EP1677798A2 - Once-a-day, oral, controlled-release, oxycodone dosage forms - Google Patents
Once-a-day, oral, controlled-release, oxycodone dosage formsInfo
- Publication number
- EP1677798A2 EP1677798A2 EP04817492A EP04817492A EP1677798A2 EP 1677798 A2 EP1677798 A2 EP 1677798A2 EP 04817492 A EP04817492 A EP 04817492A EP 04817492 A EP04817492 A EP 04817492A EP 1677798 A2 EP1677798 A2 EP 1677798A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- auc
- oxycodone
- formulation
- hours
- auco
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Definitions
- FIG 1 is a perspective view of one embodiment of a controlled release osmotic dosage form.
- Dosage form 10 comprises wall 20 that surrounds and encloses an internal compartment (not seen in Figure 1).
- the internal compartment contains a composition comprising oxycodone, and/or one or more of its pharmaceutically acceptable acid addition salts.
- Wall 20 is provided with at least one drug delivery exit 60 for connecting the internal compartment with the exterior environment of use. Accordingly, following oral ingestion of dosage form 10, fluid is imbibed through wall 20 and oxycodone and/or one or more of its pharmaceutically acceptable acid addition salts is released through exit 60.
- the preferred geometrical embodiment in Figure 1 illustrates a standard biconvex shaped tablet, the geometry may embrace a capsule shaped caplet and other oral dosage forms.
- the final dosage form contained a color overcoat and a wax coat and had a mean release rate of 3.94 mg oxycodone hydrochloride, USP per hour (4.93 %/hr).
- the formulation of this example is summarized in Table 5 and is referred to hereinafter as the "Example 3 SZO-24 dosage form.”
- Example 4 Pharmacokinetics and Pharmacodynamics of Osmotic Oxycodone Hydrochloride (Fast and Slow) and Immediate Release Oxycodone Hydrochloride in Healthy Volunteers
- This study investigated the pharmacokinetics and pharmacodynamics of the "fast” and “slow” osmotic oxycodone HCl systems of Example 1 and immediate release (IR) oxycodone HCl in healthy male volunteers.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51588003P | 2003-10-29 | 2003-10-29 | |
PCT/US2004/036132 WO2005041968A2 (en) | 2003-10-29 | 2004-10-28 | Once-a-day, oral, controlled-release, oxycodone dosage forms |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1677798A2 true EP1677798A2 (en) | 2006-07-12 |
Family
ID=34549453
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04817492A Withdrawn EP1677798A2 (en) | 2003-10-29 | 2004-10-28 | Once-a-day, oral, controlled-release, oxycodone dosage forms |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1677798A2 (zh) |
JP (1) | JP2007509979A (zh) |
KR (1) | KR20060108690A (zh) |
CN (1) | CN1933837A (zh) |
AU (1) | AU2004285547A1 (zh) |
BR (1) | BRPI0415639A (zh) |
CA (1) | CA2546691A1 (zh) |
EC (1) | ECSP066534A (zh) |
IL (1) | IL175193A0 (zh) |
MA (1) | MA28215A1 (zh) |
NO (1) | NO20062398L (zh) |
RU (1) | RU2006118323A (zh) |
WO (1) | WO2005041968A2 (zh) |
ZA (1) | ZA200604310B (zh) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
KR20130010512A (ko) | 1999-10-29 | 2013-01-28 | 유로-셀티크 소시에떼 아노뉨 | 서방성 하이드로코돈 제형 |
EP1337244A4 (en) | 2000-10-30 | 2006-01-11 | Euro Celtique Sa | HYDROCODON FORMULATIONS WITH CONTROLLED RELEASE |
UA81224C2 (uk) * | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
US20110104214A1 (en) | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
CA2713128C (en) | 2008-01-25 | 2016-04-05 | Gruenenthal Gmbh | Pharmaceutical dosage form |
US9226907B2 (en) | 2008-02-01 | 2016-01-05 | Abbvie Inc. | Extended release hydrocodone acetaminophen and related methods and uses thereof |
WO2009135680A1 (en) | 2008-05-09 | 2009-11-12 | Grünenthal GmbH | Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step |
CN102639118B (zh) | 2009-07-22 | 2015-07-29 | 格吕伦塔尔有限公司 | 氧化稳定的抗干扰剂型 |
ES2534908T3 (es) | 2009-07-22 | 2015-04-30 | Grünenthal GmbH | Forma de dosificación de liberación controlada extruida por fusión en caliente |
US20110150989A1 (en) * | 2009-12-22 | 2011-06-23 | Mallinkckrodt Inc. | Methods of Producing Stabilized Solid Dosage Pharmaceutical Compositions Containing Morphinans |
US9884022B2 (en) * | 2010-04-07 | 2018-02-06 | Lupin Limited | Controlled release pharmaceutical compositions of tapentadol |
PL2611426T3 (pl) | 2010-09-02 | 2014-09-30 | Gruenenthal Gmbh | Postać dawkowania zawierająca nieorganiczne sole, odporna na zgniatanie |
MX2013002293A (es) | 2010-09-02 | 2013-05-09 | Gruenenthal Gmbh | Forma de dosificacion resistente a alteracion que comprende un polimero anionico. |
