EP1293190B1 - Transfertset comprising a bottle, a cartridge and a device for two-way transfer of a liquid between the bottle and the cartridge - Google Patents

Transfertset comprising a bottle, a cartridge and a device for two-way transfer of a liquid between the bottle and the cartridge Download PDF

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Publication number
EP1293190B1
EP1293190B1 EP20020292139 EP02292139A EP1293190B1 EP 1293190 B1 EP1293190 B1 EP 1293190B1 EP 20020292139 EP20020292139 EP 20020292139 EP 02292139 A EP02292139 A EP 02292139A EP 1293190 B1 EP1293190 B1 EP 1293190B1
Authority
EP
European Patent Office
Prior art keywords
piston
needle
carpule
cartridge
bottle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP20020292139
Other languages
German (de)
French (fr)
Other versions
EP1293190A1 (en
Inventor
Jean-Pascal Delay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sedat SAS
Original Assignee
Sedat SAS
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Filing date
Publication date
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Publication of EP1293190A1 publication Critical patent/EP1293190A1/en
Application granted granted Critical
Publication of EP1293190B1 publication Critical patent/EP1293190B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/062—Carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means

Definitions

  • the needle ensuring the communication between the cartridge and the bottle is carried by a pierceable shuttle initially free to slide axially relative to the body.
  • the object of the invention is to propose a transfer device whose operating sequence is simplified.
  • the subject of the invention is a bidirectional transfer device, of the aforementioned type, characterized in that the hollow needle is integral with the body and is axially fixed relative to the body.
  • the transfer device 10 shown in FIG. 1 is generally cylindrical in shape of the X-X axis. It is adapted to ensure the bidirectional transfer of a fluid between a cartridge 12, visible in Figures 2 and 4, and a bottle 14, visible in these figures.
  • the device 10 essentially comprises a body 16 having, at a lower end, means 18 for attaching the bottle, a mobile support member 20 for supporting the body of the cartridge, this equipment being adapted to slide relative to the body 16 and a spacer 22 forming a pusher adapted to bear on the piston of the cartridge 12.
  • the device further comprises a hollow needle 24 integral with the body 16. In Figure 2, the latter is shown away from the body 16 to be visible.
  • the cartridge 12 is intended to perform an injection after having been extracted from the transfer device and equipped with an injection needle and an actuating pusher. It comprises a cylindrical tank 25 having, at the front, a narrowed neck closed by a pierceable lid 26. The lid 26 is adapted to be perforated by an injection needle mounted on the cartridge for injection.
  • the carpule further comprises a perforable piston 27 sliding axially inside the reservoir 25. Initially, the cartridge contains a solvent.
  • the bottle 14 comprises a glass body having a neck closed by a perforable lid 28.
  • the neck has a peripheral rim defining a shoulder 29.
  • the bottle 14 contains a lyophilizate to be dissolved in the solvent contained in the carpule.
  • the body 16 generally has a tubular shape. It has, at its lower end, a cap 30 defining a housing 31 for receiving the bottle 14.
  • the housing 31 is defined by a cylindrical wall 32 closed by a bowl 34 for receiving the neck of the bottle 14.
  • the bowl 34 is delimited laterally by a cylindrical wall 36 of smaller diameter than the cylindrical wall 32. It is closed by a transverse wall 37 forming a bottom.
  • the bowl is connected to the cylindrical wall 32 by a frustoconical section 38.
  • projections 40 On the inner surface of the cylindrical wall 32 are provided projections 40 to ensure axial retention of the bottle by resilient engagement of the projections behind the neck of the bottle.
  • the bottom 37 of the bowl is traversed axially by the transfer needle 24.
  • This needle is retained by a collar 42 projecting out of the housing 30.
  • the collar 42 provides an axial connection of the body 16 and the needle 24.
  • the needle 24 has a first end 24A projecting inside the housing 30. This end is adapted to perforate the lid 28 closing the bottle 14.
  • the needle 24 extends on the other side of the bottom 37 over most of the length of the body 16. It has on this side of the bottom 37 a 24B perforation end of the piston of the cartridge.
  • the body 16 has a tubular trunk 50 extending the cylindrical wall 32 of the cap.
  • the tubular trunk 50 surrounds the side wall 36. Between the cylindrical wall 36 and the lower end of the tubular trunk 50 is defined an annular space 52.
  • the tubular trunk 50 has longitudinal lumens and windows ensuring the elastic interlocking of protrusions provided on the movable retaining member 20 of the carpule and on the spacer 22.
  • the spacer 22 has, at a lower end, a base 60 in the form of a bell adapted to engage around the bowl 34. At its other free end, it has a profile 62 for hooking and bearing on the piston of the carpule.
  • the spacer 22 has a cylindrical wall 64 axially surrounding the needle 24.
  • the outer diameter of the cylindrical wall 64 is smaller than the inner diameter of the tank of the carpule, to allow the spacer to enter the carpule .
  • the base 60 is integral with the end of the cylindrical wall 64.
  • This base has a peripheral skirt 66 adapted to be received in the annular space 52.
  • This skirt is connected to the cylindrical wall 64 by a ring 68.
  • the skirt 66 externally has two diametrically opposed snap protrusions 70. These projections are adapted to be received, as shown in Figure 3, in two windows 72 formed in the tubular trunk 50 of the body. These windows 72 are arranged away from the cap 30.
  • Two identical windows 74 are formed in the vicinity of the cap 29 and are adapted to receive the latching projections 70 after displacement of the spacer 22 along the needle 24 towards the bottle 14.
  • the attachment and support profile 62 of the pierceable piston of the carpule comprises a threaded end 75 extending axially in the extension of the cylindrical wall 64.
  • This threaded end has a outer diameter reduced and has an external thread adapted to cooperate with a thread formed in a threaded recess of the pierceable piston 27 of the cartridge.
  • a shoulder 76 is provided at the end of the cylindrical wall 64 to ensure the connection of this wall 64 to the tip 75. This shoulder also allows the support of the piston of the cartridge.
