EP2626133A1 - Système micro-fluidique - Google Patents
Système micro-fluidique Download PDFInfo
- Publication number
- EP2626133A1 EP2626133A1 EP12154899.4A EP12154899A EP2626133A1 EP 2626133 A1 EP2626133 A1 EP 2626133A1 EP 12154899 A EP12154899 A EP 12154899A EP 2626133 A1 EP2626133 A1 EP 2626133A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- micro
- channel
- fluidic system
- polytetrafluoroethylene
- reinforced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
Definitions
- WO03/039736 relates to a micro reactor system for the continuous synthesis, which provides defined reaction chambers and conditions for said synthesis, as well as to the uses of said micro reactor in carrying out chemical reactions.
- micro-fluidic system comprising
- the micro-fluidic system of the invention may have one or more of the following advantages: the micro-fluidic system may have a good resistance to high stresses due to fluidic pressures or high temperatures and/or is able to undergo multiple heating and cooling cycles without being affected in terms of strength and/or chemical resistance.
- the second element is in communication, for example fluid communication, with the channel and is contacted by the fluids (for example the chemicals or product and by-products of a chemical reaction) during operation of the micro-fluidic system.
- the second element may be any element with does not form an integral part with the first element.
- the second element is preferably detachable from the first element
- Examples of the second element include but are not limited to valves, for example check valves, sealing elements, ferrules, nuts, elements in the back pressure regulator, luer connectors, unions, holder parts, etc.
- valves for example check valves, sealing elements, ferrules, nuts, elements in the back pressure regulator, luer connectors, unions, holder parts, etc.
- the second element may for example also be a connector, such as a nut-and-ferrule connector.
- a nut-and-ferrule connector may be provided at an outlet of the channel.
- a conically shaped ferrule holding a tube may be inserted in a counteracting conically shaped hole in a second element provided at an outlet of the channel.
- a nut may then be screwed into another element, for instance a holder part, which is provided with screw thread.
- the conically shaped ferrule contracts, clamps the tube and thus provides a sealed connection between the outlet of the channel and the tube.
- a nut-and-ferrule connector may also be combined into a single piece.
- nut and ferrule connectors having a different shape for example a flatbottom shape may be used as a second element.
- the tensile modulus of the reinforced polytetrafluoroethylene is at most 7000MPa, for example at most 6000MPa, for example at most 5000MPa, for example at most 4500MPa.
- the tensile modulus of the reinforced polytetrafluoroethylene is at least 1500MPa, for example at least 1600MPa, for example at least 1700MPa, for example at least 1800MPa, for example at least 1900 MPa, for example at least 2000MPa.
- PTFE polytetrafluoroethylene
- fillers for example fibers to PTFE.
- natural and synthetic fibers for instance wood, glass, carbon fibers or mica may be used to reinforce PTFE.
- PTFE is reinforced with mica, for example with natural or with synthetic mica (Mg 3 K[AIF 2 O(SiO 3 ) 3 ), more preferably with synthetic mica, more preferably with synthetic fluorinated mica, also known as fluorophlogite or KMg 3 (AlSi 3 O 10 )F 2 .
- synthetic fluorinated mica also known as fluorophlogite or KMg 3 (AlSi 3 O 10 )F 2 .
- PTFE reinforced with synthetic fluorinated mica is commercially available as for example FluorosintTM 500, FluorosintTM 207, FluorosintTM HPV, FluorosintTM MT-01.
- the amount of fillers, preferably fibers in PTFE may for example be in the range of from 10 to 40wt% based on the second material.
- micro-fluidic system of the invention can suitably be used to perform chemical reactions at a temperature in the range of for example from -20 to 200°C and/or at a pressure in the range of for example from atmospheric pressure (101.325 kPa) to 80bar, for example from atmospheric pressure to 20 bar.
