EP1409052A1 - Dispositif pour inhaler des medicaments par assistance respiratoire sous pression - Google Patents

Dispositif pour inhaler des medicaments par assistance respiratoire sous pression

Info

Publication number
EP1409052A1
EP1409052A1 EP00979602A EP00979602A EP1409052A1 EP 1409052 A1 EP1409052 A1 EP 1409052A1 EP 00979602 A EP00979602 A EP 00979602A EP 00979602 A EP00979602 A EP 00979602A EP 1409052 A1 EP1409052 A1 EP 1409052A1
Authority
EP
European Patent Office
Prior art keywords
storage container
wall
distributor
mouthpiece
medication
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00979602A
Other languages
German (de)
English (en)
Inventor
Michael Hermanussen
Karl-Heinz Rolli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP1409052A1 publication Critical patent/EP1409052A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A61M15/0088—Inhalation chambers with variable volume
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0057—Pumps therefor
    • A61M16/0078—Breathing bags
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/20—Valves specially adapted to medical respiratory devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/20—Valves specially adapted to medical respiratory devices
    • A61M16/208—Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
    • A61M16/209—Relief valves

Definitions

  • inhalation takes place by actively expanding the chest muscles and creating a pressure drop in them so that air is sucked in, i.e. according to the pressure drop m flows to the lungs.
  • Exhalation takes place passively, as a result of an elastic increase in the pressure in the chest causing an increase in pressure in the lungs, so that the used air is expelled from the chest and lungs.
  • the mean pressure level at which inhalation and exhalation alternate corresponds to the atmospheric pressure.
  • Delay chambers such as spacers, in which a certain volume of breathing air is enriched with aerosol or powder inhalation before inhalation and made available for inhalation are also advantageous. This improves the effectiveness of inhaled medication.
  • the disadvantage of such simple, easily portable, non-electrically operated inhalation techniques that can be used by the patient in an emergency is that they can only be operated at atmospheric pressure. Lung sections that do not take part in spontaneous breathing due to the collapse of small airways described above are therefore not accessible at atmospheric pressure even during emergency treatment with inhaled medication.
  • a very simple, small, portable, easy-to-use, integrated and self-sufficient device is provided, which can be conveniently packed in a handbag.
  • the device consists of a closed system, which is breathed back without one
  • the necessary valves and hose systems are missing, and the exhaled gas is not processed, for example by carbon dioxide absorbers, so that Use of the device according to the invention is limited to a few minutes, ie to the duration of the acute shortness of breath, specifically because of the carbon dioxide enrichment.
  • the device contains a mouthpiece that can be firmly enclosed by the lips, a storage container that has a variable volume for absorbing breathing gas, directly or via a distributor with the mouthpiece in stream.
  • Connection connection is connectable and has the properties of a delay chamber, an adjustable, gas-tight seal between the mouthpiece and the storage container, and at least one connection for the medication supply in the form of aerosol or powder inhalation to the storage container, the medication supply either directly or indirectly via a distributor.
  • the storage container has a wall which is variable for its volume change and which can be expanded against a restoring force by respiratory gas flowing in under pressure, so that under the action of the restoring force a pressure-assisted ventilation takes place when inhaling the breathing gas containing the medicament.
  • the patient tightly encloses the mouthpiece with his lips, either puts on a nose clip or closes his palate arbitrarily to prevent the physiological airway through the nose, and then opens the gas-tight seal between the mouthpiece and the storage container with elastic wall by pressing with the finger or by means of a device which automatically opens the closure when first inhaled.
  • the increased pressure in the elastic-walled storage container is now established directly in the patient's lungs via the airways, and oxygen and medication escape into the lungs of the patient Patients until the pressure difference between the reservoir with elastic walls and the lungs is balanced. Oxygen and medication are also pressed into those sections of the lung that were not accessible at atmospheric pressure due to the narrowing and previously collapsed airways.
  • the lungs are now inflated and the pressure in them no longer corresponds to the atmospheric pressure, but rather the pressure which is predetermined by the elasticity of the wall of the storage container or by a spring force device in the case of wall elements of the storage container which can be displaced relative to one another .
  • the pressure which is predetermined by the elasticity of the wall of the storage container or by a spring force device in the case of wall elements of the storage container which can be displaced relative to one another .
  • the patient obtains breathing gas and medication from a closed system into which he breathes back without processing the exhaled gas, there is a consumption of oxygen and an enrichment with carbon dioxide.
  • the latter in particular has the effect that the patient must interrupt inhalation with the device according to the invention after a short time, within which the condition of acute shortness of breath should have improved.
  • the device can be made even smaller and lighter, and the valve can no longer be closed between the gas storage container with pressure-resistant wall and the storage container with variable wall. In this case, however, a new gas storage container must be installed before the next application.
  • the central functional element of the invention is the storage container with a variable or at least partially elastic wall, which is responsible both for the ventilation pressure and, in the sense of a delay chamber, provides a certain volume of breathing air which is inhaled with aerosol or powder before inhalation. Inhalate is enriched.
