EP1450943A1 - Mikroreaktorsystem - Google Patents
MikroreaktorsystemInfo
- Publication number
- EP1450943A1 EP1450943A1 EP02802627A EP02802627A EP1450943A1 EP 1450943 A1 EP1450943 A1 EP 1450943A1 EP 02802627 A EP02802627 A EP 02802627A EP 02802627 A EP02802627 A EP 02802627A EP 1450943 A1 EP1450943 A1 EP 1450943A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- microreactor system
- process modules
- microreactor
- connection
- connecting elements
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00801—Means to assemble
- B01J2219/0081—Plurality of modules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/028—Modular arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
Definitions
- the invention relates to a microreactor system for continuous synthesis with the features mentioned in the preamble of claim 1.
- microreactor systems have therefore been developed which take advantage of the continuous process control, but are designed for a much lower total turnover.
- the microreactors provide a defined reaction space, which usually contains additional structural elements to influence the reaction conditions.
- EP 1 031 375 A2 shows a microreactor for carrying out chemical reactions, which comprises individual, freely interchangeable microstructured elements.
- Microreactors of the type mentioned have the advantage that process engineering syntheses can be carried out under continuous synthetic conditions, such as have hitherto only been known from large-scale industry.
- the thermal course of the reaction can also be checked with a precision that was previously unknown. the, since there are often very small wall thicknesses between the channels leading the reaction medium and a heat exchanger medium.
- the small volumes in which small quantities of substances react with one another allow particularly reliable process control, in particular when carrying out critical or dangerous syntheses.
- microreactors consist of individual process modules with different tasks.
- the process modules provide, among other things, defined reaction spaces in which the reactants are mixed and often thermally induced or controlled with one another. Additional process modules allow the reaction medium to linger and post-treatment, for example by extraction, phase separation or temperature control.
- the individual process modules must be in fluid communication with each other.
- WO 95/26796 by Bard et al. describes a microreactor system that is based on the aforementioned modular concept.
- the individual process modules are laterally mounted on a support structure.
- the carrier structure contains small channels, via which a fluid connection between the individual process modules of the microreactor is established.
- a reactor module, a separation module and an analyzer module are connected in series on the support structure.
- the microreactor system shown has the disadvantage that the connection channels are firmly integrated in the support structure and thus a rigid connection system is specified. This limits the flexibility of the microreactor system and cannot be adapted to the often very different requirements of chemical synthesis.
- Ehrfeld et al. (WO 00/62018) describe a microreactor system which is composed of individual process modules and in which the individual process modules are provided with connecting elements via a connecting system, which connect to one another in a form-fitting manner during assembly such that fluid channels leading from one process module to another are connected to one another in a sealed manner.
- connecting elements are form-fitting if they are an integral part of the modules.
- positive and non-positive connections In the former, the force transmission takes place via their shape, in the latter by frictional friction (K.H. Decker: "Machine elements - design and calculation", 10th edition, Carl Hanser Verlag, Vienna, 1990, page 212). The document does not provide any clues as to how sensors and actuators required for regulation and control can be included in the system.
- the invention has for its object to provide a microreactor system which consists of easily exchangeable process modules and which has a simple and flexible connection system for the media to be conveyed in the microreactor system.
- the microreactor system should preferably be as compact as possible, user-friendly and automated. It should be possible to adjust the sensors and actuators required for regulation and control as flexibly as possible to the respective requirements.
- the microreactor system has a modular structure
- a process unit is composed of process modules which can be non-positively connected to one another, and
- the frictional connection between the respectively adjacent process modules or the process modules and the microreactor system can be achieved by connecting elements which are detachably or non-detachably connected to the process modules and / or the microreactor system, with fluid-conducting connections between the process module via these connecting elements. len among themselves or between the process modules and external connections of the microreactor system. This advantageously ensures that a process-technically secure, in particular reproducible, fluid connection of the process modules to one another and to external connections of the microreactor system is obtained in a simple manner.
- Retaining plates are preferably provided, which preferably have connection openings and / or integrated connecting elements on the inner sides facing the process modules.
- the connecting elements are either already an integral part of the holding plates or they are only arranged at a suitable point during the assembly of the process unit.
- a holding device which is further preferably provided, the clamping forces required to achieve the frictional connection are transmitted to all connecting elements of the connecting system. As a result, these are plastically or elastically deformed so that a good seal between the connection opening and the connecting element is obtained.
- the clamping force can be generated via mechanical, hydraulic, pneumatic and / or electrical devices.
- connection elements for connecting two opposite and preferably circular connection openings are preferably designed as double-sided, conical connection pipes, ie in the form of a double cone. Further training is also conceivable.
