EP2531165B1 - Procédé pour prélever des fluides dans des flacons - Google Patents
Procédé pour prélever des fluides dans des flacons Download PDFInfo
- Publication number
- EP2531165B1 EP2531165B1 EP10801102.4A EP10801102A EP2531165B1 EP 2531165 B1 EP2531165 B1 EP 2531165B1 EP 10801102 A EP10801102 A EP 10801102A EP 2531165 B1 EP2531165 B1 EP 2531165B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- container
- fluid channel
- opening
- inlet opening
- basic body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Not-in-force
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/201—Piercing means having one piercing end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/2013—Piercing means having two piercing ends
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2055—Connecting means having gripping means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2058—Connecting means having multiple connecting ports
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
Definitions
- the present invention relates to a device for withdrawing a fluid from at least one container, in particular from a container closed by a pierceable closure, e.g. a vial with septum closure.
- the present invention relates to a device for filling an applicator with at least one fluid reservoir of one or more vials.
- the task is to produce and discharge a mixture of two or more flowable components in a predetermined mixing ratio.
- An example is the preparation of an adhesive for technical or medical applications, e.g. a medical glue based on fibrin.
- Another example is the preparation of a multi-component bone cement using a monomer.
- US 6,488,650 discloses several embodiments of a filling device that makes it possible to treat a dual syringe type applicator with two reservoirs of two vials.
- the device has a connection region on which two connections for the reservoirs are formed.
- On the opposite side of a hood for receiving the vials is formed.
- the septa of the vials are pierced by hollow needles, which communicate via fluid channels with the connections for the reservoirs.
- the fluid channels divert the fluids between the vials and the reservoir ports so that the reservoir spacing may be less than the pitch of the hollow needles.
- the structure of such a filling device is relatively complicated: the device comprises two separately formed housing halves, which must be connected together to form the connection area and the hood. Before connecting the two halves, the fluid channels are inserted with the connections for the reservoirs and with the hollow needles in the housing halves. This leads to a relatively complicated manufacturing process and correspondingly increased costs. In addition, the loss volume of such a device is relatively large.
- FIGS. 8 Figure 14 discloses a filling device for a dual-syringe applicator of vials.
- This filling device has a disk-like base body with a bottom side and a top side. On the upper side, two inlet openings spaced from one another, which are connected to piercing members in cup-like vial holders, are formed. At the bottom two outlet openings are formed with a smaller distance, to which the applicator is connectable. In each case an inlet opening and outlet opening are connected to one another by a fluid channel running perpendicular to these openings.
- This filling device also has a relatively large loss volume.
- the vials are usually simply inserted into the device to puncture the septa. In some of these devices, the vials are then, after complete insertion into the device and after puncture of the septa, fixed by a latching connection to the device.
- known devices are usually not suitable to the vials directly to the Store as it can not be ruled out that the septum of a vial is inadvertently punctured during transport or handling.
- the present invention provides an adapter-like device which makes it possible to remove a fluid from a container, wherein the fluid is deflected in the device, e.g. to fill at least one reservoir of an applicator from at least one container with a fluid, wherein the device has a reduced loss volume.
- a device for removing a fluid from at least one container has a base body with an upper side and a lower side, in which at least one fluid channel running along a longitudinal direction with a constant or variable cross-section is formed.
- At the top of the base body is at least one angled (ie angle not equal to 0 °, preferably amount of the angle> 30 °, more preferably perpendicular) formed to the fluid passage inlet opening which opens into the fluid channel, and at the bottom of the base body is at least one angled (Preferably, the amount of the angle> 30 °, more preferably perpendicular) to the fluid passage extending outlet opening formed, which also opens into the fluid channel.
- the outlet opening is arranged offset relative to the inlet opening, ie the outlet opening and the inlet opening open at different locations along the fluid channel.
- the device also includes at least one container port for connecting a container to the inlet port, which may be done in any manner.
- at least one insertion opening extending along the longitudinal direction is formed in the base body and opening into the fluid passage, and an insert member is inserted through the insertion opening into the fluid passage. This insert element extends into the fluid channel in such a way that it reduces the cross section of the fluid channel in a region between the inlet opening and the outlet opening.
- the insert element may have the form of a pin which extends into the fluid channel along the longitudinal axis.
- the insert preferably sits sealingly in the fluid channel, i. it preferably has a peripheral surface (lateral surface) which abuts substantially sealingly between a boundary wall of the fluid channel between the inlet opening and the outlet opening and forms a fluid connection of reduced cross-section alone or together with a boundary wall of the fluid channel.
- a first annular groove may be formed, which is at least partially (preferably completely ) extends around the insert element, and in the region of the outlet opening, a second annular groove can be formed in the peripheral surface, which likewise extends at least partially (preferably completely) around the insert element.
- the mentioned fluid connection is formed.
- This can e.g. may be formed in the form of a connecting groove connecting the two annular grooves or may be e.g. be formed as a bore through the insert element.
- a connection groove is preferred.
- a flattening may be formed in the peripheral surface of the insert element (i.e., on its outer circumference) defining a gap between the boundary wall of the fluid channel and the insert element.
- the gap forms at least part of the fluid connection mentioned.
- connecting groove or flattening can also be advantageously used if no annular grooves are present, for example because the insert element is not rotationally symmetrical and therefore can be introduced in any case only in a single, fixed orientation with respect to a rotation about the longitudinal axis.
- the connecting groove or flattening may be parallel to the longitudinal direction or obliquely thereto, for example helically wound or meander-shaped, extend, but the shortest possible configuration is preferred in order to keep the loss volume low.
- the insert element is preferably arranged sealingly in the base body, so that the fluid can not reach these areas.
- a first latching structure may be formed on the insert element, and then a complementary second latching structure is formed on the base body. These locking structures then work together to hold the insert latching in the base member.
