EP1151295A4 - Verfahren zur identifizierung therapeutisch effektiver antineoplastischer substanzen mittels kultivierter zellen mit intakten zellmembranen und damit zusammenhängende produkte - Google Patents
Verfahren zur identifizierung therapeutisch effektiver antineoplastischer substanzen mittels kultivierter zellen mit intakten zellmembranen und damit zusammenhängende produkteInfo
- Publication number
- EP1151295A4 EP1151295A4 EP00907081A EP00907081A EP1151295A4 EP 1151295 A4 EP1151295 A4 EP 1151295A4 EP 00907081 A EP00907081 A EP 00907081A EP 00907081 A EP00907081 A EP 00907081A EP 1151295 A4 EP1151295 A4 EP 1151295A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- therapeutically effective
- cultured cells
- cell membranes
- antineoplastic agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229940034982 antineoplastic agent Drugs 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 210000000170 cell membrane Anatomy 0.000 title 1
- 210000004748 cultured cell Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11810299P | 1999-02-01 | 1999-02-01 | |
US118102P | 1999-02-01 | ||
US45459599A | 1999-12-07 | 1999-12-07 | |
US454595 | 1999-12-07 | ||
PCT/US2000/002329 WO2000045165A1 (en) | 1999-02-01 | 2000-02-01 | Methods of identifying therapeutically effective antineoplastic agents with cultured cells having intact cell membranes and corresponding products |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1151295A1 EP1151295A1 (de) | 2001-11-07 |
EP1151295A4 true EP1151295A4 (de) | 2005-03-30 |
Family
ID=26815975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00907081A Withdrawn EP1151295A4 (de) | 1999-02-01 | 2000-02-01 | Verfahren zur identifizierung therapeutisch effektiver antineoplastischer substanzen mittels kultivierter zellen mit intakten zellmembranen und damit zusammenhängende produkte |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1151295A4 (de) |
AU (1) | AU2864100A (de) |
WO (1) | WO2000045165A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6342611B1 (en) | 1997-10-10 | 2002-01-29 | Cytovia, Inc. | Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof |
US6248904B1 (en) | 1998-07-21 | 2001-06-19 | Cytovia, Inc. | Fluorescence dyes and their applications for whole-cell fluorescence screening assays for caspases, peptidases, proteases and other enzymes and the use thereof |
AU2001278135A1 (en) | 2000-08-03 | 2002-02-18 | Cytovia, Inc. | Method of identifying immunosuppressive agents |
KR100545930B1 (ko) * | 2001-05-11 | 2006-01-25 | 우석대학교 산학협력단 | 첼리도닌 또는 그 유도체를 포함하는 약제학적 조성물 |
DE10206849A1 (de) * | 2002-02-18 | 2005-07-28 | Aventis Pharma Deutschland Gmbh | Phenalenon-Derivate, Verfahren zur Herstellung und Verwendung derselben |
US7253206B2 (en) | 2002-02-18 | 2007-08-07 | Sanofi-Aventis Deutschland Gmbh | Phenalenone derivatives, processes for preparation and use thereof |
US8053477B2 (en) * | 2002-03-29 | 2011-11-08 | University Of Maryland, Baltimore | Inhibitors of the S100-p53 protein-protein interaction and method of inhibiting cancer employing the same |
WO2004002428A2 (en) * | 2002-07-01 | 2004-01-08 | Cytovia, Inc. | Derivatives of gambogic acid and induce apoptosis |
WO2004032876A2 (en) * | 2002-10-11 | 2004-04-22 | Board Of Regents, The University Of Texas System | Deguelin as a chemopreventive agent for lung cancer |
ATE509630T1 (de) * | 2004-09-02 | 2011-06-15 | Bionaut Pharmaceuticals Inc | Pankreaskrebsbehandlung mit na+/k+-atpase-hemmern |
EP1789090A2 (de) * | 2004-09-02 | 2007-05-30 | Bionaut Pharmaceuticals, Inc. | Kombinatorische chemotherapiebehandlung mit na+/k+-atpase-hemmern |
EP1655027A1 (de) * | 2004-11-04 | 2006-05-10 | Biofrontera Pharmaceuticals GmbH | Verwendung von 9-(N-methyl-piperidyliden-4)-thioxanthene zur Behandlung von pulmoler Hypertension und Migräne |
JP2009274956A (ja) * | 2006-08-28 | 2009-11-26 | Univ Nihon | ニーム種子由来の悪性腫瘍治療薬 |
WO2008058269A2 (en) * | 2006-11-09 | 2008-05-15 | Foldrx Pharmaceuticals, Inc. | Compounds and methods for modulating protein trafficking |
JP2008222603A (ja) * | 2007-03-09 | 2008-09-25 | Institute Of Physical & Chemical Research | 神経変性疾患の予防・治療剤 |
EP2420239B1 (de) * | 2007-04-13 | 2015-01-14 | Southern Research Institute | Clomipramine als Anti-Angiogenese-Mittel |
