EP1755546A2 - Produits pour la peau et/ou les cheveux, contenant des composes a structure isoprenoide - Google Patents

Produits pour la peau et/ou les cheveux, contenant des composes a structure isoprenoide

Info

Publication number
EP1755546A2
EP1755546A2 EP05756894A EP05756894A EP1755546A2 EP 1755546 A2 EP1755546 A2 EP 1755546A2 EP 05756894 A EP05756894 A EP 05756894A EP 05756894 A EP05756894 A EP 05756894A EP 1755546 A2 EP1755546 A2 EP 1755546A2
Authority
EP
European Patent Office
Prior art keywords
skin
hair
methyl
acid
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05756894A
Other languages
German (de)
English (en)
Inventor
Rainer Wolber
Inge Kruse
Kathrin Schlenz
Cathrin Scherner
Karen Tom Dieck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of EP1755546A2 publication Critical patent/EP1755546A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/04—Preparations for care of the skin for chemically tanning the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
    • A61Q5/065—Preparations for temporary colouring the hair, e.g. direct dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners

Definitions

  • the present invention relates to agents for use on the skin and / or hair, in particular for increasing skin tanning and melanin synthesis in the skin or hair.
  • the invention comprises cosmetic or dermatological preparations containing compounds with an isopronoid structure. The use of the preparations leads to the induction and intensification of the natural tanning mechanisms of the skin, to the intensification of the hair color and thus also to an increase in skin or hair protection.
  • UVC range rays with a wavelength that is less than 290 nm
  • UVB range rays in the range between 290 nm and 320 nm, the so-called UVB range, cause Erythema, a simple sunburn or even more or less severe burns on the skin.
  • UVA range It is also important to have filter substances available for the range between approximately 320 nm and approximately 400 nm, the so-called UVA range, since their rays can also cause damage. It has been proven that UVA radiation leads to damage to the elastic and collagen fibers of the connective tissue, which causes the skin to age prematurely, and that it can be seen as the cause of numerous phototoxic and photoallergic reactions. The damaging influence of UVB radiation can be intensified by UV-A radiation.
  • UVA radiation can also cause skin damage by, among other things, damaging the skin's own keratin or elastin. This reduces the elasticity and water retention capacity of the skin, ie the skin becomes less supple and tends to wrinkle. This type of wrinkling is also known as light-related skin aging. The remarkably high incidence of skin cancer in areas with strong sun Irradiation shows that the genetic information in the cells is apparently also damaged by sunlight.
  • UV radiation can also lead to photochemical reactions, in which case the photochemical reaction products interfere with the skin's metabolism.
  • Such photochemical reaction products are predominantly radical compounds, e.g. Hydroxyl radicals.
  • Undefined radical photo products which are created in the skin itself, can also display uncontrolled subsequent reactions due to their high reactivity.
  • Singlet oxygen a non-radically excited state of the oxygen molecule can also occur under UV radiation, as can short-lived epoxies and many others.
  • Singlet oxygen for example, is characterized by increased reactivity compared to the triplet oxygen that is normally present (radical ground state). However, there are also excited, reactive (radical) triplet states of the oxygen molecule.
  • Such processes are significantly involved in light-related skin aging (including wrinkling) through oxidative damage to various skin structures.
  • UV radiation also belongs to ionizing radiation. There is therefore a risk that ionic species can also be formed when exposed to UV, which in turn can then have an oxidative effect on the biochemical processes.
  • the pigmentation of human skin is essentially caused by the presence of melanin.
  • Melanin and its breakdown products (melanoids), carotene, the degree of blood circulation as well as the nature and thickness of the stratum corneum and other skin layers leave skin tones of practically white (with reduced filling or in the absence of blood vessels) or yellowish over light brown-reddish, bluish to brown different shades and finally appear almost black.
  • the individual skin regions show different depths of color due to different amounts of melanin.
  • melanin protects the skin from penetrating UV radiation.
  • the number of melanin granules produced in the melanocytes determines whether the skin is light or dark.
  • melanin is also in the stratum spinosum and even in the stratum corneum. It weakens the UV radiation by up to approx. 90% before it reaches the corium.
  • melanocytes contain melanosomes, in which the melanin is formed. When stimulated by UV radiation, among other things, melanin is increasingly formed. This is ultimately transported into the horny layer (comeocytes) via the living layers of the epidermis (keratinocytes) and causes the more or less pronounced brown to brown-black skin color.
  • Melanin is formed as the final stage of an oxidative process in which tyrosine, with the help of the enzyme tyrosinase, is converted into brown to brown-black eumelanins (DHICA and DHI melanin) over several intermediate stages or with the participation of sulfur-containing compounds to reddish pheomelanin.
  • DHICA and DHI melanin are produced via the common intermediate stages dopaquinone and dopachrome.
  • the latter is implemented, partly with the participation of further enzymes, either in indole-5,6-quinone carboxylic acid or in indole-5,6-quinone, from which the two eumelanins mentioned arise.
  • the formation of phaeomelanin occurs among other things via the intermediates dopaquinone and cysteinyldopa.
  • the object of the present invention is therefore to provide an agent, in particular a cosmetic or dermatological preparation, which enhances the natural tanning of the skin by means of increased melanin synthesis and at the same time leads to an increased protection of the skin.
  • an agent in particular a cosmetic or dermatological preparation, which enhances the natural tanning of the skin by means of increased melanin synthesis and at the same time leads to an increased protection of the skin.
  • the following skin types are generally distinguished:
  • Skin type I never tans, always gets a sunburn.
  • Skin type II hardly tans, easily gets a sunburn.
  • Skin type III tans well on average.
  • Skin type IV tans lightly and persistently, almost never gets sunburned.
  • Skin type V dark, often almost black skin, never gets sunburned.
  • the natural shielding of harmful UV radiation is a tangible advantage of natural skin tanning.
  • a "healthy" skin color has also been a sign of sporting activity in particular and is therefore considered desirable by a wide range of consumers.
