EP1234614A1 - Mit Stegen unterteiltes Messgefäss zur Aufnahme von Reagenzien, dessen Herstellung und Verwendung - Google Patents

Mit Stegen unterteiltes Messgefäss zur Aufnahme von Reagenzien, dessen Herstellung und Verwendung Download PDF

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Publication number
EP1234614A1
EP1234614A1 EP01104779A EP01104779A EP1234614A1 EP 1234614 A1 EP1234614 A1 EP 1234614A1 EP 01104779 A EP01104779 A EP 01104779A EP 01104779 A EP01104779 A EP 01104779A EP 1234614 A1 EP1234614 A1 EP 1234614A1
Authority
EP
European Patent Office
Prior art keywords
container
container according
reagents
chambers
cover
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01104779A
Other languages
German (de)
English (en)
French (fr)
Inventor
Hans-Jürgen KOLDE
Holger Eggert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tem Innovations GmbH
Original Assignee
Pentapharm GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pentapharm GmbH filed Critical Pentapharm GmbH
Priority to EP01104779A priority Critical patent/EP1234614A1/de
Priority to JP2002567468A priority patent/JP2004527738A/ja
Priority to US10/468,974 priority patent/US20040071604A1/en
Priority to PCT/EP2002/002100 priority patent/WO2002068120A2/de
Priority to AU2002233364A priority patent/AU2002233364A1/en
Publication of EP1234614A1 publication Critical patent/EP1234614A1/de
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/54—Labware with identification means
    • B01L3/545—Labware with identification means for laboratory containers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Definitions

