WO2006131677A3 - Procede pour le diagnostic/pronostic du cancer du sein - Google Patents

Procede pour le diagnostic/pronostic du cancer du sein Download PDF

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Publication number
WO2006131677A3
WO2006131677A3 PCT/FR2006/050531 FR2006050531W WO2006131677A3 WO 2006131677 A3 WO2006131677 A3 WO 2006131677A3 FR 2006050531 W FR2006050531 W FR 2006050531W WO 2006131677 A3 WO2006131677 A3 WO 2006131677A3
Authority
WO
WIPO (PCT)
Prior art keywords
seq
prognosis
breast cancer
amplifying
primers
Prior art date
Application number
PCT/FR2006/050531
Other languages
English (en)
Other versions
WO2006131677A2 (fr
Inventor
Thibaut Verjat
Original Assignee
Biomerieux Sa
Thibaut Verjat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomerieux Sa, Thibaut Verjat filed Critical Biomerieux Sa
Priority to US11/919,923 priority Critical patent/US20080274465A1/en
Priority to EP06764851A priority patent/EP1891238A2/fr
Publication of WO2006131677A2 publication Critical patent/WO2006131677A2/fr
Publication of WO2006131677A3 publication Critical patent/WO2006131677A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne un procédé pour le diagnostic/pronostic du cancer du sein comprenant les étapes suivantes : A - on extrait le matériel nucléique d'un échantillon biologique, B - on utilise au moins une paire d'amorces d'amplification pour obtenir des amplicons d'au moins une séquence cible du matériel nucléique, C - on utilise au moins une sonde de détection pour détecter la présence desdits amplicons caractérisé en ce que, lors de l'étape B, ladite paire d'amorce comprend au moins une amorce d'amplification comprenant au moins 10 motifs nucléotidiques d'une séquence nucléotidique choisie parmi SEQ ID N° I à SEQ ID N°8 et/ou lors de l'étape C), ladite sonde de détection comprend au moins 10 motifs nucléotidiques d'une séquence nucléotidique choisie parmi SEQ ID N°9 à SEQ ID N°10. L'invention concerne également des amorces d'amplification et des sondes d'hybridation qui peuvent être mises en œuvre dans ce procédé, ainsi qu'un kit de diagnostic/pronostic du cancer du sein.
PCT/FR2006/050531 2005-06-09 2006-06-07 Procede pour le diagnostic/pronostic du cancer du sein WO2006131677A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11/919,923 US20080274465A1 (en) 2005-06-09 2006-06-07 Method for Breast Cancer Diagnosis/Prognosis
EP06764851A EP1891238A2 (fr) 2005-06-09 2006-06-07 Procede pour le diagnostic/pronostic du cancer du sein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0551548 2005-06-09
FR0551548A FR2886946B1 (fr) 2005-06-09 2005-06-09 Procede pour le diagnoctic/pronostic du cancer du sein

Publications (2)

Publication Number Publication Date
WO2006131677A2 WO2006131677A2 (fr) 2006-12-14
WO2006131677A3 true WO2006131677A3 (fr) 2007-03-29

Family

ID=35695888

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2006/050531 WO2006131677A2 (fr) 2005-06-09 2006-06-07 Procede pour le diagnostic/pronostic du cancer du sein

Country Status (5)

Country Link
US (1) US20080274465A1 (fr)
EP (1) EP1891238A2 (fr)
CN (1) CN101223287A (fr)
FR (1) FR2886946B1 (fr)
WO (1) WO2006131677A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107652358A (zh) * 2017-09-06 2018-02-02 华中师范大学 一种uPAR靶向性多肽、探针和活体分子显像方法
CN108929906A (zh) * 2018-08-24 2018-12-04 山东德诺生物科技有限公司 用于检测rs1799889的引物探针组及其应用
CN110358829A (zh) * 2019-07-09 2019-10-22 江苏医药职业学院 检测重组人肽基脯氨酰顺反异构酶-h表达水平的试剂的应用和试剂盒
FR3106834A1 (fr) * 2020-01-30 2021-08-06 Ocean Diagnostics Nouveau procédé de PCR multiplexe et utilisation
CN114525252B (zh) * 2022-03-10 2023-12-01 广州源井生物科技有限公司 一种提高mda-mb-231单细胞克隆形成率的单克隆增强培养基与培养方法及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002006462A2 (fr) * 2000-07-13 2002-01-24 Quebepharma Inc. Regulation de l'expression d'un gene au niveau de nucleotides methyles

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19711932A1 (de) * 1997-03-21 1998-09-24 Anne Katrin Dr Werenskiold In vitro-Verfahren zum Prognostizieren des Krankheitsverlaufs von Patienten mit Mammakarzinom und/oder zum Diagnostizieren eines Mammakarzinoms
FI20011542A (fi) * 2001-07-13 2003-01-14 Fit Biotech Oyj Plc Urosognaasigeenin monistuman käyttö
WO2003014298A2 (fr) * 2001-08-03 2003-02-20 Origene Technologies, Inc. Polynucleotides et polypeptides selectifs pour la prostate et presentant une longueur totale de chaine
US20060084056A1 (en) * 2002-02-13 2006-04-20 Nadia Harbeck Methods for selecting treatment regimens and predicting outcomes in cancer patients

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002006462A2 (fr) * 2000-07-13 2002-01-24 Quebepharma Inc. Regulation de l'expression d'un gene au niveau de nucleotides methyles

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANDREASEN PETER A ET AL: "The urokinase-type plasminogen activator system in cancer metastasis: A review", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 72, no. 1, 1997, pages 1 - 22, XP002210773, ISSN: 0020-7136 *
ARENS NORBERT ET AL: "In vitro suppression of urokinase plasminogen activator in breast cancer cells - A comparison of two antisense strategies", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 26, no. 1, January 2005 (2005-01-01), pages 113 - 119, XP009061234, ISSN: 1019-6439 *
DUFFY M J ET AL: "The urokinase plasminogen activator system: a rich source of tumour markers for the individualised management of patients with cancer", CLINICAL BIOCHEMISTRY, vol. 37, no. 7, July 2004 (2004-07-01), pages 541 - 548, XP002367135, ISSN: 0009-9120 *
PAKNESHAN POUYA ET AL: "Demethylation of urokinase promoter as a prognostic marker in patients with breast carcinoma.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. 1 MAY 2004, vol. 10, no. 9, 1 May 2004 (2004-05-01), pages 3035 - 3041, XP002367134, ISSN: 1078-0432 *
PEDERSEN A N ET AL: "Determination of the complex between urokinase and its type-I inhibitor in plasma from healthy donors and breast cancer patients", CLINICAL CHEMISTRY, AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY, WASHINGTON, DC, US, vol. 45, no. 8, 1999, pages 1206 - 1213, XP002968350, ISSN: 0009-9147 *
VERJAT THIBAULT ET AL: "Multiparametric duplex real-time nucleic acid sequence-based amplification assay for mRNA profiling.", BIOTECHNIQUES. SEP 2004, vol. 37, no. 3, September 2004 (2004-09-01), pages 476 - 481, XP001208312, ISSN: 0736-6205 *

Also Published As

Publication number Publication date
FR2886946B1 (fr) 2007-08-10
FR2886946A1 (fr) 2006-12-15
EP1891238A2 (fr) 2008-02-27
CN101223287A (zh) 2008-07-16
WO2006131677A2 (fr) 2006-12-14
US20080274465A1 (en) 2008-11-06

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