EP2531165A2 - Procédé pour prélever des fluides dans des flacons - Google Patents

Procédé pour prélever des fluides dans des flacons

Info

Publication number
EP2531165A2
EP2531165A2 EP10801102A EP10801102A EP2531165A2 EP 2531165 A2 EP2531165 A2 EP 2531165A2 EP 10801102 A EP10801102 A EP 10801102A EP 10801102 A EP10801102 A EP 10801102A EP 2531165 A2 EP2531165 A2 EP 2531165A2
Authority
EP
European Patent Office
Prior art keywords
container
fluid channel
base body
fluid
inlet opening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP10801102A
Other languages
German (de)
English (en)
Other versions
EP2531165B1 (fr
Inventor
William Brem
Ralph Egon Kayser
Andy Greter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medmix Systems AG
Original Assignee
Medmix Systems AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medmix Systems AG filed Critical Medmix Systems AG
Publication of EP2531165A2 publication Critical patent/EP2531165A2/fr
Application granted granted Critical
Publication of EP2531165B1 publication Critical patent/EP2531165B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2058—Connecting means having multiple connecting ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents

Definitions

  • the present invention relates to an apparatus for withdrawing a fluid from at least one container, in particular from a container closed by a pierceable closure, e.g. a vial with septum closure.
  • the present invention relates to a device for filling an applicator with at least one fluid reservoir of one or more vials.
  • the task is to produce and discharge a mixture of two or more flowable components in a predetermined mixing ratio.
  • an adhesive for technical or medical applications, eg a fibrin-based medical adhesive.
  • Another example is the preparation of a multi-component bone cement using a monomer.
  • drugs that are made by mixing two or more components that are non-storable in the mixed state. In this case, it is desirable to first store the components separately and to mix them just prior to their administration. Similar objects also arise in other pharmaceutical or chemical systems of two or more components that are not stable in the mixed state.
  • the device has a connection region on which two connections for the reservoirs are formed. On the opposite side of a hood for receiving the vials is formed.
  • the septa of the vials are pierced by hollow needles, which communicate via fluid channels with the connections for the reservoirs.
  • the fluid channels divert the fluids between the vials and the reservoir ports so that the reservoir spacing may be less than the pitch of the hollow needles.
  • the structure of such a filling device is relatively complicated: the device comprises two separately formed housing halves, which must be connected together to form the connection area and the hood. Before connecting the two halves, the fluid channels are inserted with the connections for the reservoirs and with the hollow needles in the housing halves.
  • FIGS. 8-14 discloses in FIGS. 8-14 a filling device for a double-syringe applicator made of vials.
  • This filling device has a disc-like base body with a bottom and a top. At the top two inlet openings are spaced apart from each other, which are connected to piercing organs in cup-like Vialhaltern. At the bottom two outlet ports are formed with a smaller distance, to which the applicator is connectable. In each case one inlet opening and outlet opening are connected to one another by a fluid channel running perpendicular to these openings.
  • This filling device also has a relatively large loss volume.
  • the vials are usually simply inserted into the device to puncture the septa. In some of these devices, the vials are then, after complete insertion into the device and after piercing the septa, fixed by a snap connection to the device.
  • known devices are usually not suitable to the vials directly to the Store as it can not be ruled out that the septum of a vial is inadvertently punctured during transport or handling.
  • the present invention provides an adapter-like device which makes it possible to remove a fluid from a container, wherein the fluid is deflected in the device, e.g. to fill at least one reservoir of an applicator from at least one container with a fluid, wherein the device has a reduced loss volume.
  • a device for removing a fluid from at least one container is specified.
  • the device has a base body with an upper side and a lower side, in which at least one fluid channel running along a longitudinal direction with a constant or variable cross-section is formed.
  • At the top of the base body is at least one angled (ie angle not equal to 0 °, preferably amount of the angle> 30 °, more preferably perpendicular) formed to the fluid passage inlet opening, which opens into the fluid channel, and at the bottom of the base body is at least one angled (Preferably, the amount of the angle> 30 °, more preferably perpendicular) to the fluid passage extending outlet opening formed, which also opens into the fluid channel.
  • the outlet opening is arranged offset to the inlet opening, ie the outlet opening and the inlet opening open at different locations along the fluid channel.
  • the device also includes at least one container port to connect a container to the inlet port, which may be done in any manner.
  • At least one insertion opening extending along the longitudinal direction is formed in the base body and opening into the fluid passage, and an insert member is inserted into the fluid passage through the insertion opening.
  • This insert member extends into the fluid channel such that it reduces the cross section of the fluid channel in a region between the inlet opening and the outlet opening.
  • the insert element may have the form of a pin which extends into the fluid channel along the longitudinal axis.
