WO2022128164A1 - Extraits d'espèces d'isochrysis / espèces de tisochrysis - Google Patents
Extraits d'espèces d'isochrysis / espèces de tisochrysis Download PDFInfo
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- WO2022128164A1 WO2022128164A1 PCT/EP2021/051840 EP2021051840W WO2022128164A1 WO 2022128164 A1 WO2022128164 A1 WO 2022128164A1 EP 2021051840 W EP2021051840 W EP 2021051840W WO 2022128164 A1 WO2022128164 A1 WO 2022128164A1
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- WIPO (PCT)
- Prior art keywords
- extract
- isochrysis
- skin
- cell material
- tisochrysis
- Prior art date
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Abstract
L'invention concerne un extrait de CO2 fluide supercritique de l'Isochrysis sp. et/ou Tisochrysis sp. comprenant a) pas plus de 1,5 % en poids de caroténoïdes, b) pas plus de 2,0 % en poids de chlorophylles, et c) au moins 15 % en poids d'acides gras libres, chaque pourcentage en poids étant basé sur le poids total de l'extrait, l'extrait ayant une valeur de couleur gardner inférieure ou égale à 9 à une concentration d'extrait de 0,018 % dans l'huile.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2021404384A AU2021404384A1 (en) | 2020-12-14 | 2021-12-14 | Extracts of isochrysis species / tisochrysis species |
EP21834804.3A EP4259090A1 (fr) | 2020-12-14 | 2021-12-14 | Extraits d'espèces d'isochrysis / d'espèces de tisochrysis |
CA3201865A CA3201865A1 (fr) | 2020-12-14 | 2021-12-14 | Extraits d'especes d'isochrysis / d'especes de tisochrysis |
PCT/EP2021/085773 WO2022129101A1 (fr) | 2020-12-14 | 2021-12-14 | Extraits d'espèces d'isochrysis / d'espèces de tisochrysis |
BR112023011127A BR112023011127A2 (pt) | 2020-12-14 | 2021-12-14 | Extratos de espécies de isocrise/espécies de tisocrise |
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Citations (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4251195A (en) | 1975-12-26 | 1981-02-17 | Morishita Jinta Company, Limited | Apparatus for making miniature capsules |
EP0389700A1 (fr) | 1988-01-29 | 1990-10-03 | FUJI CAPSULE KABUSHIKI KAISHA (also trading as FUJI CAPSULE CO., LTD.) | Gélules d'agar |
EP0584178A1 (fr) | 1991-05-15 | 1994-03-02 | Stiefel Laboratories | Composition et procede pour ameliorer le bronzage de la peau. |
JPH07196478A (ja) | 1993-12-30 | 1995-08-01 | Hajime Sugii | 安全性の高い食品及び医薬品用ソフトカプセル |
US6214376B1 (en) | 1998-08-25 | 2001-04-10 | Banner Pharmacaps, Inc. | Non-gelatin substitutes for oral delivery capsules, their composition and process of manufacture |
WO2001076572A2 (fr) | 2000-04-12 | 2001-10-18 | bitop Aktiengesellschaft für biotechnische Optimierung | Utilisation de solutes compatibles en tant que substances aux proprietes de piegeage de radicaux |
WO2002015868A2 (fr) | 2000-08-18 | 2002-02-28 | Bitop Gesellschaft Für Biotechnische Optimierung Mbh | Formulations cosmetiques |
WO2003055587A1 (fr) | 2001-12-24 | 2003-07-10 | Symrise Gmbh & Co.Kg | Microcapsules a remplissage mononucleaire |
