EP1246803A1 - Piperidine et derives de la piperazine utilises comme antagonistes de recepteur 5-ht2a - Google Patents

Piperidine et derives de la piperazine utilises comme antagonistes de recepteur 5-ht2a

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Publication number
EP1246803A1
EP1246803A1 EP01905650A EP01905650A EP1246803A1 EP 1246803 A1 EP1246803 A1 EP 1246803A1 EP 01905650 A EP01905650 A EP 01905650A EP 01905650 A EP01905650 A EP 01905650A EP 1246803 A1 EP1246803 A1 EP 1246803A1
Authority
EP
European Patent Office
Prior art keywords
ethyl
fluorophenyl
hydrochloride
piperidine
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01905650A
Other languages
German (de)
English (en)
Inventor
Karl-August Ackermann
Henning Böttcher
Helmut Prücher
Christoph Van Amsterdam
Christoph Seyfried
Hartmut Greiner
Gerd Bartoszyk
Jürgen Harting
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of EP1246803A1 publication Critical patent/EP1246803A1/fr
Withdrawn legal-status Critical Current

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    • C07—ORGANIC CHEMISTRY
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
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    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
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    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Definitions

  • the invention relates to compounds of the formula
  • R 1 , R 2 are each independently an unsubstituted or substituted by R 3 , R 4 and / or R 5 or
  • Naphthyl or Het 1 , R 3 , R 4 , R 5 each independently of one another shark, A, OA, OH, CN, N0 2 , NH 2 ,
  • NHA NHA, NA 2 , NH-acyl, acyl, -SA, -SOA, S0 2 A, COOA or
  • alkyi with 1 -6 C atoms
  • alk alkylene with 1-6 C atoms
  • the invention was based on the task of finding new compounds with valuable properties, in particular those which can be used for the production of medicaments. It has been found that the compounds of the formula I and their physiologically acceptable salts and solvates have valuable pharmacological properties with good tolerability, since they have effects on the central nervous system. The connections are strong
  • test can be used, for example, for in-vitro detection of the affinity for 5-HT ⁇ receptors.
  • the 5-HT 2A receptors are exposed to both [ 3 H] ketanserin (a substance known for its affinity for the receptor) and the test compound.
  • the decrease in the affinity of [ 3 H] ketanserin for the receptor is an indication of the affinity of the test substance for the 5-HT2A receptor.
  • the detection is carried out analogously to the description by JE Leysen et al., Molecular
  • the activity of the compounds according to the invention as 5-HT 2A receptor antagonists can be determined in vitro analogously to W. Feniuk et al., Mechanisms of 5-hydroxytryptamine-induced vasoconstriction, in: The Peripheral Actions of 5-Hydroxytryptamine, ed. Fozard JR, Oxford University Press, New York, 1989, p.1 10.
  • the contractility of the rat tail artery, caused by 5-hydroxytryptamine is mediated by 5-HT 2A receptors.
  • vascular rings prepared from the ventral rat tail artery, are perfused in an organ bath with an oxygen-saturated solution.
  • a response to the cumulative concentration of 5-HT is obtained by adding increasing concentrations of 5-hydroxytryptamine to the solution.
  • the test compound is then added to the organ bath in suitable concentrations and a second concentration curve for 5-HT is measured.
  • the strength of the test compound on the shift of the 5-HT-induced concentration curve to higher 5-HT concentrations is a measure of the 5-HT 2A receptor anatgonistic property in vitro.
  • the 5-HTz ⁇ -antagonistic property can be determined in vivo analogously to MDSerdar et al., Psychopharmacoiogy, 1996, 128: 198-205.
  • the compounds of the formula I are suitable both in veterinary and in human medicine for the treatment of functional disorders of the central nervous system and of inflammation. They can be used for prophylaxis and to combat the consequences of cerebral infarction (apoplexia cerebri) such as stroke and cerebral ischemia, as well as for
  • Alzheimer's disease sleep disorders, tardive dyskinesia, Leming disorders, age-related memory disorders, eating disorders such as bulimia, drug abuse and / or sexual dysfunction. Furthermore, they are suitable for the treatment of endocrine diseases such as hyperprolactinaemia, also for vasospasm, hypertension and gastrointestinal diseases.
  • endocrine diseases such as hyperprolactinaemia, also for vasospasm, hypertension and gastrointestinal diseases.