- the first latching structure may include an annular bead on the insert element, while the second latching structure comprises a complementary annular groove in a jacket wall of the fluid channel or the insertion opening.
- the fluid channel and the insert element of complementary shape and at least partially (preferably at least in the region between the inlet opening and outlet opening) to the insertion towards conically widened. This makes it very easy to achieve the desired sealing effect between the peripheral surface of the insert element and the boundary wall of the fluid channel, even in the presence of dimensional tolerances.
- the device can be used in particular as a filling device or adapter for filling at least one reservoir of an applicator from at least one container, in particular a vial.
- the applicator can be a syringe-like applicator in which the reservoir is delimited by a movable piston, so that the reservoir can be filled by retracting the piston from a distal end position into a proximal direction.
- the device preferably has an applicator connection in order to connect the reservoir of the applicator to the outlet opening.
- the applicator connection can be equipped with a holding device, in particular with a detachable latching connection, for the applicator. It can be made in one piece with the base body or separately from it.
- the applicator connection is formed, for example, by a female luer cone; However, preferred is a special embodiment in which the loss volume is less than in a normal standardized luer connection, for example, an embodiment according to the embodiments described below.
- the device serves to remove the fluid from at least one vial or other container with a pierceable closure, it preferably has in the region of the container connection a hollow needle-like piercing member connected to the inlet opening in order to pierce a closure of the container.
- the device in the region of the container connection preferably has a container receptacle which is designed to hold the container to the device.
- the device can also be used for other purposes, e.g. as an adapter for connecting a container to an accessory, e.g. a mixer or atomizer. Also in such applications, it may be desirable to divert fluid between the container and the accessory while minimizing the loss volume.
- the container may then be e.g. a carpule (i.e., a container with a pierceable closure and displaceable piston) or a single or multiple syringe, and the container port may then be designed accordingly.
- a suitably designed connection for the accessory can then be present.
- the device can be configured for the simultaneous removal of fluids from at least two containers.
- the two fluid channels preferably run collinearly one behind the other along the longitudinal direction, wherein the insert elements are introduced from two opposite sides into the two fluid channels.
- a second fluid passage having a constant or variable cross-section running along the longitudinal direction is formed on the upper side of the base body, a second inlet opening extending at an angle to the second fluid channel, which opens into the second fluid channel, and at the bottom the base body is angled to the second fluid channel extending) second outlet opening, which opens with respect to the longitudinal direction offset from the second inlet opening of the second fluid channel.
- the device then has a second container port to connect a second container to the second inlet port.
- the base body is then running along the longitudinal direction, the the first insertion opening facing away from the second inlet opening, which opens into the second fluid channel, and the filling device has a second insert element, which is inserted through the second insertion opening into the second fluid channel and reduces the cross section of the second fluid channel between the second inlet opening and the second outlet opening.
- the present invention provides an adapter-like device for withdrawing a fluid from at least one container closed by a pierceable closure, which makes it possible to store the container on the device without unintentionally opening the container.
- a pierceable closure Such a device is specified in claim 12.
- the two aspects of the invention can be used individually or combined with each other.
- the container receptacle In order to securely hold the container to the device prior to puncturing the closure and to prevent accidental puncturing, the container receptacle has a first latching structure to move the container to a storage position where the container is farther from the base body than in the removal position (And in the thereby the closure is not pierced) to fix by a releasable locking connection to the container receptacle.
- the container is also fixed in the removal position, and the container receptacle then additionally has a second latching structure for this purpose in order to secure the container in the removal position To fix removal position by a latching connection to the container receptacle.
- the latching structures can interact directly or indirectly with the container.
- the container can be inserted directly into the container receptacle, the latching structures being attached directly to a corresponding retention structure, e.g. a rejuvenation, attack the container, or the container may be held on a separate holder which is inserted into the container receptacle or pushed onto this, wherein the latching structures of the container receptacle cooperate with a corresponding retention structure of the holder.
- the container receptacle has only a single latching structure, while the container or the holder has two retention structures, wherein in the storage position, the first of these retention structures with the (single) latching structure cooperates, while in the removal position, the second of these retention structures the latching structure cooperates.
- the container receptacle has a preferably at least partly cylindrical jacket wall.
- the first latching structure and the second latching structure each comprise a spring arm formed in the casing wall, at the free end of which a latching nose extending into the interior of the casing wall is formed. This allows a very simple and inexpensive production.
- the latching structures are preferably arranged offset with respect to the circumferential direction of the jacket wall, in particular by approximately 180 ° offset, i. diametrically opposite one another in order to take up as little space as possible with the greatest possible stability of the container receptacle.
- the container receptacle can in particular be constructed as follows: It has a bottom, from which a pin extends into the inlet opening of the base body. Through the pin and bottom through a passage opening is formed, and the piercing member is held in the passage opening.
- a device can also be designed as a filling device for an applicator, with an applicator connection of the type specified above. But it can also turn, for example, to remove a fluid from a Serving carpule.
- this device can also be designed for the simultaneous removal of fluids from at least two containers.
- the latching structures can be designed so that they fix the two or more containers simultaneously in the storage position or in the removal position.
- the container receptacle may include a cover, e.g. a bottom-extending skirt, which covers the insertion opening for the insert element. This additionally secures the insert element in the base body.
- the base body, the container receptacle and the applicator connection are preferably made of a thermoplastic material by injection molding.
- the filling device 200 has a base body 210 of elongated, substantially disk-shaped basic shape.
- a central, cylindrical thickening 211 is formed on the base body 210, to which the two halves of a flat supporting plate 212 connect.
- the thickening 211 defines with its cylinder axis a longitudinal direction.
- each of the two ends of the cylindrical thickening 211 forth a blind hole-like longitudinal bore is formed, which ends in each case shortly before the center of the thickening ( FIGS. 3 and 4 ).
- Each of these holes widens slightly conically towards its open end to form a fluid channel.
- the two holes are collinear with each other, ie they lie on the same axis one behind the other.