  • the insert member is preferably sealing in the fluid channel, ie it preferably has a peripheral surface (skirt surface) substantially sealingly abutting a boundary wall of the fluid channel between the inlet port and the outlet port, and communicating with a reduced fluid port alone or together with a confining wall of the fluid channel Cross-section.
  • a first annular groove may be formed, which is at least partially (preferably completely ) extends around the insert element, and in the region of the outlet opening, a second annular groove can be formed in the peripheral surface, which likewise extends at least partially (preferably completely) around the insert element.
  • the mentioned fluid connection is formed. This may be formed, for example, in the form of a connecting groove which connects the two annular grooves, or it may be formed, for example, as a bore through the insert element.
  • a connection groove is preferred.
  • a flattening may be formed, which delimits a gap between the boundary wall of the fluid channel and the insert element.
  • the gap forms at least part of the fluid connection mentioned.
  • Such a connecting groove or flattening can also be advantageously used if no annular grooves are present, for example because the insert element is not rotationally symmetrical and therefore can be guided in any case only in a single, fixed orientation with respect to a rotation about the longitudinal axis.
  • the connecting groove or flattening may be parallel to the longitudinal direction or obliquely thereto, for example, helically wound or meandering, extend, but the shortest possible configuration is preferred in order to keep the loss volume low.
  • the insert element is preferably arranged sealingly in the base body, so that the fluid can not get into these areas.
  • a first latching structure may be formed on the insert element, and then a complementary second latching structure is formed on the base body. These locking structures then work together to hold the insert latching in the base member.
  • the first latching structure may comprise an annular bead on the insert element, while the second latching structure comprises a complementary annular groove in a jacket wall of the fluid channel or the import opening.
  • the fluid channel and the insert element of complementary shape and at least partially (preferably at least in the area between inlet opening and outlet opening) widen conically towards the entrance opening.
  • the device can be used in particular as a filling device or adapter for filling at least one reservoir of an applicator from at least one container, in particular a vial.
  • the applicator can be a syringe-like applicator in which the reservoir is delimited by a movable piston, so that the reservoir can be filled by retracting the piston from a distal end position into a proximal direction.
  • the device preferably has an applicator connection in order to connect the reservoir of the applicator to the outlet opening.
  • the applicator connection can be equipped with a holding device, in particular with a detachable latching connection, for the applicator. It can be made in one piece with the base body or separately from it.
  • the applicator connection is formed, for example, by a female luer cone;
  • preferred is a special embodiment in which the loss volume is less than in a normal standardized luer connection, for example, an embodiment according to the embodiments described below.
  • the device serves to remove the fluid from at least one vial or other container with a pierceable closure, it preferably has in the region of the container connection a hollow needle-like piercing member connected to the inlet opening in order to pierce a closure of the container.
  • the device in the region of the container connection preferably has a container receptacle which is designed to hold the container to the device.
  • the device can also be used for other purposes, such as an adapter for connecting a container to an accessory, such as a mixer or atomizer. Also in such applications, it may be desirable to divert fluid between the container and the accessory while minimizing the loss volume.
  • the container may then be eg a carpule (ie a container with pierceable closure and displaceable piston) or a single or multiple syringe, and the container connection may then be designed accordingly.
  • a suitably designed connection for the accessory can then be present.
  • the device can be configured for the simultaneous removal of fluids from at least two containers.
  • the two fluid channels preferably run collinearly one behind the other along the longitudinal direction, wherein the insert elements are introduced from two opposite sides into the two fluid channels.
  • a second fluid channel having a constant or variable cross-section running along the longitudinal direction is formed, on the upper side of the base body there is formed an second inlet opening extending at an angle to the second fluid channel, which opens into the second fluid channel, and at the bottom of the base body is an angled to the second fluid channel extending second outlet opening formed, which opens with respect to the longitudinal direction offset from the second inlet opening of the second fluid channel.
  • the device then has a second container port to connect a second container to the second inlet port.
  • the base body is then running along the longitudinal direction, the The first filling device facing away from the second trained Einmhrörrhung, which opens into the second fluid channel, and the Befullvorraum has a second insert element, which is inserted through the second Emglassöffhung in the second fluid channel and reduces the cross section of the second fluid channel between the second inlet opening and the second Auslassöffiiung.