WO2004050069A1 (fr) | 2002-12-05 | 2004-06-17 | Symrise Gmbh & Co. Kg | Capsules fourrees sans soudures |
WO2005032501A1 (fr) | 2003-09-08 | 2005-04-14 | Beiersdorf Ag | Produits a utiliser sur la peau et/ou les cheveux, contenant des composes cyclohexene 4 fois substitues |
WO2005102252A2 (fr) | 2004-04-26 | 2005-11-03 | Beiersdorf Ag | Produits pour la peau et/ou les cheveux, contenant des composes a structure isoprenoide |
WO2005107692A1 (fr) | 2004-05-03 | 2005-11-17 | Symrise Gmbh & Co. Kg | Composes de benzylidene-$g(b)-dicarbonyl servant de nouveaux absorbeurs a uv |
WO2005123101A1 (fr) | 2004-06-18 | 2005-12-29 | Symrise Gmbh & Co. Kg | Extrait de mures sauvages |
WO2006010661A1 (fr) | 2004-07-24 | 2006-02-02 | Beiersdorf Ag | Produits pour la peau et/ou les cheveux contenant des composes destines a accentuer le bronzage |
WO2006015954A1 (fr) | 2004-08-07 | 2006-02-16 | Symrise Gmbh & Co. Kg | Nitriles alpha-benzoyl-cinnamiques constituant de nouveaux absorbeurs uv |
US20060089413A1 (en) | 2002-11-25 | 2006-04-27 | Symrise Gmbh & Co. Kg | Anthranilic acid amides and derivatives thereof as cosmetic and pharmaceutical agents |
WO2006045760A1 (fr) | 2004-10-25 | 2006-05-04 | Symrise Gmbh & Co. Kg | Utilisation de flavanones glycosylees pour brunir la peau ou les cheveux |
WO2006053912A1 (fr) | 2004-11-22 | 2006-05-26 | Symrise Gmbh & Co. Kg | Formules comprenant des céramides et/ou des pseudocéramides et de l’alpha-bisabolol et application à la réparation de peau endommagée |
WO2007110415A2 (fr) | 2006-03-27 | 2007-10-04 | Symrise Gmbh & Co. Kg | Utilisation de trimères diacétyliques et formulations cosmétiques ou thérapeutiques contenant ces composés |
US20080070825A1 (en) | 2006-09-16 | 2008-03-20 | Symrise Gmbh & Co. Kg | 2-Methyl-2-alkenyl-substituted 1,3-dioxanes as odoriferous substances |
WO2008046676A1 (fr) | 2006-10-20 | 2008-04-24 | Henkel Ag & Co. Kgaa | Agent cosmétique contenant de la purine et/ou un dérivé de purine et de la taurine |
WO2008046795A1 (fr) | 2006-10-20 | 2008-04-24 | Symrise Gmbh & Co. Kg | Utilisation de c10-c14-alcanediols pour l'élaboration d'une composition destinée à la prophylaxie et/ou au traitement de l'apparition de pellicules déclenchée par malassezia et compositions à base de c10-c14-alcanediols |
EP2168570A2 (fr) | 2008-09-30 | 2010-03-31 | Symrise GmbH & Co. KG | Extraits d'isochrysis sp. |
WO2012033855A1 (fr) * | 2010-09-07 | 2012-03-15 | Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University | Production industrielle d'acide docosahexaénoïque à l'aide de microalgues phototrophes |
KR101410632B1 (ko) * | 2014-04-04 | 2014-06-23 | 주식회사 리스토어랩스 | 미세조류 유래 푸코잔틴을 포함하는 화장료조성물 및 그 제조방법 |
WO2015142999A1 (fr) * | 2014-03-19 | 2015-09-24 | U.S. Nutraceuticals, Llc D/B/A Valensa International | Composition et procédé pour améliorer les profils lipidiques sanguins et réduire la peroxydation des lipoprotéines basse densité (ldl) chez les humains au moyen d'huiles à base d'algues et d'astaxanthine |
