EP1439393A3 - Nachweisverfahren TIMP 1 verwendend für Kolonkrebs-Diagnose - Google Patents
Nachweisverfahren TIMP 1 verwendend für Kolonkrebs-Diagnose Download PDFInfo
- Publication number
- EP1439393A3 EP1439393A3 EP03257868A EP03257868A EP1439393A3 EP 1439393 A3 EP1439393 A3 EP 1439393A3 EP 03257868 A EP03257868 A EP 03257868A EP 03257868 A EP03257868 A EP 03257868A EP 1439393 A3 EP1439393 A3 EP 1439393A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- colorectal cancer
- detecting
- timp
- colon cancer
- detection methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57419—Specifically defined cancers of colon
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43355402P | 2002-12-13 | 2002-12-13 | |
US433554P | 2002-12-13 | ||
US49139703P | 2003-07-31 | 2003-07-31 | |
US491397P | 2003-07-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1439393A2 EP1439393A2 (de) | 2004-07-21 |
EP1439393A3 true EP1439393A3 (de) | 2004-08-11 |
Family
ID=32600155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03257868A Withdrawn EP1439393A3 (de) | 2002-12-13 | 2003-12-15 | Nachweisverfahren TIMP 1 verwendend für Kolonkrebs-Diagnose |
Country Status (3)
Country | Link |
---|---|
US (1) | US20040157278A1 (de) |
EP (1) | EP1439393A3 (de) |
JP (1) | JP2004198419A (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9562049B2 (en) | 2012-12-21 | 2017-02-07 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
US9567340B2 (en) | 2012-12-21 | 2017-02-14 | Medimmune Limited | Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases |
Families Citing this family (102)
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US20060154245A1 (en) * | 1999-04-09 | 2006-07-13 | Rigshospitalet | Method for detecting, screening and/or montoring a cancer in individual |
ATE298890T1 (de) | 1999-04-09 | 2005-07-15 | Rigshospitalet | Gewebeinhibitor der matrix-metalproteinase typ 1 (timp-1) als krebsmarker |
US7374886B2 (en) * | 1999-04-09 | 2008-05-20 | Rigshospitalet | Tissue inhibitor of matrix metalloproteinases type-1 (TIMP-1) as a cancer marker and postoperative marker for minimal residual disease or recurrent disease in patients with a prior history of cancer |
US7678889B2 (en) * | 2002-08-06 | 2010-03-16 | Diadexus, Inc. | Compositions and methods relating to ovarian specific genes and proteins |
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WO2005094863A1 (en) * | 2004-03-30 | 2005-10-13 | Den Kgl.Veterinær-Og Landbohøjskole | Improvements in cancer treatment and cancer treatment efficacy prediction by blocking and decting protease inhibitors |
KR101200133B1 (ko) | 2004-06-01 | 2012-11-13 | 제넨테크, 인크. | 항체 약물 접합체 및 방법 |
US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
CA2580141C (en) | 2004-09-23 | 2013-12-10 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
JP2006166732A (ja) * | 2004-12-13 | 2006-06-29 | Okayama Univ | 消化器中の新生物の検出方法 |
ATE430936T1 (de) * | 2004-12-23 | 2009-05-15 | Hoffmann La Roche | Verwendung von cyfra 21-1 und osteopontin als marker für kolorektalkarzinome |
ES2323429T3 (es) * | 2004-12-23 | 2009-07-15 | F. Hoffmann-La Roche Ag | Uso de la asc, como marcador para cancer colorrectal. |
ES2717627T3 (es) | 2005-07-29 | 2019-06-24 | Siemens Healthcare Diagnostics Inc | Métodos, kits, sistemas y bases de datos relacionados con enfermedades neoplásicas |
CA2632327A1 (en) * | 2005-12-22 | 2007-06-28 | F. Hoffmann-La Roche Ag | Use of a marker combination comprising osteopontin and carcinoembryonic antigen in the assessment of colorectal cancer |
WO2007079218A2 (en) | 2005-12-30 | 2007-07-12 | Dyax Corp. | Metalloproteinase binding proteins |
US7943328B1 (en) | 2006-03-03 | 2011-05-17 | Prometheus Laboratories Inc. | Method and system for assisting in diagnosing irritable bowel syndrome |
DK2021794T3 (da) * | 2006-05-19 | 2010-10-11 | Hoffmann La Roche | Anvendelse af protein S100A 12 som en markør for colorektal cancer |
US20080119433A1 (en) * | 2006-07-06 | 2008-05-22 | Aaron Thomas Tabor | Compositions and Methods for Genetic Modification of Cells Having Cosmetic Function to Enhance Cosmetic Appearance |