- an inlet opening 213 is formed in the region of the thickening for each of the holes ( Fig. 4 ).
- This inlet opening 213 connects the respective bore, each with a cup-shaped container receptacle 220.
- the container receptacle 220 has a circumferential cylindrical jacket wall which is formed multiple slotted from its upper edge, so that each of the interrupted by a slot portions of the jacket wall forms a spring arm. Retaining lugs protrude inwardly at the free ends of these resilient arm portions to latch a container 300 in a picking position on the container receptacle.
- the containers 300 are present here in the form of so-called vials with septum closure.
- Each container comprises a Be Strukturerköper 310, which is preferably made of glass, but may also consist of special plastic.
- a circumferential cylindrical jacket wall 312 which has a taper 313 near the bottom distal end.
- the mantle wall widens slightly again and delimits a container opening.
- the associated closure 320 comprises a septum 321 (a pierceable, self-closing Membrane, see Fig. 4 ) held by a crimped metal cover leaving a central part of the septum on the container opening.
- a piercing member 230 of relatively hard plastic is inserted into the inlet opening 213, terminating in a tip 231 at its upper end. Laterally at the tip 231, a removal opening 232 is formed, which is connected to a central withdrawal channel 233, which in turn opens into the inlet opening 213 of the base body 210.
- an outlet opening 214 is formed which leads to an applicator connection 240.
- the applicator port 240 is formed integrally with the base body 210, but may be separately formed in front of the base body 210 and connected to the base body 210 in a suitable manner, e.g. glued or welded, be.
- a double-syringe-like applicator 100 can be attached and detachably fastened.
- the applicator has an applicator body 110 with two cylindrical, parallel, proximally open reservoirs 111, 112 of equal or (here) different volume.
- the reservoirs open at their distal ends into outlets 116, 117.
- a piston 121, 122 is inserted in the open proximal ends of the reservoirs in each case a piston 121, 122 is inserted.
- the two pistons are connected together at their proximal ends to form a piston unit.
- an actuating surface 123 is formed for a user's thumb.
- a retaining flange 113 serves to hold the applicator by means of index and middle fingers.
- the applicator can be handled in this respect as a commercial double syringe.
- the present connection between the applicator 100 and the filling device 200 functionally corresponds substantially to the in WO 2007/109915 described connection between a syringe / cartridge and an accessory.
- the applicator 100 and the filling device 200 comprise retention means configured according to this document.
- the applicator connection is designed as follows: Each of the outlet openings 214 of the two fluid channels opens into one conically widening insertion region for the outlets 116, 117 of the applicator 100. These outlets are correspondingly formed to be complementary to the insertion regions and can be inserted into these insertion regions.
- the applicator connection 240 has a cylindrical receiving region 241, which radially surrounds the insertion regions and the webs with the latching noses and on which two opposite snap-in openings are formed.
- the latching noses 115 snap when inserting the applicator into the snap-in openings of the receiving region 241.
- the receiving region 241 is elastically deformable such that the latching connection between the latching noses 115 and the corresponding snap-in openings by pressure on a relative to the cylinder axis of the receiving area by approximately 90 degrees from the Einschnappötechnisch offset wall portion of the receiving area 241 is releasable again.
- the receiving area 241 is deformed such that the snap-in openings are pressed radially outward away from the latching noses 115 and thereby get out of engagement with the latching noses.
- two opposite pressure wings 243 are formed on the support plate 212.
- a lateral compression of the two pressure vanes 243 is transferred offset to the Einschnappö réelleen on the cylindrical receiving portion 241 of the applicator 240 and thereby leads to release the locking connection between the applicator 100 and the filling device 200th
- a Codiereriel 114 on the applicator 100 and a corresponding Codiereriel 242 on the filling device 200 indicate the correct orientation of the applicator 100 when connecting to the filling device 200 at.
- the terminals themselves are formed differently to ensure that the applicator 100 only in the correct orientation can be connected to the filling device 200.
- each of the two longitudinally extending bores of the base body 210 is inserted in each case a pin-shaped or needle-shaped insert element 250, which in the Fig. 5 is shown alone.
- the insert member 250 serves to reduce the cross section of the fluid passage formed by the bore between the inlet port 213 and the outlet port 214.
- the insert element 250 is formed substantially complementary to the bore in the base body 210 and in particular also extends slightly towards the free end of the bore, so that it rests with its peripheral surface substantially sealingly against the boundary wall of the bore.
- a first annular groove 251 is formed in the peripheral surface of the insert element 250, while a second annular groove 252 is formed in the region of the outlet opening 214.
- These annular grooves are interconnected by a longitudinally extending connecting groove.
- the annular grooves 251, 252 and the connecting groove 253 establish a fluid communication between the inlet port 213 and the outlet port 214, which is commonly defined by the grooves and the boundary wall of the fluid channel.
- a straight connecting groove and a different shape can be selected.
- a flattening may also be provided on the circumferential surface, or the connecting groove may be replaced by a fine, eg diagonal, bore connecting the annular grooves.
- the insert element 250 can be easily slid into the open end of the bore in any orientation along the longitudinal direction with the open end of the bore forming an insertion opening 216 for the insert element. Because of the circumferential annular grooves 251, 252, it does not depend on the exact orientation of the insert element with respect to a rotation of the insert element about the longitudinal axis. In order to secure the insert element 250 in the bore, it has in the region of the insertion opening an annular bead 254 which engages in an annular groove 215 of the base body 210. This allows a further securing of the insert element 250 in the base body 210, e.g. a bonding or welding, omitted.
- the applicator 100 For filling the two reservoirs 111, 112 of the applicator 100 is complete with inserted piston 121, 122 attached to the filling device 200.
- the containers 300 are inserted into the corresponding container receptacles until they reach the removal position in which the septa of the container 300 are pierced and the containers are latched to the container receptacles.