  • the invention relates to a container for holding reagents for analysis with various analytical methods, a method of manufacturing a measuring vessel a measuring vessel and the use of such a measuring vessel.
  • a known method for measuring the coagulation properties of blood is the coagulation by measuring a Relative movement of a cuvette containing a blood sample determined relative to a stamp. To perform various Tests on the blood sample will test this one or more Reagents added.
  • the reagents are usually in in liquid form and are used by those performing the tests Laboratories or hospitals kept in large quantities. Often, the entire stock quantity is not used for a test series of reagent consumed so that the reagent expires, which is uneconomical. This problem also occurs with others especially medical, biochemical, environmental or food analysis methods.
  • the object is achieved by a container according to claim 1, a method according to claim 14, a measuring vessel according to claim 16 and the use of such Claim 17 or 18.
  • An essential aspect of the invention is that for the required amount of reagents directly in the test Container is made available.
  • the reagents can in solid form, e.g. dried or lyophilized.
  • the container according to the invention 1 designed as a cuvette in a first embodiment.
  • a cuvette can be used, for example, in a device for measuring the coagulation properties of blood or other test liquids.
  • the cuvette points a substantially flat bottom 2 and one of them extending cylindrical wall 3 with an upper edge 4.
  • a support 6 on the bottom 2 formed on which a rod-shaped magnetic stirrer or Stirring fish 7 made of stainless steel or soft iron rests.
  • the in Fig. 1 embodiment extend from the Pad 6 from in the radial direction to the cylinder wall 3 in essentially straight webs 8, by the adjacent on the floor Chambers 9a, 9b, 9c are formed.
  • the height the webs are small in relation to the height of the cylinder wall.
  • the height of the webs is only about 1 mm. at an inner diameter of the cuvette of about 0.8 cm the volume of the available for the reagents Chambers about 15-20 ⁇ l.
  • the amount of edition 6 is so much greater than the height of the webs 8 that the agitator fish 7th can rotate freely.
  • a drive for the stir fish is not shown electric motor provided.
  • the control of the Stirring device is continuous or pulsed.
  • the cuvette is made of a material that is the reagents to be introduced and the blood or test liquid is not attacked, for example made of plastic.
  • the support 6 and the webs 8 are preferably integrated formed with the cell bottom 2.
  • the cuvette has a lid 10 at its open end closable.
  • a first Step the reagents 12, 13, 14 into the chambers 9a, 9b, 9c on the cell bottom 2 by means of a multiple compartment dispenser or one Automatic pipetting machines in the required quantities at a few ⁇ l lie, filled, with a confluence of the Reagents is prevented by the webs 8. Subsequently the reagent drops are dried in the cuvette or lyophilized.
  • the dried or lyophilized Reagents as shown in Fig. 3 by which Filling the blood sample 15 itself or by previous dissolving dissolved with water using a pipette 16.
  • the cuvette is then in the device for measuring the coagulation properties used, a stamp 11 in the sample dips.
  • the coagulation properties are measured then in a known manner by measuring the relative rotational movement the stamp to the cuvette.
  • the blood sample 15 is mixed with the reagents 12, 13, 14 by the movement of the stirring fish 7.
  • the cylindrical shape for the method of measuring the coagulation properties of blood or other test fluid suitable for the relative movement of the cuvette and stamp the shape of the cuvette does not have to be used for other analysis methods be cylindrical.
  • the cuvette has flat side surfaces.
  • the floor can also be concave, for example.
  • An appropriate number of webs that create the chambers is depending on the application or the number of reagents required. Their height depends on the required chamber volume and the number of reagents required.
  • the Pad 6 with the stirring fish 7 is not absolutely necessary, but beneficial. For some applications, a stir fish not necessarily required.
  • the cuvette has a shoulder 17 on its side wall, which is used to grip and position the cuvette and which a code, for example a barcode and / or color code for labeling the cuvette.
  • a code for example a barcode and / or color code for labeling the cuvette.
  • the Bridges are not straight, but curved, e.g. curled or propeller-shaped, trained, causing the dissolution of the in the reagents contained in the chambers by an additional Swirling can be improved.
  • the invention is the cover 100 formed with a central opening 101, as in Fig. 5, in which a closure element in the form of a lyophilization stopper 102, as shown in FIG. 6, can be used is.
  • the lyophilization stopper 102 has a head 103 with a diameter that is larger than the diameter of the Opening 101 so that the head completely covers the opening can, and a closure portion 104 for insertion into the Opening 101 and to close the same.
  • the outside diameter of the head 103 is e.g. as large as the outside diameter of the cover so that the stopper is in place Condition flush with the lid on the outside.
  • the outside diameter of the closure section is such that the closure section 104 just fits through the opening 101 and closes it.
  • the closure portion 104 is slotted formed, with a slot 105 that starts out from a distance from the head 103 to the one opposite the head End of the closure portion extends.
  • a slot 105 that starts out from a distance from the head 103 to the one opposite the head End of the closure portion extends.
  • two legs 106, 107 are formed, the relative are elastically bendable to a certain extent.
  • On The slot 105 has its end facing away from the head 103 a cylindrical widening 108 with a diameter, about the diameter of the stir bar or stir bar 7 corresponds to receiving the stir bar 7. Due to the Elasticity of the legs is the stir bar 7 in the closure part clamped.
  • the length of the stir bar is greater than the diameter of the opening 101 in the lid 100.
  • the Lyophilization stopper 102 through the opening 101 of the lid performed or pressed into the lid when the lid not yet placed on the cuvette or container 1 is.
  • the impression takes place so far that there is still one Section 105a, 105b of the slot 105 above and below the lid 100 is located.
  • the stir bar 7 between the legs of the plug jammed.
  • the lid, together with the stopper and the clamped to it Stirring rod pressed onto the cuvette in which liquid reagents are already in the chambers.
  • it will be lyophilization was carried out, vapors produced, 8 and 9, via the slot sections 105a, 105b can escape.
  • the stopper as shown in Fig.
  • the stirring rod is still held on the stopper.
  • the the cuvette for example, is sealed in a bag welded, on which the expiry date is indicated.
  • For use is withdrawn from the lyophilization stopper. there the stir bar falls into the cuvette. Through the now exposed The sample to be measured can be introduced through the opening.
  • the cover according to the invention is not limited to this that together with a cuvette that described the above Combing is used. It can also be for others Serve measuring vessels that have no chambers.
  • the advantage is that only one or two exact pipetting is required are. Furthermore, there is no loss of reagents and no deterioration of the reagents.
  • the cuvette is easy to make, can be filled with a standard filling machine and in a conventional dryer or lyophilizer be put. Instead of the effort involved in manufacturing liquid reagents, especially in combinations, can Filling in separate form. This also makes it possible the easy handling of unstable substances such as different Enzymes that are often only elaborate in certain solutions Combinations can be stabilized.
  • the production the cuvette is associated with only low costs.
  • the application of the container 1 described above is not in the field of measuring coagulation properties of Limited blood or other test fluids.
  • the container 1 can also be used for other analysis methods, for example in clinical or food analysis.
  • a method according to the invention for producing a Measuring vessel for any analysis includes the provision of a container described above, the filling of the reagents into the appropriate chambers, drying or lyophilizing of the introduced reagents and the oversight of the Container with a lid, which can also be welded on, for example Foil can be formed.
  • the so produced Measuring vessels can be provided in large quantities and allow the analysis to be carried out without stockpiling of liquid reagents.
  • the invention serves Container as a combined reagent carrier and as Measuring vessel.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
EP01104779A 2001-02-27 2001-02-27 Mit Stegen unterteiltes Messgefäss zur Aufnahme von Reagenzien, dessen Herstellung und Verwendung Withdrawn EP1234614A1 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01104779A EP1234614A1 (de) 2001-02-27 2001-02-27 Mit Stegen unterteiltes Messgefäss zur Aufnahme von Reagenzien, dessen Herstellung und Verwendung
JP2002567468A JP2004527738A (ja) 2001-02-27 2002-02-27 さまざまな分析方法による分析のための試薬用コンテナ、測定容器を作製するための方法、測定容器および測定容器の使用
US10/468,974 US20040071604A1 (en) 2001-02-27 2002-02-27 Container for reagents for the analysis by various analytical methods,method for producing a measuring vessel, measuring vessel and use of said measuring vessel
PCT/EP2002/002100 WO2002068120A2 (de) 2001-02-27 2002-02-27 Behälter zur aufnahme von reagenzien zur analyse mit verschiedenen analytischen verfahren, verfahren zum herstellen eines messgefässes, messgefäss und verwendung eines solchen messgefässes
AU2002233364A AU2002233364A1 (en) 2001-02-27 2002-02-27 Container for reagents for the analysis by various analytical methods, method for producing a measuring vessel, measuring vessel and use of said measuring vessel

