EP2626133A1 - Mikrofluidisches System - Google Patents

Mikrofluidisches System Download PDF

Info

Publication number
EP2626133A1
EP2626133A1 EP12154899.4A EP12154899A EP2626133A1 EP 2626133 A1 EP2626133 A1 EP 2626133A1 EP 12154899 A EP12154899 A EP 12154899A EP 2626133 A1 EP2626133 A1 EP 2626133A1
Authority
EP
European Patent Office
Prior art keywords
micro
channel
fluidic system
polytetrafluoroethylene
reinforced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP12154899.4A
Other languages
English (en)
French (fr)
Inventor
designation of the inventor has not yet been filed The
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHEMTRIX BV
Original Assignee
CHEMTRIX BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHEMTRIX BV filed Critical CHEMTRIX BV
Priority to EP12154899.4A priority Critical patent/EP2626133A1/de
Publication of EP2626133A1 publication Critical patent/EP2626133A1/de
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials

Definitions

  • WO03/039736 relates to a micro reactor system for the continuous synthesis, which provides defined reaction chambers and conditions for said synthesis, as well as to the uses of said micro reactor in carrying out chemical reactions.
  • micro-fluidic system comprising
  • the micro-fluidic system of the invention may have one or more of the following advantages: the micro-fluidic system may have a good resistance to high stresses due to fluidic pressures or high temperatures and/or is able to undergo multiple heating and cooling cycles without being affected in terms of strength and/or chemical resistance.
  • the second element is in communication, for example fluid communication, with the channel and is contacted by the fluids (for example the chemicals or product and by-products of a chemical reaction) during operation of the micro-fluidic system.
  • the second element may be any element with does not form an integral part with the first element.
  • the second element is preferably detachable from the first element
  • Examples of the second element include but are not limited to valves, for example check valves, sealing elements, ferrules, nuts, elements in the back pressure regulator, luer connectors, unions, holder parts, etc.
  • valves for example check valves, sealing elements, ferrules, nuts, elements in the back pressure regulator, luer connectors, unions, holder parts, etc.
  • the second element may for example also be a connector, such as a nut-and-ferrule connector.
  • a nut-and-ferrule connector may be provided at an outlet of the channel.
  • a conically shaped ferrule holding a tube may be inserted in a counteracting conically shaped hole in a second element provided at an outlet of the channel.
  • a nut may then be screwed into another element, for instance a holder part, which is provided with screw thread.
  • the conically shaped ferrule contracts, clamps the tube and thus provides a sealed connection between the outlet of the channel and the tube.
  • a nut-and-ferrule connector may also be combined into a single piece.
  • nut and ferrule connectors having a different shape for example a flatbottom shape may be used as a second element.
  • the tensile modulus of the reinforced polytetrafluoroethylene is at most 7000MPa, for example at most 6000MPa, for example at most 5000MPa, for example at most 4500MPa.
  • the tensile modulus of the reinforced polytetrafluoroethylene is at least 1500MPa, for example at least 1600MPa, for example at least 1700MPa, for example at least 1800MPa, for example at least 1900 MPa, for example at least 2000MPa.
  • PTFE polytetrafluoroethylene
  • fillers for example fibers to PTFE.
  • natural and synthetic fibers for instance wood, glass, carbon fibers or mica may be used to reinforce PTFE.
  • PTFE is reinforced with mica, for example with natural or with synthetic mica (Mg 3 K[AIF 2 O(SiO 3 ) 3 ), more preferably with synthetic mica, more preferably with synthetic fluorinated mica, also known as fluorophlogite or KMg 3 (AlSi 3 O 10 )F 2 .
  • synthetic fluorinated mica also known as fluorophlogite or KMg 3 (AlSi 3 O 10 )F 2 .
  • PTFE reinforced with synthetic fluorinated mica is commercially available as for example FluorosintTM 500, FluorosintTM 207, FluorosintTM HPV, FluorosintTM MT-01.
  • the amount of fillers, preferably fibers in PTFE may for example be in the range of from 10 to 40wt% based on the second material.
  • micro-fluidic system of the invention can suitably be used to perform chemical reactions at a temperature in the range of for example from -20 to 200°C and/or at a pressure in the range of for example from atmospheric pressure (101.325 kPa) to 80bar, for example from atmospheric pressure to 20 bar.
EP12154899.4A 2012-02-10 2012-02-10 Mikrofluidisches System Ceased EP2626133A1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP12154899.4A EP2626133A1 (de) 2012-02-10 2012-02-10 Mikrofluidisches System

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12154899.4A EP2626133A1 (de) 2012-02-10 2012-02-10 Mikrofluidisches System

Publications (1)

Publication Number Publication Date
EP2626133A1 true EP2626133A1 (de) 2013-08-14

Family

ID=45592217

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12154899.4A Ceased EP2626133A1 (de) 2012-02-10 2012-02-10 Mikrofluidisches System

