EP1151295A4 - Techniques d'identification d'agents antineoplastiques therapeutiquement efficaces avec des cellules de culture a membrane cellulaire intacte et produits correspondant - Google Patents

Techniques d'identification d'agents antineoplastiques therapeutiquement efficaces avec des cellules de culture a membrane cellulaire intacte et produits correspondant

Info

Publication number
EP1151295A4
EP1151295A4 EP00907081A EP00907081A EP1151295A4 EP 1151295 A4 EP1151295 A4 EP 1151295A4 EP 00907081 A EP00907081 A EP 00907081A EP 00907081 A EP00907081 A EP 00907081A EP 1151295 A4 EP1151295 A4 EP 1151295A4
Authority
EP
European Patent Office
Prior art keywords
methods
therapeutically effective
cultured cells
cell membranes
antineoplastic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00907081A
Other languages
German (de)
English (en)
Other versions
EP1151295A1 (fr
Inventor
Eckard Weber
Ben Y Tseng
John Drewe
Sui Xiong Cai
Shailaja Kasibhatla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytovia Therapeutics LLC
Original Assignee
Cytovia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytovia Inc filed Critical Cytovia Inc
Publication of EP1151295A1 publication Critical patent/EP1151295A1/fr
Publication of EP1151295A4 publication Critical patent/EP1151295A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP00907081A 1999-02-01 2000-02-01 Techniques d'identification d'agents antineoplastiques therapeutiquement efficaces avec des cellules de culture a membrane cellulaire intacte et produits correspondant Withdrawn EP1151295A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11810299P 1999-02-01 1999-02-01
US118102P 1999-02-01
US45459599A 1999-12-07 1999-12-07
US454595 1999-12-07
PCT/US2000/002329 WO2000045165A1 (fr) 1999-02-01 2000-02-01 Techniques d'identification d'agents antineoplasiques therapeutiquement efficaces avec des cellules de culture a membrane cellulaire intacte et produits correspondants

Publications (2)

Publication Number Publication Date
EP1151295A1 EP1151295A1 (fr) 2001-11-07
EP1151295A4 true EP1151295A4 (fr) 2005-03-30

Family

ID=26815975

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00907081A Withdrawn EP1151295A4 (fr) 1999-02-01 2000-02-01 Techniques d'identification d'agents antineoplastiques therapeutiquement efficaces avec des cellules de culture a membrane cellulaire intacte et produits correspondant

Country Status (3)