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01104779A EP1234614A1 (de) 2001-02-27 2001-02-27 Mit Stegen unterteiltes Messgefäss zur Aufnahme von Reagenzien, dessen Herstellung und Verwendung

Publications (1)

Publication Number Publication Date
EP1234614A1 true EP1234614A1 (de) 2002-08-28

Family

ID=8176616

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01104779A Withdrawn EP1234614A1 (de) 2001-02-27 2001-02-27 Mit Stegen unterteiltes Messgefäss zur Aufnahme von Reagenzien, dessen Herstellung und Verwendung

Country Status (5)

Country Link
US (1) US20040071604A1 (enrdf_load_stackoverflow)
EP (1) EP1234614A1 (enrdf_load_stackoverflow)
JP (1) JP2004527738A (enrdf_load_stackoverflow)
AU (1) AU2002233364A1 (enrdf_load_stackoverflow)
WO (1) WO2002068120A2 (enrdf_load_stackoverflow)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011120556A1 (en) * 2010-03-30 2011-10-06 C A Casyso Ag Composition for the determination of coagulation characteristics of a test liquid
CN101750487B (zh) * 2008-12-02 2013-07-03 博阳生物科技（上海）有限公司 干法光激化学发光免疫检测试剂盒及其制备与应用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0701821D0 (en) * 2007-02-01 2007-03-14 Pentapharm Ag Diagnostic composition and its use in the determination of coagulation characteristics of a test liquid
JP4940085B2 (ja) * 2007-10-02 2012-05-30 興和株式会社 エンドトキシン測定用の容器
EP2934338A1 (de) * 2012-12-22 2015-10-28 Frost Diagnostika GmbH Vorrichtung zur entnahme und aufbereitung einer probe
CN204514902U (zh) * 2014-12-22 2015-07-29 天津市天大天发科技有限公司 推拉式药物溶出试验仪附件收纳装置
EP3317422B1 (en) 2015-07-01 2019-08-28 Leyser Lab GmbH Diagnostic kit for viscoelastic analysis and its uses
ES2842245T3 (es) 2016-04-15 2021-07-13 Enicor Gmbh Punta de pipeta y sus usos y métodos

Citations (14)

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GB1218746A (en) * 1966-12-15 1971-01-13 Xerox Corp Automatic chemical analyser
US3759374A (en) * 1969-07-03 1973-09-18 Merck Patent Gmbh Cuvette
GB1462895A (en) * 1974-10-15 1977-01-26 Teckton Inc Food container for use in heating food with microwave energy
EP0130708A1 (en) * 1983-06-06 1985-01-09 Gilford Instrument Laboratories, Inc. Stabilized clinical control reagents
EP0137292A2 (de) * 1983-09-08 1985-04-17 Farmos-Yhtyma Oy Reaktionsbehälter für immunologische Analysen
US4639242A (en) * 1985-02-04 1987-01-27 Babson Arthur L Vessel and procedure for automated assay
US4769025A (en) * 1984-11-20 1988-09-06 Walter Sarstedt Kunststoff-Spritzguswerk Blood storage device
EP0328932A2 (en) * 1988-02-19 1989-08-23 Becton, Dickinson and Company Body fluid sample collection tube assembly
US4872572A (en) * 1987-12-24 1989-10-10 Helvoet Pharma N.V. Lyophilization stopper (case II)
US4980293A (en) * 1988-09-02 1990-12-25 Multi-Technology Inc. Dispensing reagents in a specimen well
EP0408144A2 (en) * 1989-07-14 1991-01-16 EASTMAN KODAK COMPANY (a New Jersey corporation) Extracting device for extracting antigens
WO1998006496A1 (en) * 1996-08-12 1998-02-19 Hampshire Advisory And Technical Services Limited Diagnostic test container
EP0837331A1 (fr) * 1996-10-15 1998-04-22 Laboratoires Merck-Clevenot Appareil automatique de dosage immunologique
FR2758799A1 (fr) * 1997-01-24 1998-07-31 Stago Diagnostica Bouchage pour flacon de reactif utilisable par un automate d'analyse

