EP1830947A4 - CLEANING OF IMMUNOGLOBULINS - Google Patents

CLEANING OF IMMUNOGLOBULINS

Info

Publication number
EP1830947A4
EP1830947A4 EP05815565A EP05815565A EP1830947A4 EP 1830947 A4 EP1830947 A4 EP 1830947A4 EP 05815565 A EP05815565 A EP 05815565A EP 05815565 A EP05815565 A EP 05815565A EP 1830947 A4 EP1830947 A4 EP 1830947A4
Authority
EP
European Patent Office
Prior art keywords
immunoglobulins
purification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05815565A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1830947A1 (en
Inventor
Hans Berg
Hans J Johansson
Gunnar Malmquist
Per-Mikael Aaberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Global Life Sciences Solutions USA LLC
Original Assignee
GE Healthcare Bio Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36588164&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP1830947(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from SE0403057A external-priority patent/SE0403057D0/sv
Application filed by GE Healthcare Bio Sciences Corp filed Critical GE Healthcare Bio Sciences Corp
Publication of EP1830947A1 publication Critical patent/EP1830947A1/en
Publication of EP1830947A4 publication Critical patent/EP1830947A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Fodder In General (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP05815565A 2004-12-14 2005-12-12 CLEANING OF IMMUNOGLOBULINS Withdrawn EP1830947A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0403057A SE0403057D0 (sv) 2004-12-14 2004-12-14 Purification of immunoglobulins
US63831604P 2004-12-22 2004-12-22
PCT/SE2005/001900 WO2006065208A1 (en) 2004-12-14 2005-12-12 Purification of immunoglobulins

Publications (2)

Publication Number Publication Date
EP1830947A1 EP1830947A1 (en) 2007-09-12
EP1830947A4 true EP1830947A4 (en) 2012-04-18

Family

ID=36588164

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05815565A Withdrawn EP1830947A4 (en) 2004-12-14 2005-12-12 CLEANING OF IMMUNOGLOBULINS

Country Status (5)