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Micromachines (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12154899.4A EP2626133A1 (fr) | 2012-02-10 | 2012-02-10 | Système micro-fluidique |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12154899.4A EP2626133A1 (fr) | 2012-02-10 | 2012-02-10 | Système micro-fluidique |
Publications (1)
Publication Number | Publication Date |
---|---|
EP2626133A1 true EP2626133A1 (fr) | 2013-08-14 |
Family
ID=45592217
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12154899.4A Ceased EP2626133A1 (fr) | 2012-02-10 | 2012-02-10 | Système micro-fluidique |
Country Status (1)
Country | Link |
---|---|
EP (1) | EP2626133A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111246936A (zh) * | 2017-10-25 | 2020-06-05 | 深圳华大生命科学研究院 | 用于核酸合成的微流控芯片 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001017797A1 (fr) * | 1999-09-10 | 2001-03-15 | Caliper Technologies Corp. | Procedes et dispositifs de microfabrication |
WO2001025138A1 (fr) * | 1999-10-04 | 2001-04-12 | Nanostream, Inc. | Dispositifs microfluidiques modulaires comprenant des masques perfores intercales |
WO2003039736A1 (fr) | 2001-11-06 | 2003-05-15 | Cpc-Cellular Process Chemistry Systems Gmbh | Systeme microreacteur |
WO2004022233A1 (fr) | 2002-09-06 | 2004-03-18 | Epigem Limited | Systeme microfluidique modulaire |
US20050139993A1 (en) * | 2003-12-26 | 2005-06-30 | Lee Dae S. | Plastic microfabricated structure for biochip, microfabricated thermal device, microfabricated reactor, microfabricated reactor array, and micro array using the same |
WO2007021762A2 (fr) * | 2005-08-09 | 2007-02-22 | The University Of North Carolina At Chapel Hill | Procedes et materiaux permettant de fabriquer des dispositifs microfluidiques |
WO2007112945A1 (fr) | 2006-03-31 | 2007-10-11 | Lonza Ag | Système de micro-réacteur |
US20110135546A1 (en) * | 2008-06-02 | 2011-06-09 | Boehringer Ingelheim Microparts Gmbh | Microfluidic foil structure for metering of fluids |
-
2012
- 2012-02-10 EP EP12154899.4A patent/EP2626133A1/fr not_active Ceased
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001017797A1 (fr) * | 1999-09-10 | 2001-03-15 | Caliper Technologies Corp. | Procedes et dispositifs de microfabrication |
WO2001025138A1 (fr) * | 1999-10-04 | 2001-04-12 | Nanostream, Inc. | Dispositifs microfluidiques modulaires comprenant des masques perfores intercales |
WO2003039736A1 (fr) | 2001-11-06 | 2003-05-15 | Cpc-Cellular Process Chemistry Systems Gmbh | Systeme microreacteur |
WO2004022233A1 (fr) | 2002-09-06 | 2004-03-18 | Epigem Limited | Systeme microfluidique modulaire |
US20050139993A1 (en) * | 2003-12-26 | 2005-06-30 | Lee Dae S. | Plastic microfabricated structure for biochip, microfabricated thermal device, microfabricated reactor, microfabricated reactor array, and micro array using the same |
WO2007021762A2 (fr) * | 2005-08-09 | 2007-02-22 | The University Of North Carolina At Chapel Hill | Procedes et materiaux permettant de fabriquer des dispositifs microfluidiques |
WO2007112945A1 (fr) | 2006-03-31 | 2007-10-11 | Lonza Ag | Système de micro-réacteur |
US20110135546A1 (en) * | 2008-06-02 | 2011-06-09 | Boehringer Ingelheim Microparts Gmbh | Microfluidic foil structure for metering of fluids |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111246936A (zh) * | 2017-10-25 | 2020-06-05 | 深圳华大生命科学研究院 | 用于核酸合成的微流控芯片 |
CN111246936B (zh) * | 2017-10-25 | 2022-05-03 | 深圳华大生命科学研究院 | 用于核酸合成的微流控芯片 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11158522B2 (en) | Fluid delivery system | |
JP6851198B2 (ja) | 真空システムのパイプカップリング | |
US20120114534A1 (en) | Micro-fluidic system and the use thereof | |
US20210199226A1 (en) | Profile connection | |
EP2626133A1 (fr) | Système micro-fluidique | |
EP3993991A1 (fr) | Raccord profilé | |
JP2017501379A (ja) | マイクロ流体装置のパッケージインターフェイス | |
Sabourin et al. | One-step fabrication of microfluidic chips with in-plane, adhesive-free interconnections | |
Immanuel et al. | Surface activation of poly (methyl methacrylate) for microfluidic device bonding through a H2O plasma treatment linked with a low-temperature annealing | |
US20160054272A1 (en) | Liquid Delivery Device and Chemical Analysis Apparatus Using Liquid Delivery Device | |
US20210207754A1 (en) | Profile disconnection | |
Etxeberria et al. | Critical Study on the Tube-to-Chip Luer Slip Connectors | |
US10328409B2 (en) | Methods for performing flow reactions utilizing high temperature hydrofluoric acid | |
US11813581B2 (en) | Method and adapter for conveying plural liquid streams | |
AU2014264738B2 (en) | An apparatus for germ reduction of a fluid and a process for use thereof | |
JP4502651B2 (ja) | 弁およびその弁を有する流体システム | |
Tamanaha et al. | Reusable, compression-sealed fluid cells for surface mounting to planar substrates | |
JP2011112530A (ja) | シール材およびそれを備えたフローセル | |
US20230109444A1 (en) | High-pressure priming valve | |
DE102009020696A1 (de) | Permeationszelle | |
Lee et al. | Numerical Analysis of Y-shaped Check Valve for Power Plant | |
CN105756924A (zh) | 输送含固体颗粒的粘稠液体的装置及其应用 | |
JP2005305443A (ja) | 脱気装置及び脱気方法 | |
González-Jiménez et al. | PRESSURE DROP APPROACH TO ESTIMATE THE APPARENT SLIP LENGTH IN A PDMS MICRO-CHANNEL | |
KR20210095706A (ko) | 밀봉 포트를 갖춘 범용 관 스터브 플러그 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED |
|
18R | Application refused |
Effective date: 20130905 |