  • the present invention provides an adapter-like device for withdrawing a fluid from at least one container closed by a pierceable closure, which makes it possible to store the container on the device without unintentionally opening the container.
  • a pierceable closure Such a device is specified in claim 12.
  • the two aspects of the invention can be used individually or combined with each other.
  • an apparatus for removing a fluid from at least one of a container closed by a pierceable closure, in particular a vial which comprises:
  • a base body in which an inlet port and an outlet port are formed, which are connected by a fluid passage;
  • a hollow needle-like piercing member connected to the inlet opening in order to pierce the closure of the container, in particular a septum closure, in a removal position of the container;
  • the container receptacle In order to securely hold the container to the device prior to piercing the closure and to prevent accidental puncturing, the container receptacle has a first latching structure to move the container to a storage position where the container is farther from the base body than in the removal position (And in the thereby the closure is not pierced) to fix by a releasable locking connection to the Be bacheloreraufhahme.
  • the container is also fixed in the removal position, and the Be Daveeraufhahme then additionally has a second latching structure to the container in the To fix removal position by a latching connection to the container space.
  • the latching structures can interact directly or indirectly with the container.
  • the container can be inserted directly into the container space, the latching structures being attached directly to a corresponding retention structure, e.g. a rejuvenation, attack the container, or the container may be held on a separate holder which is inserted into the container space or pushed onto this, wherein the latching structures of the container space cooperate with a corresponding Trocldialte Modell of the holder.
  • the container space has only a single latching structure, while the container or the holder has two retaining structures, wherein in the storage position, the first of these retention structures with the (single) latching structure cooperates, while in the removal position, the second of these Hincl holding structures cooperates with the latching structure.
  • the container receptacle has a preferably at least partially cylindrical jacket wall.
  • the first latching structure and the second latching structure each comprise a spring arm formed in the casing wall, at the free end of which a latching nose extending into the interior of the casing wall is formed. This allows a very simple and inexpensive production.
  • the latching structures are preferably arranged offset with respect to the circumferential direction of the jacket wall, in particular by approximately 180 ° offset, i. diametrically opposite one another in order to claim as little space as possible with the greatest possible stability of the container receptacle.
  • the container space can be constructed in particular as follows: It has a bottom, from which a pin extends into the inlet opening of the base body. Through the pin and bottom through a passage opening is formed, and the piercing member is held in the passage opening.
  • a device can also be designed as a filling device for an applicator, with an applicator connection of the type specified above. But it can also turn, for example, to remove a fluid from a Serving carpule.
  • this device can also be designed for the simultaneous removal of fluids from at least two containers.
  • the latching structures can be designed so that they fix the two or more containers simultaneously in the storage position or in the removal position.
  • the container receptacle may include a cover, e.g. an apron extending downwardly from the floor, which covers the insertion opening for the insert element. This additionally secures the insert element in the base body.
  • a cover e.g. an apron extending downwardly from the floor, which covers the insertion opening for the insert element. This additionally secures the insert element in the base body.
  • the base body, the container frame and the applicator connection are preferably made of a thermoplastic by injection molding.
  • FIG. 1 shows a perspective view of a first embodiment of a filling device according to the invention
  • FIG. 2 shows the filling device of FIG. 1 with inserted vials
  • FIG. 3 shows a central longitudinal section through the filling device of FIG. 2;
  • Fig. 4 is a detail view of the area A of Fig. 3;
  • Fig. 5 is an enlarged perspective view of an insert member
  • FIG. 6 is a perspective view of a second embodiment of a filling device according to the invention.
  • FIG. 7 shows a partial view of a central longitudinal section through the filling device of FIG. 6; FIG. and
  • FIG. 8 shows a detailed view of the region B of FIG. 7.
  • FIGS. 1 to 5 illustrate a first exemplary embodiment of a filling device according to the invention.
  • the filling device 200 has a base body 210 of elongate, substantially disk-shaped basic shape.
  • a central, cylindrical thickening 211 is formed, to which the two halves of a flat support plate 212 connect.
  • the thickening 211 defines with its cylinder axis a longitudinal direction.
  • a blind hole-like longitudinal bore is formed, each ending just before the middle of the thickening ( Figures 3 and 4).
  • Each of these holes widens slightly conically towards its open end to form a fluid channel.
  • the two holes are collinear with each other, i. they lie on the same axis one behind the other.
  • an inlet opening 213 is formed in the region of the thickening for each of the bores (FIG. 4).
