EP1293190B1 - Transfereinheit bestend aus einem Flacon, einer Ampulle, und einer Vorrichtung zum bidirektionalen Übertragen einer in dem Flacon enthaltenen Flüssigkeit in die Ampulle - Google Patents

Transfereinheit bestend aus einem Flacon, einer Ampulle, und einer Vorrichtung zum bidirektionalen Übertragen einer in dem Flacon enthaltenen Flüssigkeit in die Ampulle Download PDF

Info

Publication number
EP1293190B1
EP1293190B1 EP20020292139 EP02292139A EP1293190B1 EP 1293190 B1 EP1293190 B1 EP 1293190B1 EP 20020292139 EP20020292139 EP 20020292139 EP 02292139 A EP02292139 A EP 02292139A EP 1293190 B1 EP1293190 B1 EP 1293190B1
Authority
EP
European Patent Office
Prior art keywords
piston
needle
carpule
cartridge
bottle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP20020292139
Other languages
English (en)
French (fr)
Other versions
EP1293190A1 (de
Inventor
Jean-Pascal Delay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sedat SAS
Original Assignee
Sedat SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sedat SAS filed Critical Sedat SAS
Publication of EP1293190A1 publication Critical patent/EP1293190A1/de
Application granted granted Critical
Publication of EP1293190B1 publication Critical patent/EP1293190B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/062—Carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means