  • the end piece 75 is extended inside the cylindrical body by a collar 77.
  • the endpiece 75 and the collar 77 internally define a passage 78 for guiding the needle 24 and in particular its end section completed by the perforation end 24B.
  • the dimensions of the needle 24 and the various components of the spacer 22 are such that, when the spacer 22 is in its initial position, with the latching projections 70 received in the windows 72 (FIGS. 3 and 4), the perforation end 24B of the needle is disposed inside the passage 78.
  • the mobile unit 20 for supporting and moving the reservoir of the carpule comprises a carpule holder 80 and a cap 82 screwed onto the carpule support. Between these is delimited a housing 84 of axial immobilization of the reservoir 25 of the carpule.
  • the carpule support 80 has a tubular section 86 whose inside diameter corresponds to the outside diameter of the tank 25 of the carpule.
  • This tubular section has on its outer surface a thread adapted to cooperate with a complementary thread formed at the end of the cap 82.
  • the latter has a cylindrical side wall 88 in which is partially received the tubular portion 86 of the carpule support.
  • This side wall 88 is closed by a transverse wall 90 forming a bearing surface for the hand.
  • the cylindrical section has a ring 91 forming a shoulder for the support of the rear end of the tank.
  • the ring 91 is extended by a peripheral lip 92 surrounding the cylindrical wall 64 of the spacer to ensure axial guidance of the moving element 20 with respect to the spacer 22.
  • the support 80 has an outer skirt 94 surrounding the tubular section 86 between the threading for the connection of the cap 82 and the end of the section 86 equipped with the lip 92.
  • This skirt 94 externally has a first pair of protrusions. snapping 98 diametrically opposed and adapted to be initially received in two windows 100 formed near the upper end of the tubular portion of the body.
  • another pair of diametrically opposed projections 104 are provided externally to the free end of the skirt 94. These are received in diametrically opposite longitudinal slots 106 extending substantially along the length of the tubular trunk 50 from the body.
  • the device is initially in the storage state shown in FIG. 3. In this state, no vial or cartridge is placed in the device.
  • the carpule 12 is first put in place in the moving assembly 20, as illustrated in FIG. 4.
  • the cap 82 is unscrewed from the carpule holder 80.
  • the carpule is then introduced with its rear end engaged in the space delimited by the cylindrical section 86.
  • the pierceable piston 27 is screwed onto the endpiece 75 of the spacer. In this position, the rear end of the cartridge bears against the ring 91 of the cartridge holder 80.
  • the cap 82 is then screwed onto the cartridge holder 80. This screwing is performed until the transverse wall 90 of the cap bears on the front end of the cartridge, so that the reservoir 25 of the carpule is secured axially relative to the moving assembly 20.
  • the bottle 14 is then engaged in the housing 30, as illustrated in FIG. 4.
  • the bottle 14 is retained in the housing 30 by the elastic engagement projections 40 applied against the shoulder 29.
  • the perforable seal 28 is perforated by the transfer needle 24 from its end 24A.
  • the moving assembly 20 is caused to move along the body.
  • the detent projections 98 emerge from the windows 100, thus allowing the mobile assembly 20 to slide inside the tubular trunk 50 of the body.
  • the perforated piston of the cartridge is held in abutment on the spacer 22 and is thus immobilized relative to the body.
  • the body of the carpule being displaced by the sliding of the moving element 20, a relative displacement between the piston and the cartridge body occurs, the piston gradually sinking into the body.
  • the liquid contained in the carpule is then ejected through the needle 24 into the bottle 14.
  • the projections 104 received in the longitudinal slots 106 provide a guide in translation and immobilization in rotation of the moving element relative to the body.
  • the detent projections 98 are also received in the slots 106.
  • the device is slightly shaken to ensure dissolution of the lyophilisate in the solvent initially contained in the carpule.
  • the device is completely returned.
  • the bottle 14 is above the carpule.
  • the end 24A of the needle is in the lower part of the vial allowing suction extraction of most of the contained mixture.
  • the suction is ensured by the moving equipment 20 which is brought away from the bottle 14.
  • the body 16 is held in one hand while the cap 90 is pulled in the direction of the needle.
  • the piston 27 traversed by the needle 24 is held immobilized relative to the body by the engagement of the latching projections 70 in the windows 74.
  • the mobile assembly 20 which is secured to the cylindrical reservoir 25 moves inside the body in the direction of the needle 24, so that the piston moves relative to the cylindrical reservoir, thereby creating a depression in the carpule, which causes the recall of the mixture contained in the bottle 14.
  • the displacement of the moving element 20 is interrupted when the detent tongues 98 reach the upper end of the longitudinal slots 106.
  • the presence of the projections 98 and stop stops formed by the ends of the slots 106 makes it possible to avoid that the moving element 20 is too far from the body, thus avoiding any risk of accidental disengagement of the piston 27 from the tank 25.
  • the cap 82 is finally disassembled and the carpule is extracted from the moving equipment. This cartridge is then used to make an injection after it has been equipped with an injection needle and a push rod screwed into the pierceable piston.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Jet Pumps And Other Pumps (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
  • Basic Packing Technique (AREA)
  • External Artificial Organs (AREA)

Abstract

The liquid transfer apparatus consists of a housing with a connector (30) for fitting it to a flask, a tube holder (80) and a mobile component (20), and a spacer (22) acting as a stop for a moving perforable piston inside the tube. The apparatus incorporates a hollow needle (24) that is fixed axially relative to the housing, while the spacer can be moved between a first position in which the piston is held at a distance from the needle, and a second position in which the needle passes through the piston.

