EP1461060A2 - Kosmetisches mittel enthaltend ein murumuru-samenöl - Google Patents

Kosmetisches mittel enthaltend ein murumuru-samenöl

Info

Publication number
EP1461060A2
EP1461060A2 EP03709853A EP03709853A EP1461060A2 EP 1461060 A2 EP1461060 A2 EP 1461060A2 EP 03709853 A EP03709853 A EP 03709853A EP 03709853 A EP03709853 A EP 03709853A EP 1461060 A2 EP1461060 A2 EP 1461060A2
Authority
EP
European Patent Office
Prior art keywords
agents
composition
murumuru
oil
seeds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03709853A
Other languages
English (en)
French (fr)
Inventor
Antoine Piccirelli
Philippe Msika
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Expanscience SA
Original Assignee
Laboratoires Expanscience SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Expanscience SA filed Critical Laboratoires Expanscience SA
Publication of EP1461060A2 publication Critical patent/EP1461060A2/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/001—Preparations for care of the lips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
    • A61Q1/06—Lipsticks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair

Definitions

  • the present invention relates to a cosmetic or pharmaceutical composition containing an oil extracted from Murumuru seeds.
  • the invention also relates to a cosmetic treatment method for treating the skin, mucous membranes, nails or hair.
  • Another subject of the invention is the use of oil extracted from Murumuru seeds as an excipient in a cosmetic or pharmaceutical composition, as well as the use of oil extracted from Murumuru seeds as active principle, advantageously as a moisturizing agent, in a cosmetic composition.
  • the invention also relates to the use of oil extracted from Murumuru seeds as a food or as a food supplement.
  • the Murumuru also known as the Astrocaryum murumuru
  • the Palm trees of the genus Astrocaryum include about fifty solitary species, present in tropical America, from Mexico to the south of Brazil.
  • the Astrocaryum murumuru species is spontaneous and widespread in the Amazon, especially in the State of Para. This species of palm trees is particularly fond of moist soils, riversides and swamp forests known as "Igapos" in the lower Amazon (Belém region). It is found in particular on the island of Marajo.
  • the Murumuru has a stem (like a "trunk"), with a diameter of 20 to 30 cm, covered with strong horizontal spines, dense and aggressive, 12 to 15 cm long.
  • the leaves are 3 to 4 meters long. They are pinnate and have lanceolate leaflets, dark green on the underside and silvery above. The flowers are born in the axils of old dead leaves. They are monoecious and united on the same spadix.
  • the fruits are grouped in the form of clusters. Their number can reach 300 per tree. They are drupes of oval to piriform shape. When ripe, the color of the fruit, quite bright, is yellow or orange.
  • the fruit contains a bitter, edible yellow pulp, which decomposes quickly when the fruit falls to the ground, as well as a seed traditionally known as "nuts".
  • the latter conical in shape, includes a woody shell and a white almond.
  • the Murumuru seed represents around 33% of the fruit and its lipid content, by hexane extraction, is around 27%.
  • the oils obtained from seeds of Astrocaryum murumuru have a consistency of "butter", solid at room temperature, while the oils from pulps are fluid, which translates into a difference in chemical composition between the two types of oils, particularly with regard to the distribution of fatty acids.
  • the oil extracted from Murumuru seeds will be designated Murumuru butter in the context of the present invention.
  • Murumuru butter is a butter with a shorter fatty chain (C ⁇ 2 -C ⁇ 4 ) than shea or cocoa (mainly C ⁇ 8 ). This difference in fatty acid composition leads to differences in their properties.
  • Murumuru butter is much more stable than shea butter, the peroxide index evolving much less quickly with Murumuru butter during accelerated aging tests of the thin layer type (butter deposited on a glass wall, in the form of a thin film and subjected to 50 ° C, to a current of hot air).
  • Table 1 shows the evolution of the peroxide index during an accelerated aging test of the thin layer type with Murumuru butter and with shea butter.
  • Murumuru seeds containing the total lipids of these seeds, has already been used for the preparation of detergents and semi-synthetic emulsifiers (FR 971 322), but it has never been used in cosmetic formulations or pharmaceuticals. Indeed, Murumuru oil has already been used, after saponification of the fatty acids contained in this oil, to manufacture solid soaps (FR 999 573), but the patent application FR 999 573 does not specify whether it acts of oil extracted from Murumuru seeds or oil extracted from Murumuru pulps.
  • the oil extracted from Murumuru seeds in particular the oil whose fatty acids are in the form of triglycerides, and not in the form of salts, has never been used in cosmetic formulations, nor in pharmaceutical formulations.
  • the Applicant has surprisingly discovered that the oil extracted from Murumuru seeds, in particular the oil, all of the fatty acids of which are in the form of triglycerides, could be used in a cosmetic composition, advantageously administered externally. topically, to act in particular as a care product, body hygiene product, makeup product or deodorant product for the skin, mucous membranes, nails or even the hair, in particular as a moisturizing agent.
  • the oil extracted from Murumuru seeds could be used in a cosmetic or pharmaceutical composition, advantageously as an excipient, in substitution for synthetic short-chain triglycerides (capric and caprylic), triglycerides ethoxylated, hydrogenated soybean oils, lipophilic matrices in general which are used as excipient bases in suppositories, as excipients for filling conventional capsules and capsules (vegetable or gelatin-based), or even oily gels.