- the connecting elements can have a bipyramidal external design, so that they can be inserted sealingly into square or square connection openings. Such configurations ensure that a line contact occurs between the connecting element and the opening edge of the connection openings, which leads to high sealing forces and thus to a reliable seal.
- connection system also includes sealing elements for the complete sealing of connection openings over which no fluid medium is to be routed.
- sealing elements In their basic structure - with the exception of a fluid connection - these can correspond to the connecting elements.
- the connecting elements are preferably formed from the same materials from which the process modules are made in order to keep the risk of undesired interaction with the fluid media, reactants and products as low as possible and to exclude sealing problems due to different coefficients of thermal expansion.
- they can be made of inert materials such as metal, glass, ceramics, semiconductor materials. materials or plastics.
- the use of hard materials has the advantage that high clamping forces are tolerated.
- the connecting element is preferably coated with a plastically or elastically deformable material, in particular a metal, so that the sealing properties are further improved.
- connection elements or the sealing elements have in common that very short fluid connections can be realized between adjacent process modules or process modules and connection plate. Such short fluid connections lead to an increase in the process reliability of the microreactor system mentioned.
- the holding plates preferably have connection points for the fluidic connection of the process unit to the periphery, for example conveyor units for the supply of reactants, removal devices for product acceptance or thermostats.
- a sensor system can be assigned to the individual modules of the microreactor as an independent, interchangeable functional unit.
- the sensor system includes sensors for recording measured values such as temperature, pressure, flow, radiation, concentration, distance or viscosity of the medium.
- a force sensor for detecting the clamping force of the holding device or a distance sensor for detecting the distance between the holding plates can be provided.
- the synthesis can be regulated or controlled based on the measured values provided by the sensor system. With the help of an unit, the user can control the reaction conditions, change them if necessary and have certain process sequences run automatically.
- Figure 1 is a schematic diagram of a microreactor system for continuous synthesis, consisting of
- reaction media 24, 26, 32, 34
- heat transfer media 28, 30
- FIG. 2 shows a schematic sectional view through a process unit in the area of two process modules
- FIG. 3 shows two schematic sectional views of conical connecting elements of the connecting system
- FIG. 4 shows a basic structure of a microreactor system with an operating unit for a single-stage synthesis
- FIG. 5 shows a basic structure of a device for a two-stage synthesis with two micro-reactor systems and an operating unit.
- a process unit 10 as a central component of a microreactor system 11 according to the invention for continuous synthesis is shown schematically in FIG.
- the process unit 10 comprises the individual process modules 38, 40, 42, 44.
- the process unit 10 is comprised by a holding device 12 with two holding plates 14, 16 and at least one clamping element 18.
- the individual process modules 38, 40, 42, 44 of the process unit 10 are clamped into the holding device 12 in a manner which will be explained in more detail below.
- a clamping element 18 is preferably provided to apply a clamping force that is as uniform as possible.
- the clamping element 18 provides the clamping force required for the sealing and secure positioning of the process modules 38, 40, 42, 44 in a mechanical, hydraulic, pneumatic and / or electrical way.
- Connection points 22 are provided on the holding plates 14, 16 for the fluidic connection of the process unit 10 to the periphery.
- two feed units are provided for the supply of a first or a second reactant (reactant supply 24, 26).
- Two thermostats 28, 30 allow the targeted temperature control of the process modules 38, 40, 42, 44 by supplying or removing a suitable heat exchange medium.
- Another connection point 22 is used to connect a conveyor unit, which enables the introduction of an additional medium for post-processing of the reaction mixture (additional medium supply 32).
- a removal device 34 is schematically indicated in the area of the holding plate 16, which is used to remove the product or to remove the additional medium required for post-processing.
- the individual process modules 38, 40, 42, 44 usually consist of metal (in particular stainless steel), glass, ceramic, semiconductor materials (in particular based on silicon) or plastics. The selection of materials depends on the intended use.
- An inner surface of the process modules 38, 40, 42, 44 has been micromechanically structured in a known manner, as is described, for example, in EP 1 123 734 A2.
- At least one channel is included which leads through the system and is connected to an inlet and outlet of the process modules 38, 40, 42, 44 (connection openings 54).
- An interaction of the individual reaction spaces forms the volume in which the desired synthesis is to take place.
- further structures are provided which, for example, guide the heat exchange medium supplied by the thermostats 28, 30 into the immediate vicinity of the reaction medium.
- connection openings 54 must also be made in the process module 38, 40, 42, 44 for the heat exchange medium.