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DE2830532A1 (de) * 1978-07-12 1980-01-31 Eichenauer Fa Fritz Elektrischer heizkoerper fuer fluide medien
US5096676A (en) * 1989-01-27 1992-03-17 Mcpherson Alexander Crystal growing apparatus
US5366869A (en) * 1991-11-08 1994-11-22 Sheldon Goldstein Multiple coagulation test device and method
US5318203A (en) * 1993-07-01 1994-06-07 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Dual chamber dispenser
US5419278A (en) * 1994-05-25 1995-05-30 Carter; Daniel C. Vapor equilibration tray for growing protein crystals
JP4321738B2 (ja) * 1998-06-24 2009-08-26 チェン アンド チェン エルエルシー 液体試料試験システム
US6106783A (en) * 1998-06-30 2000-08-22 Microliter Analytical Supplies, Inc. Microplate assembly and closure
US6345733B1 (en) * 2000-05-05 2002-02-12 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Dual compartment package
US6913732B2 (en) * 2001-03-19 2005-07-05 Corning Incorporated Microplate for performing crystallography studies and methods for making and using such microplates
US7005008B2 (en) * 2001-06-18 2006-02-28 Greiner Bio-One Gmbh Reaction vessel
US6656267B2 (en) * 2001-07-10 2003-12-02 Structural Genomix, Inc. Tray for macromolecule crystallization and method of using the same

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1218746A (en) * 1966-12-15 1971-01-13 Xerox Corp Automatic chemical analyser
US3759374A (en) * 1969-07-03 1973-09-18 Merck Patent Gmbh Cuvette
GB1462895A (en) * 1974-10-15 1977-01-26 Teckton Inc Food container for use in heating food with microwave energy
EP0130708A1 (en) * 1983-06-06 1985-01-09 Gilford Instrument Laboratories, Inc. Stabilized clinical control reagents
EP0137292A2 (de) * 1983-09-08 1985-04-17 Farmos-Yhtyma Oy Reaktionsbehälter für immunologische Analysen
US4769025A (en) * 1984-11-20 1988-09-06 Walter Sarstedt Kunststoff-Spritzguswerk Blood storage device
US4639242A (en) * 1985-02-04 1987-01-27 Babson Arthur L Vessel and procedure for automated assay
US4872572A (en) * 1987-12-24 1989-10-10 Helvoet Pharma N.V. Lyophilization stopper (case II)
EP0328932A2 (en) * 1988-02-19 1989-08-23 Becton, Dickinson and Company Body fluid sample collection tube assembly
US4980293A (en) * 1988-09-02 1990-12-25 Multi-Technology Inc. Dispensing reagents in a specimen well
EP0408144A2 (en) * 1989-07-14 1991-01-16 EASTMAN KODAK COMPANY (a New Jersey corporation) Extracting device for extracting antigens
WO1998006496A1 (en) * 1996-08-12 1998-02-19 Hampshire Advisory And Technical Services Limited Diagnostic test container
EP0837331A1 (fr) * 1996-10-15 1998-04-22 Laboratoires Merck-Clevenot Appareil automatique de dosage immunologique
FR2758799A1 (fr) * 1997-01-24 1998-07-31 Stago Diagnostica Bouchage pour flacon de reactif utilisable par un automate d'analyse

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101750487B (zh) * 2008-12-02 2013-07-03 博阳生物科技（上海）有限公司 干法光激化学发光免疫检测试剂盒及其制备与应用
WO2011120556A1 (en) * 2010-03-30 2011-10-06 C A Casyso Ag Composition for the determination of coagulation characteristics of a test liquid
AU2010350041B2 (en) * 2010-03-30 2014-06-26 C A Casyso Ag Composition for the determination of coagulation characteristics of a test liquid
EP3002591A1 (en) * 2010-03-30 2016-04-06 C A Casyso AG Composition for the determination of coagulation characteristics of a test liquid

Also Published As

Publication number Publication date
WO2002068120A3 (de) 2002-12-27
AU2002233364A1 (en) 2002-09-12
US20040071604A1 (en) 2004-04-15
JP2004527738A (ja) 2004-09-09
WO2002068120A2 (de) 2002-09-06

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