  • the oils extracted from Murumuru seeds turn out to be natural compounds, cosmetically and pharmaceutically acceptable, non-aggressive or toxic for the skin, hypoallergenic, soothing, hydrating and anti-inflammatory for the skin.
  • Murumuru oils are commercially available and can be used crude or refined in cosmetic or pharmaceutical compositions.
  • the present invention thus relates to a cosmetic composition containing an oil extracted from Murumuru seeds.
  • the present invention also relates to a pharmaceutical composition containing an oil extracted from Murumuru seeds.
  • the oil from the Murumuru seeds can be obtained according to the method consisting in extracting the total lipids from the Murumuru seeds previously dried and ground, using a solvent for the oils, then evaporating said solvent.
  • the Murumuru seeds according to the present invention can thus be ground, for example using a cylinder or hammer mill.
  • the solvent for oils, used to extract the total lipids from the seeds forming the oil is a conventional organic solvent for extracting lipids.
  • the solvent is advantageously chosen from the group consisting of aliphatic alkanes, aromatic alkanes, aliphatic alcohols and their halogen derivatives. Even more advantageously according to the present invention, the organic solvent is hexane.
  • the extraction of total lipids from Murumuru seeds is advantageously carried out by soxhlet extraction which is a technology well known to those skilled in the art.
  • the organic solvent is evaporated, preferably by evaporation under vacuum.
  • the oil from the Murumuru seeds can be obtained according to the process consisting in extracting the lipids from the Murumuru seeds by mechanical pressure of the seeds when cold, advantageously using a continuous screw press, to lead, after filtration, to virgin oils of first pressure.
  • all of the fatty acids in the oil of Murumuru seeds are in the form of triglycerides.
  • in the form of triglycerides is meant in the sense of the present invention in particular the fatty acids which have not been saponified and which are not thus found in the form of salts.
  • the oil extracted from Murumuru seeds can be used as an active principle or as an excipient in the cosmetic and pharmaceutical compositions according to the present invention.
  • the oil is advantageously used as an excipient in the pharmaceutical and cosmetic compositions according to the present invention, but it can also be advantageously used as active principle, in particular as a moisturizing agent, in the cosmetic compositions according to the present invention.
  • the oil extracted from Murumuru seeds is used in a cosmetic or pharmaceutical composition as an excipient, as a vehicle, or as an ingredient for excipient, in substitution for the short chain synthetic triglycerides (capric and caprylic), ethoxylated triglycerides, hydrogenated soybean oils, or lipophilic matrices.
  • the oil extracted from Murumuru seeds can be used as a fatty support in various cosmetic or pharmaceutical compositions, advantageously containing at least one liposoluble active principle.
  • the oil extracted from Murumuru seeds can be used as an excipient base in suppositories, as an excipient for filling conventional soft capsules and capsules (vegetable or gelatin-based), or as an excipient in oily gels, sticks such as lipsticks or so-called moisturizing or sun lipsticks, cosmetic products such as balms, ointments, ointments, creams or even oil-in-water emulsions, water-in-oil, multiple emulsions, transparent emulsions, PI T. emulsions, sprays, emulsions without emulsifier (stable dispersions), makeup products for the cheeks, eyelashes, nails, or eyes.
  • the oil extracted from Murumuru seeds can be used in crude form or in refined form in the cosmetic and pharmaceutical compositions according to the present invention.
  • refining is meant within the meaning of the present invention, the unitary operations for the purification of lipids of plant origin well known from those skilled in the art, among which mention may be made in particular of chemical neutralization, degumming, discoloration, deodorization and refrigeration.
  • the oil is present at a concentration of between 0.1 and 50%, preferably between 1 and 30% by weight, more preferably between 1 and 25% by weight, relative to the total weight. cosmetic or pharmaceutical composition.
  • the oil is present at a concentration of between 5 and 30%, preferably between 7 and 30%, and even more preferably between 10 and 30% by weight, relative the total weight of the composition.
  • the cosmetic or pharmaceutical composition according to the present invention is advantageously in oily form, in the form of an oil-in-water or water-in-oil or multiple emulsion, in the form of an aqueous or oily gel, in the form of a liquid, pasty or solid anhydrous product, or in the form of an oil dispersion in an aqueous phase using spherules, the spherules possibly being polymeric nanoparticles such as nanospheres and nanocapsules or better lipid vesicles of ionic and / or non-ionic type.
  • the cosmetic or pharmaceutical composition is formulated to be administered by topical, oral, sublingual, subcutaneous, intramuscular, intravenous, intratracheal, intranasal, intranasal, transdermal or rectal route.
  • said composition when the composition is formulated to be administered topically, said composition, which can be more or less fluid, is in the form of white or colored cream, ointment, milk, lotion, ointment, serum, paste, foam, aerosol or stick.
  • composition when the composition is formulated to be administered orally, said composition can be in the form of tablets, capsules, powders, granules, solutions or even oral suspensions.
  • the composition according to the present invention may also contain the adjuvants customary in the cosmetic or pharmaceutical field, such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic active agents, preservatives, antioxidants, solvents, perfumes, fillers, filters, pigments, chelating agents, odor absorbers and coloring matters.