Definitions

  • the needle ensuring the communication between the cartridge and the bottle is carried by a pierceable shuttle initially free to slide axially relative to the body.
  • the object of the invention is to propose a transfer device whose operating sequence is simplified.
  • the subject of the invention is a bidirectional transfer device, of the aforementioned type, characterized in that the hollow needle is integral with the body and is axially fixed relative to the body.
  • the transfer device 10 shown in FIG. 1 is generally cylindrical in shape of the X-X axis. It is adapted to ensure the bidirectional transfer of a fluid between a cartridge 12, visible in Figures 2 and 4, and a bottle 14, visible in these figures.
  • the device 10 essentially comprises a body 16 having, at a lower end, means 18 for attaching the bottle, a mobile support member 20 for supporting the body of the cartridge, this equipment being adapted to slide relative to the body 16 and a spacer 22 forming a pusher adapted to bear on the piston of the cartridge 12.
  • the device further comprises a hollow needle 24 integral with the body 16. In Figure 2, the latter is shown away from the body 16 to be visible.
  • the cartridge 12 is intended to perform an injection after having been extracted from the transfer device and equipped with an injection needle and an actuating pusher. It comprises a cylindrical tank 25 having, at the front, a narrowed neck closed by a pierceable lid 26. The lid 26 is adapted to be perforated by an injection needle mounted on the cartridge for injection.
  • the carpule further comprises a perforable piston 27 sliding axially inside the reservoir 25. Initially, the cartridge contains a solvent.
  • the bottle 14 comprises a glass body having a neck closed by a perforable lid 28.
  • the neck has a peripheral rim defining a shoulder 29.
  • the bottle 14 contains a lyophilizate to be dissolved in the solvent contained in the carpule.
  • the body 16 generally has a tubular shape. It has, at its lower end, a cap 30 defining a housing 31 for receiving the bottle 14.
  • the housing 31 is defined by a cylindrical wall 32 closed by a bowl 34 for receiving the neck of the bottle 14.
  • the bowl 34 is delimited laterally by a cylindrical wall 36 of smaller diameter than the cylindrical wall 32. It is closed by a transverse wall 37 forming a bottom.
  • the bowl is connected to the cylindrical wall 32 by a frustoconical section 38.
  • projections 40 On the inner surface of the cylindrical wall 32 are provided projections 40 to ensure axial retention of the bottle by resilient engagement of the projections behind the neck of the bottle.
  • the bottom 37 of the bowl is traversed axially by the transfer needle 24.
  • This needle is retained by a collar 42 projecting out of the housing 30.
  • the collar 42 provides an axial connection of the body 16 and the needle 24.
  • the needle 24 has a first end 24A projecting inside the housing 30. This end is adapted to perforate the lid 28 closing the bottle 14.
  • the needle 24 extends on the other side of the bottom 37 over most of the length of the body 16. It has on this side of the bottom 37 a 24B perforation end of the piston of the cartridge.
  • the body 16 has a tubular trunk 50 extending the cylindrical wall 32 of the cap.
  • the tubular trunk 50 surrounds the side wall 36. Between the cylindrical wall 36 and the lower end of the tubular trunk 50 is defined an annular space 52.
  • the tubular trunk 50 has longitudinal lumens and windows ensuring the elastic interlocking of protrusions provided on the movable retaining member 20 of the carpule and on the spacer 22.
  • the spacer 22 has, at a lower end, a base 60 in the form of a bell adapted to engage around the bowl 34. At its other free end, it has a profile 62 for hooking and bearing on the piston of the carpule.
  • the spacer 22 has a cylindrical wall 64 axially surrounding the needle 24.
  • the outer diameter of the cylindrical wall 64 is smaller than the inner diameter of the tank of the carpule, to allow the spacer to enter the carpule .
  • the base 60 is integral with the end of the cylindrical wall 64.
  • This base has a peripheral skirt 66 adapted to be received in the annular space 52.
  • This skirt is connected to the cylindrical wall 64 by a ring 68.
  • the skirt 66 externally has two diametrically opposed snap protrusions 70. These projections are adapted to be received, as shown in Figure 3, in two windows 72 formed in the tubular trunk 50 of the body. These windows 72 are arranged away from the cap 30.
  • Two identical windows 74 are formed in the vicinity of the cap 29 and are adapted to receive the latching projections 70 after displacement of the spacer 22 along the needle 24 towards the bottle 14.
  • the attachment and support profile 62 of the pierceable piston of the carpule comprises a threaded end 75 extending axially in the extension of the cylindrical wall 64.
  • This threaded end has a outer diameter reduced and has an external thread adapted to cooperate with a thread formed in a threaded recess of the pierceable piston 27 of the cartridge.
  • a shoulder 76 is provided at the end of the cylindrical wall 64 to ensure the connection of this wall 64 to the tip 75. This shoulder also allows the support of the piston of the cartridge.
  • the end piece 75 is extended inside the cylindrical body by a collar 77.
  • the endpiece 75 and the collar 77 internally define a passage 78 for guiding the needle 24 and in particular its end section completed by the perforation end 24B.