  • Representatives of skin types I and II who want to enjoy such a skin tint are therefore dependent on self-tanning preparations anyway
  • representatives of skin type III who do not expose themselves too much to the risks of sunbathing and still want to look tanned are grateful target groups for self-tanning preparations.
  • the object of the present invention is therefore also to provide preparations which do not have the disadvantages of make-up tanning preparations.
  • DHA dihydroxyacetone
  • Dihydroxyacetone can be referred to as ketotriose and reacts as a reducing sugar with the amino acids of the skin or the free amino and imino groups of keratin via a series of intermediates in the sense of a Maillard reaction to brown-colored substances, so-called melanoids, which gel - occasionally also called melanoidins.
  • a particular disadvantage of tanning with dihydroxyacetone is that, in contrast to "sun-tanned" skin, the skin tanned with it is not protected against sunburn.
  • Another disadvantage of dihydroxyacetone is that it, especially under the influence of ultraviolet radiation, albeit in mostly small amounts, formaldehyde is split off, so there was an urgent need to find ways in which the decomposition of dihydroxyacetone can be effectively countered.
  • An object of the present invention is to find alternatives to DHA as a self-tanning agent which do not have any disadvantageous properties, as are known from DHA. ";
  • Another type of artificial tanning which is also completely independent of UV light, can be brought about by the hormones which are usually released in the body also as a result of (natural) UV radiation and ultimately stimulate the melanocytes to synthesize melanin.
  • proopiomelanocortin POMC
  • aMSH proopiomelanocortin
  • synthetic variants such as NDP
  • these hormones can in principle cause browning, however, their use in cosmetics is forbidden because they are clearly pharmacologically active substances (hormones) that should not be used widely without medical indication.
  • the hair is divided into the hair shaft protruding from the skin and the oblique hair root reaching into the subcutis, the layers of which correspond approximately to those of the epidermis.
  • the thickened lower end of the root, the hair bulb sits on a vascular connective tissue cone, the hair papilla, protruding into it (both as a hair floor).
  • Melanin is responsible for the personal hair color.
  • Melanin is formed in the melanocytes, cells that occur in the hair bulb in association with the keratinocytes of the hair market.
  • Melanocytes contain as characteristic cell organelles Melanosomes, in which the melanin is formed. This is transferred via the long dendrites of the melanocytes into the keratinocytes of the precortical matrix and creates the more or less pronounced blonde to brown-black hair color.
  • DHICA and DHI melanin are produced via the common intermediate stages dopaquinone and dopachrome. The latter is implemented, partly with the participation of further enzymes, either in indole-5,6-quinone carboxylic acid or in indole-5,6-quinone, from which the two eumelanins mentioned arise.
  • the formation of phaeomelanin occurs among other things via the intermediates dopaquinone and cysteinyldopa. Cysteine is also necessary if the phaeomelanin is to be created for blonde and reddish hair.
  • Eumelanin is the black-brown pigment. It is mainly about the depth of color of the hair. In brown and black hair it occurs in clearly recognizable granules.
  • Phaeomelanin is the red pigment. It is responsible for light blonde, blonde and red hair. The structure of this melanin is much finer and smaller. The different hair colors result from the different proportions of the melanin types: • Blond hair contains little eumelanin and a lot of phaeomelanin. • Dark hair contains a lot of eumelanin and little phaeomelanin. • Red hair also has little eumelanin and a lot of phaeomelanin. • All shades of hair in between result from different mixing ratios of the two melanin types.
  • the pigment formation process can only proceed if sufficient tyrosinase is available. This enzyme is produced less frequently with age. This gradually leads to gray hair. The reason: with little tyrosinase, less and less tyrosine is formed. The production of melanin also decreases. The missing melanin is replaced by the storage of air bubbles. The hair appears gray. This process is usually insidious. It begins at the temples and then extends to the entire hair on the head. Then it hits the beard and eyebrows. Finally, all of the body's hair is gray.
  • gray hair is called canities.
  • canities There are several ways of graying. Premature graying, from the age of 20, is also called Canities praecox.
  • Symptoms of canities can have various causes. These include: • Pernicious anemia (Vitami ⁇ -B deficiency anemia), • Severe endocrinological disorders, e.g. B. in thyroid disease. • acute, febrile illnesses, • drug side effects, • cosmetics, • metals.
  • the cosmetic industry uses lead acetate in some countries, which is toxic and is therefore prohibited in the European Cosmetics Regulation. This lead acetate is preferably applied to the hair as a solution and remains there for a long time without being washed off.
  • Coupler and developer components are also referred to as oxidation dye precursors.
  • M-Phenylenediamine derivatives, naphthols, resorcinol and resorcinol derivatives, pyrazolones and m-aminophenols are generally used as coupler components.
  • Particularly suitable coupler substances are -naphthol, 1,5-, 2,7- and 1,7-dihydroxy-naphthalene, 5-amino-2-methylphenol, m-aminophenol, resorcinol, resorcinol monomethyl ether, m-phenylenediamine, 2, 4-diaminophenoxyethanol, 1-phenyl-3-methyl-5-pyrazolone, 2,4-dichloro-3-aminoph "enol, 1, 3-bis (2,4-diaminophenoxy) -propane, 2-chlororesorcinol, 4- Chlororesorcinol, 2-chloro-6-methyl-3-aminophenol, 2-methyiresorcinol and 5-methylresorcinol.
  • Oxidation dye precursors sometimes have a sensitizing effect on people with sensitive skin. Direct dyes are applied under gentler conditions, but their disadvantage is that the dyeings often have inadequate fastness properties.
  • the object of the present invention is to improve the independent melanin production of the hair, but without coloring agents and in particular oxidizing agents such. B. H 2 0 2 to be instructed.
  • the agents must have no or only a very low sensitization potential.
  • R ROH, branched or unbranched alkanols.
  • R ROH, branched or unbranched alkanols.
  • the use of preparations containing 9-retinal and / or 9-retinal-alkanolamine Schiff base leads to the induction and intensification of the tanning mechanisms of the skin and to the intensification of the hair color.