US20080085524A1 (en) | 2006-08-15 | 2008-04-10 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
FR2919063B1 (fr) * | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage du leucocyte elastase inhibitor pour le diagnostic in vitro du cancer colorectal. |
FR2919062B1 (fr) * | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage de l'aminoacylase 1 pour le diagnostic in vitro du cancer colorectal. |
FR2919064B1 (fr) * | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage de l'apolipoproteine all pour le diagnostic in vitro du cancer colorectal |
FR2919061B1 (fr) * | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage de la plastine-i pour le diagnostic in vitro du cancer colorectal. |
US9726670B2 (en) * | 2007-07-19 | 2017-08-08 | Biomerieux | Method for the assay of liver fatty acid binding protein, ACE and CA 19-9 for the in vitro diagnosis of colorectal cancer |
FR2919065B1 (fr) | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage de l'apolipoproteine ai pour le diagnostic in vitro du cancer colorectal |
FR2919060B1 (fr) * | 2007-07-19 | 2012-11-30 | Biomerieux Sa | Procede de dosage de l'ezrine pour le diagnostic in vitro du cancer colorectal. |
AU2008338421A1 (en) | 2007-12-17 | 2009-06-25 | Dyax Corp. | Compositions and methods for treating osteolytic disorders comprising MMP-14 binding proteins |
FR2933773B1 (fr) | 2008-07-10 | 2013-02-15 | Biomerieux Sa | Procede de dosage de la proteine disulfide isomerase pour le diagnostic in vitro du cancer colorectal |
EP2169078A1 (de) | 2008-09-26 | 2010-03-31 | Fundacion Gaiker | Verfahren und Kits zur Diagnose und Abstufung von Kolorektalkrebs |
JP4841656B2 (ja) * | 2009-08-03 | 2011-12-21 | 株式会社江東微生物研究所 | 予後予測のための大腸癌組織の検査方法 |
IN2012DN03025A (de) | 2009-09-09 | 2015-07-31 | Ct Se Llc | |
BR112012026213B1 (pt) | 2010-04-15 | 2021-12-28 | Medimmune Limited | Compostos de pirrolobenzodiazepinas, conjugado das mesmas, composição farmacêutica compreendendo o conjugado e uso do mesmo para o tratamento de uma doença proliferativa |
CA2799540A1 (en) | 2010-06-08 | 2011-12-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
JP6081911B2 (ja) | 2010-06-14 | 2017-02-15 | リケラ バイオメッド エスエーLykera Biomed Sa | S100a4抗体およびその治療上の使用 |
DK2829881T3 (en) * | 2010-07-14 | 2017-12-04 | Vision Tech Bio Pty Ltd | Colorectal cancer diagnostic |
JP5889912B2 (ja) | 2010-11-17 | 2016-03-22 | ジェネンテック, インコーポレイテッド | アラニニルメイタンシノール抗体コンジュゲート |
US20140199324A1 (en) * | 2011-03-24 | 2014-07-17 | Daniel T. Dransfield | Evaluating protein expression in patient stratification and other therapeutic, diagnostic and prognostic methods for cancer |
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CA2844822A1 (en) * | 2011-08-31 | 2013-03-07 | Oncocyte Corporation | Methods and compositions for the treatment and diagnosis of colorectal cancer |
KR101877598B1 (ko) | 2011-10-14 | 2018-07-11 | 메디뮨 리미티드 | 피롤로벤조디아제핀 및 그의 컨주게이트 |
US10314909B2 (en) | 2011-10-21 | 2019-06-11 | Dyax Corp. | Combination therapy comprising an MMP-14 binding protein |
WO2013092960A1 (en) | 2011-12-22 | 2013-06-27 | Fundacion Gaiker | Methods and kits for the diagnosis of colorectal cancer |
WO2013130093A1 (en) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarkers for treatment with anti-tubulin chemotherapeutic compounds |
HUE035694T2 (en) | 2012-10-12 | 2018-05-28 | Adc Therapeutics Sa | Pirrolobenzodiazepine anti-CD22 antibody conjugates |
SI2906296T1 (en) | 2012-10-12 | 2018-06-29 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
ES2703151T3 (es) | 2012-10-12 | 2019-03-07 | Adc Therapeutics Sa | Conjugados de anticuerpos de pirrolobenzodiazepinas |
NZ707486A (en) | 2012-10-12 | 2018-09-28 | Adc Therapeutics Sa | Pyrrolobenzodiazepine - anti-psma antibody conjugates |
PT2839860T (pt) | 2012-10-12 | 2019-07-29 | Medimmune Ltd | Pirrolobenzodiazepinas e conjugados das mesmas |
ES2660029T3 (es) | 2012-10-12 | 2018-03-20 | Medimmune Limited | Conjugados de anticuerpo-pirrolobenzodiazepinas |
EP2906250B1 (de) | 2012-10-12 | 2018-05-30 | ADC Therapeutics SA | Pyrrolobenzodiazepin-anti-psma-antikörperkonjugate |
JP6444902B2 (ja) | 2013-03-13 | 2018-12-26 | メドイミューン・リミテッドMedImmune Limited | ピロロベンゾジアゼピン及びその結合体 |
