EP1084118A1 - Reduced particle size form of 1-(6-chloronaphth-2- ylsulphonyl) -4- 4-(4pyridyl) benzoyl] piperazine - Google Patents
Reduced particle size form of 1-(6-chloronaphth-2- ylsulphonyl) -4- 4-(4pyridyl) benzoyl] piperazineInfo
- Publication number
- EP1084118A1 EP1084118A1 EP99919395A EP99919395A EP1084118A1 EP 1084118 A1 EP1084118 A1 EP 1084118A1 EP 99919395 A EP99919395 A EP 99919395A EP 99919395 A EP99919395 A EP 99919395A EP 1084118 A1 EP1084118 A1 EP 1084118A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- chloronaphth
- ylsulphonyl
- benzoyl
- piperazine
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Definitions
- Factor Xa is one of a cascade of proteases involved in the complex process of blood coagulation.
- the protease known as thrombin is the final 5 protease in the cascade and Factor Xa is the preceding protease which cleaves prothrombin to generate thrombin.
- a Compound of the invention refers to either one of features (a), (b) or (c) described above. 5
- reduced particle size we refer to solid Compound 1, or a pharmaceutically-acceptable salt thereof, or a solvate of either thereof, reduced by suitable processing techniques to a solid of smaller particle size and, consequently, greater surface area. Any number of processing techniques known in the pharmaceutical field may be used to reduce solid particle size, such as grinding, milling and micronising, reference should be made 10 to Remington: The Science and Practise of Pharmacy, 19 th Ed., pages 1598-1602, for a more exhaustive review.
- a powder of which not less than 90% by weight of the particles pass through a sieve with a nominal mesh aperture of 45 ⁇ m.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9809350 | 1998-05-02 | ||
| GBGB9809350.3A GB9809350D0 (en) | 1998-05-02 | 1998-05-02 | Novel salt |
| PCT/GB1999/001316 WO1999057112A1 (en) | 1998-05-02 | 1999-04-27 | Reduced particle size form of 1-(6-chloronaphth-2- ylsulphonyl) -4-[4-(4pyridyl) benzoyl] piperazine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP1084118A1 true EP1084118A1 (en) | 2001-03-21 |
Family
ID=10831311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP99919395A Withdrawn EP1084118A1 (en) | 1998-05-02 | 1999-04-27 | Reduced particle size form of 1-(6-chloronaphth-2- ylsulphonyl) -4- 4-(4pyridyl) benzoyl] piperazine |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1084118A1 (no) |
| JP (1) | JP2002513789A (no) |
| KR (1) | KR20010043216A (no) |
| CN (1) | CN1308629A (no) |
| AU (1) | AU3719699A (no) |
| BR (1) | BR9910176A (no) |
| CA (1) | CA2331041A1 (no) |
| EE (1) | EE200000638A (no) |
| GB (1) | GB9809350D0 (no) |
| HU (1) | HUP0102394A3 (no) |
| IL (1) | IL139405A0 (no) |
| NO (1) | NO20005498L (no) |
| PL (1) | PL343705A1 (no) |
| SK (1) | SK16522000A3 (no) |
| WO (1) | WO1999057112A1 (no) |
| ZA (1) | ZA200006036B (no) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9815377A (pt) | 1997-09-30 | 2001-01-16 | Daiichi Pharmaceutical Co Ltda | Derivados de sulfonil |
| TWI288745B (en) | 2000-04-05 | 2007-10-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| US7365205B2 (en) | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
| PT1569912E (pt) | 2002-12-03 | 2015-09-15 | Pharmacyclics Llc | Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA56197C2 (uk) * | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
| CA2287292A1 (en) * | 1997-05-30 | 1998-12-03 | Takeda Chemical Industries, Ltd. | Sulfonamide derivatives, their production and use |
| BR9815377A (pt) * | 1997-09-30 | 2001-01-16 | Daiichi Pharmaceutical Co Ltda | Derivados de sulfonil |
-
1998
- 1998-05-02 GB GBGB9809350.3A patent/GB9809350D0/en not_active Ceased
-
1999
- 1999-04-27 BR BR9910176-9A patent/BR9910176A/pt not_active IP Right Cessation
- 1999-04-27 CN CN99808217A patent/CN1308629A/zh active Pending
- 1999-04-27 CA CA002331041A patent/CA2331041A1/en not_active Abandoned
- 1999-04-27 KR KR1020007012149A patent/KR20010043216A/ko not_active Application Discontinuation
- 1999-04-27 AU AU37196/99A patent/AU3719699A/en not_active Abandoned
- 1999-04-27 EE EEP200000638A patent/EE200000638A/xx unknown
- 1999-04-27 IL IL13940599A patent/IL139405A0/xx unknown
- 1999-04-27 PL PL99343705A patent/PL343705A1/xx not_active Application Discontinuation
- 1999-04-27 WO PCT/GB1999/001316 patent/WO1999057112A1/en not_active Application Discontinuation
- 1999-04-27 JP JP2000547082A patent/JP2002513789A/ja active Pending
- 1999-04-27 EP EP99919395A patent/EP1084118A1/en not_active Withdrawn
- 1999-04-27 HU HU0102394A patent/HUP0102394A3/hu unknown
- 1999-04-27 SK SK1652-2000A patent/SK16522000A3/sk unknown
-
2000
- 2000-10-25 ZA ZA200006036A patent/ZA200006036B/en unknown
- 2000-11-01 NO NO20005498A patent/NO20005498L/no not_active Application Discontinuation
Non-Patent Citations (1)
| Title |
|---|
| See references of WO9957112A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| NO20005498D0 (no) | 2000-11-01 |
| NO20005498L (no) | 2000-11-01 |
| SK16522000A3 (sk) | 2001-05-10 |
| CN1308629A (zh) | 2001-08-15 |
| PL343705A1 (en) | 2001-08-27 |
| AU3719699A (en) | 1999-11-23 |
| IL139405A0 (en) | 2001-11-25 |
| EE200000638A (et) | 2002-04-15 |
| HUP0102394A2 (hu) | 2001-12-28 |
| ZA200006036B (en) | 2002-01-25 |
| HUP0102394A3 (en) | 2003-01-28 |
| KR20010043216A (ko) | 2001-05-25 |
| JP2002513789A (ja) | 2002-05-14 |
| GB9809350D0 (en) | 1998-07-01 |
| WO1999057112A1 (en) | 1999-11-11 |
| CA2331041A1 (en) | 1999-11-11 |
| BR9910176A (pt) | 2001-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20001204 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| AX | Request for extension of the european patent |
Free format text: AL PAYMENT 20001204;LT PAYMENT 20001204;LV PAYMENT 20001204;MK PAYMENT 20001204;RO PAYMENT 20001204;SI PAYMENT 20001204 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20031101 |
|
| RTI1 | Title (correction) |
Free format text: REDUCED PARTICLE SIZE FORM OF 1-(6-CHLORONAPHTH-2- YLSULPHONYL) -4- 4-(4PYRIDYL) BENZOYL PIPERAZINE |
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| REG | Reference to a national code |
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