Description

La présente invention concerne un dispositif de transfert bidirectionnel d'un liquide entre un flacon muni d'un bouchon perforable et une carpule comprenant un réservoir cylindrique dans lequel coulisse un piston perforable, du type comprenant

  • un corps comportant des moyens d'accrochage du flacon ;
  • une aiguille creuse présentant une première extrémité pour la perforation du piston de la carpule et une seconde extrémité adaptée pour la perforation du bouchon du flacon ;
  • un équipage mobile déplaçable par rapport au corps suivant la direction de l'axe de l'aiguille, lequel équipage mobile comporte des moyens de solidarisation axiale du réservoir de la carpule suivant la direction de l'axe de l'aiguille ; et
  • une entretoise interposée entre le corps et le piston perforable de la carpule, laquelle entretoise forme une butée d'arrêt du piston perforable par rapport au corps.
The present invention relates to a bidirectional transfer device for a liquid between a bottle provided with a pierceable stopper and a cartridge comprising a cylindrical reservoir in which a perforable piston, of the type comprising
  • a body comprising means for fastening the bottle;
  • a hollow needle having a first end for perforation of the cartridge piston and a second end adapted for perforation of the vial stopper;
  • a movable element displaceable relative to the body in the direction of the axis of the needle, which movable element comprises means for axially securing the tank of the cartridge in the direction of the axis of the needle; and
  • a spacer interposed between the body and the pierceable piston of the cartridge, which spacer forms a stopper of the pierceable piston relative to the body.

Un tel dispositif de transfert bidirectionnel est décrit notamment dans la demande de brevet FR-2.790.948.Such a bidirectional transfer device is described in particular in the patent application FR-2,790,948.

Dans ce document, l'aiguille assurant la mise en communication de la carpule et du flacon est portée par une navette perforable initialement libre de coulisser axialement par rapport au corps.In this document, the needle ensuring the communication between the cartridge and the bottle is carried by a pierceable shuttle initially free to slide axially relative to the body.

La séquence de fonctionnement de ce dispositif est relativement complexe.The sequence of operation of this device is relatively complex.

L'invention a pour but de proposer un dispositif de transfert dont la séquence de fonctionnement est simplifiée.The object of the invention is to propose a transfer device whose operating sequence is simplified.

A cet effet, l'invention a pour objet un dispositif de transfert bidirectionnel, du type précité, caractérisé en ce que l'aiguille creuse est solidaire du corps et est fixe axialement par rapport au corps.For this purpose, the subject of the invention is a bidirectional transfer device, of the aforementioned type, characterized in that the hollow needle is integral with the body and is axially fixed relative to the body.

Suivant des modes particuliers de réalisation, le dispositif de transfert comporte l'une ou plusieurs des caractéristiques suivantes :

  • ladite entretoise est déplaçable par rapport au corps entre une position initiale dans laquelle elle maintient le piston perforable à l'écart de la première extrémité de l'aiguille et une position finale dans laquelle l'aiguille est engagée au travers du piston perforable,
  • l'équipage mobile et le corps comportent des moyens de limitation du déplacement de l'équipage mobile par rapport au corps suivant le sens d'extraction du piston perforable hors du réservoir cylindrique,
  • l'équipage mobile et le corps comportent des moyens de guidage en translation et d'immobilisation en rotation de l'un par rapport à l'autre.
According to particular embodiments, the transfer device comprises one or more of the following characteristics:
  • said spacer is movable relative to the body between an initial position in which it holds the pierceable piston away from the first end of the needle and a final position in which the needle is engaged through the pierceable piston,
  • the moving element and the body comprise means for limiting the displacement of the moving element relative to the body in the direction of extraction of the pierceable piston from the cylindrical reservoir,
  • the moving assembly and the body comprise means for guiding in translation and immobilizing in rotation with respect to one another.

L'invention sera mieux comprise à la lecture de la description qui va suivre, donnée uniquement à titre d'exemple et faite en se référant aux dessins, sur lesquels :

  • la figure 1 est une vue en perspective du dispositif de transfert selon l'invention ;
  • la figure 2 est une vue en perspective éclatée du dispositif de transfert de la figure 1 associé à un flacon et à une carpule ;
  • la figure 3 est une vue en coupe longitudinale du dispositif de transfert représenté sans flacon ni carpule ; et
  • les figures 4, 5, 6 et 7 sont des vues en coupe longitudinale du dispositif de transfert associé à un flacon et à une carpule, représenté à des stades successifs d'utilisation.
The invention will be better understood on reading the description which follows, given solely by way of example and with reference to the drawings, in which:
  • Figure 1 is a perspective view of the transfer device according to the invention;
  • Figure 2 is an exploded perspective view of the transfer device of Figure 1 associated with a vial and a carpule;
  • Figure 3 is a longitudinal sectional view of the transfer device shown without bottle or cartridge; and
  • Figures 4, 5, 6 and 7 are longitudinal sectional views of the transfer device associated with a bottle and a carpule, shown at successive stages of use.

