both sides of the nozzle, which extend at a distance from the outside of the nozzle 11 in the axial direction. In the vicinity of the end edges of these arms 15 are recessed notches 17 which are provided for locking with a locking rib 19 which is located on a serving as another part of the system transfer device 21. The locking comes off when, starting from the in Fig.
  • Fig. 5 a plug connection with the transfer device 21 is made, as shown in Fig. 5 is shown.
  • FIG. 6 Further details of the connector produced with the transfer device 21 are in Fig. 6 on a larger scale clarifies the in Fig. 5 area indicated by VI. As can be seen, this is the nozzle 11 on the head part. 5 within an enlarged seat 23 in a hollow connecting pin 25 of the transfer device 21, wherein the socket 11 in the seat 23 fits, that is, under seal, is added. Like also out Fig. 6 Most clearly seen is the locking rib 19 on the outside of the pin 25 in the vicinity of the free end.
  • the detent notches 17 having arms 15 extending from the head portion 5, starting on the outside of the pin 25 to over the locking rib 19 which snaps into the notches 17.
  • Figs. 5, 7A, 7B and 7C illustrate the further functional sequence when using the system according to the invention.
  • the transfer device 21 in extension of the seat 23 of the connecting pin 25 on an axial passageway 29, which extends through a thickening 31 which a stop shoulder 32 (FIG. Fig. 4 ) and extends therethrough and ends in an axially protruding cannula 33.
  • a glass bottle 35 functioning as a second container of the system with a closure 37 which can be penetrated through the cannula 33 can be placed against the stop shoulder 32 so that the end of the cannula 33 extends into the interior of the bottle 35.
  • Fig. 4 contains for the preparation of the medium to be produced in the initial state, in Fig. 4 is shown, for example, a dry substance 39, to which the fluid, for example a solvent 41, see Fig. 5 , will be added.
  • Fig. 7A shows as the next step the operating state in which after the mixing of the dry matter 35 with the solvent 41 is the finished medium 43 is located in the bottle 35.
  • Fig. 7B is presented, so that the system is reversed, whereupon, as in Fig. 7C shown, the compressed bellows 3 is now released, so that the medium 43 is sucked out of the bottle 35 in the bellows ampoule 1 by its increase in volume, see Fig. 7C , After releasing the plug-in connection with the transfer device 21, the finished medium is now provided in the ampoule 1.
  • 8 and 9 show a variant of the system, wherein a connecting means is provided to bring the second container forming bottle 35 easily and conveniently in defined alignment with the transfer device 21.
  • a special feature of the aid is that it simultaneously forms a protective casing for the cannula 33 of the transfer device 21 and thus also a casing for the bottle 35, as is apparent from 8 and 9 can be seen.
  • These figures show that the bottle 35 with inserted cannula is surrounded by a sleeve body 45 in the form of a hollow cylinder which is open at the end facing away from the transfer device 21, so that the bottle in the axial direction in the sleeve body 45 from the open end can be inserted and placed in a position in which the cannula 33 enters the bottle 35.
  • the sleeve body 45 has, at the end lying on the stop shoulder 32 of the transfer device 21, an end plate 44 surrounding a central passage opening for the cannula 33.
  • the sleeve body 45 is preferably formed of a transparent plastic material so that, in use of the system, the process of mixing fluid 41 and dry matter 39 can be visually observed.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pens And Brushes (AREA)
  • Prostheses (AREA)
  • Detergent Compositions (AREA)

Claims (16)