  • the amounts of these various adjuvants are those conventionally used in cosmetics or in pharmaceuticals, and for example from 0.01% to 80% by weight, relative to the total weight of the composition.
  • These adjuvants depending on their nature, can be introduced into the fatty phase, into the aqueous phase, into the lipid vesicles and / or into the nanoparticles.
  • the proportion of the fatty phase can range from 5% to 80% by weight, and preferably from 5% to 50% by weight, relative to the total weight of the composition.
  • the oils, emulsifiers and coemulsifiers used in the composition in the form of an emulsion are chosen from those conventionally used in the field under consideration.
  • the emulsifier and the coemulsifier are present in the composition in a proportion ranging from 0.3% to 30% by weight, and preferably from 0.5% to 20% by weight, relative to the total weight of the composition .
  • mineral oils other oils of vegetable origin (apricot oil, sunflower oil, plum oil), oils of animal origin, synthetic oils , silicone oils and fluorinated oils (perfluoropolyethers).
  • Fatty alcohols such as cetyl alcohol, fatty acids, or waxes such as beeswax can also be used as fats according to the present invention.
  • emulsifiers and coemulsifiers which can be used according to the present invention, there may be mentioned in particular fatty acid esters of polyethylene glycol, such as PEG-40 stearate or PEG-100 stearate, esters of fatty acid and of polyol, such as glyceryl stearate and sorbitan tristearate.
  • hydrophilic gelling agents which can be used according to the present invention, mention may in particular be made of carboxyvinyl polymers (carbomer), acrylic copolymers such as acrylate / alkylacrylate copolymers, polyacrylamides, polysaccharides, natural gums and clays.
  • carboxyvinyl polymers carboxyvinyl polymers (carbomer)
  • acrylic copolymers such as acrylate / alkylacrylate copolymers
  • polyacrylamides such as acrylate / alkylacrylate copolymers
  • polyacrylamides such as acrylate / alkylacrylate copolymers
  • polyacrylamides such as acrylate / alkylacrylate copolymers
  • polyacrylamides such as acrylate / alkylacrylate copolymers
  • polyacrylamides such as acrylate / alkylacrylate copolymers
  • polyacrylamides such as acrylate / alkylacrylate copolymers
  • the cosmetic or pharmaceutical composition also contains at least one compound chosen from the group consisting of hydrophilic active agents, lipophilic active agents, agents modulating differentiation and / or proliferation and / or skin pigmentation, antibacterial agents, agents modulating bacterial adhesion to the skin and / or mucous membranes, antifungal agents, soothing agents, anti-pruritic agents, keratolytic agents, anti-free radical agents, anti-seborrheic agents, anti-dandruff agents, agents with anti-acne activity, anti-irritant agents, hydrating agents, vitamins, anti-inflammatory agents, UVA and UVB filters, matting agents, light-reflecting pigments, active agents wrinkles, anti-glycation agents, Heat Shock Protein modulators and enzyme inhibitors.
  • hydrophilic active agents e.g., lipophilic active agents, agents modulating differentiation and / or proliferation and / or skin pigmentation
  • antibacterial agents agents modulating bacterial adhesion to the skin and / or mucous membranes
  • lipophilic active agents which can be used according to the present invention, there may be mentioned in particular retinol (vitamin A) and its derivatives, tocopherol (vitamin E) and its derivatives, essential fatty acids, ceramides, essential oils, salicylic acid and its derivatives.
  • composition according to the present invention may also contain other active agents intended in particular for the prevention and / or treatment of skin conditions.
  • active agents there may be mentioned in particular agents modulating differentiation and / or proliferation and / or skin pigmentation such as retinoic acid and its isomers, retinol and its esters, vitamin D and its derivatives, phyto -estrogens and kojic acid; antibacterial agents such as octanediol and conventional preservatives (quaternary ammonium, ...); agents modulating bacterial adhesion to the skin and / or mucous membranes such as certain sugar derivatives; antifungal agents, in particular compounds belonging to the class of imidazoles or their salts, compounds of the allylamine family, glycine derivatives (sodium hydroxymethylglycinate for example), piroctone olamine or even octopirox; soothing agents such as salicylic acid, lupeol, allantoin, blueberry water, Silanedi
  • anti-pruritic agents such as glycine
  • keratolytic agents such as alpha and beta-hydroxycarboxylic or beta-ketocarboxylic acids, their salts, amides or esters and more particularly hydroxy acids such as glycolic acid, lactic acid, salicylic acid, acid citric and in general fruit acids
  • anti-free radical agents such as alpha-tocopherol or its esters, carotenoids, isoflavones, OPCs, flavonoids, superoxide dismutases, certain metal chelators or ascorbic acid and its esters
  • anti-seborrheic agents such as retinoids, sabal, Pygeum Africanum extract, zinc salts.
  • anti-dandruff agents such as octopirox, zinc pyrithione or piroctone olamine ; agents having anti-acne activity such as retinoids, retinol, retinaldehyde, vitamins PP, benzoyl peroxides, erythromycin; anti-irritant agents such as thermal waters, polysaccharides, in particular with regard to irritant compounds possibly present in the compositions of the present invention; moisturizers such as polyols (eg glycerin); vitamins (for example D-panthenol or vitamins C, D, B6); anti-inflammatory agents such as thermal waters, polysaccharides; UVA and UVB filters such as organic and mineral screens; matting or coloring agents and light-reflecting pigments such as mixtures of titanium and mica or iron oxide; anti-wrinkle active agents such as retinol and its derivatives (