  • This inlet opening 213 connects the respective bore with a respective cup-shaped container receptacle 220.
  • the container receptacle 220 has a circumferential cylindrical jacket wall which is designed to be multiply slotted from its upper edge so that each of the sections of the jacket wall interrupted by a slot forms a spring arm , Retaining lugs protrude inwardly at the free ends of these resilient arm portions to latch a container 300 in a picking position on the container receptacle.
  • the containers 300 are present here in the form of so-called vials with septum closure.
  • Each container comprises a Be Strukturerköper 310, which is preferably made of glass, but may also consist of special plastic.
  • a circumferential cylindrical jacket wall 312 which has a taper 313 near the bottom distal end.
  • the associated closure 320 comprises a septum 321 (a pierceable, self-closing Membrane, see Fig. 4), which is supported by a crimped metal cover leaving a central part of the septum on the container opening.
  • a piercing member 230 of relatively hard plastic is inserted into the inlet opening 213, ending in a tip 231 at its upper end.
  • a removal opening 232 is formed, which is connected to a central withdrawal channel 233, which in turn opens into the inlet opening 213 of the base body 210.
  • an outlet opening 214 is formed which leads to an applicator connection 240.
  • the applicator port 240 is formed integrally with the base body 210, but may be separately formed in front of the base body 210 and connected to the base body 210 in a suitable manner, e.g. glued or welded, be.
  • a double-syringe-like applicator 100 can be attached and detachably fastened.
  • the applicator has an applicator body 110 with two cylindrical, parallel, proximally open reservoirs 111, 112 of equal or (here) different volume.
  • the reservoirs open at their distal ends into outlets 116, 117.
  • a piston 121, 122 is inserted in the open proximal ends of the reservoirs in each case a piston 121, 122 is inserted.
  • the two pistons are connected together at their proximal ends to form a piston unit.
  • an actuating surface 123 is formed for a user's thumb.
  • a retaining flange 113 serves to hold the applicator by means of index and middle fingers.
  • the applicator can be handled in this respect as a commercial double syringe.
  • the present connection between the applicator 100 and the filling device 200 functionally corresponds essentially to the connection between a syringe / cartridge and an accessory described in WO 2007/109915.
  • the applicator 100 and the filling device 200 comprise retention means configured according to this document.
  • the applicator connection is designed as follows: Each of the outlet openings 214 of the two fluid channels opens into one conically widening import area for the outlets 116, 117 of the applicator 100. These outlets are designed to be complementary to the Emscented Schemeen and can be plugged into these import areas.
  • the applicator near its distal end, adjacent to the outlets, on two opposite sides two webs with latching noses 115 on.
  • the applicator connection 240 has a cylindrical receiving region 241 which radially surrounds the insertion regions and the webs with the latching noses and on which two opposite snap-in openings are formed.
  • the latching noses 115 snap when inserting the applicator in the Einschnappöfrhungen the receiving area 241 a.
  • the receiving area 241 is elastically deformable in such a way that the latching connection between the latching noses 115 and the corresponding latching openings is compressed by pressure on a wall area offset from the latching openings by approximately 90 degrees with respect to the cylinder axis of the receiving area of the receiving area 241 is releasable again.
  • the receiving area 241 is deformed such that the Einschnappöfmungen be pressed radially outwardly away from the latching lugs 115 and thereby get out of engagement with the latching noses.
  • two opposite pressure wings 243 are formed on the support plate 212.
  • a lateral compression of the two pressure vanes 243 is transferred offset to the Einschnappöfmungen on the cylindrical on ahme Colour 241 of the applicator 240 and thereby leads to release the locking connection between the applicator 100 and the filling device 200.
  • a Codiereriel 114 on the applicator 100 and a corresponding Codierflügel 242 the filling device 200 indicate the correct orientation of the applicator 100 when connecting to the filling device 200.
  • the terminals themselves are formed differently to ensure that the applicator 100 only in the correct orientation can be connected to the filling device 200.
  • each of the two longitudinally extending bores of the base body 210 is inserted in each case a pin-shaped or needle-shaped insert element 250, which is shown in FIG. 5 alone.
  • the insert member 250 serves to reduce the cross section of the fluid passage formed by the bore between the inlet port 213 and the outlet port 214.
  • the insert element 250 is formed substantially complementary to the bore in the base body 210 and in particular also extends slightly towards the free end of the bore, so that it rests with its peripheral surface substantially sealingly against the boundary wall of the bore.
  • a first annular groove 251 is formed in the circumferential surface of the insert element 250, while a second annular groove 252 is formed in the region of the outlet opening 214.
  • These annular grooves are interconnected by a longitudinally extending connecting groove.
  • the annular grooves 251, 252 and the communication groove 253 provide a fluid communication between the intake port 213 and the exhaust port 214, which is common to the grooves and the boundary wall of the fluid passage.
  • a straight connecting groove and a different shape can be selected.