CN105142674B (zh) | 2013-03-13 | 2018-11-13 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓和其结合物 |
NZ710745A (en) | 2013-03-13 | 2019-03-29 | Genentech Inc | Pyrrolobenzodiazepines and conjugates thereof |
AU2014307080B2 (en) | 2013-08-12 | 2018-06-07 | Genentech, Inc. | 1-(chloromethyl)-2,3-dihydro-1H-benzo(E)indole dimer antibody-drug conjugate compounds, and methods of use and treatment |
EP3054983B1 (de) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepin-antikörper-konjugate |
GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
EP3054985B1 (de) | 2013-10-11 | 2018-12-26 | Medimmune Limited | Pyrrolobenzodiazepin-antikörper-konjugate |
WO2015052535A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
CA2928952A1 (en) | 2013-12-16 | 2015-06-25 | Genentech, Inc. | Peptidomimetic compounds and antibody-drug conjugates thereof |
JP6895254B2 (ja) | 2013-12-16 | 2021-06-30 | ジェネンテック, インコーポレイテッド | ペプチド模倣化合物及びその抗体−薬物コンジュゲート |
CA2929565A1 (en) | 2013-12-16 | 2015-06-25 | Genentech, Inc. | 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment |
CN107110865B (zh) * | 2014-08-22 | 2020-01-10 | 雅培制药有限公司 | 用于结肠直肠癌的早期检测的方法 |
US10188746B2 (en) | 2014-09-10 | 2019-01-29 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
EP3191134B1 (de) | 2014-09-12 | 2019-11-20 | Genentech, Inc. | Anthracyclindisulfidzwischenprodukte, antikörper-wirkstoff-konjugate und verfahren |
US10077318B2 (en) | 2014-09-12 | 2018-09-18 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
MA40575A (fr) | 2014-09-17 | 2016-03-24 | Genentech Inc | Pyrrolobenzodiazépines et conjugués à base de disulfure d'anticorps associés |
AU2015352545B2 (en) | 2014-11-25 | 2020-10-15 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
WO2016090050A1 (en) | 2014-12-03 | 2016-06-09 | Genentech, Inc. | Quaternary amine compounds and antibody-drug conjugates thereof |
EP3236995A4 (de) | 2014-12-23 | 2018-07-18 | University of Maryland, Baltimore | Muc1-köderpeptide zur behandlung und prävention von bakteriellen infektionen |
GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
MA43345A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation |
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GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
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JP6943872B2 (ja) | 2016-03-25 | 2021-10-06 | ジェネンテック, インコーポレイテッド | 多重全抗体及び抗体複合体化薬物定量化アッセイ |
GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
JP2019522633A (ja) | 2016-05-20 | 2019-08-15 | ジェネンテック, インコーポレイテッド | Protac抗体コンジュゲート及び使用方法 |
US20170370906A1 (en) | 2016-05-27 | 2017-12-28 | Genentech, Inc. | Bioanalytical analysis of site-specific antibody drug conjugates |
EP3464280B1 (de) | 2016-06-06 | 2021-10-06 | F. Hoffmann-La Roche AG | Silvestrol-antikörper-arzneimittelkonjugate und verfahren zur verwendung |
EP3496763A1 (de) | 2016-08-11 | 2019-06-19 | Genentech, Inc. | Pyrrolobenzodiazepin-prodrugs und antikörperkonjugate davon |
EP3522933B1 (de) | 2016-10-05 | 2021-12-15 | F. Hoffmann-La Roche AG | Verfahren zur herstellung von antikörperarzneimittelkonjugaten |
GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
RS61795B1 (sr) | 2017-02-08 | 2021-06-30 | Adc Therapeutics Sa | Konjugati pirolobenzodiazepin antitela |
WO2018192944A1 (en) | 2017-04-18 | 2018-10-25 | Medimmune Limited | Pyrrolobenzodiazepine conjugates |
EP3612234B1 (de) | 2017-04-20 | 2024-03-13 | ADC Therapeutics SA | Kombinationstherapie mit anti-axl-antikörper-arzneimittel-konjugat |
MX2019015042A (es) | 2017-06-14 | 2020-08-06 | Adc Therapeutics Sa | Regimen de dosificacion. |
AU2018316532B2 (en) | 2017-08-18 | 2022-11-24 | Medimmune Limited | Pyrrolobenzodiazepine conjugates |
IL273387B2 (en) | 2017-09-20 | 2023-10-01 | Ph Pharma Co Ltd | Thylanstatin analogs |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
JP2022505450A (ja) | 2018-10-24 | 2022-01-14 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | コンジュゲート化された化学的分解誘導物質および使用方法 |
WO2020123275A1 (en) | 2018-12-10 | 2020-06-18 | Genentech, Inc. | Photocrosslinking peptides for site specific conjugation to fc-containing proteins |
GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
WO2020213344A1 (ja) * | 2019-04-18 | 2020-10-22 | 学校法人慶應義塾 | 大腸癌の発癌リスクを検出する方法及びキット |
GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
WO2023152133A1 (en) * | 2022-02-08 | 2023-08-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for diagnosing colorectal cancer |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001012781A1 (en) * | 1999-08-13 | 2001-02-22 | Human Genome Sciences, Inc. | 13 human colon and colon cancer associated proteins |
WO2002086085A2 (en) * | 2001-04-24 | 2002-10-31 | Bayer Corporation | Human timp-1 antibodies |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7374886B2 (en) * | 1999-04-09 | 2008-05-20 | Rigshospitalet | Tissue inhibitor of matrix metalloproteinases type-1 (TIMP-1) as a cancer marker and postoperative marker for minimal residual disease or recurrent disease in patients with a prior history of cancer |
US6397036B1 (en) * | 1999-08-23 | 2002-05-28 | Mindblazer, Inc. | Systems, methods and computer program products for collaborative learning |
US20030061330A1 (en) * | 2000-09-29 | 2003-03-27 | Frisco Lynn A. | Web-based collaborative project and process management solution |
WO2002044923A1 (en) * | 2000-11-30 | 2002-06-06 | Webtone Technologies, Inc. | Web session collaboration |
US6968346B2 (en) * | 2001-04-23 | 2005-11-22 | International Business Machines Corporation | XML-based system and method for collaborative web-based design and verification of system-on-a-chip |
US7039677B2 (en) * | 2002-05-07 | 2006-05-02 | International Business Machines Corporation | Threaded text-based chat collaboration |
-
2003
- 2003-12-12 US US10/734,564 patent/US20040157278A1/en not_active Abandoned
- 2003-12-12 JP JP2003414126A patent/JP2004198419A/ja active Pending
- 2003-12-15 EP EP03257868A patent/EP1439393A3/de not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001012781A1 (en) * | 1999-08-13 | 2001-02-22 | Human Genome Sciences, Inc. | 13 human colon and colon cancer associated proteins |
WO2002086085A2 (en) * | 2001-04-24 | 2002-10-31 | Bayer Corporation | Human timp-1 antibodies |
Non-Patent Citations (5)
Title |
---|
HARADA K ET AL: "Human REG I gene is up-regulated in intrahepatic cholangiocarcinoma and its precursor lesions.", HEPATOLOGY (BALTIMORE, MD.) UNITED STATES MAY 2001, vol. 33, no. 5, May 2001 (2001-05-01), pages 1036 - 1042, XP002282254, ISSN: 0270-9139 * |
HOLTON-ANDERSEN M N ET AL: "Measurement of the noncomplexed free fraction of tissue inhibitor of metalloproteinases 1 in plasma by immunoassay", CLINICAL CHEMISTRY, AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY. WINSTON, US, vol. 48, no. 8, August 2002 (2002-08-01), pages 1305 - 1313, XP002959679, ISSN: 0009-9147 * |
OKUNO K ET AL: "Gene expression analysis in colorectal cancer using practical DNA array filter.", DISEASES OF THE COLON AND RECTUM. UNITED STATES FEB 2001, vol. 44, no. 2, February 2001 (2001-02-01), pages 295 - 299, XP009031427, ISSN: 0012-3706 * |
PELLEGRINI P ET AL: "Simultaneous measurement of soluble carcinoembryonic antigen and the tissue inhibitor of metalloproteinase TIMP1 serum levels for use as markers of pre-invasive to invasive colorectal cancer.", CANCER IMMUNOLOGY, IMMUNOTHERAPY: CII. GERMANY SEP 2000, vol. 49, no. 7, September 2000 (2000-09-01), pages 388 - 394, XP002282255, ISSN: 0340-7004 * |
XIAIQING LU ET AL: "IMMUNOLOGICAL QUANTIFATION OF LEVELS OF TISSUE INHIBITOR OF METALLOPROTEINASE-1 IN HUMAN COLON CANCER", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 51, no. 23, PART 1, 1 December 1991 (1991-12-01), pages 6231 - 6235, XP000609477, ISSN: 0008-5472 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9562049B2 (en) | 2012-12-21 | 2017-02-07 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
US9567340B2 (en) | 2012-12-21 | 2017-02-14 | Medimmune Limited | Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases |
Also Published As
Publication number | Publication date |
---|---|
US20040157278A1 (en) | 2004-08-12 |
EP1439393A2 (de) | 2004-07-21 |
JP2004198419A (ja) | 2004-07-15 |
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