  • the dimensions of the needle 24 and the various components of the spacer 22 are such that, when the spacer 22 is in its initial position, with the latching projections 70 received in the windows 72 (FIGS. 3 and 4), the perforation end 24B of the needle is disposed inside the passage 78.
  • the mobile unit 20 for supporting and moving the reservoir of the carpule comprises a carpule holder 80 and a cap 82 screwed onto the carpule support. Between these is delimited a housing 84 of axial immobilization of the reservoir 25 of the carpule.
  • the carpule support 80 has a tubular section 86 whose inside diameter corresponds to the outside diameter of the tank 25 of the carpule.
  • This tubular section has on its outer surface a thread adapted to cooperate with a complementary thread formed at the end of the cap 82.
  • the latter has a cylindrical side wall 88 in which is partially received the tubular portion 86 of the carpule support.
  • This side wall 88 is closed by a transverse wall 90 forming a bearing surface for the hand.
  • the cylindrical section has a ring 91 forming a shoulder for the support of the rear end of the tank.
  • the ring 91 is extended by a peripheral lip 92 surrounding the cylindrical wall 64 of the spacer to ensure axial guidance of the moving element 20 with respect to the spacer 22.
  • the support 80 has an outer skirt 94 surrounding the tubular section 86 between the threading for the connection of the cap 82 and the end of the section 86 equipped with the lip 92.
  • This skirt 94 externally has a first pair of protrusions. snapping 98 diametrically opposed and adapted to be initially received in two windows 100 formed near the upper end of the tubular portion of the body.
  • another pair of diametrically opposed projections 104 are provided externally to the free end of the skirt 94. These are received in diametrically opposite longitudinal slots 106 extending substantially along the length of the tubular trunk 50 from the body.
  • the device is initially in the storage state shown in FIG. 3. In this state, no vial or cartridge is placed in the device.
  • the carpule 12 is first put in place in the moving assembly 20, as illustrated in FIG. 4.
  • the cap 82 is unscrewed from the carpule holder 80.
  • the carpule is then introduced with its rear end engaged in the space delimited by the cylindrical section 86.
  • the pierceable piston 27 is screwed onto the endpiece 75 of the spacer. In this position, the rear end of the cartridge bears against the ring 91 of the cartridge holder 80.
  • the cap 82 is then screwed onto the cartridge holder 80. This screwing is performed until the transverse wall 90 of the cap bears on the front end of the cartridge, so that the reservoir 25 of the carpule is secured axially relative to the moving assembly 20.
  • the bottle 14 is then engaged in the housing 30, as illustrated in FIG. 4.
  • the bottle 14 is retained in the housing 30 by the elastic engagement projections 40 applied against the shoulder 29.
  • the perforable seal 28 is perforated by the transfer needle 24 from its end 24A.
  • the moving assembly 20 is caused to move along the body.
  • the detent projections 98 emerge from the windows 100, thus allowing the mobile assembly 20 to slide inside the tubular trunk 50 of the body.
  • the perforated piston of the cartridge is held in abutment on the spacer 22 and is thus immobilized relative to the body.
  • the body of the carpule being displaced by the sliding of the moving element 20, a relative displacement between the piston and the cartridge body occurs, the piston gradually sinking into the body.
  • the liquid contained in the carpule is then ejected through the needle 24 into the bottle 14.
  • the projections 104 received in the longitudinal slots 106 provide a guide in translation and immobilization in rotation of the moving element relative to the body.
  • the detent projections 98 are also received in the slots 106.
  • the device is slightly shaken to ensure dissolution of the lyophilisate in the solvent initially contained in the carpule.
  • the device is completely returned.
  • the bottle 14 is above the carpule.
  • the end 24A of the needle is in the lower part of the vial allowing suction extraction of most of the contained mixture.
  • the suction is ensured by the moving equipment 20 which is brought away from the bottle 14.
  • the body 16 is held in one hand while the cap 90 is pulled in the direction of the needle.
  • the piston 27 traversed by the needle 24 is held immobilized relative to the body by the engagement of the latching projections 70 in the windows 74.
  • the mobile assembly 20 which is secured to the cylindrical reservoir 25 moves inside the body in the direction of the needle 24, so that the piston moves relative to the cylindrical reservoir, thereby creating a depression in the carpule, which causes the recall of the mixture contained in the bottle 14.
  • the displacement of the moving element 20 is interrupted when the detent tongues 98 reach the upper end of the longitudinal slots 106.
  • the presence of the projections 98 and stop stops formed by the ends of the slots 106 makes it possible to avoid that the moving element 20 is too far from the body, thus avoiding any risk of accidental disengagement of the piston 27 from the tank 25.
  • the cap 82 is finally disassembled and the carpule is extracted from the moving equipment. This cartridge is then used to make an injection after it has been equipped with an injection needle and a push rod screwed into the pierceable piston.

