EP1213580B1 - Dispositif pour mesurer les activités ioniques - Google Patents

Dispositif pour mesurer les activités ioniques Download PDF

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Publication number
EP1213580B1
EP1213580B1 EP01128468A EP01128468A EP1213580B1 EP 1213580 B1 EP1213580 B1 EP 1213580B1 EP 01128468 A EP01128468 A EP 01128468A EP 01128468 A EP01128468 A EP 01128468A EP 1213580 B1 EP1213580 B1 EP 1213580B1
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EP
European Patent Office
Prior art keywords
solution
supplying
surface area
block
openings
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP01128468A
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German (de)
English (en)
Other versions
EP1213580A2 (fr
EP1213580A3 (fr
Inventor
Masaaki Terashima
Osamu Seshimoto
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Fujifilm Corp
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Fujifilm Corp
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Publication of EP1213580A2 publication Critical patent/EP1213580A2/fr
Publication of EP1213580A3 publication Critical patent/EP1213580A3/fr
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Publication of EP1213580B1 publication Critical patent/EP1213580B1/fr
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/307—Disposable laminated or multilayered electrodes

Definitions

  • This invention relates to a device for measuring ionic activities of various ionic components contained in a sample solution, which is favorably employable for simultaneous analysis of ionic components in liquid samples such as a whole blood sample, a serum sample, and a urine sample.
  • An ionic activity-measuring device utilizing an ion selective electrode is widely employed for analyzing ionic components in a liquid sample such as a whole blood sample or a serum sample.
  • the ionic activity-measuring device comprises a non-electroconductive support 11, a pair of electrodes each of which comprises a silver metal layer 12a, 12b and a silver halide layer 13a, 13b, a common electrolytic material layer 14, a common ion selective membrane 15, and a common nan-electroconductive cover sheet 16 having a pair of openings 17a, 17b for receiving and keeping a sample solution and a reference solution, respectively, each opening being placed over each electrode unit, and having thereon an a bridge member 18 for electrically bridging the sample solution received in one opening 17a and the reference solution received in another opening 17b.
  • Each silver metal layer 12a, 12b has an exposed surface 10a, 10b, respectively.
  • the ion selective electrode can measure an ionic activity of an ionic component such as H + , Li + , Na + , K + , Mg 2+ , Ca 2+ , Cl - , HCO 3 - , or CO 3 2- , by employing an appropriate ion selective membrane.
  • an ionic component such as H + , Li + , Na + , K + , Mg 2+ , Ca 2+ , Cl - , HCO 3 - , or CO 3 2- , by employing an appropriate ion selective membrane.
  • United States Patent No. 4,789,435 describes an ion selective electrode assembly comprising plural ion selective electrodes for analyzing plural ionic components such as Na + , K + , and Cl - , simultaneously.
  • one of plural ion selective electrodes has an ion selective membrane differing from that of other ion selective electrode in chemical composition.
  • the invention resides in a device for measuring ionic activity which comprises:
  • Preferred devices according to the invention are as follows.
  • US-A-4 510 035 discloses an ionic activity-measuring device according to the preamble of claim 1.
  • the ionic activity-measuring device of the present invention is further described by referring to the fig.
  • Fig. 2 is a schematic view of a typical structure of the ionic activity-measuring device according to the invention
  • Fig. 3 is a schematic view of the device of Fig. 2 in a disassembled form.
  • an ionic activity-measuring device 20 is composed of a block 21 of rectangular parallelepiped which has a hollow space in its inside, and three sets of ion selective electrode sheets 22, 23, 24 which are attached to the side surfaces and bottom surface of the block 21.
  • a bridge member (fiber bridge) 26 for electrically connecting the received sample solution with the received reference solution is fixed.
  • a pair of openings 27a, 27b for supplying separately the received sample solution and the received reference solution onto the ion selective electrode sheet.
  • the block 21 is made of water-impermeable, electrically insulating material such as polystyrene.
  • the fiber bridge 26 is made from polyethylene terephthalate thrown fibers.
  • Each of the ion selective electrode sheets 22, 23, 24 is composed of an non-electroconductive support, a silver layer, a silver chloride layer, an electrolytic material layer and an ion selective membrane, as shown in Fig. 1.
  • the ion selective electrode sheets 22, 23, 24 preferably have ion selective membranes different from each other, so that ionic activities of plural ionic components are measured in one device.
  • the ion selective electrode sheet 22 is fixed to the surface of the block 21 under such condition that the uppermost ion selective membrane 221 faces the openings 27a, 27b and the electrode terminals 222 are extended from the edges of the block 21.
  • (1) indicates a upper surface of the hollow block 21, (2) is a front view, and (3) is a side view.
  • the inner hollow space of the block 21 has a pair of solution reservoirs 30a, 30b which are separated by a partition 31 to supply the sample solution received in the opening 25a and the reference solution received in the opening 25b separately to the solution-supplying openings 27a, 28a, 29a, and the solution-supplying openings 27b, 28b, 29b, respectively.
  • the block 21 typically has a dimension of 4 mm x 20 mm x 4 mm (height), as illustrated in Fig. 4.