- the process unit 10 shown here by way of example contains a total of four process modules 38, 40, 42, 44.
- the two reactants are conveyed via the conveying units 24, 26 into a first process module 38, in which the two reactants are mixed with one another and in ther using thermostat 28 - are reacted with one another in a mixed, controlled manner.
- a first process module 38 in which the two reactants are mixed with one another and in ther using thermostat 28 - are reacted with one another in a mixed, controlled manner.
- the reaction medium arrives in a second process module 40 and a third process module 42, which essentially serve to provide the reaction medium with a certain dwell time and thus reaction time. This response time can be varied by the number of process modules used to provide response time.
- the second and third process modules 40 and 42 can also be tempered, this time using the thermostat 30.
- a subsequent fourth process Dul 44 is followed by a post-processing step in which an additional medium provided by the conveying unit 32 can be mixed into the reaction medium.
- an additional medium provided by the conveying unit 32 can be mixed into the reaction medium.
- quenching quenching the reaction
- Other post-processing steps are also possible, such as the continuous mixing of a two-phase reaction medium, extraction of by-products, filtration, phase separation, drying, crystallization, rectification, distillation or adsorption.
- the individual treatment steps can be combined as required and are designed so that they can be carried out continuously.
- the reaction medium is finally removed from the process unit via the device 34.
- Thermal control of the reaction conditions under which the continuous synthesis is to take place is of course not only limited to the area of the process modules 38, 40, 42, 44, as in the case shown, but can also be done in the area of the reactant supply 24, 26, the additional medium supply 32 and the removal devices 32, 34 for the product and the additional medium can be achieved by means of suitable thermostats.
- the microreactor system 11 comprises a sensor system 62 integrated in the holding device 12 and / or implemented as an independent, interchangeable functional unit of the system.
- a distance sensor 46 is shown here, which detects the distance between the holding plates 14 and 16 and thus provides an indirect measurement for the identification and the number of process modules.
- a force sensor is integrated in the holding device 12.
- Additional sensors 48 are assigned to the individual process modules 38, 40, 42, 44. For example, they allow the acquisition of measured values such as temperature, pressure, flow, radiation, concentration and the viscosity of the medium. Such sensors 48 are known and are therefore not explained in more detail here. All that remains to be said at this point is that the sensors 48 represent completely independent and interchangeable functional units, which can be assigned to the individual process modules 38, 40, 42, 44 as required.
- connection system that enables the supply and removal of the individual media into the process modules 38, 40, 42, 44 is based on conical connection elements 50.
- the geometry of the connection elements 50 supports the exact positioning of the individual process modules 38 when assembling the process unit 10 , 40, 42, 44 and, when the clamping force is applied by the holding device 12, leads to self-sealing of the connection system on the basis of a frictional connection.
- FIG. 2 shows a schematic sectional view through a process unit 10 with only two process modules 38, 40 for the reaction and for the residence of the reaction medium.
- a connecting element 50 serves as a plates 14, 16 integrated connecting tube that tapers in the direction of the process modules 38, 40.
- the process modules 38, 40 have the required connection openings 54 on their upper and lower sides.
- a double-sided, tapered connecting tube Arranged between the process modules 38, 40 is a double-sided, tapered connecting tube as a connecting element 50, via which the fluid reaction medium can enter or exit.
- the essential requirements for such a connection system are their tightness and flexibility.
- the connecting elements 50 should consist of the same materials as the process modules 38, 40 in order to avoid / reduce incompatibilities.
- the polymeric sealing materials frequently used in the prior art which can corrode when using aggressive reaction media, are to be dispensed with. Rather, a reliable sealing of the connection points 22 is to be made possible by the highest possible clamping force applied by the holding device 12.
- Metals, in particular stainless steel, or also glass, ceramics or plastics come into question.
- the use of semiconductor materials based on silicon is also possible. In the case of very hard materials, an elastic or plastic deformation of the connecting elements 50 required for sealing is only possible with a very high expenditure of force.
- the connecting elements 50 have been coated with a softer material, preferably a metal. Due to the stacked arrangement of the process modules, the connecting elements 50 only have to bridge very short distances. As a result, non-temperature-controlled transition points, in which crystallization and / or decomposition of thermolabile substances can easily occur, are kept very short. In addition, dead volumes that negatively influence the retention time behavior are kept extremely small.
- a plate-shaped positioning device 58 which holds the connecting element 50, facilitates the relative alignment of the process modules 38, 40 and the installation and removal of the same.
- the positioning device 58 has corresponding cutouts into which the connecting elements 50 can be inserted.