Claims (4)

  1. Übertragungsgerät, umfassend eine Flasche (14), die mit einem perforierbaren Stopfen (28) versehen ist, eine Karpule (12), die einen zylindrischen Behälter (25) umfasst, in dem ein perforierbarer Kolben (27) gleitet, und eine Vorrichtung zur bidirektionalen Übertragung einer Flüssigkeit zwischen der Flasche (14) und der Karpule (12), wobei die Vorrichtung umfasst:
    - einen Körper (16), der Mittel (18) zum Einhaken der Flasche (14) umfasst;
    - eine hohle Nadel (24), die ein erstes Ende (24B) zum Perforieren des Kolbens (27) der Karpule und ein zweites Ende (24A) aufweist, das für die Perforierung des Stopfens (28) der Flasche ausgelegt ist;
    - ein bewegliche Einrichtung (20), die bezüglich des Körpers (16) in der Richtung der Achse der Nadel (24) beweglich ist, wobei diese bewegliche Einrichtung (20) Mittel zur axialen festen Verbindung des Behälters (25) der Karpule gemäß der Richtung der Achse der Nadel (24) umfasst; und
    - ein Zwischenstück (22), das zwischen den Körper (16) und den perforierbaren Kolben (27) der Karpule eingesetzt ist, wobei dieses Zwischenstück (22) einen Stoppanschlag für den perforierbaren Kolben (27) bezüglich des Körpers (16) bildet,
    dadurch gekennzeichnet, dass die hohle Nadel (24) mit dem Körper (16) fest verbunden ist und axial bezüglich des Körpers (16) feststehend ist.
  2. Übertragungsgerät nach Anspruch 1, dadurch gekennzeichnet, dass das Zwischenstück (22) bezüglich des Körpers (16) zwischen einer Anfangsstellung, in der es den perforierbaren Kolben (27) in einem Abstand von dem ersten Ende (24B) der Nadel hält, und einer Endstellung beweglich ist, in der die Nadel (24) durch den perforierbaren Kolben (27) eingesteckt ist.
  3. Übertragungsgerät nach Anspruch 1 oder 2, dadurch gekennzeichnet, dass die bewegliche Einrichtung (20) und der Körper (16) Mittel (98, 106) zur Begrenzung der Bewegung der beweglichen Einrichtung (20) bezüglich des Körpers (16) in der Richtung des Auszugs des perforierbaren Kolbens (27) aus dem zylindrischen Behälter umfassen.
  4. Übertragungsgerät nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass die bewegliche Einrichtung (20) und der Körper (16) Mittel (104, 106) zur Führung in Translation und zur Blockierung in Drehung in Bezug aufeinander umfassen.
EP20020292139 2001-09-17 2002-08-29 Transfereinheit bestend aus einem Flacon, einer Ampulle, und einer Vorrichtung zum bidirektionalen Übertragen einer in dem Flacon enthaltenen Flüssigkeit in die Ampulle Expired - Lifetime EP1293190B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0112007 2001-09-17
FR0112007A FR2829691B1 (fr) 2001-09-17 2001-09-17 Dispositif de transfert bidirectionnel d'un liquide entre un flacon et une carpule