Country Link
EP (1) EP1830947A4 (cg-RX-API-DMAC10.html)
JP (1) JP5787461B2 (cg-RX-API-DMAC10.html)
AU (1) AU2005317279C1 (cg-RX-API-DMAC10.html)
CA (1) CA2586803C (cg-RX-API-DMAC10.html)
WO (1) WO2006065208A1 (cg-RX-API-DMAC10.html)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101374454B1 (ko) 2005-03-31 2014-03-17 추가이 세이야쿠 가부시키가이샤 회합제어에 의한 폴리펩티드 제조방법
JP5144499B2 (ja) 2006-03-31 2013-02-13 中外製薬株式会社 二重特異性抗体を精製するための抗体改変方法
EP4793360A2 (en) 2006-03-31 2026-08-19 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
CN101522278B (zh) 2006-09-29 2016-08-10 通用电气健康护理生物科学股份公司 用于抗体分离的包含来自金黄色葡萄球菌a蛋白的结构域c的层析配体
SG149759A1 (en) * 2007-07-10 2009-02-27 Millipore Corp Media for affinity chromatography
ES2687808T3 (es) 2007-09-26 2018-10-29 Chugai Seiyaku Kabushiki Kaisha Región constante de anticuerpo modificado
EP3127921A1 (en) 2007-09-26 2017-02-08 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substition in cdr
TWI544077B (zh) 2009-03-19 2016-08-01 中外製藥股份有限公司 Antibody constant region change body
US8277649B2 (en) * 2009-12-14 2012-10-02 General Electric Company Membranes and associated methods for purification of antibodies
EP2543730B1 (en) 2010-03-04 2018-10-31 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
KR101855714B1 (ko) 2010-03-05 2018-05-10 베링거 인겔하임 인터내셔날 게엠베하 항체의 선택적 농축
WO2011114405A1 (en) * 2010-03-17 2011-09-22 Panasonic Corporation A method for binding a protein consisting of protein a or consisting of at least one domain of the a to e domains of the protein a to the substrate
KR20130055569A (ko) 2010-03-31 2013-05-28 제이에스알 가부시끼가이샤 친화성 크로마토그래피용 충전제
US9162161B2 (en) 2010-03-31 2015-10-20 Jsr Corporation Filler for affinity chromatography
CN105859889B (zh) 2010-11-17 2020-01-07 中外制药株式会社 具有代替凝血因子viii的功能的功能的多特异性抗原结合分子
TWI736437B (zh) 2010-11-30 2021-08-11 日商中外製藥股份有限公司 細胞傷害誘導治療劑
EP3040344B1 (en) 2013-08-30 2021-04-28 Kaneka Corporation Fab region-binding peptide
EP3042192A4 (en) * 2013-09-04 2017-04-26 Sten Ohlson Weak affinity chromatography
JP6230853B2 (ja) * 2013-09-06 2017-11-15 株式会社日立製作所 タンパク質の精製方法及び精製装置
CA2925256C (en) 2013-09-27 2023-08-15 Chugai Seiyaku Kabushiki Kaisha Method for producing polypeptide heteromultimer
EP3076170B1 (en) 2013-11-27 2023-09-06 JSR Corporation Solid-phase carrier and production method for filler for affinity chromatography
EP3094391B1 (en) 2014-01-17 2024-11-20 Repligen Corporation Sterilizing chromatography columns
EP3160982B1 (en) 2014-06-24 2020-10-28 Cytiva BioProcess R&D AB Chromatography method
WO2015199196A1 (ja) 2014-06-27 2015-12-30 Jsr株式会社 アフィニティークロマトグラフィー用担体
US20170334947A1 (en) * 2014-08-28 2017-11-23 Kaneka Corporation Affinity separation matrix for fab region-containing peptide
JPWO2016121701A1 (ja) 2015-01-26 2017-11-09 株式会社カネカ 免疫グロブリンκ鎖可変領域含有タンパク質精製用アフィニティー分離マトリックス
JP6663360B2 (ja) 2015-01-26 2020-03-11 株式会社カネカ 変異型免疫グロブリンκ鎖可変領域結合性ペプチド
JP7082484B2 (ja) 2015-04-01 2022-06-08 中外製薬株式会社 ポリペプチド異種多量体の製造方法
SG11201803989WA (en) * 2015-12-28 2018-06-28 Chugai Pharmaceutical Co Ltd Method for promoting efficiency of purification of fc region-containing polypeptide
AU2017255077B2 (en) 2016-04-28 2024-05-16 Chugai Seiyaku Kabushiki Kaisha Antibody-containing preparation
WO2017195638A1 (ja) 2016-05-09 2017-11-16 株式会社カネカ 抗体またはκ鎖可変領域含有抗体断片の精製方法
JPWO2017195641A1 (ja) * 2016-05-11 2019-03-07 株式会社カネカ アフィニティ分離マトリックスの製造方法およびアフィニティ分離マトリックス
GB201703116D0 (en) * 2017-02-27 2017-04-12 Ge Healthcare Bioprocess R&D Ab A seperation matrix and a method of seperating antibodies
JP7209298B2 (ja) 2017-03-31 2023-01-20 公立大学法人奈良県立医科大学 血液凝固第ｖｉｉｉ因子の機能を代替する多重特異性抗原結合分子を含有する、血液凝固第ｉｘ因子異常症の予防および／または治療に用いられる医薬組成物
KR20260090008A (ko) 2017-11-01 2026-06-16 추가이 세이야쿠 가부시키가이샤 생물 활성이 저하된 항체 배리언트 및 아이소폼

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
US5089605A (en) * 1987-03-13 1992-02-18 Repligen Corporation Immobilized immunoglobulin-binding proteins
US5445732A (en) * 1992-06-19 1995-08-29 Sepracor Inc. Passivated porous polymer supports and methods for the preparation and use of same
WO1994022918A1 (en) * 1993-03-29 1994-10-13 Minnesota Mining And Manufacturing Company Method of coupling ligands within porous supports (p.e. azlactone) and uses thereof
SE9503925D0 (sv) * 1995-11-07 1995-11-07 Pharmacia Biotech Ab Separationsmedium för IgG
SE9601368D0 (sv) * 1996-04-11 1996-04-11 Pharmacia Biotech Ab Process for the production of a porous cross-linked polysaccharide gel
EP1693402A3 (en) * 1997-01-07 2009-05-27 Kaneka Corporation Cellulosic particles, spherical object comprising cross-linked polymer particles, and adsorbent for body fluid purification
SE9700383D0 (sv) * 1997-02-04 1997-02-04 Pharmacia Biotech Ab An adsorption/separation method and a medium for adsorption/separation
SE0004929D0 (sv) * 2000-12-29 2000-12-29 Apbiotech Ab A method for producing liquid chromatography matrices
SE0200943D0 (sv) * 2002-03-25 2002-03-25 Amersham Biosciences Ab Mutant protein
SE0300482D0 (sv) * 2003-02-21 2003-02-21 Amersham Biosciences Ab Inorganic beads with hierarchical pore structures
US7700743B2 (en) * 2003-07-22 2010-04-20 Millipore Corporation Immobilised affinity medium and its use in separation
US20080312425A1 (en) * 2004-08-30 2008-12-18 Lonza Biologics Plc. Ion Exchange Chromatography and Purification of Antibodies