DK2736495T3 (da) | 2011-07-29 | 2017-11-13 | Gruenenthal Gmbh | Misbrugsbestandig tablet som tilvejebringer øjeblikkelig frigivelse af lægemiddel |
RS56527B1 (sr) | 2011-07-29 | 2018-02-28 | Gruenenthal Gmbh | Tableta za trenutno oslobađanje leka rezistentna na zloupotrebu |
EP2819656A1 (en) | 2012-02-28 | 2015-01-07 | Grünenthal GmbH | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
MX362357B (es) | 2012-04-18 | 2019-01-14 | Gruenenthal Gmbh | Forma de dosificacion farmaceutica resistente a la adulteracion y resistente a la liberacion inmediata de la dosis. |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
AU2014273226B2 (en) | 2013-05-29 | 2019-06-27 | Grunenthal Gmbh | Tamper resistant dosage form with bimodal release profile |
US10154966B2 (en) | 2013-05-29 | 2018-12-18 | Grünenthal GmbH | Tamper-resistant dosage form containing one or more particles |
JP6449871B2 (ja) | 2013-07-12 | 2019-01-09 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | エチレン−酢酸ビニルポリマーを含有する改変防止剤形 |
BR112016010482B1 (pt) | 2013-11-26 | 2022-11-16 | Grünenthal GmbH | Preparação de uma composição farmacêutica em pó por meio de criomoagem |
MX2016014738A (es) | 2014-05-12 | 2017-03-06 | Gruenenthal Gmbh | Formulacion en capsula de liberacion inmediata resistente a alteraciones que comprende tapentadol. |
CN106456550A (zh) | 2014-05-26 | 2017-02-22 | 格吕伦塔尔有限公司 | 避免乙醇剂量倾泻的多颗粒 |
CA2983642A1 (en) | 2015-04-24 | 2016-10-27 | Grunenthal Gmbh | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
CA2998259A1 (en) | 2015-09-10 | 2017-03-16 | Grunenthal Gmbh | Protecting oral overdose with abuse deterrent immediate release formulations |
WO2018029226A1 (en) | 2016-08-10 | 2018-02-15 | F. Hoffmann-La Roche Ag | Pharmaceutical compositions comprising akt protein kinase inhibitors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5914131A (en) * | 1994-07-07 | 1999-06-22 | Alza Corporation | Hydromorphone therapy |
UA81224C2 (uk) * | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
WO2003092648A1 (en) * | 2002-04-29 | 2003-11-13 | Alza Corporation | Methods and dosage forms for controlled delivery of oxycodone |
EP1513497A2 (en) * | 2002-05-31 | 2005-03-16 | Alza Corporation | Dosage forms and compositions for osmotic delivery of variable dosages of oxycodone |
-
2004
- 2004-10-28 CA CA002546691A patent/CA2546691A1/en not_active Abandoned
- 2004-10-28 WO PCT/US2004/036132 patent/WO2005041968A2/en active Application Filing
- 2004-10-28 BR BRPI0415639-0A patent/BRPI0415639A/pt not_active IP Right Cessation
- 2004-10-28 AU AU2004285547A patent/AU2004285547A1/en not_active Abandoned
- 2004-10-28 JP JP2006538357A patent/JP2007509979A/ja not_active Withdrawn
- 2004-10-28 CN CNA2004800394188A patent/CN1933837A/zh active Pending
- 2004-10-28 EP EP04817492A patent/EP1677798A2/en not_active Withdrawn
- 2004-10-28 RU RU2006118323/15A patent/RU2006118323A/ru unknown
- 2004-10-28 KR KR1020067010336A patent/KR20060108690A/ko not_active Application Discontinuation
-
2006
- 2006-04-25 IL IL175193A patent/IL175193A0/en unknown
- 2006-04-28 EC EC2006006534A patent/ECSP066534A/es unknown
- 2006-04-28 MA MA28979A patent/MA28215A1/fr unknown
- 2006-05-26 NO NO20062398A patent/NO20062398L/no not_active Application Discontinuation
- 2006-05-26 ZA ZA200604310A patent/ZA200604310B/en unknown
Non-Patent Citations (1)
Title |
---|
See references of WO2005041968A2 * |
Also Published As
Publication number | Publication date |
---|---|
ZA200604310B (en) | 2007-11-28 |
KR20060108690A (ko) | 2006-10-18 |
CA2546691A1 (en) | 2005-05-12 |
JP2007509979A (ja) | 2007-04-19 |
WO2005041968A2 (en) | 2005-05-12 |
MA28215A1 (fr) | 2006-10-02 |
RU2006118323A (ru) | 2007-12-10 |
IL175193A0 (en) | 2008-04-13 |
CN1933837A (zh) | 2007-03-21 |
AU2004285547A1 (en) | 2005-05-12 |
BRPI0415639A (pt) | 2006-12-12 |
NO20062398L (no) | 2006-07-27 |
WO2005041968A3 (en) | 2006-06-22 |
ECSP066534A (es) | 2006-11-24 |
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Legal Events
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR |
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AX | Request for extension of the european patent |
Extension state: AL HR LT LV MK |
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RAX | Requested extension states of the european patent have changed |
Extension state: MK Payment date: 20060622 Extension state: LV Payment date: 20060622 Extension state: LT Payment date: 20060622 Extension state: HR Payment date: 20060622 Extension state: AL Payment date: 20060622 |
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Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20080430 |