Publications (2)

Publication Number Publication Date
EP1293190A1 EP1293190A1 (de) 2003-03-19
EP1293190B1 true EP1293190B1 (de) 2006-10-25

Family

ID=8867364

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20020292139 Expired - Lifetime EP1293190B1 (de) 2001-09-17 2002-08-29 Transfereinheit bestend aus einem Flacon, einer Ampulle, und einer Vorrichtung zum bidirektionalen Übertragen einer in dem Flacon enthaltenen Flüssigkeit in die Ampulle

Country Status (7)

Country Link
US (1) US6752180B2 (de)
EP (1) EP1293190B1 (de)
JP (2) JP4790198B2 (de)
AT (1) ATE343362T1 (de)
DE (1) DE60215598T2 (de)
ES (1) ES2275821T3 (de)
FR (1) FR2829691B1 (de)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL114960A0 (en) 1995-03-20 1995-12-08 Medimop Medical Projects Ltd Flow control device
US20050137566A1 (en) * 2003-12-23 2005-06-23 Fowles Thomas A. Sliding reconstitution device for a diluent container
ES2333710T3 (es) * 2002-04-24 2010-02-26 Ares Trading S.A. Dispositivo para preparar un liquido medicinal.
EP2311408B1 (de) 2003-03-14 2019-02-20 DePuy Spine, Inc. Hydraulische Vorrichtung zur Knochenzementeinspritzung bei perkutaner Vertebroplastie
US8066713B2 (en) 2003-03-31 2011-11-29 Depuy Spine, Inc. Remotely-activated vertebroplasty injection device
US8415407B2 (en) 2004-03-21 2013-04-09 Depuy Spine, Inc. Methods, materials, and apparatus for treating bone and other tissue
US8579908B2 (en) 2003-09-26 2013-11-12 DePuy Synthes Products, LLC. Device for delivering viscous material
WO2005041846A2 (en) * 2003-10-30 2005-05-12 Teva Medical Ltd. Safety drug handling device
IL161660A0 (en) 2004-04-29 2004-09-27 Medimop Medical Projects Ltd Liquid drug delivery device
FR2869795B1 (fr) * 2004-05-07 2006-08-04 Sedat Sa Dispositif de transfert bidirectionnel
CN101065080B (zh) 2004-07-30 2021-10-29 德普伊新特斯产品有限责任公司 用于处理骨和其他组织的材料和器械
US7665923B2 (en) * 2004-09-27 2010-02-23 Medical Instill Technologies, Inc. Laterally-actuated dispenser with one-way valve for storing and dispensing metered amounts of substances
AT501282B8 (de) * 2005-02-01 2007-02-15 Pro Med Medizinische Produktio Vorrichtung zur dosierten abgabe von flüssigkeit in einen behälter
US7597680B2 (en) * 2005-02-09 2009-10-06 Kaken Pharmaceutical Co., Ltd. Syringe device and method of preparing medicine using the device
US20060184103A1 (en) * 2005-02-17 2006-08-17 West Pharmaceutical Services, Inc. Syringe safety device
US7905868B2 (en) 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US9381024B2 (en) 2005-07-31 2016-07-05 DePuy Synthes Products, Inc. Marked tools
US9918767B2 (en) 2005-08-01 2018-03-20 DePuy Synthes Products, Inc. Temperature control system
EP1919432B1 (de) 2005-08-11 2011-10-19 Medimop Medical Projects Ltd. Transfervorrichtungen für flüssige arzneimittel zur ausfallsicheren korrekten rastverbindung auf medizinischen ampullen
US8360629B2 (en) 2005-11-22 2013-01-29 Depuy Spine, Inc. Mixing apparatus having central and planetary mixing elements
WO2007118372A1 (fr) * 2006-04-18 2007-10-25 Zhongshan Botai Pharmaceutic Instruments Co., Ltd. Seringue stérilisée servant au mélange de médicaments
DE102006041499A1 (de) * 2006-08-31 2008-03-20 Primojex Gmbh Injektionseinrichtung
EP2068898A4 (de) 2006-09-14 2011-07-20 Depuy Spine Inc Knochenzement und anwendungsverfahren dafür
CA2564061A1 (en) * 2006-10-16 2008-04-16 Duoject Medical Systems Inc. Reconstitution system for mixing the contents of a vial containing a first substance with a second substance stored in a cartridge
AU2012216856B2 (en) * 2006-10-19 2014-12-11 Depuy Spine, Inc. Fluid delivery system
CA2665995C (en) * 2006-10-19 2011-11-29 Oren Globerman Fluid delivery system
US8132695B2 (en) 2006-11-11 2012-03-13 Medical Instill Technologies, Inc. Multiple dose delivery device with manually depressible actuator and one-way valve for storing and dispensing substances, and related method
IL182605A0 (en) 2007-04-17 2007-07-24 Medimop Medical Projects Ltd Fluid control device with manually depressed actuator
CA2685474C (en) 2007-04-30 2014-07-08 Medtronic Minimed, Inc. Reservoir filling, bubble management, and infusion medium delivery systems and methods with same
US7963954B2 (en) 2007-04-30 2011-06-21 Medtronic Minimed, Inc. Automated filling systems and methods
WO2009026443A2 (en) 2007-08-21 2009-02-26 Gilero, Llc Vial access and injection system
EP2190518B1 (de) 2007-09-18 2016-01-27 Medimop Medical Projects Ltd. Medikamenten-misch- und injektionsgerät
IL186290A0 (en) 2007-09-25 2008-01-20 Medimop Medical Projects Ltd Liquid drug delivery devices for use with syringe having widened distal tip
DE102008003103A1 (de) * 2008-01-01 2009-07-02 Lts Lohmann Therapie-Systeme Ag Einweginjektor mit zweikolbigem Zweikammersystem
WO2009146088A1 (en) * 2008-04-01 2009-12-03 Yukon Medical, Llc Dual container fluid transfer device
USD641080S1 (en) 2009-03-31 2011-07-05 Medimop Medical Projects Ltd. Medical device having syringe port with locking mechanism
AU2010236426B2 (en) 2009-04-14 2013-08-29 Yukon Medical, Llc Fluid transfer device
TWI519330B (zh) * 2009-06-02 2016-02-01 賽諾菲阿凡提斯德意志有限公司 使用者可選擇式之醫療模組
AR076720A1 (es) * 2009-06-02 2011-06-29 Sanofi Aventis Deutschland Modulo medicinal con protector de agua
USD630732S1 (en) 2009-09-29 2011-01-11 Medimop Medical Projects Ltd. Vial adapter with female connector
IL201323A0 (en) 2009-10-01 2010-05-31 Medimop Medical Projects Ltd Fluid transfer device for assembling a vial with pre-attached female connector
SG181420A1 (en) * 2009-10-30 2012-07-30 Revance Therapeutics Inc Device and method for topical application of therapeutics or cosmetic compositions