  • a flattening may also be provided on the circumferential surface, or the connecting groove may be formed by a fine, e.g. diagonal hole to be replaced.
  • the insert member 250 can be easily and in any orientation along the longitudinal direction in the open end of the bore insert, wherein the open end of the bore forms an Emgradöffhung 216 for the insert element. Because of the circumferential annular grooves 251, 252, it does not depend on the exact orientation of the insert element with respect to a rotation of the insert element about the longitudinal axis. In order to secure the insert element 250 in the bore, it has an annular bead 254 in the region of the insertion opening, which engages in an annular groove 215 of the base body 210. This allows a further securing of the insert element 250 in the base body 210, e.g. a bonding or welding, omitted.
  • the applicator 100 For filling the two reservoirs 111, 112 of the applicator 100 is complete with inserted piston 121, 122 attached to the filling device 200.
  • the containers 300 are inserted into the corresponding container receptacles until they reach the removal position in which the septa of the container 300 are pierced and the containers are latched to the container receptacles.
  • the piston unit 120 is withdrawn to separately and simultaneously remove the fluids from the two containers and to transfer them into the reservoirs 111, 112. Only a small amount of the respective fluid is lost in the filling device.
  • an accessory such as a mixer or a sprayer, can be connected to the applicator, and the fluids can be discharged through the accessory from the applicator.
  • FIGS. 6 to 8 illustrate a second embodiment of a filling device according to the invention.
  • This embodiment differs from the first embodiment, mainly by the embodiment, the Be Daveeraufhahmen.
  • the Be Daveeraufhahmen 260 are here formed as a fireplace-like, cylindrical structures having a sufficiently large length to accommodate the respective container in length completely. While the container housings of the first embodiment were integrally formed with the base body 210, the container housings 260 of the second embodiment are formed separately from the base body 210 and connected thereto through a suitable connection, e.g. B. a welding connection connected.
  • the respective inlet opening 213 in the base body 210 in this embodiment has a larger diameter than in the first embodiment.
  • the container space 260 has a bottom 264 from which a pin 265 extends into the inlet opening 213.
  • a passage opening 266 through bottom 264 and pin 265 connects between the withdrawal channel of the piercing member 230 and the fluid channel in the base body 210, the piercing member 230 being inserted into a region of the enlarged diameter passage opening 266 and having a lower edge on a stop edge 267 is seated.
  • a cylindrical shell wall 261 up.
  • a part-cylindrical apron-like cover down which surrounds the base body 210 laterally partially and in particular the Einruhrötrhung 216 for the insert element 250 covers.
  • a latching structure 262, 263 is formed on two opposite sides.
  • the first latching structure 262 lies further away from the base body 210 than the second latching structure 263.
  • Each of the latching structures comprises a spring arm, at the free end of a latching lug is formed, which extends into the interior of the Be bachelorerholzhahme 260 inside.
  • the second latching structure 263 is arranged so that it fixes the container 300 in a completely inserted removal position in which the piercing member 230 has pierced the closure 220 by a latching connection.
  • the latching lug of the second latching structure 263 engages in the region of the taper 313 of the container body and thus prevents the container from being withdrawn from the container receptacle.
  • the first latching structure 262 fixes the container to the container receptacle when the container is in a storage position in which the closure 320 is arranged at a certain distance from the tip of the piercing member 230.
  • the first latching structure 262 prevents the container 300 from being pulled out, on the other hand this latching structure also impedes further movement of the container 300 in the direction of the piercing member 230.
  • this latching structure In order to advance the container further in the direction of the piercing member 230 and thus puncture the closure, must an increased force is expended. About an away from the base body inclined surface is pressed by this increased force, the locking lug to the outside and releases the container for further movement.
  • the Be Davenauerhahmen may be formed in a different manner than in the manner shown here.
  • a single Be mutualeraufhahme receiving both containers together for. B. in the manner of a common hood for both Container.
  • the containers are held in a holding structure, and that the holding structure with the containers inserted therein is completely inserted into a corresponding Be mutualeraufiiahme, as is the case for example in some embodiments of the aforementioned US 6,488,650.
  • Such a filling device can also be used for filling different types of reservoirs from containers with a pierceable closure.
  • cartridges containers with septum closure and displaceable piston
  • another type of accessory may be connected, e.g. a mixer to mix the contents of two cartridges.
  • the loss volume is reduced by using an insert element of the type mentioned, and / or if the carpules can be kept spaced from the piercing member by using suitable latching structures.
  • Applicator body 240 applicator port first reservoir 241 receiving area second reservoir 242 Codierhoffl
  • Piston unit 254 annular bead first piston 260 container housing second piston 261 shell wall
  • Support plate 267 stop edge