- the positioning devices 58 are either formed from the same material as the process modules 38, 40 or preferably have plastically deformable or elastic properties.
- the device 58 itself can also serve as a seal between two process modules.
- the fluid connection between adjacent process modules is then established via openings in the device 58.
- the recesses provided per se for receiving the connecting elements 50 serve as a fluid connection. In the event that only a very small dead volume can be tolerated, the openings must be kept as small as possible.
- a sealing element 60 is inserted between the two connection openings 54 instead of the connection elements 50. In FIG. 1, the heat exchange media of the thermostats 28, 30 between the process modules 38, 40 are separated from one another by such a sealing element 60.
- the sealing element 60 also serves as a support element in order to transmit the clamping force applied by the holding device 12 as evenly as possible to the individual process modules 38, 40, 42, 44.
- conical connecting elements 50 has the advantage that they fit on connection openings 54 with varying opening cross sections (FIG. 3). Deviations in the individual opening cross sections due to production can thus be tolerated.
- FIG. 4 shows a basic illustration of a micro-reactor system 11 which can be used to carry out a one-stage synthesis under continuous conditions.
- the process unit 10 comprises a total of three process modules 38, 40, 44 - the first module 38 for mixing and reacting, the second module 40 for lingering and the third module 44 for aftertreatment.
- the product is then collected in a suitable storage container via the removal device 34.
- the fluid connection within the process unit 10 is given by the previously described connection system with the conical connection elements 50 and indicated by the dotted arrow.
- a sensor system 62 enables the detection of operating parameters such as the temperature, the pressure, the concentration of the reactants, the flow conditions or the viscosity of the reaction medium.
- the microreactor system also contains an actuator system 64 which, with the aid of selected actuators, allows physical states of the reaction medium (temperature, pressure, flow velocity, concentration, phase state, etc.) to be changed.
- the entire synthesis process can thus be regulated or controlled and is accessible to automation.
- An operating unit 66 with an easily understandable user and operating surface serves to further simplify the work. All relevant process parameters can be checked and, if necessary, reset via the operating unit 66.
- the information network which connects the sensors 62, actuators 64 and the operating unit 66, is indicated by the arrows. In the course of automation, the number and type of process modules 38, 40, 44 used can be determined, for example, via a distance sensor 46 (as in the process unit 10 according to FIG.
- FIG. 5 shows such a microreactor system for a two-stage synthesis.
- a first process unit 70 supplies an intermediate product which is fed into a second process unit 74 via a suitable device 72 with a further reactant. After the reaction of the intermediate product with the further reactants and post-processing of the reaction medium, the desired end product can be collected by means of the removal device 34.
- the individual process units 70, 74 of such microreactor systems can be individually equipped, here exemplarily with process modules 38, 40, (42 in stage 1), 44, and are provided with independent sensors 62 and actuators 64. The entire reaction chain can be monitored, controlled and operated centrally by the operating unit 66.
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10155010A DE10155010A1 (de) | 2001-11-06 | 2001-11-06 | Mikroreaktorsystem |
DE10155010 | 2001-11-06 | ||
PCT/EP2002/011763 WO2003039736A1 (de) | 2001-11-06 | 2002-10-21 | Mikroreaktorsystem |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1450943A1 true EP1450943A1 (de) | 2004-09-01 |
Family
ID=7705142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02802627A Withdrawn EP1450943A1 (de) | 2001-11-06 | 2002-10-21 | Mikroreaktorsystem |
Country Status (5)
Country | Link |
---|---|
US (1) | US7468165B2 (de) |
EP (1) | EP1450943A1 (de) |