  • Each of the solution-receiving openings 25a, 25b has a dimension of 3 mm x 3 mm.
  • Each of the solution-supplying openings 27a, 27b has a dimension of 2 mm x 2 mm, while each of the solution reservoirs 30a, 30b has a dimension of 3 mm x 3 mm x 3.5 mm.
  • the structure of the block 21 is not limited to that illustrated in Fig. 4.
  • the partition 31 is a plate arranged in the inner hollow space at the center position. Otherwise, a part of the partition 31' extends to both side portions into the reservoirs 30a, 30b so as to reduce the volume of the reservoir, as is shown in Fig. 5.
  • a pair of porous materials 32a, 32b are placed independently in both reservoirs to transmit the sample solution and the reference solution, separately, as is shown in Fig. 6.
  • Each of the solution-supplying openings 27a, 27b, 28a, 28b can have a slanting ceiling from the inside to the outside, as is shown in Fig. 7, so that air bubbles are not produced in the opening.
  • the upper surface of the block 21 can have a groove for protecting the fiber bridge 26 and further for reducing a required volume of the solutions.
  • the fiber bridge 26 can be placed and fixed in the groove.
  • the ion activity-measuring device of the invention is not limited to the above-mentioned structure having three sets of the ion selective electrode sheets. For instance, only two sets of the ion selective electrode sheets 22, 23 are attached to the side surfaces, as is illustrated in Fig. 8-(1). Otherwise, four sets of ion selective electrode sheets 22, 23, 24, 33a (in combination with 34b) are attached to the side surfaces and the bottom surface, as is illustrated in Fig. 8- (2)
  • ion selective electrode sheets 42a, 42b, 42c, 43a, 43b, 43c, 44 attached to the block 41 on the upper surface, bottom surface, the side surfaces, as is illustrated in Fig. 9.
  • the electrode sheets 42a to 42c, and 43a to 43c are placed in parallel.
  • the solution-receiving openings 45a, 45b and the fiber bridge 46 are arranged on the upper surface of the block 42.
  • the electrode sheets attached to the upper surface and bottom surface can be two sets or four sets in place of the above-mentioned three sets.
  • the electrode sheets may be not attached to the side surfaces, or may be attached only one of the upper surface and bottom surface.
  • the ionic activity-measuring device can be composed of a vertically extended block 51 and several sets of ion selective electrode sheets 52a, 52b, 52c, ---, 53a, 53b, 53c, ----, 54, which are attached to the side surfaces and the bottom surface, as is illustrated in Fig. 10. On the side surfaces, the electrode sheets are arranged in parallel. On the upper surface of the block 51 are provided the solution-receiving openings 55a, 55b and the fiber bridge 56.
  • the ion selective electrode sheets attached to the side surface can be two or three sheets. The electrode sheet may not attached to the bottom surface, and may be attached to one side surface only.
  • An ionic activity-measuring device not according to the invention could be composed of a block 61 in a drum form and three sets of ion selective electrode sheets 62, 63, 64 which are attached to the side surfaces and the bottom surface, as is illustrated in Fig. 11. On the upper surface of the block 61, two solution-receiving openings 65a, 65b and one fiber bridge 66 are place.
  • the ion selective electrode sheets attached to the side surface and the bottom surface can be two, four or more sheets.
  • Another ionic activity-measuring device not according to the invention could be composed of a block 71 composed two drums united to each other and two sets of ion selective electrode sheets 72a, 72b, 73a, 73b, as illustrated in Fig. 12.
  • the electrode sheet is composed of a pair of single electrode 72a (73a) and single electrode 72b (73b), which are separated from each other.
  • solution-receiving openings 75a, 75b and a fiber bridge 76 are provided on the upper surface of the block 71.
  • Three or more electrode sheets can be attached to the side surface, and an ion selective electrode sheet can be attached to the bottom surface.
  • the drum structure can be replaced with other structures such as polygonal pillar such as pentagonal pillar, hexagonal pillar, and octagonal pillar.
  • polygonal pillar such as pentagonal pillar, hexagonal pillar, and octagonal pillar.
  • On the side surfaces and/or bottom surfaces can be attached ion se-lective electrode sheets.
  • plastic material such as polyolefin (e.g., polystyrene) is molded to produce a block of Fig. 3.
  • polyolefin e.g., polystyrene
  • ion selective electrode sheets each of which has a different ion selective membrane are prepared in one of known manners describe, for instance, in United Stated Patents No. 4,053,381 , No. 4,171,246 , No. 4,219,968 , and Research Disclosure, No. 16113 (1977, September ).
  • a representative ion selective electrode sheet is illustrated in Fig. 3.
  • the three sets of ion selective electrode sheets are attached to the side surfaces and the bottom surface of the block using a double adhesive-coated tape.
  • a fiber bridge made of a polyethylene terephthalate thrown fiber is placed to connect the solution-receiving openings and fixed to the surface using appropriate adhesive.
  • the ionic activity-measuring devices can be manufactured in a mass scale, and a plurality of devices can be conveyed and stored after the devices 20 are encased in a frame 34 made of plastic material, as is shown in Fig. 13-(1).
  • a frame 34 made of plastic material, as is shown in Fig. 13-(1).
  • each device is separated together with its casing, and placed in a potentiometer for the desired measurement.
  • two block units 511, 512 (551a, 551b, 552a, 552b: solution-receiving opening, 571a, 571b: solution-supplying opening) are produced in several numbers and jointed together in the vertical direction to give the desired vertically extended block 51.