  • the compounds according to the invention can also be used together with other active ingredients in the treatment of schizophrenia.
  • Other compounds which may be used are the compounds mentioned in WO 99/11641 on page 13, lines 20-26.
  • the invention relates to the piperidine and piperazine derivatives of the formula I and their physiologically acceptable acid addition salts.
  • the invention also relates to the solvates, e.g. Hydrates or alcoholates, of these compounds.
  • the invention accordingly relates to the compounds of the formula I and processes for the preparation of compounds of the formula I according to claim 1.
  • radicals R 1 and / or R 2 optionally converting one of the radicals R 1 and / or R 2 into another radical R 1 and / or R 2 , for example by cleaving an OA group to form an OH group and / or a CHO group into a CN Group converts
  • Claim 1 wherein X is CH, is characterized in that
  • R 2 has the meaning given in claim 1, with a compound of formula V.
  • radicals R 1 and / or R 2 optionally converting one of the radicals R 1 and / or R 2 into another radical R 1 and / or R 2 , for example by cleaving an OA group to form an OH group and / or a CHO group into a CN Group converts
  • the invention also relates to the compounds of the formula I as claimed in claim 1, and to their physiologically acceptable salts and solvates as medicaments.
  • the invention relates in particular to the compounds of the formula I. wherein
  • R 1 , R 2 are each independently an unsubstituted or substituted by R 3 , R 4 and / or R 5 or
  • Naphthyl or Het 1 , R 3 , R 4 , R 5 each independently of one another shark, A, OA, OH, CN, N0 2 , NH 2 ,
  • NHA NHA, NA 2 , NH-acyl, acyl, -SA, -SOA, S0 2 A, COOA or
  • alkyl with 1-6 C atoms alk alkylene with 1-6 C atoms
  • the present invention also provides the compounds of formula I and their enantiomers and diastereomers and salts thereof.
  • the radical A is alkyl and has 1 to 6, preferably 1, 2, 3 or 4, in particular 1 or 2, carbon atoms.
  • Alkyl therefore means in particular, for example, methyl, furthermore ethyl, n-propyl, isopropyl, n-butyl, sec-butyl or tert-butyl, furthermore also pentyl, 1-, 2- or 3-methylbutyl, 1, 1-, 1 , 2- or 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1-, 2-, 3- or 4-methylpentyl, 1, 1-,
  • Acyl preferably has 1-6 C atoms and means e.g. Formyl, acetyl, propionyl, butyryl, also trifluoroacetyl.
  • Alkylene has 1, 2, 3, 4, 5 or 6 carbon atoms, is unbranched or branched and preferably means methylene, ethylene, propylene, or butylene
  • Alkylene very particularly preferably means ethylene.
  • OA is preferably methoxy, trifluoromethoxy, and also ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy or tert-butoxy.
  • R 1 and R 2 each independently represent unsubstituted, preferably - as indicated - substituted by R 3 and / or R 4 substituted phenyl or naphthyl, in particular preferably phenyl, o-, m- or p-tolyl, o-, m- or p-ethylphenyl, o-, m- or p-propylphenyl, o-, m- or p-
  • R 1 and R 2 are each independently Het 1 .
  • Het 1 is preferably 2- or 3-furyl, 2- or 3-thienyl, 1-, 2- or 3-pyrrolyl, 1-, 2, 4- or 5-imidazolyl, 1-, 3-, 4- or 5 -Pyrazolyl, 2-, 4- or
  • 5-oxazolyl 3-, 4- or 5-isoxazolyl, 2-, 4- or 5-thiazolyl, 3-, 4- or 5-isothiazolyl, 2-, 3- or 4-pyridyl, 2-, 4-, 5- or 6-pyrimidinyl, further preferably 1, 2,3-thazol-1-, -4- or -5-yl, 1, 2,4-triazol-1-, -3- or 5-yl, 1- or 5-tetrazolyl, 1, 2,3-oxadiazol-4- or -5-yl, 1, 2,4-oxadiazol-3- or - 5-yl, 1, 3,4-thiadiazol-2- or -5 -yl, 1, 2,4-thiadiazol-3- or -5-yl, 1, 2,3-
  • R 1 very particularly preferably denotes phenyl, p-chlorophenyl, p-fluorophenyl, thiophene-2-yl, 5-chloro-thiophene-2-yl, 2,5-dichloro-thiophene-3-yl and 2- or 3-furyl ,
  • R 2 very particularly preferably denotes 4-propylphenyl, 2-isopropylphenyl, butyl, 2,4,6-trimethylphenyl, 2- or 4-methoxyphenyl, 2-, 3- or 4-methoxycarbonylphenyl, 2-, 3- or 4-ethoxycarbonylphenyl , 2- or 4-chlorophenyl, 2-nitrophenyl, 4'-biphenyl, 2,4,6-trimethylphenyl, 3,4-
  • the invention also relates to the compounds 4- ⁇ 4- [2- (4-
  • the invention relates in particular to those compounds of the formula I in which at least one of the radicals mentioned has one of the preferred meanings indicated above.