  • the invention comprises the use of such agents and the compounds according to the invention as agents for increasing the tan or the melanin synthesis in the skin or hair. It was surprising and unforeseeable for the person skilled in the art that agents for use on the skin and / or hair, in particular cosmetic or dermatological preparations, containing one or more compounds of the structure
  • the C3-R3 and the C4-R5 compounds are preferably saturated.
  • the two ends, Rx and Ry, of the hydrocarbon compounds composed of 1-7 subunits can be both non-polar and polar, but it is preferred that at least one end (Rx or Ry ) has a polar grouping, the residues should therefore be selected as follows:
  • - n is an integer from 1 to 7 and
  • R4 carbonyl oxygen
  • Ry - ⁇ - *
  • R 2 or - R1, R2, R3 and R5 independently of one another preferably represent hydrogen and / or methyl radicals, including propyl, isopropyl, butyl, tert-butyl, hydroymethyl, hydroxyethyl, hydroxypropyl, hydroxy and / or alkyl carboxylates with alkyl radicals selected from methyl, ethyl , Propyl or butyl, are possible residues.
  • - R9 is selected from hydrogen and / or hydroxy
  • R11 is selected from methyl, hydroxymethyl, hydrogen, prop-2-yl, isobutyl, but-2-yl, pyrrolidin-1, 2-diyl, 1 H-indol-3-yl-methyl , Benzyl; 2- (methylthio) ethyl, 4-hydroxy-benzyl, 1-hydroxyethyl, mercaptomethyl, 2-amino-2-oxoethyl, carboxymethyl, carboxyethyl, 4-aminobutyl, 3 - ⁇ [amino (imino ) methyl] amino ⁇ propyl, 3-amino-3-oxopropyl, hydrogen and N-Me, 3-aminopropyl, ethyl, 1H-imidazol-4-yl-methyl, butyl, propyl, 4- Amino-3-hydroxy-butyl-, 4-hydroxy-pyrrolidin-1, 2-diyl-, hydroxyethyl- or 2-mercaptoeth
  • - R10 is selected from hydroxy- (-OH), peptidically N-linked amino acid residues selected from Ala, Ser, Gly, Val, Leu, lle, Pro, Trp, Phe, Met Tyr, Thr, Cys, Asn, Asp, Glu, Lys, Arg, Gin, H, Orn, Sar, Hyl, Hyp, Hse or Hey, preferably Ala, Ser or Gly, residues of the structure
  • - R12 is selected from mono- to polysaccharides, preferably uniform and / or mixed mono-, di- or trisaccharides, preferably glucose, glycerose, erythrose, threose, ribose, arabinose, lyxose, xylose, allose, altrose, galactose, gulose, idose , Mannose or talose; - R4 'is selected from amino acid residues Ala, Ser, Gly, Val, Leu, lle, Pro, Trp, Phe, Met Tyr, Thr, Cys, Asn, Asp, Glu, Lys, Arg, Gin, H, Orn, Sar, Hyl, Hyp, Hse, Hey, preferably Ala, Ser or Gly, or residues of the structure
  • R13 is selected from methyl, hydroxymethyl hydrogen, prop-2-yl, isobutyl, but-2-yl, pyrrofidin-1, 2-diyl, 1H-indol-3-yl-methyl, benzyl -; 2- (methylthio) ethyl, 4-hydroxybenzyl, hydroxyethyl, mercaptomethyl, 2-amino-2-oxoethyl, carboxymethyl, carboxyethyl, 4-aminobutyl, 3 - ⁇ [amino (imino) methyl] ar ⁇ ino ⁇ propyl, 3-amino-3-oxopropyl, hydrogen and N-Me, 3-aminopropyl, ethyl, 1H-imidazol-4-yl-methyl, butyl, propyl, 4-amino -3-hydroxy-butyl-, 4-hydroxy-pyrrolidin-1, 2-diyl-, hydroxyethyl- or 2-mercap
  • - R14 is selected from hydroxy- (-OH), hydrogen (-H) and / or peptidically-O-bound amino acid residues selected from Ala, Ser, Gly, Val, Leu, lle, Pro, Trp, Phe, Met Tyr, Thr , Cys, Asn, Asp, Glu, Lys, Arg, Gin, H, Orn, Sar, Hyl, Hyp, Hse, Hey, preferably Ala, Ser or Gly,
  • - R15 is selected from mono- to polysaccharides, preferably uniform and mixed mono-, di- or trisaccharides, preferably glucose, glycerose, erythrose, threose, ribose, arabinose, lyxose, xylose, allose, altrose, galactose, gulose, idose, Mannose or Talose.
  • the substances with an isoprenoid structure are ideal for bringing about increased tanning of the skin.
  • All compounds of the structures listed above which the person skilled in the art can select from the respective groups have proven suitable.
  • the person skilled in the art, particularly for cosmetic or dermatological application purposes will preferably only select those whose tolerability, toxicology or the like are not critical.
  • the skin's own melanin has various functions, such as, for example, "detoxification'Ybinding of toxic substances / pharmaceuticals.
  • the function of melanin as a natural UV filter for protection against damaging UV rays and the antioxidant function of melanin as protection against reactive oxygen species (oxidative Stress), which can occur due to solar radiation, among other things, is very important for the skin, also with regard to homeostasis, avoidance of skin aging, avoidance of sunburn, etc. This should not only result in a cosmetic benefit in the sense of increased tanning due to the increased Melanin synthesis in the skin after topical application of compounds with isoprenoid structure which increase the melanogenesis according to the invention, but also provide additional protection through the various protective functions of melanin.
  • the compounds according to the invention are suitable for enhancing the physiological tanning of the skin by means of an increased melanin synthesis and thus also for increasing the skin's own protection.
  • a major advantage is that this physiological tanning is achieved without having to be exposed to natural solar radiation with its damaging influences on the skin or that this is only necessary to a comparatively small extent in order to achieve the desired skin tanning.
  • uneven skin pigmentations (“uneven skin tone") are also compensated.