  • a central distributor or, like a bagpipe, the mouthpiece and the connections for the gas storage container with pressure-resistant wall and the bottles for spray inhalation of medication m right into the storage container with elastic wall.
  • FIG. 1 is a front view in a schematic representation of a first exemplary embodiment of a device for inhaling medicaments according to the invention
  • FIG. 2 shows a side view of the device for inhalation
  • FIG. 4 is a side view in a schematic representation of a second exemplary embodiment of a device according to the invention.
  • a first exemplary embodiment of a device 1 for improved inhalation of medication by means of supportive pressure ventilation has a mouthpiece 2 and a distributor 3 to which the mouthpiece 2 is connected.
  • An adjustable, gas-tight closure 8 is arranged between the mouthpiece 2 and the distributor 3.
  • Balloon are each attached to separate connections 6 and 7 of the distributor 3.
  • the storage container 5 can also be designed in the manner of an accordion with an internal tension spring (not shown), which loads the accordion in the direction of a reduction in volume.
  • Valve 11 at port 7 can compressed breathing gas from the Gas storage container 4 through the distributor 3 m flow the storage container 5 and increase its volume against the elastic force of the wall of the storage container 5.
  • a commercially available bottle 9 for spray inhalation of medication is attached to a separate connection 10 of the distributor 3. From the bottle 9 can, for. B. by finger pressure, the medicament as an aerosol or powder inhalate through the distributor 3 into the storage container 5 acting like a delay chamber.
  • the mouthpiece 2 with the adjustable, gas-tight closure 8 as well as the gas storage container 4 with pressure-resistant wall and at least one commercially available bottle 9 for spray inhalation of medication are connected directly by means of separate connections ⁇ en storage container 5 connected with elastic wall (shown nient).
  • the use of the device 1 for improved inhalation of medication by means of supporting pressure ventilation without a distributor basically corresponds to the variant with a distributor.
  • the distributor 3 contains only the three connections for the mouthpiece 2, the bottle 9 and the storage container 5, which however, the fourth connection 7 has been omitted.
  • the breathing gas for pressure-supporting inhalation is introduced into the storage container 5 by removing it from or at a breathing gas source, e.g. B. a breathing gas bottle or a breathing gas connection in a laboratory, connected and filled.
  • the storage container 5 is then connected to the connection 6 of the distributor 3, the medication is introduced from the bottle 9 into the storage container 5 and, after opening the closure 8, the breathing gas containing the medicament can be inhaled via the mouthpiece 2.
  • a balloon is used as storage container 5, the elastic balloon connection is attached to the respiratory gas source and after filling, as in a conventional balloon, e.g. B. temporarily closed by being pressed together, DIS the balloon connection attached to connection 6 of distributor 3
  • a further exemplary embodiment of the device shown in FIG. 4 contains a storage container 12 with a wall which encloses the variable volume and consists of two fixed telescopic, e.g. B. cylindrical wall elements 13 and 14, which by a z. B. inside the reservoir 12 arranged tension spring 15 are biased in the direction of a volume reduction of the reservoir 12.
  • the mouthpiece 2 is connected directly to the wall element 14 of the storage container 12 via a connecting pipe 16, which contains an adjustable closure 8 which can be actuated manually or automatically when first inhaled.
  • the wall element 14 contains a connection 17 for the bottle 9 containing a medicament and a filling connection 18 for breathing gas, on which a shut-off valve 19 is arranged.
  • the supply age 12 thus contains a wall made of rigid wall elements which, however, because of the elastic restoring force of the tension spring 15, form a wall that is elastic with respect to the variable volume.
  • the breathing gas filling connection 18 is connected to a breathing gas source and the storage container 12 is filled with breathing gas flowing in under pressure, the two wall elements 13 and 14 simultaneously shifting against the force of the tension spring 15 with an increase in volume.
  • the shut-off valve 19 is closed and the storage container 12 is removed from the breathing gas source. After the medicament has been introduced from the bottle 9 into the storage container 12, the device for inhalation is ready.
  • z. B. a foldable gas-tight, elastically stretchable or non-stretchable bag or the like can be connected to the displaceable wall element 13, which is collapsed when not in use and can be folded out for use of the device and can be inflated by breathing gas. If the volume change due to the movable wall element is not sufficient for the pressure support when inhaling, the elastic balloon-like sack can apply the additional force support.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un dispositif (1) petit et léger destiné à permettre d'inhaler des médicaments par assistance respiratoire sous pression. Ce dispositif comprend un embout buccal (2), un réservoir (5; 12), pouvant contenir un volume variable de gaz respiratoire et pouvant être relié à l'embout buccal de façon à permettre l'écoulement fluidique, soit directement, soit par l'intermédiaire d'un distributeur (3), un obturateur (8) réglable et étanche au gaz placé entre l'embout buccal (2) et le réservoir (5; 12), et au moins un raccord (10; 17) pour l'introduction de médicaments dans le réservoir (5; 12). Selon l'invention, les médicaments sont introduits soit directement, soit par l'intermédiaire d'un distributeur (3), le réservoir (5; 12) est doté d'une paroi modulable permettant la modification de son volume, paroi qui s'agrandit sous l'effet du gaz respiratoire sous pression à l'encontre d'une force de rappel, grâce à laquelle la respiration sous pression s'effectue pour l'inhalation du gaz respiratoire contenant le médicament.
EP00979602A 1999-11-20 2000-11-20 Dispositif pour inhaler des medicaments par assistance respiratoire sous pression Withdrawn EP1409052A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19955902 1999-11-20
DE19955902 1999-11-20
PCT/EP2000/011512 WO2001037910A1 (fr) 1999-11-20 2000-11-20 Dispositif pour inhaler des medicaments par assistance respiratoire sous pression