IL202070A0 (en) 2009-11-12 2010-06-16 Medimop Medical Projects Ltd Inline liquid drug medical device
IL202069A0 (en) 2009-11-12 2010-06-16 Medimop Medical Projects Ltd Fluid transfer device with sealing arrangement
DK2512399T3 (da) 2010-02-24 2015-06-22 Medimop Medical Projects Ltd Fluidoverføringsindretning med udluftningsarrangement
EP2512398B1 (de) 2010-02-24 2014-08-27 Medimop Medical Projects Ltd. Vorrichtung mit belüftetem phiolenadapter zum transport eines flüssigen arzneimittels
USD655017S1 (en) 2010-06-17 2012-02-28 Yukon Medical, Llc Shroud
US20120000569A1 (en) * 2010-07-01 2012-01-05 Wiegel Christopher D Reservoir filling aid for a medical pump
USD669980S1 (en) 2010-10-15 2012-10-30 Medimop Medical Projects Ltd. Vented vial adapter
IL209290A0 (en) 2010-11-14 2011-01-31 Medimop Medical Projects Ltd Inline liquid drug medical device having rotary flow control member
IL212420A0 (en) 2011-04-17 2011-06-30 Medimop Medical Projects Ltd Liquid drug transfer assembly
US8672883B2 (en) 2011-07-11 2014-03-18 C. Garyen Denning Fluid delivery device and methods
USD681230S1 (en) 2011-09-08 2013-04-30 Yukon Medical, Llc Shroud
US9352312B2 (en) * 2011-09-23 2016-05-31 Alere Switzerland Gmbh System and apparatus for reactions
IL215699A0 (en) 2011-10-11 2011-12-29 Medimop Medical Projects Ltd Liquid drug reconstitution assemblage for use with iv bag and drug vial
USD674088S1 (en) 2012-02-13 2013-01-08 Medimop Medical Projects Ltd. Vial adapter
USD737436S1 (en) 2012-02-13 2015-08-25 Medimop Medical Projects Ltd. Liquid drug reconstitution assembly
USD720451S1 (en) 2012-02-13 2014-12-30 Medimop Medical Projects Ltd. Liquid drug transfer assembly
WO2013134614A2 (en) * 2012-03-08 2013-09-12 Becton, Dickinson And Company Drug reconstitution system
IL219065A0 (en) 2012-04-05 2012-07-31 Medimop Medical Projects Ltd Fluid transfer device with manual operated cartridge release arrangement
USD769444S1 (en) 2012-06-28 2016-10-18 Yukon Medical, Llc Adapter device
IL221635A0 (en) 2012-08-26 2012-12-31 Medimop Medical Projects Ltd Drug vial mixing and transfer device for use with iv bag and drug vial
IL221634A0 (en) 2012-08-26 2012-12-31 Medimop Medical Projects Ltd Universal drug vial adapter
WO2014041529A1 (en) 2012-09-13 2014-03-20 Medimop Medical Projects Ltd Telescopic female drug vial adapter
USD734868S1 (en) 2012-11-27 2015-07-21 Medimop Medical Projects Ltd. Drug vial adapter with downwardly depending stopper
IL225734A0 (en) 2013-04-14 2013-09-30 Medimop Medical Projects Ltd A ready-to-use medicine vial device including a medicine vial closure, and a medicine vial closure for it
BR112015027555B1 (pt) 2013-05-10 2022-02-01 Medimop Medical Projects Ltd Dispositivo médico para uso com uma seringa sem agulha, um frasco e um veículo líquido para preencher a seringa sem agulha com uma solução de injeção para injeção em um paciente
USD767124S1 (en) 2013-08-07 2016-09-20 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
KR200486088Y1 (ko) 2013-08-07 2018-04-02 메디모프 메디컬 프로젝트스 리미티드. 주입 액체 용기와 함께 사용하기 위한 액체 전달 장치
USD765837S1 (en) 2013-08-07 2016-09-06 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
USD794183S1 (en) 2014-03-19 2017-08-08 Medimop Medical Projects Ltd. Dual ended liquid transfer spike
USD757933S1 (en) 2014-09-11 2016-05-31 Medimop Medical Projects Ltd. Dual vial adapter assemblage
WO2016110838A1 (en) 2015-01-05 2016-07-14 Medimop Medical Projects Ltd Dual vial adapter assemblages with quick release drug vial adapter for ensuring correct usage
US10357429B2 (en) 2015-07-16 2019-07-23 West Pharma. Services IL, Ltd. Liquid drug transfer devices for secure telescopic snap fit on injection vials
USD801522S1 (en) 2015-11-09 2017-10-31 Medimop Medical Projects Ltd. Fluid transfer assembly
CN108366905A (zh) 2015-11-25 2018-08-03 西部制药服务以色列有限公司 包括具有自动密封的入口阀的药瓶转接器的双瓶转接器组件
IL245803A0 (en) 2016-05-24 2016-08-31 West Pharma Services Il Ltd Devices with two vial adapters include an aerated drug vial adapter and an aerated liquid vial adapter
IL245800A0 (en) 2016-05-24 2016-08-31 West Pharma Services Il Ltd A device with two vial adapters includes two identical vial adapters
IL246073A0 (en) * 2016-06-06 2016-08-31 West Pharma Services Il Ltd A fluid transport device for use with a slide-driven piston medicine pump cartridge
IL247376A0 (en) 2016-08-21 2016-12-29 Medimop Medical Projects Ltd Injector assembly
USD832430S1 (en) 2016-11-15 2018-10-30 West Pharma. Services IL, Ltd. Dual vial adapter assemblage
IL249408A0 (en) 2016-12-06 2017-03-30 Medimop Medical Projects Ltd A device for transporting fluids for use with an infusion fluid container and a hand tool similar to a plunger to release a vial from it
IL251458A0 (en) 2017-03-29 2017-06-29 Medimop Medical Projects Ltd Liquid drug delivery devices are user-operated for use in pre-prepared liquid drug delivery assemblies (rtu)
USD819805S1 (en) * 2017-04-28 2018-06-05 Ucb Biopharma Sprl Injector
IL254802A0 (en) 2017-09-29 2017-12-31 Medimop Medical Projects Ltd A device with two vial adapters includes two identical perforated vial adapters
JP1630477S (de) 2018-07-06 2019-05-07
USD923812S1 (en) 2019-01-16 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
JP1648075S (de) 2019-01-17 2019-12-16
WO2020157719A1 (en) 2019-01-31 2020-08-06 West Pharma. Services Il, Ltd Liquid transfer device
IL307176A (en) 2019-04-30 2023-11-01 West Pharma Services Il Ltd A fluid delivery device with a dual-canal infusion tip
GB201918663D0 (en) * 2019-12-17 2020-01-29 Oribiotech Ltd A connector
USD956958S1 (en) 2020-07-13 2022-07-05 West Pharma. Services IL, Ltd. Liquid transfer device