  • the invention therefore preferably relates to cosmetic or dermatological preparations containing compounds according to the invention, as defined above.
  • the agents can also be used in polymer matrices, in a skin and / or wound dressing, a plaster, a cloth or pad, a spray or in a textile.
  • the subject of the invention is also the use of the thus produced
  • E / Z Both the E or Z isomer as well as the isomer mixture.
  • R1, R2, R3 each as a methyl radical
  • R5 H
  • n 1
  • R4 'as a radical of the structure 0-R15 with R15 -glucosyl.
  • R1, R2, R3 each as a methyl radical
  • R5 H
  • n 1
  • R4 'as a radical of the structure 0-R15 with R15 -1, 4-di-glucosyl.
  • R1, R2, R3 each as a methyl radical
  • R5 H
  • n 2
  • R11 methyl and R10 is a hydroxy radical, ⁇ / - [(1E Z, 2E Z, 4EZZ, 6EZ, 8E Z) -3J, 11-trimethyldodeca-2,4,6,8,10-pentaen-1-ylidenes] butan-1-amines
  • R1, R2 and R3 are each methyl radicals
  • R5 H
  • n 2
  • R4 is N-alkyl (N-butyl)
  • R1, R2, R3 each as a methyl radical
  • R5 H
  • R1, R2, R3 each as a methyl radical
  • R5 H
  • n 1
  • R4 'as a radical of the structure 0-R15 with R15 -1, 4-di-glucosyl.
  • R1, R2, R3 each as a methyl radical
  • R5 H
  • n 2
  • R1, R2, R3 each as a methyl radical
  • R5 H
  • n 2
  • R4 'as a radical of the structure O-Rl 5 with R15 -1, 4-di-glucosyl.
  • R3 as a proton and R5 as a methyl radical
  • n 1
  • R4 'as a radical of the structure 0-R15 with R15 -glucosyl.
  • R3 and R5 are methyl or hydrogen and between C1 and C2 as well as C3 and C4 there is a double bond, R4 is preferably carbonyl oxygen and N-OH, the following applies to the double bond isomers when E / Z is given: E or Z alone Isomer, as is the mixture of isomers.
  • R3 is a proton and R5 is a methyl radical
  • R3 as protons and R5 as methyl radicals
  • n 2 and R4 'is CH2CO-alkyl, preferably methyl
  • the following compounds have proven to be combination partners, i.e. in addition to the compounds with isoprenoid structure in the agents according to the invention, which, in combination with the isoprenoid structure compounds, show synergistic effects, both in terms of the tanning effect and in relation to the enodgenic self-protection.
  • Phytofluen 7,7 ', 8,8', H, 12-hexahydro- ⁇ ,,-carotene, of the structure
  • Another preferred compound is ⁇ -carotene, 7J ', 8,8'-tetrahydro- ⁇ , ⁇ -carotene, the
  • a melanogenesis assay was carried out after 3 days of incubation of primary normal human melanocytes with test substance versus control.
  • a melanogenesis assay was carried out after 3 days of incubation of primary normal human melanocytes with test substance versus control.
  • a melanogenesis assay was carried out after 3 days of incubation of primary normal human melanocytes with test substance versus control.
  • a melanogenesis assay was carried out after 3 days of incubation of primary normal human melanocytes with test substance versus control.
  • Melanin synthesis and are preferably used as sole additives or as a mixture in cosmetic or dermatological preparations.
  • agent there is also a polymer matrix, a skin and / or wound dressing, a plaster, a cloth or
  • Pad a spray, a pen or textiles, such as bandages or
  • Bathing textiles in order to ensure continuous tanning, are preferred as agents according to the invention. It is advantageous in the case of bandages equipped with the compounds according to the invention that the skin underneath undergoes the same brown color as the uncovered skin while the bandage is being worn.
  • the compounds according to the invention are in topical compositions, in particular cosmetic or dermatological preparations, lead to the induction of skin pigmentation. Melanogenesis is increased, there is more melanin in the skin, the skin becomes brown and the skin's own protection is physiologically increased. Even when applied topically to hair, the compounds according to the invention, in suitable preparations, lead to an intensification of the hair color, with which natural graying of the hair can also be avoided and even reversed.
  • the activation of the skin's own tanning and the intensification of hair coloring can of course be done with and without the involvement of UV light.
  • the compounds according to the invention are characterized inter alia by also in that they induce the formation of skin's own pigments in the skin, for example after topical application, increase the melanin synthesis and in this way produce an increased tan of the skin. They are harmless to health, non-irritating and easy to use, and the resulting shade naturally corresponds to that of the natural, healthy skin color.
  • the tan obtained is - since it corresponds to the natural tanning - lightfast and not washable.
  • the agents according to the invention also surprisingly intensify the tanning of already tanned skin and moreover delay the bleaching of tanned skin. Another advantage of the present invention results from the protective properties of natural melanin formed in the skin.
  • melanin In addition to various other functions of the skin's own melanin (such as “detoxification” or binding of toxic substances and / or pharmaceuticals, etc.), these functions of melanin are also very important for the skin, i.a. regarding homeostasis, skin aging prevention and the like:
  • Melanin acts as a natural UV filter to protect against damaging UV rays and also as an antioxidant to protect against reactive oxygen species (oxidative stress), which can occur, among other things, from sun exposure.
  • the agents according to the invention induce the formation of skin and hair-specific pigments in the skin and hair, intensify the existing natural and / or artificial tanning of the skin, compensate for inconsistent pigmentation of the skin, intensify the natural hair color and leave the tanning and hair coloring last longer.
  • the formulations according to the invention are extremely satisfactory preparations which are distinguished by a uniform coloring effect.
  • the formulations according to the invention are easier to formulate, give the skin and hair a natural appearance faster and better, make the tanning and hair coloring last longer, work better than moisturizing preparations, better promote smoothing of the skin , ⁇ are characterized by better care, have better sensory properties, such as spreadability on the skin and hair or the ability to be absorbed into the skin, and ⁇ would offer better / risk-free protection of the skin and hair (against UV radiation) than the cosmetic preparations of the prior art.