ES2594602A1 (es) * | 2015-06-17 | 2016-12-21 | Neoalgae Micro Seaweeds Products S.L. | Procedimiento de obtención de un aceite |
WO2019037843A1 (fr) * | 2017-08-23 | 2019-02-28 | Symrise Ag | Utilisations d'extraits d'isochrysis sp |
-
2021
- 2021-01-27 WO PCT/EP2021/051840 patent/WO2022128164A1/fr active Application Filing
Patent Citations (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4251195A (en) | 1975-12-26 | 1981-02-17 | Morishita Jinta Company, Limited | Apparatus for making miniature capsules |
EP0389700A1 (fr) | 1988-01-29 | 1990-10-03 | FUJI CAPSULE KABUSHIKI KAISHA (also trading as FUJI CAPSULE CO., LTD.) | Gélules d'agar |
EP0584178A1 (fr) | 1991-05-15 | 1994-03-02 | Stiefel Laboratories | Composition et procede pour ameliorer le bronzage de la peau. |
JPH07196478A (ja) | 1993-12-30 | 1995-08-01 | Hajime Sugii | 安全性の高い食品及び医薬品用ソフトカプセル |
US6214376B1 (en) | 1998-08-25 | 2001-04-10 | Banner Pharmacaps, Inc. | Non-gelatin substitutes for oral delivery capsules, their composition and process of manufacture |
WO2001076572A2 (fr) | 2000-04-12 | 2001-10-18 | bitop Aktiengesellschaft für biotechnische Optimierung | Utilisation de solutes compatibles en tant que substances aux proprietes de piegeage de radicaux |
WO2002015868A2 (fr) | 2000-08-18 | 2002-02-28 | Bitop Gesellschaft Für Biotechnische Optimierung Mbh | Formulations cosmetiques |
WO2003055587A1 (fr) | 2001-12-24 | 2003-07-10 | Symrise Gmbh & Co.Kg | Microcapsules a remplissage mononucleaire |
US20060089413A1 (en) | 2002-11-25 | 2006-04-27 | Symrise Gmbh & Co. Kg | Anthranilic acid amides and derivatives thereof as cosmetic and pharmaceutical agents |
WO2004050069A1 (fr) | 2002-12-05 | 2004-06-17 | Symrise Gmbh & Co. Kg | Capsules fourrees sans soudures |
WO2005032501A1 (fr) | 2003-09-08 | 2005-04-14 | Beiersdorf Ag | Produits a utiliser sur la peau et/ou les cheveux, contenant des composes cyclohexene 4 fois substitues |
WO2005102252A2 (fr) | 2004-04-26 | 2005-11-03 | Beiersdorf Ag | Produits pour la peau et/ou les cheveux, contenant des composes a structure isoprenoide |
WO2005107692A1 (fr) | 2004-05-03 | 2005-11-17 | Symrise Gmbh & Co. Kg | Composes de benzylidene-$g(b)-dicarbonyl servant de nouveaux absorbeurs a uv |
WO2005123101A1 (fr) | 2004-06-18 | 2005-12-29 | Symrise Gmbh & Co. Kg | Extrait de mures sauvages |
WO2006010661A1 (fr) | 2004-07-24 | 2006-02-02 | Beiersdorf Ag | Produits pour la peau et/ou les cheveux contenant des composes destines a accentuer le bronzage |
WO2006015954A1 (fr) | 2004-08-07 | 2006-02-16 | Symrise Gmbh & Co. Kg | Nitriles alpha-benzoyl-cinnamiques constituant de nouveaux absorbeurs uv |
WO2006045760A1 (fr) | 2004-10-25 | 2006-05-04 | Symrise Gmbh & Co. Kg | Utilisation de flavanones glycosylees pour brunir la peau ou les cheveux |
WO2006053912A1 (fr) | 2004-11-22 | 2006-05-26 | Symrise Gmbh & Co. Kg | Formules comprenant des céramides et/ou des pseudocéramides et de l’alpha-bisabolol et application à la réparation de peau endommagée |