- the piston unit 120 is withdrawn to separately and simultaneously remove the fluids from the two containers and to transfer them into the reservoirs 111, 112. Only a small amount of the respective fluid is lost in the filling device.
- an accessory such as a mixer or a sprayer, can be connected to the applicator, and the fluids can be discharged through the accessory from the applicator.
- FIGS. 6 to 8 a second embodiment of a filling device according to the invention is illustrated.
- This embodiment differs from the first embodiment mainly by the embodiment, the container receptacles.
- the container receptacles 260 are formed here as a chimney-like, cylindrical structures which have a sufficiently large length to accommodate the respective container in full length. While the container receptacles of the first embodiment were formed integrally with the base body 210, the container receptacles 260 of the second embodiment are formed separately from the base body 210 and connected thereto through a suitable connection, e.g. B. a welding connection connected.
- the respective inlet opening 213 in the base body 210 in this embodiment has a larger diameter than in the first embodiment.
- the container receptacle 260 has a bottom 264 from which a pin 265 extends into the inlet opening 213.
- a passage opening 266 through bottom 264 and pin 265 connects between the withdrawal channel of the piercing member 230 and the fluid channel in the base body 210, the piercing member 230 being inserted into a region of the enlarged diameter passage opening 266 and having a lower edge on a stop edge 267 is seated.
- a cylindrical shell wall 261 up.
- a part-cylindrical apron-like cover down which partially surrounds the base body 210 laterally and in particular covers the insertion opening 216 for the insert element 250.
- each case a latching structure 262, 263 is formed on two opposite sides.
- the first latching structure 262 lies further away from the base body 210 than the second latching structure 263.
- Each of the latching structures comprises a spring arm, at the free end of a latching lug is formed, which extends into the interior of the container receptacle 260 inside.
- the second latching structure 263 is arranged so that it fixes the container 300 in a completely inserted removal position in which the piercing member 230 has pierced the closure 220 by a latching connection.
- the latching lug of the second latching structure 263 engages in the region of the taper 313 of the container body and thus prevents retraction of the container from the container receptacle.
- the first latching structure 262 fixes the container to the container receptacle when the container is in a storage position in which the closure 320 is arranged at a certain distance from the tip of the piercing member 230.
- the first latching structure 262 on the one hand prevents the container 300 from being pulled out, on the other hand this latching structure also impedes further movement of the container 300 in the direction of the piercing member 230.
- the container receptacles may be formed in a different manner than in the manner shown here.
- a single container receptacle receives both containers together, for. B. in the manner of a common hood for both Container.
- the containers are held in a holding structure, and that the holding structure with the containers inserted therein is completely inserted into a corresponding container receptacle, as for example in some embodiments of the already mentioned US 6,488,650 the case is.
- a latching does not take place directly between the container receptacle and the respective container, but that such a latching takes place between the container receptacle and the holding structure inserted therein.
- applicator of the type specified here, of course, other types of applicators can be used, in particular applicators, as in WO 2009/144085 or WO 2007/109915 are illustrated. Conventional double syringes or unit-connected individual syringes can also be used. Accordingly, it is also possible to design the applicator according to different. In particular, of course, the distance of the outlet openings differently, in particular larger, can be selected as needed, as in the embodiments illustrated here. While the type of attachment of the applicator to the filling device shown here is advantageous, another type of connection between the filling device and the applicator can also be selected, for example a conventional luer connection.
- Such a filling device can also be used for filling different types of reservoirs from containers with a pierceable closure.
- cartridges containers with septum closure and displaceable piston
- another type of accessory may be connected, e.g. a mixer to mix the contents of two cartridges.
- the loss volume is reduced by using an insert element of the type mentioned, and / or if the carpules can be kept spaced from the piercing member by using suitable latching structures.
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
Claims (14)
- Dispositif pour prélever un fluide dans au moins un récipient, dans lequel le dispositif présente :un corps de base (210) comprenant une face supérieure et une face inférieure dans laquelle au moins un canal de fluide passant dans un sens longitudinal avec une section transversale constante ou modifiable est formé, sachant qu'au moins une ouverture d'admission (213) coudée par rapport au canal de fluide est formée sur la face supérieure du corps de base (210), laquelle débouche dans le canal de fluide, et sachant qu'au moins une sortie d'évacuation (214) coudée par rapport au canal de fluide est formée sur la face inférieure du corps de base (210), laquelle sort du canal de fluide en étant décalée de l'ouverture d'admission (213) par rapport au sens longitudinal ;au moins un raccord de récipient (220 ; 260) pour relier un récipient à l'ouverture d'admission (213),sachant qu'au moins une ouverture d'introduction (216) passant dans le sens longitudinal est formée dans le corps de base (210), laquelle débouche dans le canal de fluide, etsachant que le dispositif présente au moins un élément d'insertion (250) qui est introduit dans le canal de fluide à travers l'ouverture d'introduction (216) et réduit la section transversale du canal de fluide dans une zone entre l'ouverture d'admission (213) et la sortie d'évacuation (214),caractérisé en ce que le canal de fluide et l'élément d'insertion (250) sont formés en s'élargissant de façon conique au moins par tronçons en direction de l'ouverture d'introduction (216).
- Dispositif selon la revendication 1, dans lequel l'élément d'insertion (250) présente la forme d'un crayon qui s'étend le long de l'axe longitudinal.
- Dispositif selon la revendication 1 ou 2, dans lequel l'élément d'insertion (250) présente une face périphérique qui repose essentiellement en étanchéité sur une cloison de délimitation du canal de fluide, entre l'ouverture d'admission (213) et la sortie d'évacuation (214), sachant qu'une première rainure annulaire (251) est formée dans la face périphérique de l'élément d'insertion (250) au niveau de l'ouverture d'admission (213), laquelle s'étend au moins partiellement autour de l'élément d'insertion (250), sachant qu'une deuxième rainure annulaire (252) est formée au niveau de l'ouverture d'évacuation (214) dans la face périphérique, laquelle s'étend au moins partiellement autour de l'élément d'insertion (250), sachant qu'une liaison fluidique est formée entre la première rainure annulaire (251) et la deuxième rainure annulaire (252).