  • the formulations according to the invention surprisingly have no hormonal effects.
  • the content of the isoprenoid structure compounds is between 0.0001 and 30% by weight, advantageously between 0.001 and 10% by weight, particularly advantageously between 0.02 and 2% by weight, in each case based on the total weight of the compositions, preferably the cosmetic preparations.
  • a cosmetic and / or dermatological formulation according to the invention can be composed as usual and serve in particular for the treatment and care of the skin and / or hair, as a make-up product in decorative cosmetics or as a sunscreen or so-called pre- or after-sun preparation.
  • the formulations according to the invention can be used, for example, as skin protection cream, face cream, cleansing milk, sunscreen lotion, nutrient cream, day or night cream, etc. It is also possible and advantageous for the purposes of the present invention to insert the compounds according to the invention into aqueous systems or surfactant preparations for cleaning and care of the skin and hair. This includes shower gels, shampoos but also conditioners, hair care treatments, hair rinses, hair tonics, sprays etc.
  • compositions are usually inconceivable without the customary auxiliaries and additives.
  • these include, for example, consistency agents, fillers, perfume, dyes, emulsifiers, additional active ingredients such as vitamins or proteins, light stabilizers, stabilizers, insect repellents, alcohol, water, salts, antimicrobial, proteolytically or keratolytically active substances, preservatives, bactericides, substances for preventing the Foaming, pigments that have a coloring effect, thickeners, moisturizing and / or moisturizing substances, fats, oils, waxes or other common components of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents, silicone derivatives or moisturizers etc.
  • the compound or compounds according to the invention in encapsulated form, for example in collagen matrices and other customary encapsulation materials, such as, for example, cyclic oligosaccharides (in particular alpha, beta, HP-beta, ra dom-Me-beta, gamma- Cyciodextrin), said corresponding alpha- the chemical known to 'those skilled properties of the compounds according to the invention, beta- or gamma-cyclodextrins be used as Verkapselungsmatrial.
  • cyclic oligosaccharides in particular alpha, beta, HP-beta, ra dom-Me-beta, gamma- Cyciodextrin
  • the compounds according to the invention may be advantageous to present the compounds according to the invention or their mixtures in the form of cellulose encapsulations, in gelatin, wax matrices or encapsulated in liposomes.
  • cyclodextrins When encapsulated with cyclodextrins, it is assumed that the cyclodextrin skeletons act as the host molecule and the active ingredient according to the invention acts as the guest molecule.
  • cyclodextrins are dissolved in water and the active ingredient according to the invention is added. The molecular adduct then precipitates as a solid and can be subjected to the usual cleaning and preparation steps.
  • Medical topical compositions in the sense of the present invention generally contain one or more medicaments in an effective concentration.
  • medicaments in an effective concentration.
  • the formulations according to the invention are also particularly suitable for combinations with active ingredients which have a positive effect on the condition of the skin. It has been shown that active ingredients to positively influence the aging skin, which reduce the appearance of wrinkles or existing wrinkles. So especially in combination with bioquinones, especially ubiquinone Q10, creatine, Kreinin, carnitine, biotin, isoflavone, cardiolipin, lipoic acid, liponamide, folic acid and its derivatives, niacin and its derivatives, anti freezing proteins, hop and hop malt extracts.
  • bioquinones especially ubiquinone Q10, creatine, Kreinin, carnitine, biotin, isoflavone, cardiolipin, lipoic acid, liponamide, folic acid and its derivatives, niacin and its derivatives, anti freezing proteins, hop and hop malt extracts.
  • Promoting agents for the restructuring of the connective tissue can also be used very well in the formulations according to the invention. It also shows that the formulations are particularly suitable, active ingredients to support skin functions in dry skin, such as vitamin C, biotin, carnitine, creatine, propionic acid, green tea extracts, eucalyptus oil, urea and mineral salts such as.
  • active ingredients to support skin functions in dry skin such as vitamin C, biotin, carnitine, creatine, propionic acid, green tea extracts, eucalyptus oil, urea and mineral salts such as.
  • B. NaCI vitamin C
  • marine minerals and osmolytes such.
  • B. taurine, inositol, betaine quaternary ammonium compounds to use.
  • active ingredients to alleviate or positively influence irritative skin conditions has proven to be advantageous, be it with sensitive skin in general or with skin irritated by noxious substances (UV light, chemicals).
  • Active substances such as sericosides, various extracts of licorice, licochalcone, in particular are to be mentioned here Licochalcone A, sily arin, silyphos, dexpanthenol, inhibitors of prostaglandin metabolism, in particular cyclooxygenase and leukotriene metabolism, in particular 5-lipoxyenase, but also 5-lipoxvgenase inhibitor protein, FLAP.
  • the incorporation of pigmentation modulators also proved to be advantageous.
  • Active substances are to be mentioned here which reduce the pigmentation of the skin and thus lead to a cosmetically desired lightening of the skin and / or reduce the appearance of age spots and / or lighten existing age spots.
  • Examples include tyrosine sulfate, dioic acid (8-hexadecen-1, 16-dicarboxylic acid as well as lipoic acid and liponamide, various extracts of licorice.
  • Kojic acid hydroquinone, arbutin, alpha-arbutin, deoxyarbutin, fruit acids, especially alpha-hydroxy acids (AHAs) , Bearberry (Uvae ursi), ursolic acid, ascorbic acid, green tea extracts, aminoguanidine, pyridoxamine.
  • the formulations according to the invention proved to be excellent combination partners for other active ingredients which bring about an intensified or faster tanning of the skin (Advanced Glycation End Products (AGE) , ipofuscine, nucleic acid oligonucleotides, purines and pyrimidines, NO-releasing substances), be it with or without the influence of UV light.
  • AGE Advanced Glycation End Products
  • Cosmetic and dermatological preparations in the form of a sunscreen are particularly preferred. These can advantageously additionally contain at least one further UVA filter and / or at least one further UVB filter and / or at least one inorganic pigment, preferably an inorganic micropigment.