Le dispositif de transfert 10 représenté sur la figure 1 est généralement de forme cylindrique d'axe X-X. Il est adapté pour assurer le transfert bidirectionnel d'un fluide entre une carpule 12, visible sur les figures 2 et 4, et un flacon 14, visible sur ces mêmes figures.The transfer device 10 shown in FIG. 1 is generally cylindrical in shape of the X-X axis. It is adapted to ensure the bidirectional transfer of a fluid between a cartridge 12, visible in Figures 2 and 4, and a bottle 14, visible in these figures.

Le dispositif 10 comporte essentiellement un corps 16 présentant, à une extrémité inférieure, des moyens 18 d'accrochage du flacon, un équipage mobile 20 de support du corps de la carpule, cet équipage étant adapté pour coulisser par rapport au corps 16 et une entretoise 22 formant poussoir adaptée pour prendre appui sur le piston de la carpule 12.The device 10 essentially comprises a body 16 having, at a lower end, means 18 for attaching the bottle, a mobile support member 20 for supporting the body of the cartridge, this equipment being adapted to slide relative to the body 16 and a spacer 22 forming a pusher adapted to bear on the piston of the cartridge 12.

Le dispositif comporte en outre une aiguille creuse 24 solidaire du corps 16. Sur la figure 2, cette dernière est représentée à l'écart du corps 16 afin d'être visible.The device further comprises a hollow needle 24 integral with the body 16. In Figure 2, the latter is shown away from the body 16 to be visible.

Comme connu en soi et comme illustré sur la figure 4, la carpule 12 est destinée à réaliser une injection après avoir été extraite du dispositif de transfert et équipée d'une aiguille d'injection et d'un poussoir d'actionnement. Elle comporte un réservoir cylindrique 25 présentant, à l'avant, un col rétréci obturé par un opercule perforable 26. L'opercule 26 est adapté pour être perforé par une aiguille d'injection montée sur la carpule en vue de procéder à une injection. La carpule comporte en outre un piston perforable 27 coulissant axialement à l'intérieur du réservoir 25. Initialement, la carpule contient un solvant.As known per se and as illustrated in FIG. 4, the cartridge 12 is intended to perform an injection after having been extracted from the transfer device and equipped with an injection needle and an actuating pusher. It comprises a cylindrical tank 25 having, at the front, a narrowed neck closed by a pierceable lid 26. The lid 26 is adapted to be perforated by an injection needle mounted on the cartridge for injection. The carpule further comprises a perforable piston 27 sliding axially inside the reservoir 25. Initially, the cartridge contains a solvent.

Le flacon 14 comporte un corps en verre présentant un goulot obturé par un opercule perforable 28. Le goulot présente un rebord périphérique définissant un épaulement 29. Initialement, le flacon 14 contient un lyophilisat devant être dissout dans le solvant contenu dans la carpule.The bottle 14 comprises a glass body having a neck closed by a perforable lid 28. The neck has a peripheral rim defining a shoulder 29. Initially, the bottle 14 contains a lyophilizate to be dissolved in the solvent contained in the carpule.

Comme illustré aux figures, le corps 16 présente généralement une forme tubulaire. Il présente, à son extrémité inférieure, une coiffe 30 délimitant un logement 31 de réception du flacon 14. Le logement 31 est défini par une paroi cylindrique 32 obturée par une cuvette 34 de réception du goulot du flacon 14. La cuvette 34 est délimitée latéralement par une paroi cylindrique 36 de diamètre inférieur à la paroi cylindrique 32. Elle est obturée par une paroi transversale 37 formant fond. La cuvette est reliée à la paroi cylindrique 32 par un tronçon tronconique 38.As illustrated in the figures, the body 16 generally has a tubular shape. It has, at its lower end, a cap 30 defining a housing 31 for receiving the bottle 14. The housing 31 is defined by a cylindrical wall 32 closed by a bowl 34 for receiving the neck of the bottle 14. The bowl 34 is delimited laterally by a cylindrical wall 36 of smaller diameter than the cylindrical wall 32. It is closed by a transverse wall 37 forming a bottom. The bowl is connected to the cylindrical wall 32 by a frustoconical section 38.

Sur la surface intérieure de la paroi cylindrique 32 sont ménagées des saillies 40 permettant d'assurer une retenue axiale du flacon par enclenchement élastique des saillies en arrière du goulot du flacon.On the inner surface of the cylindrical wall 32 are provided projections 40 to ensure axial retention of the bottle by resilient engagement of the projections behind the neck of the bottle.

Le fond 37 de la cuvette est traversé axialement par l'aiguille de transfert 24. Cette aiguille est retenue par un collet 42 faisant saillie hors du logement 30. Le collet 42 assure une solidarisation axiale du corps 16 et de l'aiguille 24.The bottom 37 of the bowl is traversed axially by the transfer needle 24. This needle is retained by a collar 42 projecting out of the housing 30. The collar 42 provides an axial connection of the body 16 and the needle 24.

L'aiguille 24 présente une première extrémité 24A faisant saillie à l'intérieur du logement 30. Cette extrémité est adaptée pour perforer l'opercule 28 obturant le flacon 14.The needle 24 has a first end 24A projecting inside the housing 30. This end is adapted to perforate the lid 28 closing the bottle 14.

L'aiguille 24 se prolonge de l'autre côté du fond 37 sur l'essentiel de la longueur du corps 16. Elle présente de ce côté du fond 37 une extrémité 24B de perforation du piston de la carpule.The needle 24 extends on the other side of the bottom 37 over most of the length of the body 16. It has on this side of the bottom 37 a 24B perforation end of the piston of the cartridge.