Country Status (1)

Country Link
EP (1) EP2626133A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111246936A (zh) * 2017-10-25 2020-06-05 深圳华大生命科学研究院 用于核酸合成的微流控芯片

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001017797A1 (en) * 1999-09-10 2001-03-15 Caliper Technologies Corp. Microfabrication methods and devices
WO2001025138A1 (en) * 1999-10-04 2001-04-12 Nanostream, Inc. Modular microfluidic devices comprising sandwiched stencils
WO2003039736A1 (de) 2001-11-06 2003-05-15 Cpc-Cellular Process Chemistry Systems Gmbh Mikroreaktorsystem
WO2004022233A1 (en) 2002-09-06 2004-03-18 Epigem Limited Modular microfluidic system
US20050139993A1 (en) * 2003-12-26 2005-06-30 Lee Dae S. Plastic microfabricated structure for biochip, microfabricated thermal device, microfabricated reactor, microfabricated reactor array, and micro array using the same
WO2007021762A2 (en) * 2005-08-09 2007-02-22 The University Of North Carolina At Chapel Hill Methods and materials for fabricating microfluidic devices
WO2007112945A1 (en) 2006-03-31 2007-10-11 Lonza Ag Micro-reactor system
US20110135546A1 (en) * 2008-06-02 2011-06-09 Boehringer Ingelheim Microparts Gmbh Microfluidic foil structure for metering of fluids

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001017797A1 (en) * 1999-09-10 2001-03-15 Caliper Technologies Corp. Microfabrication methods and devices
WO2001025138A1 (en) * 1999-10-04 2001-04-12 Nanostream, Inc. Modular microfluidic devices comprising sandwiched stencils
WO2003039736A1 (de) 2001-11-06 2003-05-15 Cpc-Cellular Process Chemistry Systems Gmbh Mikroreaktorsystem
WO2004022233A1 (en) 2002-09-06 2004-03-18 Epigem Limited Modular microfluidic system
US20050139993A1 (en) * 2003-12-26 2005-06-30 Lee Dae S. Plastic microfabricated structure for biochip, microfabricated thermal device, microfabricated reactor, microfabricated reactor array, and micro array using the same
WO2007021762A2 (en) * 2005-08-09 2007-02-22 The University Of North Carolina At Chapel Hill Methods and materials for fabricating microfluidic devices
WO2007112945A1 (en) 2006-03-31 2007-10-11 Lonza Ag Micro-reactor system
US20110135546A1 (en) * 2008-06-02 2011-06-09 Boehringer Ingelheim Microparts Gmbh Microfluidic foil structure for metering of fluids

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111246936A (zh) * 2017-10-25 2020-06-05 深圳华大生命科学研究院 用于核酸合成的微流控芯片
CN111246936B (zh) * 2017-10-25 2022-05-03 深圳华大生命科学研究院 用于核酸合成的微流控芯片

Similar Documents

Publication Publication Date Title
US11158522B2 (en) Fluid delivery system
JP6851198B2 (ja) 真空システムのパイプカップリング
US20120114534A1 (en) Micro-fluidic system and the use thereof
Chen et al. High-pressure needle interface for thermoplastic microfluidics
WO2021133677A1 (en) Profile connection
US7867319B2 (en) Filled epoxy tubesheet
EP2626133A1 (de) Mikrofluidisches System
WO2021003244A1 (en) Profile connection
US20160243548A1 (en) Microfluidics sorter for cell detection and isolation
Pfreundt et al. An easy-to-use microfluidic interconnection system to create quick and reversibly interfaced simple microfluidic devices
US20160054272A1 (en) Liquid Delivery Device and Chemical Analysis Apparatus Using Liquid Delivery Device
JPWO2012128276A1 (ja) 液体クロマトグラフィー用カラム及びヘモグロビン類の分析方法
US10328409B2 (en) Methods for performing flow reactions utilizing high temperature hydrofluoric acid
US11813581B2 (en) Method and adapter for conveying plural liquid streams
Etxeberria et al. Critical Study on the Tube-to-Chip Luer Slip Connectors
US10315937B2 (en) Apparatus for germ reduction of a fluid and a process for use thereof
Tamanaha et al. Reusable, compression-sealed fluid cells for surface mounting to planar substrates
JP2011112530A (ja) シール材およびそれを備えたフローセル
JP4105716B2 (ja) 脱気装置及び脱気方法
US20210207754A1 (en) Profile disconnection
Herrlich et al. Solvent Bonding of a Drug Delivery Device by Using Hansen Solubility Parameters
CN212701987U (zh) 一种细胞浓缩装置
US20210364096A1 (en) High-pressure priming valve
JP2005147384A (ja) 弁およびその弁を有する流体システム
EP2862630B1 (de) Auslaufschutzeinheit für eine mikrofluidische Vorrichtung und entsprechende mikrofluidische Vorrichtung

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20130905