  • cosmetic and dermatological preparations according to the invention are able to prolong the natural tanning process.
  • cosmetic and dermatological formulations according to the invention are able to serve for the treatment of hypopigmentation (vitiligo, uneven pigmentation in aging skin, etc.).
  • Moisturizers are substances or mixtures of substances that give cosmetic or dermatological preparations the property that, after application or distribution on the skin surface, the release of moisture from the horny layer (also to reduce transepidermal water loss (TEWL) and / or to positively influence the hydration of the horny layer.
  • TEWL transepidermal water loss
  • moisturizers for the purposes of the present invention are, for example, glycerin, lactic acid, pyrrolidone carboxylic acid and urea. Furthermore, it is particularly advantageous to use polymeric moisturizers from the group of water-soluble and / or water-swellable and / or water-gelable polysaccharides. Particularly advantageous are, for example, hyaluronic acid and / or a fucose-rich polysaccharide, which is filed in the Chemical Abstracts under the registration number 178463-23-5 and z. B. under the name Fucogel®1000 from the company SOLABIA S.A. is available.
  • Glycerin can be used as a moisturizer in the sense of the present application in the range of 0.05-30% by weight, particularly preferably 1-10%.
  • antioxidants in the preparations according to the invention are generally preferred. According to the invention, all the antioxidants suitable or customary for cosmetic and / or dermatological applications can be used as favorable antioxidants.
  • antioxidants are advantageously selected from the group consisting of amino acids (e.g. glycine, histidine, tyrosine, phenylalanine, tryptophan) and their derivatives (in particular N-acetyl-tyrosine, N-acetyl-phenylalanine), imidazoles (e.g. urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L-carnosine and their derivatives (e.g. anserine), carotenoids, carotenes (e.g.
  • amino acids e.g. glycine, histidine, tyrosine, phenylalanine, tryptophan
  • imidazoles e.g. urocanic acid
  • peptides such as D, L-carnosine, D-carnosine, L-carnosine and their derivatives (e.g. anserine)
  • carotenoids e.g
  • ⁇ -carotene, J3-carotene, lycopene and their derivatives, chlorogenic acid and their derivatives, Lipoic acid and its derivatives (e.g. dihydroliponic acid), aurothioglucose, propylthiouracil and other thiols (e.g.
  • thioredoxin glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, Butyl and lauryl, palmitoyl, oleyl, linoleyl, choiesteryl and glyceryl esters) and their salts, dilauryithiodipropionate, distearylthio dipropionate, thiodipropionic acid and their derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts ) and sulfoximine compounds (e.g.
  • ⁇ -hydroxyfatty acids palmitic acid, phytic acid, lactoferin
  • -Hydroxy acids eg citric acid, lactic acid, malic acid
  • humic acid eg citric acid, lactic acid, malic acid
  • bile acid e.g. citric acid, lactic acid, malic acid
  • humic acid e.g citric acid, lactic acid, malic acid
  • bile extracts eg.g citric acid, lactic acid, malic acid
  • humic acid eg.g citric acid, lactic acid, malic acid
  • humic acid eg g citric acid, lactic acid, malic acid
  • humic acid eg citric acid, lactic acid, malic acid
  • bile extracts eg.g bilirubin, biliverdin, EDTA, EGTA
  • unsaturated fatty acids and their derivatives eg ⁇ -linolenic acid, lin
  • the amount of the aforementioned antioxidants (one or more compounds) in the preparations is preferably 0.001 to 30% by weight, particularly preferably 0.05-20% by weight, in particular 1-10% by weight, based on the total weight of the compositions the preparation. If vitamin E and / or its derivatives represent the antioxidant (s), it is advantageous to choose their respective concentrations from the range of 0.001-10% by weight, based on the total weight of the formulation. If vitamin A or vitamin A derivatives or carotenes or their derivatives represent the antioxidant or antioxidants, it is advantageous to add their respective concentrations in the range from 0.001 to 10% by weight, based on the total weight of the formulation choose.
  • Cosmetic or dermatological formulations in the sense of the present invention can preferably contain, in addition to one or more oil phases, one or more water phases and, for example, in the form of W / O-, O / W-, W / O / W- or O / W / O- Emulsions are present.
  • Such emulsions can preferably also be a microemulsion, a Pickering emulsion or a sprayable emulsion.
  • the formulations according to the invention can also advantageously be in the form of oil-free preparations, such as gels, or as anhydrous preparations.
  • formulations according to the invention can furthermore advantageously also contain dihydroxyacetone or nut extracts as well as other substances which are intended to maintain or produce the tan or to additionally reinforce them.
  • the lipid phase of the emulsions according to the invention can advantageously be selected from the following group of substances: mineral oils, mineral wax oils, such as triglycerides of capric or caprylic acid, but preferably castor oil; Fats, waxes and other natural and synthetic fat bodies, preferably esters of fatty acids with low C alcohols, e.g. with isopropanol, propylene glycol or glycerin, or esters of fatty alcohols with low C number alkanoic acids or with fatty acids; benzoates; Silicone oils such as dimethylpolysiloxanes, diethylpolysiloxanes, diphenylpolysiloxanes and mixed forms thereof.
  • mineral oils mineral wax oils, such as triglycerides of capric or caprylic acid, but preferably castor oil
  • Fats, waxes and other natural and synthetic fat bodies preferably esters of fatty acids with low C alcohols, e.g. with isopropanol,
  • the oil phase of the emulsions, oleogels or hydrodispersions or lipodispersions for the purposes of the present invention is advantageously selected from the group of esters from saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 3 to 30 C atoms, from the group of esters from aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 3 to 30 C -atoms.
  • ester oils can then advantageously be selected from the group of isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isonoylyl stearate, iso-nonylisononanoate, 2-ethyl-2-ethylhexyl, ethyl-2-ethylhexyl 2-hexyldecyl stearate, 2-octyldodecyl palmitate, oleyl oleate, olerlerucate, erucyl oleate, erucylerucate and synthetic, semisynthetic and natural mixtures of such esters, for example jojoba oil.