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

L'invention concerne un dispositif pour prélever un fluide dans au moins un contenant (300), par exemple dans un flacon, présentant une fermeture pouvant être perforée. Ce dispositif présente un corps de base (210) dans lequel est ménagé un canal à fluide. Afin de réduire le volume de perte, un insert (250) en forme de broche est introduit, à travers une ouverture d'introduction, dans le canal à fluide, ledit insert réduisant la section transversale de ce dernier. Afin de pouvoir stocker le contenant sur le dispositif, sans perforer accidentellement la fermeture, le dispositif selon l'invention peut présenter des structures d'arrêt (262, 263) qui maintiennent le contenant d'une part dans une position de prélèvement et d'autre part dans une position de stockage, différente de cette dernière, sur le dispositif. Un tel dispositif peut servir en particulier à remplir un applicateur (100) comportant un ou plusieurs réservoirs de fluide à partir d'un ou de plusieurs flacons.
EP10801102.4A 2010-02-01 2010-12-16 Procédé pour prélever des fluides dans des flacons Not-in-force EP2531165B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1152010 2010-02-01
PCT/CH2010/000314 WO2011091543A2 (fr) 2010-02-01 2010-12-16 Procédé pour prélever des fluides dans des flacons

Publications (2)

Publication Number Publication Date
EP2531165A2 true EP2531165A2 (fr) 2012-12-12
EP2531165B1 EP2531165B1 (fr) 2013-11-20

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
EP10747394.4A Active EP2531164B1 (fr) 2010-02-01 2010-08-24 Dispositif pour prélever un fluide dans un flacon
EP10801102.4A Not-in-force EP2531165B1 (fr) 2010-02-01 2010-12-16 Procédé pour prélever des fluides dans des flacons

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP10747394.4A Active EP2531164B1 (fr) 2010-02-01 2010-08-24 Dispositif pour prélever un fluide dans un flacon

Country Status (4)