- Dispositif selon l'une des revendications précédentes, dans lequel l'élément d'insertion (250) présente une face périphérique qui repose essentiellement en étanchéité sur une cloison de délimitation du canal de fluide, entre l'ouverture d'admission (213) et la sortie d'évacuation (214), et sachant qu'un méplat et/ou une rainure de liaison (253) avec une section transversale constante ou variable est formée dans la face périphérique, laquelle établit une liaison fluidique entre l'ouverture d'admission (213) et la sortie d'évacuation (214).
- Dispositif selon l'une des revendications précédentes, dans lequel une structure d'encliquetage (254) est formée sur l'élément d'insertion et dans lequel une deuxième structure d'encliquetage complémentaire (215) est formée sur le corps de base, et dans lequel les première et deuxième structures d'encliquetage coopèrent pour maintenir l'élément d'insertion (250) en encliquetage sur l'élément de base (210).
- Dispositif selon la revendication 5, dans lequel la première structure d'encliquetage (254) comprend un boudin annulaire sur l'élément d'insertion (250), et dans lequel la deuxième structure d'encliquetage (215) comprend une rainure annulaire complémentaire dans une paroi d'enveloppe du canal de fluide ou de l'ouverture d'introduction.
- Dispositif selon l'une des revendications précédentes, destiné au remplissage d'au moins un réservoir (111) d'un applicateur (100), dans lequel le dispositif présente un raccord d'applicateur (240) pour relier le réservoir (111) de l'applicateur (100) à l'ouverture d'évacuation (214).
- Dispositif selon la revendication 7, dans lequel le raccord d'applicateur (240) est formé d'un seul tenant avec le corps de base (210).
- Dispositif selon l'une des revendications précédentes pour le prélèvement simultané de fluide dans au moins deux récipients (300),
dans lequel un deuxième canal de fluide passant dans le sens longitudinal avec une section transversale constante ou modifiable est formé dans le corps de base (210), sachant qu'une deuxième ouverture d'admission coudée par rapport au deuxième canal de fluide est formée sur la face supérieure du corps de base, laquelle débouche dans le deuxième canal de fluide, et sachant qu'une deuxième sortie d'évacuation coudée par rapport au deuxième canal de fluide est formée sur la face inférieure du corps de base, laquelle sort du deuxième canal de fluide en étant décalée de la deuxième ouverture d'admission par rapport au sens longitudinal ;
sachant que le dispositif présente un deuxième raccord de récipient pour relier un deuxième récipient à la deuxième ouverture d'admission ;
sachant qu'une deuxième ouverture d'introduction détournée de la première ouverture d'introduction et passant dans le sens longitudinal est formée dans le corps de base, laquelle débouche dans le deuxième canal de fluide, et
sachant que le dispositif présente un deuxième élément d'insertion qui est introduit dans le deuxième canal de fluide à travers la deuxième ouverture d'introduction et réduit la section transversale du deuxième canal de fluide entre la deuxième ouverture d'admission et la deuxième ouverture d'évacuation. - Dispositif selon l'une des revendications précédentes, dans lequel le dispositif présente au niveau du raccord de récipient (220), un organe de perforation (230) de type aiguille creuse relié à l'ouverture d'admission pour perforer un couvercle (320) du récipient (300).
- Dispositif selon la revendication 10, dans lequel le dispositif présente une réception de récipient (260) reliée au corps de base (210) pour maintenir le récipient (300) sur le dispositif et dans lequel la réception de récipient (260) présente une première structure d'encliquetage (262) pour fixer le récipient (300) dans une position de stockage dans laquelle le récipient (300) est plus éloigné du corps de base (210) que dans la position de prélèvement, par une liaison par encliquetage séparable sur la réception de récipient (260).
- Dispositif selon la revendication 11, dans lequel la réception de récipient (260) présente en outre une deuxième structure d'encliquetage (263) pour fixer le récipient (300) dans la position de prélèvement par une liaison par encliquetage sur la réception de récipient (260).
- Dispositif selon la revendication 11 ou 12, dans lequel la réception de récipient (260) présente une paroi d'enveloppe (261) de préférence au moins partiellement cylindrique et la première structure d'encliquetage (262) et la deuxième structure d'encliquetage (263) comprennent respectivement un bras à ressort formé dans la paroi d'enveloppe sur l'extrémité libre duquel est formé un ergot d'encliquetage s'étendant à l'intérieur de la paroi d'enveloppe.