  • the oil phase can advantageously be selected from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ethers, the group of saturated or unsaturated, branched or unbranched alcohols, and also the fatty acid triglycerides, especially the triglycerol esters of saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 8 to 24, in particular 12 - 18 carbon atoms.
  • the fatty acid triglycerides can, for example, advantageously be selected from the group of synthetic, semisynthetic and natural oils, for example olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil and the like.
  • any mixtures of such oil and wax components can also be used advantageously for the purposes of the present invention. It may also be advantageous to use waxes, for example cetyl palmitate, as the sole lipid component of the oil phase.
  • the oil phase is advantageously selected from the group consisting of 2-ethylhexyl isostearate, octyldodecanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, C 2 -i 5 -alky! Benzoate, caprylic capric acid triglyceride, dicaprylyl ether.
  • Particularly advantageous are mixtures of C ⁇ 2 i5-alkyl benzoate and 2-ethylhexyl isostearate, mixtures of C 12 . ⁇ 5 -alkyl and isotridecyl isononanoate and mixtures of C 2 -i 5 alkyl benzoate, 2-ethylhexyl isostearate and isotridecyl isononanoate.
  • hydrocarbons paraffin oil, squalane and squalene are advantageously used in the context of the present invention.
  • the oil phase can advantageously also have a content of cyclic or linear silicone oils or consist entirely of such oils, although it is preferred to use an additional content of other oil phase components in addition to the silicone oil or the silicone oils.
  • Cyclomethicone (octamethylcyclotetrasiloxane) is advantageously used as the silicone oil to be used according to the invention.
  • other silicone oils can also be used advantageously for the purposes of the present invention, for example hexamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane).
  • Mixtures of cyclomethicone and isotridecyl isononanoate, cyclomethicone and 2-ethylhexyl isostearate are also particularly advantageous.
  • the aqueous phase of the preparations according to the invention optionally advantageously contains alcohols, diols or polyols of low C number, and also their ethers, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether , Diethylenglykolmonomethyl- or -monoethylether and similar products, furthermore alcohols of low C number, for example Ethanol, isopropanol, 1,2-propanediol, glycerol and in particular one or more thickeners, which one or more can advantageously be selected from the group consisting of silicon dioxide, aluminum silicates, polysaccharides and their derivatives, e.g.
  • Hyaluronic acid, xanthan gum, hydroxypropylmethyl cellulose particularly advantageously from the group of polyacrylates, preferably a polyacrylate from the group of so-called carbopoles, for example carbopoles of types 980, 981, 1382, 2984, 5984, each individually or in combination.
  • UV filter substances can also be added to the preparation according to the invention.
  • Preferred inorganic pigments are metal oxides and / or other metal compounds which are sparingly soluble or insoluble in water, in particular oxides of titanium (Ti0 2 ), zinc (ZnO), iron (e.g. Fe 2 0 3 ), zirconium (Zr0 2 ), silicon ( Si0 2 ), manganese (e.g. MnO), aluminum (Al 2 O 3 ), cerium (e.g.
  • the pigments can also advantageously be used in the form of commercially available oily or aqueous predispersions. Dispersing aids and / or solubilizing agents can advantageously be added to these predispersions.
  • the pigments can advantageously be surface-treated ("coated"), for example, a hydrophilic, amphiphilic or hydrophobic character should be formed or maintained. This surface treatment can consist in that the pigments are prepared using a thin hydrophilic and The various surface coatings can also contain water for the purposes of the present invention.
  • Inorganic surface coatings for the purposes of the present invention can consist of aluminum oxide (Al 2 O 3 ), aluminum hydroxide Al (OH) 3 , or aluminum oxide hydrate (also: alumina, CAS no .: 1333-84-2), sodium hexametaphosphate (NaP0 3 ) 6 , sodium metaphosphate (NaP0 3 ) n, silicon dioxide (Si0 2 ) (also: silica, CAS no .: 7631 -86-9), or iron oxide (Fe 2 0 3 )
  • Al 2 O 3 aluminum oxide
  • Al (OH) 3 aluminum hydroxide Al
  • aluminum oxide hydrate also: alumina, CAS no .: 1333-84-2
  • sodium hexametaphosphate (NaP0 3 ) 6 sodium metaphosphate (NaP0 3 ) n
  • silicon dioxide (Si0 2 ) also: silica, CAS no .: 7631 -86-9)
  • iron oxide Fe 2 0
  • Organic surface coatings in the sense of the present invention can consist of vegetable or animal aluminum stearate, vegetable or animal stearic acid, lauric acid, dimethylpolysiloxane (also: dimethicone), methylpolysiloxane (methicone), simethicone (a mixture of dimethylpolysiloxane with an average chain length of 200 to 350 dimethylsiloxane Units and silica gel) or alginic acid.
  • These organic surface coatings can occur alone, in combination and / or in combination with inorganic coating materials.
  • Zinc oxide particles and predispersions of zinc oxide particles suitable according to the invention are available under the following trade names from the listed companies:
  • Suitable titanium dioxide particles and predispersions of titanium dioxide particles are available under the following trade names from the companies listed:
  • Advantageous UV-A filter substances for the purposes of the present invention are di-benzoylmethane derivatives, in particular 4- (tert-butyl) -4'-methoxydibenzoylmethane (CAS No. 70356-09-1), which is available from Givaudan under the Parsol brand ® 1789 and is sold by Merck under the trade name Eusolex® 9020.
  • Advantageous further UV filter substances in the sense of the present invention are sulfonated, water-soluble UV filters, such as.
  • Advantageous UV filter substances in the sense of the present invention are also so-called broadband filters, i.e. Filter substances that absorb both UV-A and UV-B radiation.
  • Advantageous broadband filters or UV-B filter substances are, for example, triazine derivatives, such as. B.