  1. Système de préparation et de mise à disposition d'un milieu (43) susceptible de s'écouler et formé par mélange d'une substance (39) sèche à un fluide (41), notamment d'un milieu à des fins thérapeutiques, comprenant les constituants de système :
    - un premier récipient (1) recevant le fluide (41) et ayant une partie (3) de paroi déformable à l'encontre d'une force de rappel pour la variation de volume ;
    - un deuxième récipient (35) recevant la substance (39) sèche ; et
    - un dispositif (21) de transfert pour ménager une liaison pour du fluide entre le premier (1) et le deuxième récipients (35) ;
    - dans lequel le premier récipient (1) a pour sa liaison avec le dispositif (21) de transfert à une extrémité une partie (5) de tête, sur laquelle sont prévus des premiers moyens (15, 17) d'encliquetage pour la formation d'un encliquetage avec des deuxièmes moyens (19) d'encliquetage, qui sont présents sur un dispositif (23, 25) de raccord associé du dispositif (21) de transfert, et
    - dans lequel la partie (5) de tête comporte une tubulure (11) centrale en saillie, dont l'extrémité est fermée normalement par une partie (7) de fermeture qui peut être enlevée,
    - caractérisé en ce que les premiers moyens d'encliquetage de la partie (5) de tête sont formés par des bras (15) d'une seule pièce avec elle, qui s'étendent respectivement le long du côté extérieur de la tubulure (11) en formant un espace intermédiaire et aux parties d'extrémité libre desquels sont formés des corps d'encliquetage, qui font saillie en direction de la tubulure (11).
  2. Système suivant la revendication 1, caractérisé en ce que la partie formant paroi déformable à l'encontre d'une force de rappel du premier récipient (1) est formée par un soufflet (3) ayant une force de rappel inhérente à l'encontre d'une déformation.
  3. Système suivant la revendication 1 ou 2, caractérisé en ce que la partie (5) de tête a un raccord (13) luer dans la partie d'extrémité associée à la tubulure (11).
  4. Système suivant l'une des revendications précédentes, caractérisé en ce qu'il est prévu, comme partie de fermeture, une manette (7) tournante d'une pièce avec la tubulure.
  5. Système suivant l'une des revendications précédentes, caractérisé en ce que le dispositif de raccord associé au premier récipient (1) du dispositif (21) de transfert comporte un tenon (25) creux de raccord, qui, pour la formation d'une liaison par enfichage avec la tubulure (11) du premier récipient (1), a un élargissement (23) du côté de l'extrémité en tant que siège pour la réception de la tubulure (11), le tenon (25) de raccord s'étendant par sa surface de paroi extérieure dans l'espace intermédiaire compris entre les bras (15) formant les premiers moyens (17) d'encliquetage de la partie (5) de tête.
  6. Système suivant l'une des revendications précédentes, caractérisé en ce qu'il est prévu des encoches (17) d'encliquetage formées en retrait sur les corps d'encliquetage formés sur les bras (15).
  7. Système suivant les revendication 5 et 6, caractérisé en ce que, sur la surface de paroi extérieure du tenon (25) de raccord, est prévue une nervure (19) d'encliquetage en tant que moyen d'encliquetage du dispositif de transfert coopérant avec les encoches (17) d'encliquetage des bras (15) de la partie (5) de tête.
  8. Système suivant l'une des revendications 5 à 7, caractérisé en ce que le dispositif (21) de transfert a dans le prolongement du tenon (25) de raccord un canal (29) de passage, dont le tronçon d'extrémité est formé par une canule (33) en saillie, en tant que constituant du dispositif de raccord, prévu pour le deuxième récipient (35), du dispositif (21) de transfert.