- Dispositif selon l'une des revendications 11 - 13, dans lequel la réception de récipient (260) présente un fond (264) depuis lequel un tenon (265) s'étend dans l'intérieur de l'ouverture d'admission (213) du corps de base (210), sachant qu'une ouverture de passage (266) est formée par le tenon (265) et le fond (264) et sachant que l'organe de perforation (230) est maintenu dans l'ouverture de passage (266).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1152010 | 2010-02-01 | ||
PCT/CH2010/000314 WO2011091543A2 (fr) | 2010-02-01 | 2010-12-16 | Procédé pour prélever des fluides dans des flacons |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2531165A2 EP2531165A2 (fr) | 2012-12-12 |
EP2531165B1 true EP2531165B1 (fr) | 2013-11-20 |
Family
ID=42138969
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10747394.4A Active EP2531164B1 (fr) | 2010-02-01 | 2010-08-24 | Dispositif pour prélever un fluide dans un flacon |
EP10801102.4A Not-in-force EP2531165B1 (fr) | 2010-02-01 | 2010-12-16 | Procédé pour prélever des fluides dans des flacons |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10747394.4A Active EP2531164B1 (fr) | 2010-02-01 | 2010-08-24 | Dispositif pour prélever un fluide dans un flacon |
Country Status (4)
Country | Link |
---|---|
US (2) | US9402787B2 (fr) |
EP (2) | EP2531164B1 (fr) |
CN (2) | CN102791241B (fr) |
WO (2) | WO2011091542A1 (fr) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7547300B2 (en) | 2006-04-12 | 2009-06-16 | Icu Medical, Inc. | Vial adaptor for regulating pressure |
WO2010022095A1 (fr) | 2008-08-20 | 2010-02-25 | Icu Medical, Inc. | Adaptateurs de flacons anti-reflux |
CA2768985C (fr) | 2009-07-29 | 2020-03-10 | Icu Medical, Inc. | Dispositifs de transfert de fluides et procedes d'utilisation |
WO2011091542A1 (fr) * | 2010-02-01 | 2011-08-04 | Medmix Systems Ag | Dispositif pour prélever un fluide dans un flacon |
US20110253149A1 (en) * | 2010-04-20 | 2011-10-20 | Cesar Najera | Applicator for applying a barrier membrane to a body surface |
ES2545998T3 (es) * | 2010-12-30 | 2015-09-17 | Ge Healthcare Limited | Dispensación multivial |
WO2012146680A1 (fr) | 2011-04-28 | 2012-11-01 | Sanofi-Aventis Deutschland Gmbh | Technologie d'assemblage d'une interface de distribution |
EP4119121A1 (fr) | 2011-08-18 | 2023-01-18 | ICU Medical, Inc. | Adaptateurs pour flacons destinés à réguler la pression |
AU2012324021A1 (en) | 2011-12-22 | 2013-07-11 | Icu Medical, Inc. | Fluid transfer devices and methods of use |
WO2013106757A1 (fr) | 2012-01-13 | 2013-07-18 | Icu Medical, Inc. | Adaptateurs de flacon à régulation de pression et méthodes associées |
WO2013142618A1 (fr) | 2012-03-22 | 2013-09-26 | Icu Medical, Inc. | Adaptateurs de flacon à régulation de pression |
JP6067007B2 (ja) * | 2012-05-30 | 2017-01-25 | 三井化学株式会社 | 3成分接着剤用混合装置および3成分接着剤キット |
US9089475B2 (en) | 2013-01-23 | 2015-07-28 | Icu Medical, Inc. | Pressure-regulating vial adaptors |
CA2899000C (fr) | 2013-01-23 | 2022-07-12 | Icu Medical, Inc. | Adaptateurs pour flacon a regulation de pression |
CA2918381C (fr) | 2013-07-19 | 2023-01-17 | Icu Medical, Inc. | Systemes et procedes de transfert de fluides a pression regulee |
US9393177B2 (en) | 2013-08-20 | 2016-07-19 | Anutra Medical, Inc. | Cassette assembly for syringe fill system |
AU2014353184B2 (en) | 2013-11-25 | 2017-08-17 | Icu Medical, Inc. | Methods and system for filling IV bags with therapeutic fluid |
USD774182S1 (en) | 2014-06-06 | 2016-12-13 | Anutra Medical, Inc. | Anesthetic delivery device |
USD763433S1 (en) * | 2014-06-06 | 2016-08-09 | Anutra Medical, Inc. | Delivery system cassette |
AU2015277135B2 (en) | 2014-06-20 | 2020-02-20 | Icu Medical, Inc. | Pressure-regulating vial adaptors |
GB2535982A (en) * | 2015-02-13 | 2016-09-07 | Nerudia Ltd | System and apparatus |
EA202192380A1 (ru) * | 2015-06-16 | 2021-12-31 | Бёрингер Ингельхайм Ветмедика Гмбх | Система емкостей и способ приготовления смеси веществ |
HRP20231259T1 (hr) | 2015-06-16 | 2024-02-02 | Boehringer Ingelheim Vetmedica Gmbh | Sustav spajanja i spremnika s nagnutom lomljivom linijom |
MX2017016551A (es) | 2015-06-16 | 2018-05-11 | Boehringer Ingelheim Vetmedica Gmbh | Sistema de conexion y de recipiente. |
DE102015218723A1 (de) * | 2015-09-29 | 2017-03-30 | Transcoject Gmbh | Füllhilfe |
EP3383343A4 (fr) | 2015-12-04 | 2019-07-10 | ICU Medical, Inc. | Systèmes, procédés et composants pour le transfert de fluides médicaux |
USD877891S1 (en) * | 2015-12-22 | 2020-03-10 | Guangzhou Bioseal Biotech Co., Ltd. | Reconstitution and delivery device |
USD877890S1 (en) * | 2015-12-22 | 2020-03-10 | Guangzhou Bioseal Biotech Co., Ltd. | Reconstitution device |
ES2939370T3 (es) * | 2016-01-12 | 2023-04-21 | Freezio Ag | Sistema de dispensador con soporte para cartucho |
WO2017132588A1 (fr) | 2016-01-29 | 2017-08-03 | Icu Medical, Inc. | Adaptateurs pour flacon de régulation de pression |
US9956143B2 (en) * | 2016-06-14 | 2018-05-01 | Pharmac, Llc | Syringe apparatus for transferring liquids into and out of a vial having a septum |
USD851745S1 (en) | 2016-07-19 | 2019-06-18 | Icu Medical, Inc. | Medical fluid transfer system |
WO2018022640A1 (fr) | 2016-07-25 | 2018-02-01 | Icu Medical, Inc. | Systèmes, procédés et composants pour piéger des bulles d'air dans des modules et des systèmes de transfert de fluide médical. |
US10231846B2 (en) | 2016-08-19 | 2019-03-19 | Stryker European Holdings I, Llc | Bone graft delivery loading assembly |
EP3518860A4 (fr) | 2016-09-30 | 2020-06-10 | ICU Medical, Inc. | Dispositifs et procédés d'accès à un flacon à régulation de pression |
DE102016121607B4 (de) * | 2016-11-11 | 2019-05-16 | Heraeus Medical Gmbh | Vorrichtung und Verfahren zum Lagern und Mischen eines Knochenzements |
JP2020533030A (ja) * | 2017-07-20 | 2020-11-19 | ヤンセン バイオテツク,インコーポレーテツド | 薬剤混合装置 |