  • the present invention also relates to a cosmetic treatment method, characterized in that a composition is administered to a human being cosmetic according to the present invention for treating the skin, mucous membranes, nails or hair.
  • the cosmetic composition is used as a care product, body hygiene product, makeup product or deodorant product for the skin, mucous membranes, nails or hair.
  • the composition can be used as a hydrating product or as a protective product against insensible water loss from the skin.
  • the cosmetic composition according to the present invention is used to treat dry skin, dry hair or dry lips.
  • the cosmetic composition according to the present invention can also be advantageously used to treat chapped skin or lips.
  • the oil extracted from Murumuru seeds can thus advantageously be incorporated into compositions for the skin or the mucous membranes, such as moisturizing compositions, since the oil has a water retaining power and thus prevents water from s' evaporate from the skin.
  • the Murumuru oil according to the present invention can also advantageously be used in hair shampoos or conditioners, as well as in nail varnishes, intended to improve the shine and the flexibility respectively of the hair and the nails or also to revitalize respectively hair and nails.
  • the cosmetic composition according to the present invention can thus be presented in particular in the form of a moisturizing cream or lotion, a hydrating shower gel, a shampoo, a conditioner, a hair conditioner. , a detangling balm, a moisturizing lip stick, or even a lipstick or a make-up product for the face and nails.
  • the present invention also relates to the use of oil extracted from Murumuru seeds as an excipient in a cosmetic or pharmaceutical composition.
  • the present invention also relates to the use of oil extracted from Murumuru seeds as active principle, advantageously as agent moisturizer or protective agent against insensible water loss from the skin, in a cosmetic composition according to the present invention.
  • the present invention relates to the use of oil extracted from Murumuru seeds as a food or as a food supplement.
  • Example 1 Compositions of Crude Oil and Refined Oil Extracted from Murumuru Seeds
  • Example 2 Process for Refining Crude Oil Extracted from Murumuru Seeds
  • the dried product is then discolored at 90 ° C, for 30 minutes, in the presence of 1% bleaching earth.
  • Murumuru butter is finally deodorized in a thick layer type deodorizer, by injection of hot steam, under a vacuum of between 3 and 5 mbar, and at a temperature of 180-90 ° C for 5 hours.
  • the object of this study is to evaluate the effect of a refined Murumuru butter (designated by MR), obtained according to the method of Example 2, on the insensible water loss of the skin, after a single application of the butter in 10 adult female volunteers.
  • MR Murumuru butter
  • the entire study was carried out under specific, controlled and identical environmental conditions of temperature and relative humidity for each of the volunteers.
  • the measurements were carried out in a fully air-conditioned room equipped with humidity regulators (dehumidifier and humidifier).
  • the ambient temperature was maintained at 22 + 2 ° C and the relative humidity between 45 and 55%, thanks to a microprocessor connected to temperature-humidity sensors-transmitters (C.2AI KIMO).
  • C.2AI KIMO temperature-humidity sensors-transmitters
  • the stability of these parameters was continuously monitored and printed using a computerized multi-channel recorder (Eurotherm Chessell).
  • the measurement of the Insensible Water Loss was carried out using a Tewameter TM TM 210 (Courage + Khazaka electronic GmbH). This device measures the rate of evaporation of water diffusing through the stratum corneum (in g / m 2 .h), as well as the relative humidity of the ambient air (%) and the temperature.
  • the device includes 2 elements:
  • P partial pressure of water vapor in the air (mm Hg)
  • x sensor - skin distance
  • dm / dt represents the evaporation rate, proportional to the water vapor pressure gradient dp / dx measured by the 2 sensors of the device.
  • Zones 5 skin zones approximately 30 cm (6 x 5 cm) from the outside of the legs, delimited between the knee and the ankle (1 zone treated by product and a control zone to which no product has been applied) .
  • the control zone and the 4 treated zones were were determined on the right and left legs, according to a randomization.
  • the measurements were carried out, for each time of the study and for each zone, on a 10 cm sub-zone (one sub-zone per measurement time), after a delicate wiping with paper. cellulose wadding.
  • Methods of application delicate massage, uniformly, using a fingertip, to ensure the best possible penetration of the product.
  • Measurement time T0 (before application), Tl hour, T4 hours and T8 hours.
  • the following statistical analyzes: > analysis of variance, followed by a test of multiple comparisons (ANOVA and L.S.D., significance: p ⁇ 0.05) in case of normality of the distributions and homogeneity of the variances;
  • non-parametric Friedman test associated with the Wilcoxon test (“two-tail”, significance: p ⁇ 0.05) in the event of non-homogeneity of the variances or non-normality of the distributions; allowed to compare: - the values obtained after the application compared to the initial values, for each of the treated and control zones;
  • V (Tx) value at a given time on a given treated area
  • V (T0) initial value (before application) on the same treated area.
  • V (Tx) value at a given time on a given treated area
  • V (T0) initial value (before application) on the same treated area
  • V (Tx *) value at the same time T as Tx, on the control area
  • V (T0 *) initial value (before application) in the control area.
  • % percentage of variation compared to the initial measurement, on the same zone
  • P% percentage of variation compared to the initial measurement, on the same zone and compared to the values of the control zone, at the same time of the study .