Par ailleurs, le corps 16 présente un tronc tubulaire 50 prolongeant la paroi cylindrique 32 de la coiffe. Le tronc tubulaire 50 entoure la paroi latérale 36. Entre la paroi cylindrique 36 et l'extrémité inférieure du tronc tubulaire 50 est défini un espace annulaire 52.Moreover, the body 16 has a tubular trunk 50 extending the cylindrical wall 32 of the cap. The tubular trunk 50 surrounds the side wall 36. Between the cylindrical wall 36 and the lower end of the tubular trunk 50 is defined an annular space 52.

Le tronc tubulaire 50 présente des lumières longitudinales et des fenêtres assurant l'enclenchement élastique de saillies ménagées sur l'équipage mobile 20 de retenue de la carpule et sur l'entretoise 22.The tubular trunk 50 has longitudinal lumens and windows ensuring the elastic interlocking of protrusions provided on the movable retaining member 20 of the carpule and on the spacer 22.

L'entretoise 22 présente, à une extrémité inférieure, une embase 60 en forme de cloche adaptée pour s'engager autour de la cuvette 34. A son autre extrémité libre, elle présente un profil 62 d'accrochage et d'appui sur le piston de la carpule.The spacer 22 has, at a lower end, a base 60 in the form of a bell adapted to engage around the bowl 34. At its other free end, it has a profile 62 for hooking and bearing on the piston of the carpule.

Plus précisément, l'entretoise 22 présente une paroi cylindrique 64 entourant axialement l'aiguille 24. Le diamètre extérieur de la paroi cylindrique 64 est inférieure au diamètre intérieur du réservoir de la carpule, afin de permettre à l'entretois de pénétrer dans la carpule.More specifically, the spacer 22 has a cylindrical wall 64 axially surrounding the needle 24. The outer diameter of the cylindrical wall 64 is smaller than the inner diameter of the tank of the carpule, to allow the spacer to enter the carpule .

L'embase 60 est venue de matière à l'extrémité de la paroi cylindrique 64. Cette embase présente une jupe périphérique 66 adaptée pour être reçue dans l'espace annulaire 52. Cette jupe est reliée à la paroi cylindrique 64 par une couronne 68.The base 60 is integral with the end of the cylindrical wall 64. This base has a peripheral skirt 66 adapted to be received in the annular space 52. This skirt is connected to the cylindrical wall 64 by a ring 68.

A son extrémité libre, la jupe 66 présente extérieurement deux saillies d'encliquetage 70 diamétralement opposées. Ces saillies sont adaptées pour être reçues, comme illustré sur la figure 3, dans deux fenêtres 72 ménagées dans le tronc tubulaire 50 du corps. Ces fenêtres 72 sont ménagées à l'écart de la coiffe 30.At its free end, the skirt 66 externally has two diametrically opposed snap protrusions 70. These projections are adapted to be received, as shown in Figure 3, in two windows 72 formed in the tubular trunk 50 of the body. These windows 72 are arranged away from the cap 30.

Deux fenêtres identiques 74 sont ménagées au voisinage de la coiffe 29 et sont adaptées pour recevoir les saillies d'encliquetage 70 après déplacement de l'entretoise 22 le long de l'aiguille 24 en direction du flacon 14.Two identical windows 74 are formed in the vicinity of the cap 29 and are adapted to receive the latching projections 70 after displacement of the spacer 22 along the needle 24 towards the bottle 14.

A l'autre extrémité de la paroi cylindrique 64, le profil 62 d'accrochage et d'appui du piston perforable de la carpule comporte un embout fileté 75 s'étendant axialement dans le prolongement de la paroi cylindrique 64. Cet embout fileté a un diamètre extérieur réduit et présente un filetage extérieur adapté pour coopérer avec un filet ménagé dans un évidement taraudé du piston perforable 27 de la carpule.At the other end of the cylindrical wall 64, the attachment and support profile 62 of the pierceable piston of the carpule comprises a threaded end 75 extending axially in the extension of the cylindrical wall 64. This threaded end has a outer diameter reduced and has an external thread adapted to cooperate with a thread formed in a threaded recess of the pierceable piston 27 of the cartridge.

Un épaulement 76 est ménagé à l'extrémité de la paroi cylindrique 64 afin d'assurer la liaison de cette paroi 64 à l'embout 75. Cet épaulement permet par ailleurs l'appui du piston de la carpule.A shoulder 76 is provided at the end of the cylindrical wall 64 to ensure the connection of this wall 64 to the tip 75. This shoulder also allows the support of the piston of the cartridge.

L'embout 75 est prolongé à l'intérieur du corps cylindrique par un collet 77. L'embout 75 et le collet 77 délimitent intérieurement un passage 78 de guidage de l'aiguille 24 et notamment de son tronçon d'extrémité achevé par l'extrémité de perforation 24B. Les dimensions de l'aiguille 24 et des différents constituants de l'entretoise 22 sont telles que, lorsque l'entretoise 22 est dans sa position initiale, avec les saillies d'encliquetage 70 reçues dans les fenêtres 72 (figures 3 et 4), l'extrémité de perforation 24B de l'aiguille est disposée à l'intérieur du passage 78.The end piece 75 is extended inside the cylindrical body by a collar 77. The endpiece 75 and the collar 77 internally define a passage 78 for guiding the needle 24 and in particular its end section completed by the perforation end 24B. The dimensions of the needle 24 and the various components of the spacer 22 are such that, when the spacer 22 is in its initial position, with the latching projections 70 received in the windows 72 (FIGS. 3 and 4), the perforation end 24B of the needle is disposed inside the passage 78.