  • Some preferred groups of compounds can be expressed by the following partial formulas Ia to Ik, which correspond to the formula I and in which the radicals not specified have the meaning given for the formula I, but in which in la R denotes a phenyl or naphthyl radical or Het 1 substituted by R 3 , R 4 and / or R 5 ; in Ib R 1 denotes a phenyl or naphthyl radical substituted by R 3 , R 4 and / or R 5 ; in Ic R 1 a phenyl or naphthyl radical substituted by R 3 , R 4 and / or R 5 ,
  • R 2 represents a phenyl or naphthyl radical or Het 1 substituted by R 3 , R 4 and / or R 5 ; in Id R 1 is a phenyl or naphthyl radical substituted by R 3 , R 4 and / or R 5 , R 2 is a phenyl or naphthyl radical substituted by R 3 , R 4 and / or R 5 or Het 1 , Het 1 is unsubstituted or a - or twice by shark, CN,
  • R 2 is a phenyl or naphthyl radical substituted by R 3 , R 4 and / or R 5 or Het 1 , Het 1 unsubstituted or mono- or disubstituted by shark, CN,
  • R 1 is an unsubstituted or R 3 , R 4 and / or R 5 substituted phenyl or naphthyl radical
  • R 2 is an unsubstituted or R 3 , R 4 and / or R 5 substituted phenyl or naphthyl radical or Het 1 ,
  • R 3 , R 4 , R 5 each independently of one another shark, CN, -SA, A,
  • R 1 is substituted by R 3 , R 4 and / or R 5
  • Phenyl radical, R 2 is a substituted by R 3 , R 4 and / or R 5
  • R 3 , R 4 , R 5 each independently of one another shark, CN, -SA, A,
  • R 1 is a phenyl or naphthyl radical which is unsubstituted or substituted by R 3 , R 4 and / or R 5
  • R 2 is an unsubstituted or substituted by R 3 , R 4 and / or R 5 phenyl or naphthyl radical or Het 1 , R 3 , R 4 , R 5 each independently of one another shark, A, OA, NH 2 , NHA, ⁇ * NA 2 , NH-acyl, acyl or phenyl,
  • R 1 is an unsubstituted or R 3 , R 4 and / or R 5 substituted phenyl or naphthyl radical
  • R 2 is an unsubstituted or R 3 , R 4 and / or R 5 substituted phenyl or naphthyl radical or Het 1 , R 3 , R 4 , R 5 each independently of one another shark, A, OA, NH 2 , NHA,
  • NA 2 NH-acyl, acyl or phenyl, Het 1 unsubstituted or mono- or disubstituted by shark, CN,
  • R 1 is an unsubstituted or R 3 , R 4 and / or R 5 substituted phenyl or naphthyl radical
  • R 2 is an unsubstituted or R 3 , R 4 and / or R 5 substituted phenyl or naphthyl radical 33 or Het 1
  • R 3 , R 4 , R 5 are each independently of one another shark, A, OA, NH 2 , NHA, NA 2 , NH-acyl, acyl or phenyl,
  • R 1 is an unsubstituted or substituted by R 3 , R 4 and / or R 5 ,
  • R 2 is a phenyl radical which is unsubstituted or substituted by R 3 , R 4 and / or R 5
  • R 3 , R 4 , R 5 each independently represent shark, A, COOA or OA, alk alkylene with 1-4 C atoms;
  • Het 1 ⁇ 2,1, 3-benzoxadiazol- or 2,1, 3-benzothiadiazol-yl, and their physiologically acceptable salts and solvates.
  • Manufacture is otherwise produced according to methods known per se, as described in the literature (for example in standard works such as Houben-Weyl, Methods of Organic Chemistry, Georg Thieme Verlag, Stuttgart; Organic Reactions, John Wiley & Sons, Inc., New York; ) are described, namely under reaction conditions as are known and suitable for the reactions mentioned. Use can also be made of variants which are known per se and are not mentioned here in detail.