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Claims (5)

  1. Dispositif pour mesurer l'activité ionique comprenant :
    un bloc (21 ; 41 ; 51) de matériau isolant présentant un espace creux à l'intérieur, une surface de réception de solution dans laquelle sont prévues une paire d'ouvertures (25a, 25b ; 45a, 45b ; 55a, 55b) destinées à recevoir une solution échantillon et une solution de référence séparément, lesdites ouvertures étant reliées à l'espace creux, une pluralité de surfaces d'alimentation en solution dans chacune desquelles est agencée une paire d'ouvertures (27a, 27b ; 28a, 28b ; 29a, 29b) pour amener la solution échantillon et la solution de référence vers l'extérieur, de manière séparée, lesdites ouvertures étant reliées à l'espace creux ;
    un élément à pont (26 ; 46 ; 56) prévu sur la surface de réception de solution pour relier électriquement la solution échantillon reçue dans une ouverture et la solution de référence reçue dans une autre ouverture ;
    un élément de guidage (31) placé dans l'espace creux contribuant à transmettre séparément la solution échantillon reçue dans l'ouverture de la surface de réception de solution vers les ouvertures agencées sur les surfaces d'alimentation en solution pour amener la solution échantillon vers l'extérieur, et la solution de référence reçue dans l'ouverture de la surface de réception de solution vers les ouvertures agencées sur les surfaces d'alimentation en solution pour amener la solution de référence vers l'extérieur;
    et
    une pluralité d'électrodes sélectives aux ions (22-24 ; 42a-42c, 43a-43c, 44 ; 52a-52c, 53a-53c, 54) recouvertes d'une membrane sélective aux ions, chacune d'entre elles étant placée sur la surface d'alimentation en solution de manière à ce que la membrane sélective aux ions soit mise en contact avec la solution échantillon et la solution de référence de manière séparée,
    caractérisé en ce que
    le bloc (21 ; 41 ; 51) se présente sous la forme d'un parallélépipède rectangle ayant une surface supérieure sur laquelle la surface de réception de solution est agencée, et d'autres surfaces comprenant une surface inférieure et des surfaces latérales sur au moins deux desquelles la surface d'alimentation en solution est agencée.
  2. Dispositif selon la revendication 1, dans lequel l'élément de guidage est une cloison placée dans l'espace creux pour guider de manière séparée la solution échantillon et la solution de référence.
  3. Dispositif selon la revendication 1, dans lequel l'élément de guidage comprend une paire de matériaux poreux transmettant les liquides placés dans l'espace creux, l'un d'entre eux transmettant la solution échantillon et l'autre transmettant la solution de référence.
  4. Dispositif selon l'une quelconque des revendications 1 à 3, dans lequel le bloc (41) se présente sous la forme d'un parallélépipède rectangle étendu horizontalement ayant une surface supérieure sur laquelle la surface de réception de solution est agencée, une surface inférieure, et des surfaces latérales, la pluralité de surfaces d'alimentation en solution étant agencées sur au moins l'une de ces surfaces.
  5. Dispositif selon l'une quelconque des revendications 1 à 3, dans lequel le bloc (51) se présente sous la forme d'un parallélépipède rectangle étendu verticalement ayant une surface supérieure sur laquelle la surface de réception de solution est agencée, et d'autres surfaces comprenant une surface inférieure et des surfaces latérales sur au moins deux desquelles la surface d'alimentation en solution est agencée.
EP01128468A 2000-12-06 2001-12-06 Dispositif pour mesurer les activités ioniques Expired - Lifetime EP1213580B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000371634A JP2002174615A (ja) 2000-12-06 2000-12-06 イオン活量測定器具
JP2000371634 2000-12-06