Publications (1)

Publication Number Publication Date
EP1409052A1 true EP1409052A1 (fr) 2004-04-21

Family

ID=7929755

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00979602A Withdrawn EP1409052A1 (fr) 1999-11-20 2000-11-20 Dispositif pour inhaler des medicaments par assistance respiratoire sous pression

Country Status (6)

Country Link
US (1) US6701915B1 (fr)
EP (1) EP1409052A1 (fr)
JP (1) JP2003514630A (fr)
AU (1) AU1703401A (fr)
CA (1) CA2389927A1 (fr)
WO (1) WO2001037910A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070221211A1 (en) * 2006-03-27 2007-09-27 Boris Sagalovich Apparatus and process for inhaling medicines
JP2008049127A (ja) * 2006-07-24 2008-03-06 Canon Inc 吸入装置
DK3445428T3 (da) * 2016-04-18 2021-08-23 Inspiring Pty Ltd Afstandsindretning til en inhalator
KR102458332B1 (ko) * 2020-09-25 2022-10-24 인제대학교 산학협력단 기관절개 환자용 흡입기

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US2284964A (en) * 1940-07-26 1942-06-02 Air Reduction Mechanical respirator
US2582210A (en) * 1949-07-05 1952-01-08 E & J Mfg Co Apparatus for positive respiration during gas anesthesia
USRE25871E (en) * 1958-12-05 1965-10-05 Lung ventilators and control mechanism therefor
SE221323C1 (sv) * 1962-10-25 1968-07-02 Carl-Gunnar Daniel Engstroem Anordning för att i en respirator bibringa inandningsgasen en halt av aerosol
US3307542A (en) * 1963-02-05 1967-03-07 Air Shields Lung ventilating equipment
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Title
See references of WO0137910A1 *

Also Published As

Publication number Publication date
AU1703401A (en) 2001-06-04
WO2001037910A1 (fr) 2001-05-31
JP2003514630A (ja) 2003-04-22
US6701915B1 (en) 2004-03-09
CA2389927A1 (fr) 2001-05-31

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