DE102018101041A1 (de) * | 2018-01-18 | 2019-07-18 | Heraeus Medical Gmbh | Knochenzementapplikator mit verschließbarer Begasungsöffnung |
KR20210068500A (ko) * | 2018-10-03 | 2021-06-09 | 다케다 야쿠힌 고교 가부시키가이샤 | 다중 용기용 패키징 |
US11590057B2 (en) | 2020-04-03 | 2023-02-28 | Icu Medical, Inc. | Systems, methods, and components for transferring medical fluids |
WO2021226564A1 (fr) * | 2020-05-08 | 2021-11-11 | Koska Family Limited | Systèmes et procédés pour dispositifs d'administration médicaux multiliquides pré-remplis |
DE102023201022A1 (de) * | 2023-02-08 | 2024-08-08 | B. Braun Melsungen Aktiengesellschaft | Adaptervorrichtung zur Kopplung mit einem medizinischen Vial |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1173370B (it) | 1984-02-24 | 1987-06-24 | Erba Farmitalia | Dispositivo di sicurezza per collegare una siringa alla imboccatura di un flacone contenente un farmaco o di un tubicino per l'erogazione del farmaco della siringa |
IE60235B1 (en) | 1986-09-18 | 1994-06-15 | Kabi Pharmacia Ab | "Connector and disposable assembly utilising said connector" |
US4913699A (en) * | 1988-03-14 | 1990-04-03 | Parsons James S | Disposable needleless injection system |
JPH021277A (ja) * | 1988-03-31 | 1990-01-05 | Fujisawa Pharmaceut Co Ltd | 輸液容器 |
US5037390A (en) * | 1989-12-28 | 1991-08-06 | Kenneth Raines | System and method for mixing parenteral nutrition solutions |
US5199949A (en) | 1991-03-08 | 1993-04-06 | Habley Medical Technology Corp. | Multiple pharmaceutical syringe |
CN1029082C (zh) * | 1991-03-08 | 1995-06-28 | 哈伯利医用技术公司 | 多种药物注射器 |
US5304165A (en) * | 1991-12-09 | 1994-04-19 | Habley Medical Technology Corporation | Syringe-filling medication dispenser |
US5226900A (en) * | 1992-08-03 | 1993-07-13 | Baxter International Inc. | Cannula for use in drug delivery systems and systems including same |
FR2716801B1 (fr) * | 1994-03-04 | 1996-09-06 | Pasteur Merieux Serums Vacc | Ensemble pour la répartition d'une solution pharmaceutique dans des carpules ou analogues, notamment après reprise d'un produit lyophilisé. |
GB9701413D0 (en) * | 1997-01-24 | 1997-03-12 | Smithkline Beecham Biolog | Novel device |
AU9496098A (en) | 1997-10-06 | 1999-04-27 | Karl H. Ehrenfels | Fibrin sealant applicator |
US6378714B1 (en) | 1998-04-20 | 2002-04-30 | Becton Dickinson And Company | Transferset for vials and other medical containers |
US6475183B1 (en) | 1998-06-03 | 2002-11-05 | Baxter International Inc. | Direct dual filling device for sealing agents |
US6358236B1 (en) | 1998-08-06 | 2002-03-19 | Baxter International Inc. | Device for reconstituting medicaments for injection |
US6610033B1 (en) | 2000-10-13 | 2003-08-26 | Incept, Llc | Dual component medicinal polymer delivery system and methods of use |
DE502004005171D1 (de) * | 2003-03-06 | 2007-11-22 | Csl Behring Gmbh | Transfervorrichtung, insbesondere für medizinische Fluids |
US20040249235A1 (en) * | 2003-06-03 | 2004-12-09 | Connell Edward G. | Hazardous material handling system and method |
JP3883527B2 (ja) * | 2003-07-17 | 2007-02-21 | ニプロ株式会社 | トランスファーニードル |
FR2878737B1 (fr) * | 2004-12-07 | 2007-03-16 | Maptech Soc Par Actions Simpli | Dispositif de securite pour flacon a usage medical |
WO2007109915A1 (fr) | 2006-03-24 | 2007-10-04 | Medmix Systems Ag | Dispositif de distribution avec accessoires pouvant être fixés de maniere amovible |
DE102006031712B3 (de) * | 2006-07-08 | 2007-12-06 | Haindl, Hans, Dr.med. Dipl.-Ing. | Transfervorrichtung zur Überleitung einer Flüssigkeit aus einer ersten Flasche in eine zweite Flasche |
EP2279021B1 (fr) | 2008-04-18 | 2013-02-13 | Kuros Biosurgery AG | Dispositif de distribution, ensemble contenant le dispositif, et procédé d'utilisation du dispositif |
WO2011091542A1 (fr) * | 2010-02-01 | 2011-08-04 | Medmix Systems Ag | Dispositif pour prélever un fluide dans un flacon |
-
2010
- 2010-08-24 WO PCT/CH2010/000206 patent/WO2011091542A1/fr active Application Filing
- 2010-08-24 US US13/576,352 patent/US9402787B2/en active Active
- 2010-08-24 CN CN201080062915.5A patent/CN102791241B/zh active Active
- 2010-08-24 EP EP10747394.4A patent/EP2531164B1/fr active Active
- 2010-12-16 EP EP10801102.4A patent/EP2531165B1/fr not_active Not-in-force
- 2010-12-16 CN CN201080062919.3A patent/CN102770110B/zh not_active Expired - Fee Related
- 2010-12-16 US US13/576,360 patent/US20120298254A1/en not_active Abandoned
- 2010-12-16 WO PCT/CH2010/000314 patent/WO2011091543A2/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP2531165A2 (fr) | 2012-12-12 |
US20120302986A1 (en) | 2012-11-29 |
EP2531164A1 (fr) | 2012-12-12 |
CN102770110A (zh) | 2012-11-07 |
CN102770110B (zh) | 2015-09-16 |
WO2011091543A3 (fr) | 2012-08-16 |
CN102791241B (zh) | 2015-04-08 |
US9402787B2 (en) | 2016-08-02 |
WO2011091542A1 (fr) | 2011-08-04 |
WO2011091543A2 (fr) | 2011-08-04 |
CN102791241A (zh) | 2012-11-21 |
US20120298254A1 (en) | 2012-11-29 |
EP2531164B1 (fr) | 2014-05-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2531165B1 (fr) | Procédé pour prélever des fluides dans des flacons | |
EP2544648B1 (fr) | Dispositif de remplissage modulaire pour un applicateur | |
DE69712499T2 (de) | Abgabesystem für in pharmazeutischen phiolen verpackte arzneimittel | |
DE60019446T2 (de) | Flüssigkeitstransferset für phiolen und andere medizinische behälter | |
DE60315006T2 (de) | Vorrichtung zum mischen von medizinischen flüssigkeiten | |
DE69903266T2 (de) | Flüssigkeitstransfervorrichtung für phiole und verfahren | |
DE69613461T2 (de) | Durchflussregelvorrichtung | |
EP2903583B1 (fr) | Dispositif de transfert pour prélever ou transférer un fluide | |
EP2001430B1 (fr) | Systeme de preparation et de fourniture d'un fluide versable forme par melange d'une substance seche et d'un fluide | |
EP2533832B1 (fr) | Connecteur pour récipient contenant un agent actif médical | |
DE102008025011A1 (de) | Ampulle mit Ampullenhalterung | |
