EP1061931A2 - Elaboration de thrombine, produits a base de fibrine et procedes de fabrication de materiaux d'obturation a base de fibrine au moyen desdits produits - Google Patents

Elaboration de thrombine, produits a base de fibrine et procedes de fabrication de materiaux d'obturation a base de fibrine au moyen desdits produits

Info

Publication number
EP1061931A2
EP1061931A2 EP99909912A EP99909912A EP1061931A2 EP 1061931 A2 EP1061931 A2 EP 1061931A2 EP 99909912 A EP99909912 A EP 99909912A EP 99909912 A EP99909912 A EP 99909912A EP 1061931 A2 EP1061931 A2 EP 1061931A2
Authority
EP
European Patent Office
Prior art keywords
thrombin
prothrombin
fibrinogen
plasma
precipitate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99909912A
Other languages
German (de)
English (en)
Inventor
David H. Sierra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter International Inc filed Critical Baxter International Inc
Publication of EP1061931A2 publication Critical patent/EP1061931A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne l'utilisation de liposomes présentant une surface extérieure comprenant à la fois des groupements polaires acides et basiques, par exemple des liposomes de phosphatidyle, de façon à obtenir une production de thrombine rapide et à rendement élevé, à partir d'un matière contenant de la prothrombine. La matière fournissant la prothrombine peut être traitée avec la thrombine obtenue, donnant ainsi un produit autologue à base de thrombine. En outre, un composant fibrinogène peut être produit à partir du même échantillon sanguin, donnant ainsi, lorsqu'il est activé avec un produit à base de thrombine issu du même échantillon sanguin, un matériau d'obturation à base de fibrine entièrement autologue.
EP99909912A 1998-03-10 1999-03-10 Elaboration de thrombine, produits a base de fibrine et procedes de fabrication de materiaux d'obturation a base de fibrine au moyen desdits produits Withdrawn EP1061931A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7761998P 1998-03-10 1998-03-10
US77619P 1998-03-10
PCT/US1999/005034 WO1999045938A1 (fr) 1998-03-10 1999-03-10 Elaboration de thrombine, produits a base de fibrine et procedes de fabrication de materiaux d'obturation a base de fibrine au moyen desdits produits

Publications (1)

Publication Number Publication Date
EP1061931A2 true EP1061931A2 (fr) 2000-12-27

Family

ID=22139138

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99909912A Withdrawn EP1061931A2 (fr) 1998-03-10 1999-03-10 Elaboration de thrombine, produits a base de fibrine et procedes de fabrication de materiaux d'obturation a base de fibrine au moyen desdits produits

Country Status (5)

Country Link
EP (1) EP1061931A2 (fr)
JP (1) JP2002506038A (fr)
AU (1) AU2900599A (fr)
CA (1) CA2322741A1 (fr)
WO (1) WO1999045938A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102011112955A1 (de) 2011-09-13 2013-03-14 Medizinische Hochschule Hannover Verfahren zur Herstellung eines biologischen Gewebekonstrukts und Verwendung spezifisch gewonnener autologer Zellen

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000062828A1 (fr) 1996-04-30 2000-10-26 Medtronic, Inc. Fibrine autologue d'obturation et ses methodes de fabrication
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
CA2394637A1 (fr) * 1999-12-22 2001-06-28 Pierre Philippart Produit concu pour generer des os
CN102014973A (zh) 2008-02-29 2011-04-13 弗罗桑医疗设备公司 用于促进止血和/或伤口愈合的装置
EP2822474B1 (fr) 2012-03-06 2018-05-02 Ferrosan Medical Devices A/S Récipient mis sous pression contenant de la pâte hémostatique
BR112014030962A2 (pt) 2012-06-12 2017-06-27 Ferrosan Medical Devices As métodos para preparação e para reconstituição de uma composição seca adequada para uso em hemostase e cicatrização de feridas, e, kit hemostático
RU2589648C2 (ru) * 2012-09-25 2016-07-10 Стем Селл Партнерс Ллк Способ и устройство для получения сыворотки с тромбином от одного донора
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
EP3470094B1 (fr) 2013-12-11 2020-07-22 Ferrosan Medical Devices A/S Composition sèche comprenant un améliorateur d'extrusion
WO2016058612A1 (fr) 2014-10-13 2016-04-21 Ferrosan Medical Devices A/S Composition sèche destinée à être utilisée en hémostase et cicatrisation de plaie
WO2016102446A1 (fr) 2014-12-24 2016-06-30 Ferrosan Medical Devices A/S Seringue pour retenir et mélanger des première et seconde substances
WO2017005590A1 (fr) 2015-07-03 2017-01-12 Ferrosan Medical Devices A/S Seringue pour mélanger deux composants et pour conserver un vide dans une condition de stockage
EP4321182A2 (fr) 2018-05-09 2024-02-14 Ferrosan Medical Devices A/S Procédé de préparation d'une composition hémostatique
CN112997967A (zh) * 2021-03-09 2021-06-22 复旦大学附属华山医院 一种凝血酶磁珠及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5226877A (en) * 1989-06-23 1993-07-13 Epstein Gordon H Method and apparatus for preparing fibrinogen adhesive from whole blood
US5476777A (en) * 1991-12-31 1995-12-19 Zymogenetics, Inc. Methods for producing thrombin
US5266462A (en) * 1992-06-03 1993-11-30 Baxter Diagnostics Inc. Measurement of platelet activities
US5219995A (en) * 1992-07-14 1993-06-15 Alpha Therapeutic Corporation Plasma fraction purification
US5330974A (en) * 1993-03-01 1994-07-19 Fibratek, Inc. Therapeutic fibrinogen compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9945938A1 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102011112955A1 (de) 2011-09-13 2013-03-14 Medizinische Hochschule Hannover Verfahren zur Herstellung eines biologischen Gewebekonstrukts und Verwendung spezifisch gewonnener autologer Zellen
WO2013037349A1 (fr) 2011-09-13 2013-03-21 Medizinische Hochschule Hannover (Mhh) Procédé de fabrication d'un produit de synthèse tissulaire biologique et utilisation de cellules autologues obtenues de façon spécifique
US9655931B2 (en) 2011-09-13 2017-05-23 Medizinische Hochschule Hannover (Mhh) Method for producing a biological tissue construct and use of specifically obtained autologous cells

Also Published As

Publication number Publication date
JP2002506038A (ja) 2002-02-26
WO1999045938B1 (fr) 1999-12-02
WO1999045938A1 (fr) 1999-09-16
AU2900599A (en) 1999-09-27
CA2322741A1 (fr) 1999-09-16

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