Country Link
EP (1) EP1151295A4 (fr)
AU (1) AU2864100A (fr)
WO (1) WO2000045165A1 (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342611B1 (en) 1997-10-10 2002-01-29 Cytovia, Inc. Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof
WO2000004914A1 (fr) 1998-07-21 2000-02-03 Cytovia, Inc. Nouveaux colorants fluorescents et leurs applications dans des methodes de criblage par fluorescence de cellules entieres pour des caspases, peptidases, proteases et autres enzymes ainsi que procedes de leur utilisation
AU2001278135A1 (en) 2000-08-03 2002-02-18 Cytovia, Inc. Method of identifying immunosuppressive agents
WO2002092085A1 (fr) * 2001-05-11 2002-11-21 Jung, Young-Hoon Compositions pharmaceutiques renfermant de la chelidonine ou des derives de la chelidonine
DE10206849A1 (de) * 2002-02-18 2005-07-28 Aventis Pharma Deutschland Gmbh Phenalenon-Derivate, Verfahren zur Herstellung und Verwendung derselben
US7253206B2 (en) 2002-02-18 2007-08-07 Sanofi-Aventis Deutschland Gmbh Phenalenone derivatives, processes for preparation and use thereof
US8053477B2 (en) * 2002-03-29 2011-11-08 University Of Maryland, Baltimore Inhibitors of the S100-p53 protein-protein interaction and method of inhibiting cancer employing the same
US7176234B2 (en) 2002-07-01 2007-02-13 Cytovia, Inc. Derivatives of gambogic acid and analogs as activators of caspases and inducers of apoptosis
AU2003284081A1 (en) * 2002-10-11 2004-05-04 Board Of Regents, The University Of Texas System Deguelin as a chemopreventive agent for lung cancer
WO2006028969A1 (fr) * 2004-09-02 2006-03-16 Bionaut Pharmaceuticals, Inc. Traitement du cancer du pancreas au moyen d'inhibiteurs d'aptase na+/k+
WO2006029018A2 (fr) * 2004-09-02 2006-03-16 Bionaut Pharmaceuticals, Inc. Traitement chimiotherapeutique combinatoire utilisant des inhibiteurs de na+/k+-atpase
EP1655027A1 (fr) * 2004-11-04 2006-05-10 Biofrontera Pharmaceuticals GmbH Utilisation du 9-(N-methyl-piperidyliden-4)-thioxanthene pour le traitement de l'hypertension pulmonaire et la migraine
JP2009274956A (ja) * 2006-08-28 2009-11-26 Univ Nihon ニーム種子由来の悪性腫瘍治療薬
WO2008058269A2 (fr) * 2006-11-09 2008-05-15 Foldrx Pharmaceuticals, Inc. Composés et méthodes permettant de moduler l'acheminement des protéines
JP2008222603A (ja) * 2007-03-09 2008-09-25 Institute Of Physical & Chemical Research 神経変性疾患の予防・治療剤
CN101940571A (zh) * 2007-04-13 2011-01-12 南方研究所 抗血管生成剂和使用方法
EP3301116A1 (fr) * 2008-08-25 2018-04-04 Dana Farber Cancer Institute, Inc. Epitope conservé d'hémagglutinine, anticorps contre l'épitope et procédés d'utilisation
CN101869574B (zh) * 2010-07-24 2011-12-21 南京大学 哇巴因在增强非小细胞肺癌细胞敏感性中的应用
EP2721035B1 (fr) * 2011-06-15 2018-06-13 Life & Brain GmbH Composés inhibiteurs de glioblastome et leur utilisation
CN102675273A (zh) * 2012-05-03 2012-09-19 吉林大学 3-芳基-8-烯丙基-7-羟基（甲氧基）香豆素及在制备抗肿瘤药物中的应用
KR20180021080A (ko) * 2015-06-19 2018-02-28 에츠코 미야모토 단백질 분해 유도 태그 및 그 용도
AU2015101721A4 (en) * 2015-11-26 2016-01-07 Macau University Of Science And Technology Prenylated isoflavones for treatment of subjects with multidrug-resistant cancer
CN107602445B (zh) * 2016-07-12 2020-12-01 中国科学院上海药物研究所 咯哌丁胺衍生物及其在制备治疗混合谱系白血病的药物中的应用
KR102600091B1 (ko) * 2016-08-24 2023-11-09 (주)아모레퍼시픽 사이토칼라신 d를 포함하는 피부 미백용 조성물
WO2018092725A1 (fr) 2016-11-15 2018-05-24 学校法人東京理科大学 MOLÉCULE INDUISANT LA DÉGRADATION DE p53 ET COMPOSITION PHARMACEUTIQUE
BR112019009645A2 (pt) 2016-11-15 2019-09-17 Univ Tokyo Science Found molécula de indução de degradação de proteína ras e composição farmacêutica
CN108096246B (zh) * 2017-03-08 2020-07-14 中国农业科学院饲料研究所 槲皮素和乌头碱联合用于制备治疗宫颈癌药物的应用及治疗宫颈癌药物
CN107219201B (zh) * 2017-04-20 2019-11-12 浙江工商大学 利用荧光显微镜观察桔霉素免疫后牛蛙抗体和亲和的方法
CN112516134B (zh) * 2019-09-18 2023-06-06 上海医药集团股份有限公司 一种含羟基的化合物在制备药物中的应用
US20220395577A1 (en) * 2019-10-02 2022-12-15 The General Hospital Corporation Methods and materials for modulating nrf2 pathway
EP4045508A4 (fr) * 2019-10-17 2024-01-24 Chengdu Anticancer Bioscience, Ltd. Alcaloïdes de benzophénanthridine et leurs procédés d'utilisation
CN111317734A (zh) * 2020-03-27 2020-06-23 广州医科大学附属第二医院 Wnt信号通路抑制剂和应用
CN112545979B (zh) * 2021-01-12 2022-07-19 山西省肿瘤研究所 预防膀胱癌术后复发的灌注凝胶及其制备方法和应用
CN113559110A (zh) * 2021-08-27 2021-10-29 上海市第一人民医院 毒毛花苷在制备Nrf2抑制剂、与Nrf2异常活化有关疾病的药物中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821072A (en) * 1996-02-20 1998-10-13 Sloan-Kettering Institute For Cancer Research Combinations of PKC inhibitors and therapaeutic agents for treating cancers
WO1998053091A1 (fr) * 1997-05-22 1998-11-26 The Burnham Institute Technique de criblage d'agents modifiant la regulation de l'activite de la caspase, regulation dans laquelle intervient la proteine inhibitrice de l'apoptose (iap)
WO1998055863A1 (fr) * 1997-06-05 1998-12-10 Idun Pharmaceuticals, Inc. Methodes rapides d'identification des modificateurs de l'activite apoptotique cellulaire

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821072A (en) * 1996-02-20 1998-10-13 Sloan-Kettering Institute For Cancer Research Combinations of PKC inhibitors and therapaeutic agents for treating cancers
WO1998053091A1 (fr) * 1997-05-22 1998-11-26 The Burnham Institute Technique de criblage d'agents modifiant la regulation de l'activite de la caspase, regulation dans laquelle intervient la proteine inhibitrice de l'apoptose (iap)
WO1998055863A1 (fr) * 1997-06-05 1998-12-10 Idun Pharmaceuticals, Inc. Methodes rapides d'identification des modificateurs de l'activite apoptotique cellulaire

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
FULDA ET AL: "Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 57, no. 21, 1 November 1997 (1997-11-01), pages 4956 - 4964, XP002128611, ISSN: 0008-5472 *
GAMEN S ET AL: "Doxorubicin-induced apoptosis in human T-cell leukemia is mediated by caspase-3 activation in a Fas-independent way", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 417, no. 3, 17 November 1997 (1997-11-17), pages 360 - 364, XP004261485, ISSN: 0014-5793 *
KAWAHARA ATSUO ET AL: "Fas-induced DNA fragmentation and proteolysis of nuclear proteins", GENES TO CELLS, vol. 3, no. 5, May 1998 (1998-05-01), pages 297 - 306, XP002298457, ISSN: 1356-9597 *
LOS M ET AL: "REQUIREMENT OF AN ICE/CED-3 PROTEASE FOR FAS/APO-1-MEDIATED APOPTOSIS", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 375, no. 6526, 4 May 1995 (1995-05-04), pages 81 - 83, XP000574811, ISSN: 0028-0836 *
SCHWARTZ S M: "Cell death and the caspase cascade.", CIRCULATION. 27 JAN 1998, vol. 97, no. 3, 27 January 1998 (1998-01-27), pages 227 - 229, XP002298456, ISSN: 0009-7322 *
See also references of WO0045165A1 *
VILLA P ET AL: "Caspases and caspase inhibitors", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 22, no. 10, 1 October 1997 (1997-10-01), pages 388 - 393, XP004091999, ISSN: 0968-0004 *

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EP1151295A1 (fr) 2001-11-07
AU2864100A (en) 2000-08-18

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