JP (1) | JP2005507775A (de) |
DE (1) | DE10155010A1 (de) |
WO (1) | WO2003039736A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003284055A1 (en) * | 2002-10-09 | 2004-05-04 | The Board Of Trustees Of The University Of Illinois | Microfluidic systems and components |
US20050175519A1 (en) * | 2004-02-06 | 2005-08-11 | Rogers William A.Jr. | Microchannel compression reactor |
DE102004007708A1 (de) * | 2004-02-16 | 2005-08-25 | Dynamit Nobel Gmbh Explosivstoff- Und Systemtechnik | Verfahren zur Aufarbeitung von flüssigen Stoffen |
EP1604735B1 (de) | 2004-06-10 | 2017-04-19 | Corning Incorporated | Hermetische übertragungsvorrichtung und deren herstellungsverfahren |
US7795359B2 (en) * | 2005-03-04 | 2010-09-14 | Novartis Ag | Continuous process for production of polymeric materials |
DE102005028897A1 (de) * | 2005-06-17 | 2006-12-28 | Eckert & Ziegler Eurotope Gmbh | Anordnung und Verfahren zur Verarbeitung von chemischen Stoffen, Computerprogramm zur Steuerung einer solchen Anordnung sowie ein entsprechendes computerlesbares Speichermedium |
EP2251079A1 (de) * | 2009-05-11 | 2010-11-17 | Chemtrix B.V. | Mikrofluidisches System und dessen Verwendung |
TW201114481A (en) * | 2009-05-11 | 2011-05-01 | Corning Inc | Modular reactor and system |
EP2402637A1 (de) | 2010-07-01 | 2012-01-04 | Alfa Laval Corporate AB | Durchflussmoduleinschraubverschraubung |
CN103153451A (zh) | 2010-08-24 | 2013-06-12 | 切姆特利克斯有限公司 | 微流体装置 |
US9139316B2 (en) | 2010-12-29 | 2015-09-22 | Cardinal Health 414, Llc | Closed vial fill system for aseptic dispensing |
CN103596675B (zh) * | 2011-06-07 | 2016-03-16 | 康宁股份有限公司 | 流体模块悬挂系统和得到的反应器 |
US20130020727A1 (en) | 2011-07-15 | 2013-01-24 | Cardinal Health 414, Llc. | Modular cassette synthesis unit |
US9417332B2 (en) | 2011-07-15 | 2016-08-16 | Cardinal Health 414, Llc | Radiopharmaceutical CZT sensor and apparatus |
WO2013012822A1 (en) | 2011-07-15 | 2013-01-24 | Cardinal Health 414, Llc | Systems, methods, and devices for producing, manufacturing, and control of radiopharmaceuticals |
EP2626133A1 (de) | 2012-02-10 | 2013-08-14 | Chemtrix B.V. | Mikrofluidisches System |
EP3708531A4 (de) * | 2017-11-10 | 2020-09-23 | Nok Corporation | Mikrofluidischer chip und mikrofluidische vorrichtung |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0484278B1 (de) * | 1990-11-01 | 1995-04-12 | Ciba-Geigy Ag | Vorrichtung zur Aufbereitung oder Vorbereitung von flüssigen Proben für eine chemische Analyse |
US5580523A (en) * | 1994-04-01 | 1996-12-03 | Bard; Allen J. | Integrated chemical synthesizers |
DE19652823A1 (de) * | 1996-12-18 | 1998-03-26 | Guenter Prof Dr Fuhr | Strukturierter Polytetrafluorethylen-Spacer |
US5890745A (en) * | 1997-01-29 | 1999-04-06 | The Board Of Trustees Of The Leland Stanford Junior University | Micromachined fluidic coupler |
US6240790B1 (en) * | 1998-11-09 | 2001-06-05 | Agilent Technologies, Inc. | Device for high throughout sample processing, analysis and collection, and methods of use thereof |
DE19854096A1 (de) * | 1998-11-24 | 2000-05-25 | Merck Patent Gmbh | Anschlußträger für plattenförmige Mikrokomponenten |
DE29903296U1 (de) | 1999-02-24 | 2000-08-03 | CPC Cellular Process Chemistry GmbH, 60386 Frankfurt | Mikroreaktor |
DE19917330B4 (de) * | 1999-04-16 | 2004-08-26 | INSTITUT FüR MIKROTECHNIK MAINZ GMBH | Mikroreaktormodul |
DE19917398C2 (de) * | 1999-04-16 | 2002-06-20 | Accoris Gmbh | Modulares chemisches Mikrosystem |
DE10106996C2 (de) * | 2001-02-15 | 2003-04-24 | Merck Patent Gmbh | Einrichtung zur Verbindung von Mikrokomponenten |
-
2001
- 2001-11-06 DE DE10155010A patent/DE10155010A1/de not_active Withdrawn
-
2002
- 2002-10-21 EP EP02802627A patent/EP1450943A1/de not_active Withdrawn
- 2002-10-21 JP JP2003541622A patent/JP2005507775A/ja active Pending
- 2002-10-21 US US10/494,725 patent/US7468165B2/en not_active Expired - Fee Related
- 2002-10-21 WO PCT/EP2002/011763 patent/WO2003039736A1/de active Application Filing
Non-Patent Citations (1)
Title |
---|
See references of WO03039736A1 * |
Also Published As
Publication number | Publication date |
---|---|
US20050025677A1 (en) | 2005-02-03 |
DE10155010A1 (de) | 2003-05-15 |
US7468165B2 (en) | 2008-12-23 |
WO2003039736A1 (de) | 2003-05-15 |
JP2005507775A (ja) | 2005-03-24 |
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