  9. Système suivant la revendication 8, caractérisé en ce que le deuxième récipient (35) a une fermeture (37) pouvant être traversée par la canule (33).
  10. Système suivant la revendication 9, caractérisé par un moyen (44, 45) auxiliaire pour faire venir le dispositif (21) de transfert et le deuxième récipient (35) ensemble dans la relation en position prévue pour la traversée de la fermeture (37) par la canule (33).
  11. Système suivant la revendication 10, caractérisé en ce que le moyen auxiliaire comporte un corps (45) formant manchon, qui est ouvert à une extrémité et a à l'autre extrémité une plaque (44) d'extrémité ayant une ouverture centrale de passage de la canule (33) du dispositif (21) de transfert et en ce que le corps (45) formant manchon forme un guidage pour le récipient (35), lequel peut être introduit dans le corps (45) formant manchon à partir de l'extrémité ouverte en direction de la canule (33).
  12. Récipient (1) pour un système suivant l'une des revendications 1 à 11, caractérisé en ce qu'il possède une partie formant paroi déformable à l'encontre d'une force de rappel et formée par un soufflet (3) ayant une déformation inhérente à l'encontre d'une force de rappel.
  13. Récipient suivant la revendication 12, caractérisé en ce que le récipient (1) a, pour sa liaison avec le dispositif (21) de transfert, sur une extrémité du soufflet (3), une partie (5) de tête, sur laquelle sont prévus des moyens (15, 17) d'encliquetage pour la formation d'un encliquetage avec des moyens (19) d'encliquetage, qui sont présents sur un dispositif (23, 25) associé du raccord du dispositif (21) de transfert.
  14. Récipient suivant la revendication 13, caractérisé en ce que la partie (5) de tête a une tubulure (11) centrale en saillie, dont l'extrémité est fermée normalement par une partie de fermeture pouvant être retirée, de préférence une manette (7) tournante, d'une pièce avec la tubulure (11).
  15. Récipient suivant la revendication 14, caractérisé en ce que les moyens d'encliquetage de la partie (5) de tête sont formés par des bras (15) d'une pièce avec elle, s'étendant respectivement le long du côté extérieur de la tubulure (11) en formant un espace intermédiaire et aux parties d'extrémité libres desquels sont formés des corps d'encliquetage, qui sont en saillie dans la direction de la tubulure (11) et sur lesquels sont prévues des encoches (17) d'encliquetage.
  16. Utilisation d'un système suivant l'une des revendications 1 à 11 et d'un récipient suivant l'une des revendications 12 à 15, pour la préparation et la mise à disposition d'un milieu (43) susceptible de s'écouler, notamment d'un milieu à des fins thérapeutiques, dans laquelle, par application d'une force de pression sur la partie (3) de paroi déformable du premier récipient (1), dont le volume est rapetissé, du fluide étant ainsi refoulé par le dispositif (21) de transfert dans le deuxième récipient (35), après le mélange du fluide (41) avec la substance (39) sèche se trouvant dans le deuxième récipient (35), il est mis fin à l'application de la force de pression sur la partie (3) de paroi déformable, de sorte que, par l'agrandissement du volume du premier récipient (1) provoqué en raison de la force de rappel de la partie (3) de paroi, le milieu (43) est aspiré dans le premier récipient (1) et y est mis à disposition pour utilisation.
EP06841083A 2006-03-02 2006-12-21 Systeme de preparation et de fourniture d'un fluide versable forme par melange d'une substance seche et d'un fluide Not-in-force EP2001430B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL06841083T PL2001430T3 (pl) 2006-03-02 2006-12-21 System sporządzania i udostępniania utworzonego wskutek mieszania substancji suchej z płynem, płynnego czynnika