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3336924A (en) * 1964-02-20 1967-08-22 Sarnoff Two compartment syringe package
US3872867A (en) * 1971-06-02 1975-03-25 Upjohn Co Wet-dry additive assembly
US3826260A (en) * 1971-12-27 1974-07-30 Upjohn Co Vial and syringe combination
US3828779A (en) * 1972-12-13 1974-08-13 Ims Ltd Flex-o-jet
NL173477C (nl) * 1974-09-12 1984-02-01 Duphar Int Res Injektiespuit met teleskopisch orgaan tussen patroon en medicamentflesje.
JPS62194347U (de) * 1986-05-30 1987-12-10
CH676548A5 (en) * 1988-04-22 1991-02-15 Disetronic Ag Separate storage before mixture - for general components of medicine in ampoules using double ended hollow needle
AU2446392A (en) * 1991-08-07 1993-03-02 Habley Medical Technology Corporation Metered syringe filling device for pharmaceutical containers
WO1995024176A1 (en) * 1994-03-07 1995-09-14 Bioject, Inc. Ampule filling device
US5526853A (en) * 1994-08-17 1996-06-18 Mcgaw, Inc. Pressure-activated medication transfer system
US6113583A (en) * 1998-09-15 2000-09-05 Baxter International Inc. Vial connecting device for a sliding reconstitution device for a diluent container
FR2790948B1 (fr) * 1999-03-18 2001-06-22 Sedat Dispositif de transfert bidirectionnel d'un liquide entre un flacon et une capsule