EP2667838A1 (fr) | Dispositif de liaison destiné à relier un premier réservoir à un deuxième réservoir | |
DE102004036051A1 (de) | Spritze | |
DE2648795A1 (de) | Vorgefuellte, leicht betriebsfertig zu machende injektionsspritze | |
DE10034270A1 (de) | Vorratsbehältnis mit einer Dosiereinrichtung zur dosierten Abgabe eines injizierbaren Produkts an ein Injektionsgerät | |
DE29915878U1 (de) | Vorrichtung zur Umfüllung von Arzneimitteln und Kanülenanordnung | |
EP4203889A1 (fr) | Dispositif de couplage pour un adaptateur pour un flacon, adaptateur pour un flacon, ensemble comprenant un tel adaptateur, et système comprenant un tel adaptateur | |
CH633967A5 (de) | Zweikammerspritze in form einer injektionsspritze. | |
DE102005006771A1 (de) | Fluidtransfervorrichtung | |
EP2744468B1 (fr) | Adaptateur pour un dispositif de transfert de fluide et dispositif de transfert | |
WO2010085903A1 (fr) | Dispositif d'administration comprenant un élément de maintien pour le réservoir à fluide | |
EP3291787A1 (fr) | Système de prélèvement de contenu de récipient | |
WO2020239791A1 (fr) | Corps médical creux, corps médical creux doté d'un capuchon de fermeture, procédé de fabrication d'un corps médical creux, et kit | |
DE19604113C2 (de) | Einkammer-Transfersystem für Wirksubstanzen, und der daraus fertig montierte Transferbehälter | |
DE1491819C (de) | Spntzengestellanordnung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20120719 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
DAX | Request for extension of the european patent (deleted) | ||
INTG | Intention to grant announced |
Effective date: 20130613 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D Free format text: NOT ENGLISH |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: REF Ref document number: 641131 Country of ref document: AT Kind code of ref document: T Effective date: 20131215 |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D Free format text: LANGUAGE OF EP DOCUMENT: GERMAN |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: NV Representative=s name: ISLER AND PEDRAZZINI AG, CH |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R096 Ref document number: 502010005458 Country of ref document: DE Effective date: 20140116 |
|
REG | Reference to a national code |
Ref country code: NL Ref legal event code: VDEP Effective date: 20131120 |
|
REG | Reference to a national code |
Ref country code: LT Ref legal event code: MG4D |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 Ref country code: HR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20140320 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 Ref country code: NL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 Ref country code: NO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20140220 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: ES Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 Ref country code: LV Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 Ref country code: RS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 |
|
BERE | Be: lapsed |
Owner name: MEDMIX SYSTEMS A.G. Effective date: 20131231 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20140320 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R097 Ref document number: 502010005458 Country of ref document: DE |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: MM4A |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 |
|
26N | No opposition filed |
Effective date: 20140821 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20131216 Ref country code: BE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20131231 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R097 Ref document number: 502010005458 Country of ref document: DE Effective date: 20140821 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 20141211 Year of fee payment: 5 Ref country code: GB Payment date: 20141219 Year of fee payment: 5 Ref country code: CH Payment date: 20141212 Year of fee payment: 5 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FR Payment date: 20141219 Year of fee payment: 5 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MC Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SM Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R082 Ref document number: 502010005458 Country of ref document: DE Representative=s name: HOEGER, STELLRECHT & PARTNER PATENTANWAELTE MB, DE |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20131216 Ref country code: MK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 Ref country code: HU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO Effective date: 20101216 Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20131120 Ref country code: MT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 Ref country code: IT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20140221 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R119 Ref document number: 502010005458 Country of ref document: DE |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: TR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20151216 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: ST Effective date: 20160831 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20151216 Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20151231 Ref country code: DE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160701 Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20151231 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20151231 |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: MM01 Ref document number: 641131 Country of ref document: AT Kind code of ref document: T Effective date: 20151216 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: AT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20151216 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: AL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20131120 |