US20120128684A1 (en) * | 2008-08-25 | 2012-05-24 | Burnham Institute For Medical Research | Conserved Hemagglutinin Epitope, Antibodies to the Epitope and Methods of Use |
CN101869574B (zh) * | 2010-07-24 | 2011-12-21 | 南京大学 | 哇巴因在增强非小细胞肺癌细胞敏感性中的应用 |
CN103764659A (zh) * | 2011-06-15 | 2014-04-30 | 生命与大脑有限公司 | 抑制胶质母细胞瘤的化合物及其用途 |
CN102675273A (zh) * | 2012-05-03 | 2012-09-19 | 吉林大学 | 3-芳基-8-烯丙基-7-羟基(甲氧基)香豆素及在制备抗肿瘤药物中的应用 |
SG11201710272VA (en) * | 2015-06-19 | 2018-01-30 | Etsuko Miyamoto | Protein degradation inducing tag and usage thereof |
AU2015101721A4 (en) * | 2015-11-26 | 2016-01-07 | Macau University Of Science And Technology | Prenylated isoflavones for treatment of subjects with multidrug-resistant cancer |
CN107602445B (zh) * | 2016-07-12 | 2020-12-01 | 中国科学院上海药物研究所 | 咯哌丁胺衍生物及其在制备治疗混合谱系白血病的药物中的应用 |
KR102600091B1 (ko) * | 2016-08-24 | 2023-11-09 | (주)아모레퍼시픽 | 사이토칼라신 d를 포함하는 피부 미백용 조성물 |
MX2019005600A (es) | 2016-11-15 | 2019-10-09 | Univ Tokyo Science Found | Molecula que induce la degradacion de la proteina ras y composiciones farmaceuticas. |
WO2018092725A1 (ja) | 2016-11-15 | 2018-05-24 | 学校法人東京理科大学 | p53分解誘導分子及び医薬組成物 |
CN108096246B (zh) * | 2017-03-08 | 2020-07-14 | 中国农业科学院饲料研究所 | 槲皮素和乌头碱联合用于制备治疗宫颈癌药物的应用及治疗宫颈癌药物 |
CN107219201B (zh) * | 2017-04-20 | 2019-11-12 | 浙江工商大学 | 利用荧光显微镜观察桔霉素免疫后牛蛙抗体和亲和的方法 |
CN112516134B (zh) * | 2019-09-18 | 2023-06-06 | 上海医药集团股份有限公司 | 一种含羟基的化合物在制备药物中的应用 |
WO2021067799A1 (en) * | 2019-10-02 | 2021-04-08 | The General Hospital Corporation | Methods and materials for modulating nrf2 pathway |
US20240139162A1 (en) * | 2019-10-17 | 2024-05-02 | Chengdu Anticancer Bioscience, Ltd. | Benzophenanthridine Alkaloids and Their Methods of Use |
CN111317734A (zh) * | 2020-03-27 | 2020-06-23 | 广州医科大学附属第二医院 | Wnt信号通路抑制剂和应用 |
CN112545979B (zh) * | 2021-01-12 | 2022-07-19 | 山西省肿瘤研究所 | 预防膀胱癌术后复发的灌注凝胶及其制备方法和应用 |
CN113559110A (zh) * | 2021-08-27 | 2021-10-29 | 上海市第一人民医院 | 毒毛花苷在制备Nrf2抑制剂、与Nrf2异常活化有关疾病的药物中的应用 |
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US5821072A (en) * | 1996-02-20 | 1998-10-13 | Sloan-Kettering Institute For Cancer Research | Combinations of PKC inhibitors and therapaeutic agents for treating cancers |
WO1998053091A1 (en) * | 1997-05-22 | 1998-11-26 | The Burnham Institute | Screening assays for agents that alter inhibitor of apoptosis (iap) protein regulation of caspase activity |
WO1998055863A1 (en) * | 1997-06-05 | 1998-12-10 | Idun Pharmaceuticals, Inc. | Rapid methods for identifying modifiers of cellular apoptosis activity |
-
2000
- 2000-02-01 AU AU28641/00A patent/AU2864100A/en not_active Abandoned
- 2000-02-01 EP EP00907081A patent/EP1151295A4/de not_active Withdrawn
- 2000-02-01 WO PCT/US2000/002329 patent/WO2000045165A1/en not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5821072A (en) * | 1996-02-20 | 1998-10-13 | Sloan-Kettering Institute For Cancer Research | Combinations of PKC inhibitors and therapaeutic agents for treating cancers |
WO1998053091A1 (en) * | 1997-05-22 | 1998-11-26 | The Burnham Institute | Screening assays for agents that alter inhibitor of apoptosis (iap) protein regulation of caspase activity |
WO1998055863A1 (en) * | 1997-06-05 | 1998-12-10 | Idun Pharmaceuticals, Inc. | Rapid methods for identifying modifiers of cellular apoptosis activity |
Non-Patent Citations (7)
Title |
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FULDA ET AL: "Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 57, no. 21, 1 November 1997 (1997-11-01), pages 4956 - 4964, XP002128611, ISSN: 0008-5472 * |
GAMEN S ET AL: "Doxorubicin-induced apoptosis in human T-cell leukemia is mediated by caspase-3 activation in a Fas-independent way", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 417, no. 3, 17 November 1997 (1997-11-17), pages 360 - 364, XP004261485, ISSN: 0014-5793 * |
KAWAHARA ATSUO ET AL: "Fas-induced DNA fragmentation and proteolysis of nuclear proteins", GENES TO CELLS, vol. 3, no. 5, May 1998 (1998-05-01), pages 297 - 306, XP002298457, ISSN: 1356-9597 * |
LOS M ET AL: "REQUIREMENT OF AN ICE/CED-3 PROTEASE FOR FAS/APO-1-MEDIATED APOPTOSIS", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 375, no. 6526, 4 May 1995 (1995-05-04), pages 81 - 83, XP000574811, ISSN: 0028-0836 * |
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EP1151295A1 (de) | 2001-11-07 |
WO2000045165A1 (en) | 2000-08-03 |
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