EP1924686A4 - Ongules transgéniques exprimant la ctla4-ig et leurs utilisations - Google Patents

Ongules transgéniques exprimant la ctla4-ig et leurs utilisations

Info

Publication number
EP1924686A4
EP1924686A4 EP06824805A EP06824805A EP1924686A4 EP 1924686 A4 EP1924686 A4 EP 1924686A4 EP 06824805 A EP06824805 A EP 06824805A EP 06824805 A EP06824805 A EP 06824805A EP 1924686 A4 EP1924686 A4 EP 1924686A4
Authority
EP
European Patent Office
Prior art keywords
transgenic ungulates
expressing ctla4
ungulates expressing
ctla4
transgenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP06824805A
Other languages
German (de)
English (en)
Other versions
EP1924686A2 (fr
Inventor
David Lee Ayares
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Revivicor Inc
Original Assignee
Revivicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Revivicor Inc filed Critical Revivicor Inc
Priority to EP16181101.3A priority Critical patent/EP3138403A1/fr
Publication of EP1924686A2 publication Critical patent/EP1924686A2/fr
Publication of EP1924686A4 publication Critical patent/EP1924686A4/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP06824805A 2005-08-09 2006-08-09 Ongules transgéniques exprimant la ctla4-ig et leurs utilisations Ceased EP1924686A4 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP16181101.3A EP3138403A1 (fr) 2005-08-09 2006-08-09 Ongulés transgéniques exprimant la ctla4-ig et leurs utilisations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70684305P 2005-08-09 2005-08-09
PCT/US2006/030842 WO2007035213A2 (fr) 2005-08-09 2006-08-09 Ongules transgeniques exprimant la ctla4-ig et leurs utilisations

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP16181101.3A Division EP3138403A1 (fr) 2005-08-09 2006-08-09 Ongulés transgéniques exprimant la ctla4-ig et leurs utilisations

Publications (2)

Publication Number Publication Date
EP1924686A2 EP1924686A2 (fr) 2008-05-28
EP1924686A4 true EP1924686A4 (fr) 2009-11-11

Family

ID=37889290

Family Applications (2)

Application Number Title Priority Date Filing Date
EP06824805A Ceased EP1924686A4 (fr) 2005-08-09 2006-08-09 Ongules transgéniques exprimant la ctla4-ig et leurs utilisations
EP16181101.3A Ceased EP3138403A1 (fr) 2005-08-09 2006-08-09 Ongulés transgéniques exprimant la ctla4-ig et leurs utilisations

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP16181101.3A Ceased EP3138403A1 (fr) 2005-08-09 2006-08-09 Ongulés transgéniques exprimant la ctla4-ig et leurs utilisations

Country Status (6)

Country Link
US (2) US20090186097A1 (fr)
EP (2) EP1924686A4 (fr)
AU (1) AU2006292827B2 (fr)
CA (2) CA2909775A1 (fr)
NZ (1) NZ565711A (fr)
WO (1) WO2007035213A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ810903A (en) * 2009-08-14 2024-08-30 Revivicor Inc Multi-transgenic pigs for diabetes treatment
US20120263692A1 (en) * 2009-11-16 2012-10-18 Bertone Alicia L Engineered Xenogeneic Cells for Repair of Biological Tissue
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
KR101312829B1 (ko) * 2009-12-30 2013-09-27 한화엘앤씨 주식회사 ＨＯ-1 유전자 및 ＴＮＦＲ1-Ｆｃ 유전자를 동시에 발현하는 형질전환 돼지 및 그의 제조 방법
CN106432474A (zh) 2010-03-12 2017-02-22 艾伯维生物医疗股份有限公司 Ctla4蛋白和其用途
ES2680636T3 (es) * 2011-02-14 2018-09-10 Revivicor Inc. Cerdos genéticamente modificados para xenotrasplante de xenoinjertos vascularizados y derivados de los mismos
EP2699258A4 (fr) * 2011-04-15 2014-10-29 Us Sec Dep Of Health And Human Services Transfert du gène ctla-4 médié par un aav pour traiter le syndrome de sjögren
WO2012145523A2 (fr) 2011-04-20 2012-10-26 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Transfert du gène exendine 4 médié par aav vers les glandes salivaires pour protéger des sujets contre le diabète ou l'obésité
EP2890791B1 (fr) 2012-08-31 2019-03-27 The United States of America, as represented by The Secretary, Department of Health and Human Services Transfert de gène d'aquaporine à médiation par aav pour traiter le syndrome de sjogren
US20140112958A1 (en) 2012-10-24 2014-04-24 Mwm Biomodels Gmbh Pancreatic islets of transgenic LEA29Y animals for treating diabetes
US20140115728A1 (en) 2012-10-24 2014-04-24 A. Joseph Tector Double knockout (gt/cmah-ko) pigs, organs and tissues
WO2014138188A1 (fr) * 2013-03-07 2014-09-12 The General Hospital Corporation Mutants de ctla4 humain et leur utilisation
US20150004161A1 (en) * 2013-07-01 2015-01-01 University Of Maryland Fc Coupled Compositions and Methods of Their Use
US12058986B2 (en) 2017-04-20 2024-08-13 Egenesis, Inc. Method for generating a genetically modified pig with inactivated porcine endogenous retrovirus (PERV) elements
WO2020072982A1 (fr) 2018-10-05 2020-04-09 Xenotherapeutics, Inc. Produits et procédés de xénotransplantation
US10883084B2 (en) 2018-10-05 2021-01-05 Xenotherapeutics, Inc. Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same
IL302983A (en) 2020-11-20 2023-07-01 Revivicor Inc Multitransgenic pigs with growth hormone receptor silencing for xenotransplantation
AU2022347161A1 (en) 2021-09-20 2024-04-04 Revivicor, Inc. Multitransgenic pigs comprising ten genetic modifications for xenotransplantation
CN118340882A (zh) * 2024-04-17 2024-07-16 天津力华源生物科技有限公司 一种能有效治疗癌症的靶向药及其制备方法和应用

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EP1924686A2 (fr) 2008-05-28
US20130202569A1 (en) 2013-08-08
US20090186097A1 (en) 2009-07-23
AU2006292827B2 (en) 2013-02-14
AU2006292827A1 (en) 2007-03-29
NZ565711A (en) 2011-10-28
WO2007035213A3 (fr) 2007-10-11
US10300112B2 (en) 2019-05-28
WO2007035213A2 (fr) 2007-03-29
CA2617930A1 (fr) 2007-03-29
CA2909775A1 (fr) 2007-03-29

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