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US (2) US9402787B2 (fr)
EP (2) EP2531164B1 (fr)
CN (2) CN102791241B (fr)
WO (2) WO2011091542A1 (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7547300B2 (en) 2006-04-12 2009-06-16 Icu Medical, Inc. Vial adaptor for regulating pressure
WO2010022095A1 (fr) 2008-08-20 2010-02-25 Icu Medical, Inc. Adaptateurs de flacons anti-reflux
WO2011014525A2 (fr) 2009-07-29 2011-02-03 Icu Medical, Inc. Dispositifs de transfert de fluides et procédés d'utilisation
US9402787B2 (en) * 2010-02-01 2016-08-02 Medmix Systems Ag Device for removing a fluid from a vial
US20110253149A1 (en) * 2010-04-20 2011-10-20 Cesar Najera Applicator for applying a barrier membrane to a body surface
WO2012092564A2 (fr) * 2010-12-30 2012-07-05 Ge Healthcare Limited Distribution à plusieurs flacons
JP2014518664A (ja) 2011-04-28 2014-08-07 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 投薬インターフェースの接合技術
WO2013025946A1 (fr) 2011-08-18 2013-02-21 Icu Medical, Inc. Adaptateurs pour flacons destinés à réguler la pression
EP4218857A3 (fr) 2011-12-22 2023-10-25 ICU Medical, Inc. Dispostifs de transfert de fluide et procédés d'utilisation
CN104168948B (zh) 2012-01-13 2017-03-01 Icu医学有限公司 控压型管形瓶接头和方法
AU2013204180B2 (en) 2012-03-22 2016-07-21 Icu Medical, Inc. Pressure-regulating vial adaptors
JP6067007B2 (ja) * 2012-05-30 2017-01-25 三井化学株式会社 ３成分接着剤用混合装置および３成分接着剤キット
ES2739291T3 (es) 2013-01-23 2020-01-30 Icu Medical Inc Adaptadores de vial de regulación de presión
US9089475B2 (en) 2013-01-23 2015-07-28 Icu Medical, Inc. Pressure-regulating vial adaptors
WO2015009746A2 (fr) 2013-07-19 2015-01-22 Icu Medical, Inc. Systèmes et procédés de transfert de fluides à pression régulée
US9579257B2 (en) 2013-08-20 2017-02-28 Anutra Medical, Inc. Haptic feedback and audible output syringe
JP6259113B2 (ja) 2013-11-25 2018-01-10 アイシーユー・メディカル・インコーポレーテッド 点滴バッグに治療用流体を充填するための方法およびシステム
USD774182S1 (en) 2014-06-06 2016-12-13 Anutra Medical, Inc. Anesthetic delivery device
USD763433S1 (en) * 2014-06-06 2016-08-09 Anutra Medical, Inc. Delivery system cassette
AU2015277135B2 (en) 2014-06-20 2020-02-20 Icu Medical, Inc. Pressure-regulating vial adaptors
GB2535982A (en) * 2015-02-13 2016-09-07 Nerudia Ltd System and apparatus
CN108024906B (zh) 2015-06-16 2022-06-10 勃林格殷格翰维特梅迪卡有限公司 连接及容器系统
MY182973A (en) 2015-06-16 2021-02-05 Boehringer Ingelheim Vetmedica Gmbh Connecting and container system
MX2017016551A (es) * 2015-06-16 2018-05-11 Boehringer Ingelheim Vetmedica Gmbh Sistema de conexion y de recipiente.
DE102015218723A1 (de) * 2015-09-29 2017-03-30 Transcoject Gmbh Füllhilfe
JP6710758B2 (ja) 2015-12-04 2020-06-17 アイシーユー・メディカル・インコーポレーテッド 医療用流体を移送するための電子式医療用流体移送装置
USD877890S1 (en) * 2015-12-22 2020-03-10 Guangzhou Bioseal Biotech Co., Ltd. Reconstitution device
USD877891S1 (en) * 2015-12-22 2020-03-10 Guangzhou Bioseal Biotech Co., Ltd. Reconstitution and delivery device
ES2939370T3 (es) * 2016-01-12 2023-04-21 Freezio Ag Sistema de dispensador con soporte para cartucho
JP2019503256A (ja) 2016-01-29 2019-02-07 アイシーユー・メディカル・インコーポレーテッド 圧力調節バイアルアダプタ
US9956143B2 (en) * 2016-06-14 2018-05-01 Pharmac, Llc Syringe apparatus for transferring liquids into and out of a vial having a septum
USD851745S1 (en) 2016-07-19 2019-06-18 Icu Medical, Inc. Medical fluid transfer system
WO2018022640A1 (fr) 2016-07-25 2018-02-01 Icu Medical, Inc. Systèmes, procédés et composants pour piéger des bulles d'air dans des modules et des systèmes de transfert de fluide médical.
US10231846B2 (en) 2016-08-19 2019-03-19 Stryker European Holdings I, Llc Bone graft delivery loading assembly
CA3037577A1 (fr) 2016-09-30 2018-04-05 Icu Medical, Inc. Dispositifs et procedes d'acces a un flacon a regulation de pression
DE102016121607B4 (de) * 2016-11-11 2019-05-16 Heraeus Medical Gmbh Vorrichtung und Verfahren zum Lagern und Mischen eines Knochenzements
US20200163838A1 (en) * 2017-07-20 2020-05-28 Janssen Biotech, Inc. Drug mixing device
DE102018101041A1 (de) * 2018-01-18 2019-07-18 Heraeus Medical Gmbh Knochenzementapplikator mit verschließbarer Begasungsöffnung
AU2019351791A1 (en) * 2018-10-03 2021-05-06 Takeda Pharmaceutical Company Limited Packaging for multiple containers
US11590057B2 (en) 2020-04-03 2023-02-28 Icu Medical, Inc. Systems, methods, and components for transferring medical fluids
WO2021226564A1 (fr) * 2020-05-08 2021-11-11 Koska Family Limited Systèmes et procédés pour dispositifs d'administration médicaux multiliquides pré-remplis
DE102023201022A1 (de) * 2023-02-08 2024-08-08 B. Braun Melsungen Aktiengesellschaft Adaptervorrichtung zur Kopplung mit einem medizinischen Vial