Publications (3)

Publication Number Publication Date
EP1213580A2 EP1213580A2 (fr) 2002-06-12
EP1213580A3 EP1213580A3 (fr) 2002-07-03
EP1213580B1 true EP1213580B1 (fr) 2007-08-15

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EP01128468A Expired - Lifetime EP1213580B1 (fr) 2000-12-06 2001-12-06 Dispositif pour mesurer les activités ioniques

Country Status (4)

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US (1) US6869512B2 (fr)
EP (1) EP1213580B1 (fr)
JP (1) JP2002174615A (fr)
DE (1) DE60129916T2 (fr)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4171246A (en) * 1976-05-19 1979-10-16 Eastman Kodak Company Method for determining ionic activity of components of liquid drops
US4053381A (en) * 1976-05-19 1977-10-11 Eastman Kodak Company Device for determining ionic activity of components of liquid drops
JPS5817044B2 (ja) * 1977-06-08 1983-04-04 トヨタ自動車株式会社 自動車用ドアガラス装置
US4302313A (en) * 1979-07-23 1981-11-24 Eastman Kodak Company Electrode-containing device with capillary transport between electrodes
JPS58140635A (ja) * 1982-02-16 1983-08-20 Fuji Photo Film Co Ltd 液体移送分配装置およびイオン活量測定器具
JPS59188550A (ja) 1983-04-12 1984-10-25 Fuji Photo Film Co Ltd イオン活量測定装置用電気接続端子アセンブリ−
US4571293A (en) * 1984-05-10 1986-02-18 Fuji Photo Film Co., Ltd. Ion selective electrode and method of preparation thereof
US4789435A (en) * 1985-08-15 1988-12-06 Fuji Photo Film Co., Ltd. Method and device of measuring ion activity
DE3766835D1 (de) * 1986-01-31 1991-02-07 Fuji Photo Film Co Ltd Vorrichtung zur messung von ionenaktivitaet.
JP3051612B2 (ja) * 1993-09-14 2000-06-12 富士写真フイルム株式会社 電解質測定方法および装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

Also Published As

Publication number Publication date
EP1213580A2 (fr) 2002-06-12
DE60129916D1 (de) 2007-09-27
JP2002174615A (ja) 2002-06-21
EP1213580A3 (fr) 2002-07-03
US20020066670A1 (en) 2002-06-06
US6869512B2 (en) 2005-03-22
DE60129916T2 (de) 2008-05-08

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