L'équipage mobile 20 de support et de déplacement du réservoir de la carpule comporte un support de carpule 80 et un capuchon 82 vissé sur le support de carpule. Entre ceux-ci est délimité un logement 84 d'immobilisation axiale du réservoir 25 de la carpule.The mobile unit 20 for supporting and moving the reservoir of the carpule comprises a carpule holder 80 and a cap 82 screwed onto the carpule support. Between these is delimited a housing 84 of axial immobilization of the reservoir 25 of the carpule.

Le support de carpule 80 présente un tronçon tubulaire 86 dont le diamètre intérieur correspond au diamètre extérieur du réservoir 25 de la carpule. Ce tronçon tubulaire présente sur sa surface extérieure un filetage adapté pour coopérer avec un filetage complémentaire ménagé à l'extrémité du capuchon 82. Ce dernier présente une paroi latérale cylindrique 88 dans laquelle est partiellement reçu le tronçon tubulaire 86 du support de carpule. Cette paroi latérale 88 est obturée par une paroi transversale 90 formant une surface d'appui pour la main.The carpule support 80 has a tubular section 86 whose inside diameter corresponds to the outside diameter of the tank 25 of the carpule. This tubular section has on its outer surface a thread adapted to cooperate with a complementary thread formed at the end of the cap 82. The latter has a cylindrical side wall 88 in which is partially received the tubular portion 86 of the carpule support. This side wall 88 is closed by a transverse wall 90 forming a bearing surface for the hand.

A son extrémité opposée au capuchon 82, le tronçon cylindrique présente une couronne 91 formant un épaulement pour l'appui de l'extrémité arrière du réservoir. La couronne 91 est prolongée par une lèvre périphérique 92 entourant la paroi cylindrique 64 de l'entretoise afin d'assurer un guidage axial de l'équipage mobile 20 par rapport à l'entretoise 22.At its end opposite to the cap 82, the cylindrical section has a ring 91 forming a shoulder for the support of the rear end of the tank. The ring 91 is extended by a peripheral lip 92 surrounding the cylindrical wall 64 of the spacer to ensure axial guidance of the moving element 20 with respect to the spacer 22.

En outre, le support 80 présente une jupe extérieure 94 entourant le tronçon tubulaire 86 entre le filetage permettant la liaison du capuchon 82 et l'extrémité du tronçon 86 équipée de la lèvre 92. Cette jupe 94 présente extérieurement une première paire de saillies d'encliquetage 98 diamétralement opposées et adaptées pour être reçues initialement dans deux fenêtres 100 ménagées au voisinage de l'extrémité supérieure du tronçon tubulaire du corps. En outre, une autre paire de saillies 104 diamétralement opposées sont ménagées extérieurement à l'extrémité libre de la jupe 94. Celles-ci sont reçues dans des fentes longitudinales 106 diamétralement opposées s'étendant suivant l'essentiel de la longueur du tronc tubulaire 50 du corps.In addition, the support 80 has an outer skirt 94 surrounding the tubular section 86 between the threading for the connection of the cap 82 and the end of the section 86 equipped with the lip 92. This skirt 94 externally has a first pair of protrusions. snapping 98 diametrically opposed and adapted to be initially received in two windows 100 formed near the upper end of the tubular portion of the body. In addition, another pair of diametrically opposed projections 104 are provided externally to the free end of the skirt 94. These are received in diametrically opposite longitudinal slots 106 extending substantially along the length of the tubular trunk 50 from the body.

Le fonctionnement du dispositif de transfert va maintenant être décrit en regard des figures 3 à 7.The operation of the transfer device will now be described with reference to FIGS. 3 to 7.

Le dispositif est initialement dans l'état de stockage représenté sur la figure 3. Dans cet état, aucun flacon ni carpule n'est mis en place dans le dispositif.The device is initially in the storage state shown in FIG. 3. In this state, no vial or cartridge is placed in the device.

La carpule 12 est d'abord mise en place dans l'équipage mobile 20, comme illustré sur la figure 4. A cet effet, le capuchon 82 est dévissé du support de carpule 80. La carpule est alors introduite avec son extrémité arrière engagée dans l'espace délimité par le tronçon cylindrique 86. Le piston perforable 27 est vissé sur l'embout 75 de l'entretoise. Dans cette position, l'extrémité arrière de la carpule prend appui contre la couronne 91 du support de carpule 80. Le bouchon 82 est alors revissé sur le support de carpule 80. Ce vissage est effectué jusqu'à ce que la paroi transversale 90 du capuchon prenne appui sur l'extrémité avant de la carpule, de sorte que le réservoir 25 de la carpule est solidarisé axialement par rapport à l'équipage mobile 20.The carpule 12 is first put in place in the moving assembly 20, as illustrated in FIG. 4. For this purpose, the cap 82 is unscrewed from the carpule holder 80. The carpule is then introduced with its rear end engaged in the space delimited by the cylindrical section 86. The pierceable piston 27 is screwed onto the endpiece 75 of the spacer. In this position, the rear end of the cartridge bears against the ring 91 of the cartridge holder 80. The cap 82 is then screwed onto the cartridge holder 80. This screwing is performed until the transverse wall 90 of the cap bears on the front end of the cartridge, so that the reservoir 25 of the carpule is secured axially relative to the moving assembly 20.