Also Published As

Publication number Publication date
DE60215598D1 (de) 2006-12-07
ES2275821T3 (es) 2007-06-16
DE60215598T2 (de) 2007-08-30
FR2829691B1 (fr) 2004-07-09
JP2009279424A (ja) 2009-12-03
EP1293190A1 (de) 2003-03-19
US20030055376A1 (en) 2003-03-20
JP4790198B2 (ja) 2011-10-12
ATE343362T1 (de) 2006-11-15
FR2829691A1 (fr) 2003-03-21
US6752180B2 (en) 2004-06-22
JP2003111842A (ja) 2003-04-15

Similar Documents

Publication Publication Date Title
EP1293190B1 (de) Transfereinheit bestend aus einem Flacon, einer Ampulle, und einer Vorrichtung zum bidirektionalen Übertragen einer in dem Flacon enthaltenen Flüssigkeit in die Ampulle
EP1161217B1 (de) Vorrichtung zum bidirektionalen übertragen einer in einem flacon enthaltenen flüssigkeit in eine ampulle
FR2869795A1 (fr) Dispositif de transfert bidirectionnel
EP1079877B1 (de) Injektionsspritze mit einem federbeaufschlagten nadelschutz
WO1999022789A1 (fr) Injecteur automatique a retraction d'aiguille en fin d'injection
EP1027902A2 (de) Injektionsspritze mit Selbstschutz
EP1330279B1 (de) Injektionsspritze mit einem verschiebbaren nadelschutz
WO1998013006A1 (fr) Dispositif de connexion, en particulier entre un recipient avec bouchon perforable et une seringue
FR2741810A1 (fr) Seringue pour l'injection d'un melange extemporane
EP0825883A1 (de) Wiederaufladbarer auto-injektor
EP2482992B1 (de) Vorrichtung zur abgabe eines flüssigen produkts
WO2000007649A1 (fr) Seringue d'injection a protecteur d'aiguille mobile exterieurement
CH625467A5 (de) Instrument d'ecriture
CA2875492A1 (fr) Ensemble d'injection
FR2893011A1 (fr) Organe de distribution de produit fluide et distributeur utilisant un tel organe.
FR3008901A1 (fr) Systeme de distribution de liquide tel que du parfum et reservoir associe
FR2705590A1 (fr) Dispositif de distribution de liquide utilisable en position droite et ne comportant pas de tube-plongeur.
EP3972929B1 (de) Getrgetränkeabgabevorrichtung
FR2545573A1 (fr) Valve doseuse
FR2986508A1 (fr) Systeme de remplissage pour un doseur de produit anesthesique
EP0954347B1 (de) Injektionsspritze mit einer ins innere des spritzenkörpers hineinragenden nadel
FR2803530A1 (fr) Dispositif d'injection d'une dose de liquide notamment medicamenteux
FR2952813A1 (fr) Dispositif de liaison entre deux contenants, destine notamment a un usage medical
EP0537282B1 (de) Vorrichtung zum getrennten aufbewahren zweier bestandteile und zum mischen derselben beim gebrauch
FR2778852A1 (fr) Seringue d'injection a aiguille retractable

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

17P Request for examination filed

Effective date: 20030228

AKX Designation fees paid

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

17Q First examination report despatched

Effective date: 20050613

RTI1 Title (correction)

Free format text: TRANSFERTSET COMPRISING A BOTTLE, A CARTRIDGE AND A DEVICE FOR TWO-WAY TRANSFER OF A LIQUID BETWEEN THE BOTTLE AND THE CARTRIDGE

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20061025

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20061025

Ref country code: IE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20061025

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20061025

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20061025

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20061025

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: FRENCH

REF Corresponds to:

Ref document number: 60215598

Country of ref document: DE

Date of ref document: 20061207

Kind code of ref document: P

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20070125

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20070125

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20070125

GBT Gb: translation of ep patent filed (gb section 77(6)(a)/1977)

Effective date: 20070131

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20070326

NLV1 Nl: lapsed or annulled due to failure to fulfill the requirements of art. 29p and 29m of the patents act
REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2275821

Country of ref document: ES

Kind code of ref document: T3

REG Reference to a national code

Ref country code: IE

Ref legal event code: FD4D

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20070726

BERE Be: lapsed

Owner name: SEDAT

Effective date: 20070831

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20070831

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20070126

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20070831

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20070831

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20070831

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20061025

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20061025

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20070829

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20061025

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 14

REG Reference to a national code

Ref country code: DE

Ref legal event code: R082

Ref document number: 60215598

Country of ref document: DE

Representative=s name: MANITZ, FINSTERWALD & PARTNER GBR, DE

Ref country code: DE

Ref legal event code: R081

Ref document number: 60215598

Country of ref document: DE

Owner name: PEROUSE MEDICAL, FR

Free format text: FORMER OWNER: SEDAT, IRIGNY, RHONE, FR

Ref country code: DE

Ref legal event code: R082

Ref document number: 60215598

Country of ref document: DE

Representative=s name: MANITZ FINSTERWALD PATENTANWAELTE PARTMBB, DE

REG Reference to a national code

Ref country code: ES

Ref legal event code: PC2A

Owner name: PEROUSE MEDICAL

Effective date: 20151130

REG Reference to a national code

Ref country code: GB

Ref legal event code: 732E

Free format text: REGISTERED BETWEEN 20151112 AND 20151118

REG Reference to a national code

Ref country code: FR

Ref legal event code: TP

Owner name: PEROUSE MEDICAL, FR

Effective date: 20151223

REG Reference to a national code

Ref country code: FR

Ref legal event code: TP

Owner name: PEROUSE MEDICAL, FR

Effective date: 20151224

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 15

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 16

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20210816

Year of fee payment: 20

Ref country code: FR

Payment date: 20210709

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20210903

Year of fee payment: 20

Ref country code: GB

Payment date: 20210819

Year of fee payment: 20

Ref country code: DE

Payment date: 20210811

Year of fee payment: 20

REG Reference to a national code

Ref country code: DE

Ref legal event code: R071

Ref document number: 60215598

Country of ref document: DE

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20220905

REG Reference to a national code

Ref country code: GB

Ref legal event code: PE20

Expiry date: 20220828

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20220828

Ref country code: ES

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20220830