  • the starting materials for the claimed process can also be formed in situ in such a way that they are not isolated from the reaction mixture, but instead are immediately passed on to the compounds of Formula I implements. On the other hand, it is possible to carry out the reaction in stages.
  • the radical L is preferably Cl or Br; however, it can also mean 1, OH or, preferably, a reactive, functionally modified OH group, in particular alkylsulfonyloxy with 1-6 (e.g. methanesulfonyloxy) or aryisulfonyloxy with 6-10 C atoms (e.g. benzenesulfonyloxy, p-toluenesulfonyloxy, 1- or 2 - Naphthalenesulfonyloxy) or trichloromethoxy, alkoxy, such as Methoxy, ethoxy, propoxy or butoxy, also phenoxy.
  • alkylsulfonyloxy with 1-6 e.g. methanesulfonyloxy
  • aryisulfonyloxy with 6-10 C atoms e.g. benzenesulfonyloxy, p-toluenesulfonyloxy, 1- or 2 -
  • the compounds of the formula I in which X is N can preferably be obtained by reacting compounds of the formula II with compounds of the formula III.
  • the starting materials of formulas II and III are generally known; the unknown compounds of formulas II and III can easily be prepared analogously to the known compounds.
  • reaction of the compounds II and III proceeds according to methods known from the literature for the alkylation or acylation of amines. However, it is also possible to react the compounds in the presence of an inert solvent. Suitable solvents are e.g. Hydrocarbons such as benzene, toluene, xylene; Ketones such as acetone, butanone; Alcohols such as methanol, ethanol, isopropanol, N-butanol;
  • Ethers such as tetrahydrofuran (THF) or dioxane; Amides such as dimethylformamide (DMF) or N-methylpyrrolidone; Nitriles such as acetonitrile, optionally also mixtures of these solvents with one another or mixtures with water.
  • an acid-binding agent for example an alkali or alkaline earth metal hydroxide, carbonate or bicarbonate or another salt of a weak acid of the alkali or alkaline earth metals, preferably potassium, sodium or calcium, or the addition of an organic base such as triethylamine, dimethylaniiine, Pyridine or quinoline or an excess of piperazine derivative of formula II may be beneficial.
  • the reaction time is between a few minutes and 14 days. tion temperature between about 0 and 150 °, usually between 20 and 130 °.
  • compounds of the formula I in which X is CH can be prepared by reacting amines of the formula IV with a component of the formula V and then oxidizing the reaction product.
  • the oxidation generally produces a mixture of sulfinyl and sulfonyl compounds, which can be separated into the individual compounds by chromatography or by crystallization.
  • the respective components are generally known or, as already described, can be produced by known processes.
  • the reaction between the compounds of the formula IV and V proceeds under conditions as described for the reaction between the compounds of the formula II and III.
  • a base of the formula I obtained can be converted into the associated acid addition salt using an acid.
  • Acids which provide physiologically acceptable salts are suitable for this reaction.
  • Inorganic acids can be used, e.g. Sulfuric acid, hydrohalic acids such as hydrochloric acid or hydrobromic acid, phosphoric acids such as orthophosphoric acid, nitric acid, sulfamic acid, also organic acids, in particular aliphatic, alicyclic, araliphatic, aromatic or heterocyclic mono- or polybasic carboxylic, sulfonic or sulfuric acids, such as formic acid, acetic acid, acetic acid
  • the free bases of the formula I can be obtained from their salts by treatment with strong bases such as sodium or potassium hydroxide,
  • bases are alkali metal hydroxides, alkaline earth metal hydroxides or organic bases in the form of primary, secondary or tertiary
  • the invention furthermore relates to the medicaments according to the invention with 5-HT 2A receptor antagonistic activity for the treatment of psychoses, schizophrenia, depression, neurological disorders,
  • the invention also relates to a pharmaceutical preparation containing at least one medicament according to the invention and, if appropriate, carriers and / or auxiliaries and, if appropriate, other active compounds.
  • the medicinal products can be brought into a suitable dosage form together with at least one solid, liquid and / or semi-liquid carrier or auxiliary and, if appropriate, in combination with one or more further active ingredients.