Le flacon 14 est ensuite engagé dans le logement 30, comme illustré sur la figure 4. Le flacon 14 est retenue dans le logement 30 par les saillies d'enclenchement élastique 40 appliquées contre l'épaulement 29.The bottle 14 is then engaged in the housing 30, as illustrated in FIG. 4. The bottle 14 is retained in the housing 30 by the elastic engagement projections 40 applied against the shoulder 29.

Lors de la mise en place du goulot dans la coiffe 20, l'opercule perforable 28 est perforé par l'aiguille de transfert 24 depuis son extrémité 24A.When placing the neck in the cap 20, the perforable seal 28 is perforated by the transfer needle 24 from its end 24A.

Dans cette position, une force de pression est ensuite appliquée sur le capuchon 90 visant à rapprocher celui-ci du corps 50. Sous l'action de cette pression, les saillies 70 immobilisant initialement l'entretoise 22 dans sa position initiale se dégagent des fenêtres 72, permettant ainsi un déplacement de l'entretoise 22 et du piston perforable solidarisé à celle-ci en direction du flacon 14 le long de l'aiguille 24. Ce déplacement s'effectue jusqu'à ce que les saillies d'encliquetage 70 soient reçues dans les fenêtres 74.In this position, a pressure force is then applied to the cap 90 to bring it closer to the body 50. Under the action of this pressure, the projections 70 initially immobilizing the spacer 22 in its initial position emerge from the windows 72, thus allowing displacement of the spacer 22 and the pierceable piston secured thereto in the direction of the bottle 14 along the needle 24. This movement is carried out until the latching projections 70 are received in the windows 74.

Simultanément, l'équipage mobile 20 est amené à se déplacer le long du corps. En particulier, les saillies d'encliquetage 98 se dégagent des fenêtres 100, autorisant ainsi un coulissement de l'équipage mobile 20 à l'intérieur du tronc tubulaire 50 du corps.Simultaneously, the moving assembly 20 is caused to move along the body. In particular, the detent projections 98 emerge from the windows 100, thus allowing the mobile assembly 20 to slide inside the tubular trunk 50 of the body.

Lors de ce déplacement, le piston 27 de la carpule se trouve perforé par l'extrémité 24B de l'aiguille, de sorte que, à l'issue du déplacement de l'entretoise 22, et comme illustré sur la figure 5, le flacon 14 et la carpule 12 sont mis en communication au travers de l'aiguille 24.During this movement, the piston 27 of the cartridge is perforated by the end 24B of the needle, so that, after the displacement of the spacer 22, and as shown in Figure 5, the bottle 14 and the carpule 12 are communicated through the needle 24.

Lors de la poursuite du déplacement, le piston perforé de la carpule est maintenu en appui sur l'entretoise 22 et est ainsi immobilisé par rapport au corps. Le corps de la carpule étant déplacé par le coulissement de l'équipage mobile 20, un déplacement relatif entre le piston et le corps de carpule se produit, le piston s'enfonçant progressivement dans le corps. Le liquide contenu dans la carpule se trouve alors éjecté au travers de l'aiguille 24 jusque dans le flacon 14.During further displacement, the perforated piston of the cartridge is held in abutment on the spacer 22 and is thus immobilized relative to the body. The body of the carpule being displaced by the sliding of the moving element 20, a relative displacement between the piston and the cartridge body occurs, the piston gradually sinking into the body. The liquid contained in the carpule is then ejected through the needle 24 into the bottle 14.

Les saillies 104 reçues dans les fentes longitudinales 106 assurent un guidage en translation et une immobilisation en rotation de l'équipage mobile par rapport au corps. Lors du coulissement, les saillies d'encliquetage 98 sont également reçues dans les fentes 106.The projections 104 received in the longitudinal slots 106 provide a guide in translation and immobilization in rotation of the moving element relative to the body. When sliding, the detent projections 98 are also received in the slots 106.

Le déplacement s'effectue jusqu'à ce que le piston 27 atteigne l'extrémité avant de la carpule, comme illustré sur la figure 6.Displacement occurs until the piston 27 reaches the front end of the cartridge, as shown in FIG.

Dans cette position, le dispositif est légèrement secoué afin d'assurer une dissolution du lyophilisât dans le solvant contenu initialement dans la carpule.In this position, the device is slightly shaken to ensure dissolution of the lyophilisate in the solvent initially contained in the carpule.

Pour provoquer un nouveau transfert du mélange contenu dans le flacon 14, le dispositif est entièrement retourné. Ainsi, le flacon 14 se trouve au dessus de la carpule. En particulier, l'extrémité 24A de l'aiguille se trouve dans la partie inférieure du flacon permettant un prélèvement par aspiration de l'essentiel du mélange contenu. L'aspiration est assurée par l'équipage mobile 20 qui est ramené à l'écart du flacon 14. A cet effet, le corps 16 est maintenu dans une main alors que le capuchon 90 est tiré suivant la direction de l'aiguille. Lors de ce déplacement, le piston 27 traversé par l'aiguille 24 est maintenu immobilisé par rapport au corps du fait de l'enclenchement des saillies d'encliquetage 70 dans les fenêtres 74. Au contraire, l'équipage mobile 20 auquel est solidarisé le réservoir cylindrique 25 se déplace à l'intérieur du corps suivant la direction de l'aiguille 24, de sorte que le piston se déplace par rapport au réservoir cylindrique, créant ainsi une dépression dans la carpule, laquelle provoque le rappel du mélange contenu dans le flacon 14.To cause a new transfer of the mixture contained in the bottle 14, the device is completely returned. Thus, the bottle 14 is above the carpule. In particular, the end 24A of the needle is in the lower part of the vial allowing suction extraction of most of the contained mixture. The suction is ensured by the moving equipment 20 which is brought away from the bottle 14. For this purpose, the body 16 is held in one hand while the cap 90 is pulled in the direction of the needle. During this movement, the piston 27 traversed by the needle 24 is held immobilized relative to the body by the engagement of the latching projections 70 in the windows 74. On the contrary, the mobile assembly 20 which is secured to the cylindrical reservoir 25 moves inside the body in the direction of the needle 24, so that the piston moves relative to the cylindrical reservoir, thereby creating a depression in the carpule, which causes the recall of the mixture contained in the bottle 14.