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "MabSelect Xtra - Recombinant protein A-based, high-capacity affinity medium", 1 November 2004 (2004-11-01), Uppsala, pages 1 - 8, XP055015044, Retrieved from the Internet <URL:http://www.gelifesciences.co.jp/catalog/pdf/11001157.pdf> [retrieved on 20111216] *
ANONYMOUS: "Protein A Agarose Kit Catalogue No. 553-50-00", 1 September 2004 (2004-09-01), Gaithersburg, MD, pages 1 - 3, XP055014986, Retrieved from the Internet <URL:http://web.archive.org/web/20040901150500/http://www.kpl.com/docs/datasheet/5535000.PDF> [retrieved on 20111215] *
See also references of WO2006065208A1 *

Also Published As

Publication number Publication date
AU2005317279B2 (en) 2011-02-24
JP5787461B2 (ja) 2015-09-30
CA2586803C (en) 2012-12-11
WO2006065208A1 (en) 2006-06-22
JP2008523140A (ja) 2008-07-03
CA2586803A1 (en) 2006-06-22
AU2005317279C1 (en) 2014-07-17
AU2005317279A1 (en) 2006-06-22
EP1830947A1 (en) 2007-09-12

Similar Documents

Publication Publication Date Title
MA28726B1 (fr) Immunoglobulines
MA28541B1 (fr) Immunoglobulines
DK1711530T3 (da) Nogo-A-neutraliserende immunoglobuliner til behandling af neurologiske sygdomme
CY2016035I2 (el) Θεραπευτικη χρηση αντισωματων anti-cs1
DK1944322T3 (da) Behandling af TNFalfa-relaterede sygdomme
EP1786827A4 (en) PROCESS FOR IMMUNOGLOBULINE CLEANING
EP1849305A4 (en) HIDE DISORDER
DK1476162T3 (da) Kontrolleret syntese af ziprasidone
EE200300509A (et) Antikehad VLA-1 vastu
DK1587542T3 (da) Anvendelse af anti-CD100-antistoffer
DK1592384T3 (da) Cop 1 til behandling af inflammatoriske tarmsygdomme
EP1765336A4 (en) ANGIOGENESIS INHIBITORS
EP1752150A4 (en) Irinotecan PREPARATION
EP1894372A4 (en) ROUTING OF INTER-DOMAIN CALLS
EP1746141A4 (en) THICKENER
DK1578774T3 (da) Oprensning af immunoglobuliner
EP1727065A4 (en) Event sequencer
EP1907423A4 (en) CATALYTIC IMMUNOGLOBULINE
DK1377544T3 (da) Oprensning af 2-nitro-4-methylsulfonylbenzoesyre
DK1687297T3 (da) Triazindimerer til behandling af autoimmunsygdomme
MA28812B1 (fr) Combinaisons d&#39;epothilone
ITMI20041981A1 (it) &#34;convertitore dc/dc&#34;
DK1289945T3 (da) Anilindisulfidderivater til behandling af allergiske sygdomme
FR2873746B1 (fr) Element de ligne d&#39;echappement
DK2301576T3 (da) Terapeutisk anvendelse af anti-CS1-antistoffer

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20070514

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20120320

RIC1 Information provided on ipc code assigned before grant

Ipc: B01D 15/38 20060101ALI20120314BHEP

Ipc: B01J 2/00 20060101AFI20120314BHEP

Ipc: C07K 1/22 20060101ALI20120314BHEP

17Q First examination report despatched

Effective date: 20130118

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20130730