  • the invention furthermore relates to the use of the compounds according to the invention and / or of their physiologically acceptable salts and solvates for the production of a medicament with 5-HT 2A - receptor-antagonistic activity.
  • the invention also relates to the use of the compounds according to the invention and / or their physiologically acceptable salts and solvates for the manufacture of a medicament with 5-HTz ⁇ - receptor-antagonistic activity for the treatment of psychoses, schizophrenia, depression, neurological disorders, memory disorders, Parkinson's disease , amyotrophic lateral sclerosis, Alzheimer's Disease, Huntington's disease, eating disorders such as bulimia, nervous anorexia, premenstrual syndrome and / or to positively influence compulsive behavior (obsessive-compulsive disorder, OCD).
  • psychoses schizophrenia, depression, neurological disorders, memory disorders, Parkinson's disease , amyotrophic lateral sclerosis, Alzheimer's Disease, Huntington's disease, eating disorders such as bulimia, nervous anorexia, premenstrual syndrome and / or to positively influence compulsive behavior (obsessive-compulsive disorder, OCD).
  • Suitable carrier substances are organic or inorganic substances which are suitable for enteral (e.g. oral), parenteral or topical application and do not react with the new compounds, for example water, vegetable oils, benzyl alcohol, polyethylene glycols, gelatin, carbohydrates such as lactose or starch , Magnesium stearate, talc, petroleum jelly. Tablets, coated tablets, capsules, syrups, juices, drops or suppositories are used in particular for enteral administration, solutions, preferably oily or aqueous solutions, and further suspensions are used for parenteral administration.
  • Emulsions or implants for topical application of ointments, creams or powders.
  • the new compounds can also be lyophilized and the resulting lyophilisates e.g. can be used for the production of injectables.
  • the specified preparations can be sterilized and / or contain auxiliaries such as lubricants, preservatives, stabilizers and / or wetting agents, emulsifiers, salts for influencing the osmotic pressure, buffer substances, colorants, flavors and / or flavorings. If desired, they can also contain one or more other active ingredients, e.g. one or more vitamins.
  • the substances according to the invention are generally administered in analogy to known preparations, preferably in doses between about 0.1 and 500 mg, in particular between 5 and 300 mg per dosage unit.
  • the daily dosage is preferably between about 0.01 and 250 mg / kg, in particular between 0.02 and 100 mg / kg body weight.
  • the substances according to the invention are generally preferably used in doses between about 1 and 500 mg, in particular administered between 5 and 100 mg per dosage unit.
  • the daily dosage is preferably between about 0.02 and 10 mg / kg body weight.
  • the specific dose for each particular patient depends on a variety of factors, for example on the effectiveness of the particular compound used, on the age, body weight, general health, sex, on the diet, on the time and route of administration, on the rate of excretion, Drug combination and severity of the disease to which the therapy applies. Oral application is preferred.
  • customary work-up means: if necessary, the solvent is removed, water is added if necessary and, if necessary, the pH is adjusted to between 2 and 10, depending on the constitution of the end product, extracted with ethyl acetate or dichloromethane, separates, the organic phase dries over sodium sulfate, filtered, concentrated and purified by chromatography on silica gel and / or by crystallization.
  • Frontal rat cortex is homogenized in ice-cold buffer.
  • Homogenate is centrifuged at 4 ° C and 50000 X for 10 minutes. The pellet is resuspended in 2.5 ml ice-cold Tris buffer, with an additional 10 ml
  • Example A Injection glasses
  • a solution of 100 g of an active ingredient of the formula I and 5 g of disodium hydrogenphosphate in 3 l of double-distilled water is adjusted to pH 6.5 with 2N hydrochloric acid, sterile filtered, filled into injection glasses, lyophilized and sealed sterile. Each injection jar contains 5 mg of active ingredient.
  • a mixture of 20 g of an active ingredient of the formula I is melted with 100 g of soy lecithin and 1400 g of cocoa butter, poured into molds and allowed to cool. Each suppository contains 20 mg of active ingredient.
  • a solution is prepared from 1 g of an active ingredient of the formula I, 9.38 g of Na 2 HP0 4 x 2 H 2 0, 28.48 g of NaH 2 P0 4 x 12 H 2 0 and 0.1 g of benzalkonium chloride in 940 ml of double-distilled water. It is adjusted to pH 6.8, made up to 1 I and sterilized by irradiation. This solution can be used in the form of eye drops.