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1173370B (it) * 1984-02-24 1987-06-24 Erba Farmitalia Dispositivo di sicurezza per collegare una siringa alla imboccatura di un flacone contenente un farmaco o di un tubicino per l'erogazione del farmaco della siringa
IE60235B1 (en) * 1986-09-18 1994-06-15 Kabi Pharmacia Ab "Connector and disposable assembly utilising said connector"
US4913699A (en) * 1988-03-14 1990-04-03 Parsons James S Disposable needleless injection system
JPH021277A (ja) * 1988-03-31 1990-01-05 Fujisawa Pharmaceut Co Ltd 輸液容器
US5037390A (en) * 1989-12-28 1991-08-06 Kenneth Raines System and method for mixing parenteral nutrition solutions
CN1029082C (zh) * 1991-03-08 1995-06-28 哈伯利医用技术公司 多种药物注射器
US5199949A (en) * 1991-03-08 1993-04-06 Habley Medical Technology Corp. Multiple pharmaceutical syringe
US5304165A (en) * 1991-12-09 1994-04-19 Habley Medical Technology Corporation Syringe-filling medication dispenser
US5226900A (en) * 1992-08-03 1993-07-13 Baxter International Inc. Cannula for use in drug delivery systems and systems including same
FR2716801B1 (fr) * 1994-03-04 1996-09-06 Pasteur Merieux Serums Vacc Ensemble pour la répartition d'une solution pharmaceutique dans des carpules ou analogues, notamment après reprise d'un produit lyophilisé.
GB9701413D0 (en) * 1997-01-24 1997-03-12 Smithkline Beecham Biolog Novel device
AU9496098A (en) 1997-10-06 1999-04-27 Karl H. Ehrenfels Fibrin sealant applicator
US6378714B1 (en) 1998-04-20 2002-04-30 Becton Dickinson And Company Transferset for vials and other medical containers
US6475183B1 (en) 1998-06-03 2002-11-05 Baxter International Inc. Direct dual filling device for sealing agents
US6358236B1 (en) 1998-08-06 2002-03-19 Baxter International Inc. Device for reconstituting medicaments for injection
US6610033B1 (en) 2000-10-13 2003-08-26 Incept, Llc Dual component medicinal polymer delivery system and methods of use
DE502004005171D1 (de) * 2003-03-06 2007-11-22 Csl Behring Gmbh Transfervorrichtung, insbesondere für medizinische Fluids
US20040249235A1 (en) * 2003-06-03 2004-12-09 Connell Edward G. Hazardous material handling system and method
JP3883527B2 (ja) * 2003-07-17 2007-02-21 ニプロ株式会社 トランスファーニードル
FR2878737B1 (fr) * 2004-12-07 2007-03-16 Maptech Soc Par Actions Simpli Dispositif de securite pour flacon a usage medical
WO2007109915A1 (fr) 2006-03-24 2007-10-04 Medmix Systems Ag Dispositif de distribution avec accessoires pouvant être fixés de maniere amovible
DE102006031712B3 (de) * 2006-07-08 2007-12-06 Haindl, Hans, Dr.med. Dipl.-Ing. Transfervorrichtung zur Überleitung einer Flüssigkeit aus einer ersten Flasche in eine zweite Flasche
MX2010011440A (es) 2008-04-18 2010-12-21 Kuros Biosurgery Ag Un dispositivo de suministro, un kit que contiene el dispositivo, y metodo para operar el dispositivo.
US9402787B2 (en) * 2010-02-01 2016-08-02 Medmix Systems Ag Device for removing a fluid from a vial

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2011091543A2 *

Also Published As

Publication number Publication date
CN102770110A (zh) 2012-11-07
EP2531164B1 (fr) 2014-05-21
US20120298254A1 (en) 2012-11-29
EP2531164A1 (fr) 2012-12-12
EP2531165B1 (fr) 2013-11-20
CN102791241A (zh) 2012-11-21
US20120302986A1 (en) 2012-11-29
CN102770110B (zh) 2015-09-16
WO2011091542A1 (fr) 2011-08-04
WO2011091543A2 (fr) 2011-08-04
US9402787B2 (en) 2016-08-02
CN102791241B (zh) 2015-04-08
WO2011091543A3 (fr) 2012-08-16

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