Le déplacement de l'équipage mobile 20 est interrompu lorsque les sailles d'encliquetage 98 atteignent l'extrémité supérieure des fentes longitudinales 106. La présence des saillies 98 et des butées d'arrêt formées par les extrémités des fentes 106 permet d'éviter que l'équipage mobile 20 ne soit trop écarté du corps, évitant ainsi tout risque de déboîtement accidentel du piston 27 hors du réservoir 25.The displacement of the moving element 20 is interrupted when the detent tongues 98 reach the upper end of the longitudinal slots 106. The presence of the projections 98 and stop stops formed by the ends of the slots 106 makes it possible to avoid that the moving element 20 is too far from the body, thus avoiding any risk of accidental disengagement of the piston 27 from the tank 25.

Le capuchon 82 est enfin démonté et la carpule est extraite de l'équipage mobile. Cette carpule est ensuite utilisée afin de procéder à une injection après que celle-ci a été équipée d'une aiguille d'injection et d'une tige poussoir vissée dans le piston perforable.The cap 82 is finally disassembled and the carpule is extracted from the moving equipment. This cartridge is then used to make an injection after it has been equipped with an injection needle and a push rod screwed into the pierceable piston.

Claims (4)

  1. Transfer kit made up of a vial (14) fitted with a perforable cap (28), a carpule (12) made up of a cylindrical reservoir (25) in which a perforable piston (27) slides and a device for two-way transfer of a liquid between the vial (14) and the carpule (12), where the device is made up of:
    - a body (16) which has means (18) for attachment of the vial (14);
    - a hollow needle (24) which possesses a first end (24B) for perforating the piston (27) of the carpule and a second end (24A) designed to perforate the cap (28) of the vial;
    - a moving element (20) which can be moved relative to the body (16) along the direction of the axis of the needle (24), where this moving element (20) includes means for axially fixing the reservoir (25) of the carpule in the direction of the needle axis (24) ; and
    - a spacer (22) placed between the body (16) and the perforable piston (27) of the carpule, where the spacer (22) forms an end-stop for the perforable piston (27) in relation to the body (16),
    characterised by the fact that the hollow needle (24) forms part of the body (16) and is fixed in an axial direction in relation to the body (16).
  2. Transfer kit as described in claim 1, characterised by the fact that the aforementioned spacer (22) can move in relation to the body (16) between an initial position in which it holds the perforable piston (27) away from the first end (24B) of the needle and a final position in which the needle (24) is engaged through the perforable piston (27).
  3. Transfer kit as described in claim 1 or 2, characterised by the fact that the moving element (20) and the body (16) includes means (98, 106) for limiting the movement of the moving element (20) in relation to the body (16) along the direction of extraction of the perforable piston (27) from the cylindrical reservoir (25).
  4. Transfer kit as described in any of the preceding claims whatsoever, characterised by the fact that the mobile element (20) and the body the body (16) include means (104, 106) for guiding the translation movement and for immobilisation of the rotation of the one in relation to the other.
EP20020292139 2001-09-17 2002-08-29 Transfertset comprising a bottle, a cartridge and a device for two-way transfer of a liquid between the bottle and the cartridge Expired - Lifetime EP1293190B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0112007 2001-09-17
FR0112007A FR2829691B1 (en) 2001-09-17 2001-09-17 DEVICE FOR BIDIRECTIONAL TRANSFER OF A LIQUID BETWEEN A BOTTLE AND A CARPULE

Publications (2)

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EP1293190A1 EP1293190A1 (en) 2003-03-19
EP1293190B1 true EP1293190B1 (en) 2006-10-25

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EP20020292139 Expired - Lifetime EP1293190B1 (en) 2001-09-17 2002-08-29 Transfertset comprising a bottle, a cartridge and a device for two-way transfer of a liquid between the bottle and the cartridge

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US (1) US6752180B2 (en)
EP (1) EP1293190B1 (en)
JP (2) JP4790198B2 (en)
AT (1) ATE343362T1 (en)
DE (1) DE60215598T2 (en)
ES (1) ES2275821T3 (en)
FR (1) FR2829691B1 (en)

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US6752180B2 (en) 2004-06-22
US20030055376A1 (en) 2003-03-20
JP2009279424A (en) 2009-12-03
JP2003111842A (en) 2003-04-15
DE60215598D1 (en) 2006-12-07
FR2829691A1 (en) 2003-03-21
DE60215598T2 (en) 2007-08-30
EP1293190A1 (en) 2003-03-19
FR2829691B1 (en) 2004-07-09
ES2275821T3 (en) 2007-06-16
JP4790198B2 (en) 2011-10-12
ATE343362T1 (en) 2006-11-15

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