  • Example D ointment
  • 500 mg of an active ingredient of the formula I are mixed with 99.5 g of petroleum jelly under aseptic conditions.
  • a mixture of 1 kg of active ingredient of the formula I, 4 kg of lactose, 1.2 kg of potato starch, 0.2 kg of talc and 0.1 kg of magnesium stearate is compressed into tablets in a conventional manner such that each tablet contains 10 mg of active ingredient.
  • Example F coated tablets
  • Example E tablets are pressed, which are then coated in a conventional manner with a coating of sucrose, potato starch, talc, tragacanth and colorant.
  • Example G capsules
  • each capsule contains 20 mg of the active ingredient.
  • a solution of 1 kg of active ingredient of the formula I in 60 l of double-distilled water is filled into ampoules, lyophilized under aseptic conditions and sealed sterile. Each ampoule contains 10 mg of active ingredient.

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  • Public Health (AREA)
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  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Quinoline Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

L'invention concerne des composés de formule (I) dans laquelle R<1>, R<2>, X, Y et alk ont les significations données dans la revendication 1. Ces composés sont de puissants antagonistes 5-HT2A et sont appropriés pour le traitement de psychoses, schizophrénie, dépressions, troubles neurologiques, troubles de la mémoire, maladie de Parkinson, sclérose latérale amyotrophique, maladie d'Alzheimer, troubles d'alimentation tels que boulimie et anorexie mentale, syndrome prémenstruel et/ou pour influencer positivement un comportement compulsif (trouble obsessionnel compulsif, OCD).
EP01905650A 2000-01-11 2001-01-05 Piperidine et derives de la piperazine utilises comme antagonistes de recepteur 5-ht2a Withdrawn EP1246803A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10000739A DE10000739A1 (de) 2000-01-11 2000-01-11 Piperidin- und Piperazinderivate
DE10000739 2000-01-11
PCT/EP2001/000080 WO2001051469A1 (fr) 2000-01-11 2001-01-05 Piperidine et derives de la piperazine utilises comme antagonistes de recepteur 5-ht2a

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EP (1) EP1246803A1 (fr)
JP (1) JP2004500373A (fr)
KR (1) KR20020073492A (fr)
CN (1) CN1394203A (fr)
AR (1) AR030181A1 (fr)
AU (1) AU2001233685A1 (fr)
BR (1) BR0107578A (fr)
CA (1) CA2396007A1 (fr)
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DE (1) DE10000739A1 (fr)
HU (1) HUP0300052A3 (fr)
MX (1) MXPA02006809A (fr)
NO (1) NO20023293L (fr)
PL (1) PL355654A1 (fr)
RU (1) RU2002120906A (fr)
SK (1) SK9712002A3 (fr)
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GB0311349D0 (en) * 2003-05-16 2003-06-25 Merck Sharp & Dohme Therapeutic agents, compositions, preparations and uses
EP1703908A4 (fr) * 2003-12-22 2009-07-08 Amgen Inc Composes de sulfonamide d'aryle et procedes d'utilisation correspondants
WO2005118538A2 (fr) * 2004-04-20 2005-12-15 Amgen, Inc. Arylsulfonamides et leurs utilisations
TWI391387B (zh) * 2004-05-12 2013-04-01 Eisai R&D Man Co Ltd 具有哌啶環之吲哚衍生物
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JP4932717B2 (ja) * 2005-05-11 2012-05-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピペリジン環を有するインドール誘導体の製造方法
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ZA200206361B (en) 2003-11-10
RU2002120906A (ru) 2004-04-10
US20030130287A1 (en) 2003-07-10
AR030181A1 (es) 2003-08-13
BR0107578A (pt) 2002-10-01
DE10000739A1 (de) 2001-07-12
WO2001051469A1 (fr) 2001-07-19
CN1394203A (zh) 2003-01-29
SK9712002A3 (en) 2002-12-03
JP2004500373A (ja) 2004-01-08
NO20023293D0 (no) 2002-07-08
NO20023293L (no) 2002-07-08
HUP0300052A2 (en) 2003-05-28
MXPA02006809A (es) 2002-10-23
AU2001233685A1 (en) 2001-07-24
HUP0300052A3 (en) 2004-03-01
PL355654A1 (en) 2004-05-04
CA2396007A1 (fr) 2001-07-19
KR20020073492A (ko) 2002-09-26
CZ20022309A3 (cs) 2002-10-16

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