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006009611A DE102006009611A1 (de) 2006-03-02 2006-03-02 System zum Zubereiten und Bereitstellen eines durch Vermischen einer Trockensubstanz mit einem Fluid gebildeten fließfähigen Mediums
PCT/EP2006/012361 WO2007098801A1 (fr) 2006-03-02 2006-12-21 Systeme de preparation et de fourniture d'un fluide versable forme par melange d'une substance seche et d'un fluide

Publications (2)

Publication Number Publication Date
EP2001430A1 EP2001430A1 (fr) 2008-12-17
EP2001430B1 true EP2001430B1 (fr) 2011-03-16

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EP06841083A Not-in-force EP2001430B1 (fr) 2006-03-02 2006-12-21 Systeme de preparation et de fourniture d'un fluide versable forme par melange d'une substance seche et d'un fluide

Country Status (18)

Country Link
US (1) US7882859B2 (fr)
EP (1) EP2001430B1 (fr)
JP (1) JP5107941B2 (fr)
KR (1) KR101373029B1 (fr)
CN (1) CN101394824B (fr)
AT (1) ATE501702T1 (fr)
AU (1) AU2006339091B2 (fr)
BR (1) BRPI0621463B8 (fr)
CA (1) CA2642366C (fr)
DE (2) DE102006009611A1 (fr)
DK (1) DK2001430T3 (fr)
ES (1) ES2361683T3 (fr)
HK (1) HK1125821A1 (fr)
MX (1) MX2008011170A (fr)
PL (1) PL2001430T3 (fr)
PT (1) PT2001430E (fr)
RU (1) RU2431458C2 (fr)
WO (1) WO2007098801A1 (fr)

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ITMI20111798A1 (it) * 2011-10-04 2013-04-05 G21 S R L Apparecchiatura e procedimento di preparazione di cementi ossei
KR102109317B1 (ko) 2011-12-29 2020-05-29 옴릭스 바이오파머슈티컬스 리미티드 고체 단백질 조성물의 신속한 용해를 위한 방법 및 장치
EP3009354A1 (fr) 2014-10-15 2016-04-20 F. Hoffmann-La Roche AG Procédé permettant de fournir dans un récipient d'emballage primaire un produit solide séché contenant un ingrédient pharmaceutique actif
AU2016286525A1 (en) 2015-07-02 2018-02-15 Marc Andrew Koska Single use delivery device prefilled with a reconstitutable agent
WO2017001921A1 (fr) * 2015-07-02 2017-01-05 Marc Andrew Koska Dispositif de distribution multidoses
CN105125340A (zh) * 2015-09-10 2015-12-09 成都华神生物技术有限责任公司 制备药物溶液的装置及其用法以及用药装置及其用法
CN105366133A (zh) * 2015-12-08 2016-03-02 太仓云联信息科技有限公司 一种用于物资的防水包装装置
CN109069750B (zh) 2016-04-25 2021-09-07 科斯卡家族有限公司 药物输送系统
FR3067910B1 (fr) * 2017-06-23 2021-06-18 Seb Sa Appareil de fabrication d’un produit cosmetique personnalise
CN111615409A (zh) 2017-11-17 2020-09-01 科斯卡家族有限公司 用于流体输送歧管的系统和方法
IT202100011387A1 (it) * 2021-05-07 2022-11-07 Giuseppe Dionigi Dispositivo con valvola per il trasferimento di liquidi
USD992110S1 (en) 2021-08-10 2023-07-11 Koska Family Limited Sealed fluid container
GB2601913B (en) * 2021-12-10 2023-02-01 Boyle Jeremy An ampoule

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Also Published As

Publication number Publication date
ATE501702T1 (de) 2011-04-15
DK2001430T3 (da) 2011-07-04
US20090025823A1 (en) 2009-01-29
BRPI0621463A2 (pt) 2011-12-13
RU2008132772A (ru) 2010-04-10
CN101394824B (zh) 2012-09-19
CA2642366C (fr) 2013-04-02
ES2361683T3 (es) 2011-06-21
KR101373029B1 (ko) 2014-03-17
PL2001430T3 (pl) 2011-08-31
WO2007098801A1 (fr) 2007-09-07
MX2008011170A (es) 2008-09-10
JP5107941B2 (ja) 2012-12-26
DE502006009130D1 (de) 2011-04-28
KR20080099286A (ko) 2008-11-12
JP2009528100A (ja) 2009-08-06
BRPI0621463B1 (pt) 2018-01-16
CA2642366A1 (fr) 2007-09-07
AU2006339091B2 (en) 2011-11-24
DE102006009611A1 (de) 2007-09-06
RU2431458C2 (ru) 2011-10-20
US7882859B2 (en) 2011-02-08
AU2006339091A1 (en) 2007-09-07
CN101394824A (zh) 2009-03-25
EP2001430A1 (fr) 2008-12-17
HK1125821A1 (en) 2009-08-21
BRPI0621463B8 (pt) 2021-06-22
PT2001430E (pt) 2011-04-04

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