  • An advantageous broadband filter in the context of the present invention is also the 2,2'-methylene-bis- (6- (2H-benzotriazol-2-yl) -4- (1, 1, 3,3-tetramethylbutyl) phenol), which under the Trade name Tinosorb® M is available from CIBA-Ohemialen GmbH.
  • Another advantageous broadband filter for the purposes of the present invention is 2- (2H-benzotriazol-2-yl) -4-methyl-6- [2-methyl-3- [1, 3,3,3-tetramethyl-1 - [( trimethylsilyl) oxy] disiloxanyl] propyl] phenol (CAS no .: 155633-54-8) with the INCI name Drometrizole Trisiloxane, which is available under the trade name Mexoryl® XL from Chimex.
  • the other UV filter substances can be oil-soluble or water-soluble.
  • Advantageous oil-soluble UV-B and / or broadband filter substances in the sense of the present invention are e.g. For example: ⁇ 3-benzylidene camphor derivatives, preferably 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor;
  • 4-aminobenzoic acid derivatives preferably 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester, 4- (dimethylamino) benzoic acid amyl ester;
  • benzophenone preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone »As well as UV filters bound to polymers.
  • Sulfonic acid derivatives of 3-benzylidene camphor such as. B. 4- (2-oxo-3-bomylidene methyl) benzenesulfonic acid, 2-methyl-5- (2-oxo-3-bornylidene methyl) sulfonic acid and their
  • a further light protection filter substance according to the invention to be used advantageously is ethylhexyl-2-cyano-3,3-diphenylacrylate, obtainable (octocrylene) from BASF under the name Uvinul ® N 539th
  • Particularly advantageous preparations within the meaning of the present invention which are distinguished by a high or very high UV-A and / or UV-B protection, preferably contain further UV-A and in addition to the filter substance (s) according to the invention / or broadband filter, in particular dibenzoylmethane derivatives [for example the 4- (tert-butyl) -4'-methoxydibenzoylmethane], phenylene-1, 4-bis- (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid and / or their salts, the 1,4-di (2-oxo-10-sulfo-3-bornylidenemethyl) benzene and / or its salts and / or the 2,4-bis - ⁇ [4- (2-ethyl- hexyIoxy) -2-hydroxy] phenyl ⁇ -6- (4-methoxyphenyl) -1, 3,5-triazine, in each case individually or in any combination
  • Benzoxazole derivatives such as, in particular, 2,4-bis- [5-1 (dimethylpropyl) benzoxazol-2-yl- (4-phenyl) -imino] -6- (2-ethylhexyl) -imino-1 are also particularly advantageous according to the invention , 3,5-triazine with the CAS No. 288254-16-0, which is available, for example, under the trade name Uvasorb® K2A, and hydroxybenzophenones such as, in particular, the 2- (4'-diethylamine-2'-hydoxybenzoyl) benzoate or else Aminobenzophenone, which is available under the Uvinul A Plus.
  • the preparations according to the invention advantageously contain the substances which absorb UV radiation in the UV-A and / or UV-B range in a total amount of, for. B. 0.1 wt .-% to 30 wt .-%, preferably 0.5 to 20 wt .-%, in particular 1, 0 to 15.0 wt .-%, each based on the total weight of the preparations to kos -
  • metallic preparations that protect the hair or skin from the entire range of ultraviolet radiation. They can also serve as a sunscreen for the hair.
  • formulations according to the invention can advantageously, although not necessarily, also be used in combination with UV radiation - be it with artificially produced or natural ultraviolet rays - for example in order to increase natural tanning or to achieve particularly long-lasting tanning.
  • the cosmetic and dermatological formulations according to the invention are applied to the skin and / or the hair in a sufficient amount in the manner customary for cosmetics.
  • the use of the agent according to the invention is preferred - as an aqueous system and / or surfactant preparation for cleaning and care of the skin and / or hair, - as a multiple emulsion, microemulsion, pickering emulsion or sprayable emulsion, as a presun, a sunscreen or an aftersun formulation, - for topical use on skin and / or hair, - for tanning the skin, - for skin care, - for protecting the skin and / or hair from damaging UV rays, - to increase the melanin synthesis in the skin, - to prolong the brown color of the skin, - to protect the skin from oxidative stress, - to protect the skin from chronological and light-related skin aging, - to intensify the hair color, - to prevent it graying of the hair and / or to protect the hair from fading due to sunlight, - as a shower gel, shampoo, condition
  • the incorporation of the compounds into polymer matrices is thus possible without any problems. Similar to the known active ingredient release, the compounds can be released from the matrix to the skin or the hair and enable their advantageous properties there. In a plaster application or applied to textiles, bandages or the like, the compounds can penetrate the skin and bring about the desired protection, care or tanning effect.

Abstract

La présente invention concerne des produits à appliquer sur la peau ou les cheveux, destinés en particulier à accroître le bronzage ainsi que la synthèse de mélanine dans la peau ou les cheveux. Ladite invention concerne en particulier des préparations cosmétiques ou dermatologiques contenant des composés à structure isoprénoïde. L'utilisation de ces préparations permet d'induire et d'intensifier les mécanismes de bronzage de la peau, d'intensifier la couleur des cheveux et d'accroître la protection intrinsèque de la peau ou des cheveux.
EP05756894A 2004-04-26 2005-04-06 Produits pour la peau et/ou les cheveux, contenant des composes a structure isoprenoide Withdrawn EP1755546A2 (fr)

Applications Claiming Priority (2)

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DE102004020714A DE102004020714A1 (de) 2004-04-26 2004-04-26 Haut- und/oder Haarmittel enthaltend Verbindungen mit isoprenoider Struktur
PCT/EP2005/051528 WO2005102252A2 (fr) 2004-04-26 2005-04-06 Produits pour la peau et/ou les cheveux, contenant des composes a structure isoprenoide

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EP1755546A2 true EP1755546A2 (fr) 2007-02-28

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DE102004020714A1 (de) 2005-11-10
WO2005102252A3 (fr) 2006-02-09

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