WO2007110415A2 (fr) | 2006-03-27 | 2007-10-04 | Symrise Gmbh & Co. Kg | Utilisation de trimères diacétyliques et formulations cosmétiques ou thérapeutiques contenant ces composés |
US20080070825A1 (en) | 2006-09-16 | 2008-03-20 | Symrise Gmbh & Co. Kg | 2-Methyl-2-alkenyl-substituted 1,3-dioxanes as odoriferous substances |
WO2008046676A1 (fr) | 2006-10-20 | 2008-04-24 | Henkel Ag & Co. Kgaa | Agent cosmétique contenant de la purine et/ou un dérivé de purine et de la taurine |
WO2008046795A1 (fr) | 2006-10-20 | 2008-04-24 | Symrise Gmbh & Co. Kg | Utilisation de c10-c14-alcanediols pour l'élaboration d'une composition destinée à la prophylaxie et/ou au traitement de l'apparition de pellicules déclenchée par malassezia et compositions à base de c10-c14-alcanediols |
EP2168570A2 (fr) | 2008-09-30 | 2010-03-31 | Symrise GmbH & Co. KG | Extraits d'isochrysis sp. |
WO2012033855A1 (fr) * | 2010-09-07 | 2012-03-15 | Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University | Production industrielle d'acide docosahexaénoïque à l'aide de microalgues phototrophes |
WO2015142999A1 (fr) * | 2014-03-19 | 2015-09-24 | U.S. Nutraceuticals, Llc D/B/A Valensa International | Composition et procédé pour améliorer les profils lipidiques sanguins et réduire la peroxydation des lipoprotéines basse densité (ldl) chez les humains au moyen d'huiles à base d'algues et d'astaxanthine |
KR101410632B1 (ko) * | 2014-04-04 | 2014-06-23 | 주식회사 리스토어랩스 | 미세조류 유래 푸코잔틴을 포함하는 화장료조성물 및 그 제조방법 |
ES2594602A1 (es) * | 2015-06-17 | 2016-12-21 | Neoalgae Micro Seaweeds Products S.L. | Procedimiento de obtención de un aceite |
WO2019037843A1 (fr) * | 2017-08-23 | 2019-02-28 | Symrise Ag | Utilisations d'extraits d'isochrysis sp |
Non-Patent Citations (12)
Title |
---|
E. IBANEZ ET AL., CONFERENCE PAPER PRESENTED AT 12TH INTERNATIONAL SYMPOSIUM ON SUPERCRITICAL FLUIDS, 2018 |
E. M.BENDIF ET AL., J. APPL. PHYCOL., vol. 25, 2013, pages 1763 - 1776 |
E.A. BRETTMANN ET AL., EXP DERMATOL, vol. 27, no. 8, 2018, pages 859 - 866 |
GILBERT-LOPEZ ET AL., GREEN CHEM, vol. 17, 2015, pages 4599 - 4609 |
I. T. MARLOWE ET AL., BR. PHYCOL. J., vol. 19, 1984, pages 203 - 216 |
L.Y. BOURGUIGNON ET AL., J. INVEST. DERMATOL., 2006, pages 1356 - 1365 |
M. RINNERTHALER ET AL., BIOMOLECULES, vol. 5, no. 2, 2015, pages 545 - 589 |
MOLINA GRIMA E ET AL: "COMPARISON BETWEEN EXTRACTION OF LIPIDS AND FATTY ACIDS FROM MICROALGAL BIOMASS", JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, SPRINGER, DE, vol. 71, no. 9, 1 September 1994 (1994-09-01), pages 955 - 959, XP001118743, ISSN: 0003-021X, DOI: 10.1007/BF02542261 * |
S. ARCTANDER: "Perfume and Flavor Chemicals", 1969, PRIVATE PUBLISHING HOUSE |
SURBURGPANTEN: "Common Fragrance and Flavor Materials", 2006, WILEY-VCH |
T.T. PARSONSJ.D.H. STRICKLAND, J. MAR. RES., vol. 21, 1963, pages 155 - 163 |
W.B. BOLLAG ET AL., AM.J.PHYSIOL CELL PHYSIOL., 2020, Retrieved from the Internet <URL:https://doi.org/10.1152/ajpcell.00075.2020> |
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