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EP03709853A 2002-01-03 2003-01-03 Kosmetisches mittel enthaltend ein murumuru-samenöl Withdrawn EP1461060A2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0200027A FR2834206B1 (fr) 2002-01-03 2002-01-03 Composition cosmetique contenant une huile extraite de graines de murumuru, son utilisation cosmetique, et composition pharmaceutique contenant une huile extraite de graines de murumuru
FR0200027 2002-01-03
PCT/FR2003/000006 WO2003059244A2 (fr) 2002-01-03 2003-01-03 Composition cosmetique contenant une huile extraite de graines de murumuru

Publications (1)

Publication Number Publication Date
EP1461060A2 true EP1461060A2 (de) 2004-09-29

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EP03709853A Withdrawn EP1461060A2 (de) 2002-01-03 2003-01-03 Kosmetisches mittel enthaltend ein murumuru-samenöl

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Country Link
EP (1) EP1461060A2 (de)
AU (1) AU2003214289A1 (de)
FR (1) FR2834206B1 (de)
WO (1) WO2003059244A2 (de)

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FR2877577A1 (fr) * 2004-11-09 2006-05-12 Jean Pierre Maloisel Extraits de fruits d'astrocaryum aculeatum a visee anti hypertrophie benigne de la prostate, anti inflammatoire et anti oxydante
BRPI1101136A2 (pt) * 2011-03-31 2013-06-04 Natura Cosmeticos Sa composiÇço cosmÉtica para limpeza da pele contendo àleos de origem vegetal, processo de fabricaÇço da dita composiÇço e uso da referida composiÇço
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AU2003214289A8 (en) 2003-07-30
AU2003214289A1 (en) 2003-07-30
FR2834206B1 (fr) 2004-03-19
WO2003059244A2 (fr) 2003-07-24
FR2834206A1 (fr) 2003-07-04

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