EP0974584A4 - Composes a anneaux condenses, leur procede de production et leur utilisation - Google Patents

Composes a anneaux condenses, leur procede de production et leur utilisation

Info

Publication number
EP0974584A4
EP0974584A4 EP98904386A EP98904386A EP0974584A4 EP 0974584 A4 EP0974584 A4 EP 0974584A4 EP 98904386 A EP98904386 A EP 98904386A EP 98904386 A EP98904386 A EP 98904386A EP 0974584 A4 EP0974584 A4 EP 0974584A4
Authority
EP
European Patent Office
Prior art keywords
substituted
group
producing
same
fused ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP98904386A
Other languages
German (de)
English (en)
Other versions
EP0974584B1 (fr
EP0974584A1 (fr
Inventor
Tetsuya Aono
Fumio Itoh
Tomohiro Kaku
Masuo Yamaoka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of EP0974584A1 publication Critical patent/EP0974584A1/fr
Publication of EP0974584A4 publication Critical patent/EP0974584A4/fr
Application granted granted Critical
Publication of EP0974584B1 publication Critical patent/EP0974584B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP98904386A 1997-02-21 1998-02-19 Composes a anneaux condenses, leur procede de production et leur utilisation Expired - Lifetime EP0974584B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP3792797 1997-02-21
JP3792797 1997-02-21
PCT/JP1998/000688 WO1998037070A1 (fr) 1997-02-21 1998-02-19 Composes a anneaux condenses, leur procede de production et leur utilisation

Publications (3)

Publication Number Publication Date
EP0974584A1 EP0974584A1 (fr) 2000-01-26
EP0974584A4 true EP0974584A4 (fr) 2000-05-17
EP0974584B1 EP0974584B1 (fr) 2003-01-15

Family

ID=12511197

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98904386A Expired - Lifetime EP0974584B1 (fr) 1997-02-21 1998-02-19 Composes a anneaux condenses, leur procede de production et leur utilisation

Country Status (8)

Country Link
US (1) US6420375B1 (fr)
EP (1) EP0974584B1 (fr)
CN (1) CN1251577A (fr)
AT (1) ATE231128T1 (fr)
AU (1) AU6229698A (fr)
CA (1) CA2281598A1 (fr)
DE (1) DE69810760T2 (fr)
WO (1) WO1998037070A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW407153B (en) * 1997-10-27 2000-10-01 Nippon Kayaku Kk Imidazole compounds and their use
AU1872900A (en) * 1998-12-23 2000-07-31 Astrazeneca Ab Chemical compounds
ATE494388T1 (de) 1999-01-13 2011-01-15 Univ New York State Res Found Neues verfahren zum erschaffen von proteinkinase- inhibitoren
US6417366B2 (en) * 1999-06-24 2002-07-09 Abbott Laboratories Preparation of quinoline-substituted carbonate and carbamate derivatives
US6552078B2 (en) 1999-10-27 2003-04-22 Nobex Corp 6-methoxy-2-naphthylacetic acid prodrugs
TWI262791B (en) * 1999-10-27 2006-10-01 Nobex Corp 6-methoxy-2-naphthylacetic acid prodrugs
US6436990B1 (en) 1999-10-27 2002-08-20 Nobex Corporation 6-methoxy-2-naphthylacetic acid prodrugs
US7141598B2 (en) 2000-11-17 2006-11-28 Takeda Pharmaceutical Company, Ltd. Imidazole derivatives, production method thereof and use thereof
EP1344777B1 (fr) 2000-11-20 2011-03-16 Takeda Pharmaceutical Company Limited Derives de l'imidazole, leur procede de preparation et leur application
EP1348706B1 (fr) 2000-12-08 2009-08-19 Takeda Pharmaceutical Company Limited Derives thiazole substitues porteurs de groupes 3-pyridyl, procede d'elaboration et leur utilisation
US7129225B2 (en) * 2001-10-22 2006-10-31 The Research Foundation Of State University Of New York Protection against and treatment of hearing loss
US7005445B2 (en) 2001-10-22 2006-02-28 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors and methods for designing them
EP1549598A4 (fr) * 2002-06-07 2008-01-23 Cortical Pty Ltd Derives de naphtalene qui inhibent la cytokine ou l'activite biologique du facteur inhibiteur de migration du macrophage
US7838542B2 (en) 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade
US8383635B2 (en) * 2008-08-12 2013-02-26 Glaxosmithkline Llc Chemical compounds
KR101690358B1 (ko) 2009-10-29 2017-01-09 제노스코 키나아제 억제제
CN108698989B (zh) * 2016-02-10 2021-05-11 住友化学株式会社 用于制备1-甲基吡咯烷-3-醇的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027989A1 (fr) * 1993-05-21 1994-12-08 Glaxo Group Limited Derives de carbazole a activite d'inhibition de 17,20-lyase
EP0721943A1 (fr) * 1993-09-30 1996-07-17 Yamanouchi Pharmaceutical Co. Ltd. Derive d'azole et composition pharmaceutique le contenant

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642781A (en) * 1968-10-15 1972-02-15 Warner Lambert Co Substituted acrylic acids and process for their production
US4237133A (en) * 1977-11-14 1980-12-02 Pfizer Inc. 1,9-Dihydroxyoctahydrophenanthrenes
GB8417559D0 (en) * 1984-07-10 1984-08-15 Pfizer Ltd Anti-diarrhoeal agents
LU86022A1 (fr) * 1985-07-25 1987-02-04 Cird Derives aromatiques polycyliques,leur procede de preparation et leur application dans les domaines pharmaceutique et cosmetique
NZ221729A (en) 1986-09-15 1989-07-27 Janssen Pharmaceutica Nv Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions
JP2852659B2 (ja) * 1988-03-03 1999-02-03 富山化学工業株式会社 ピペラジン誘導体およびその塩
JPH07121933B2 (ja) * 1988-03-28 1995-12-25 キッセイ薬品工業株式会社 ジヒドロベンゾフラノン誘導体
US5273977A (en) * 1990-11-05 1993-12-28 Warner-Lambert Company Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
GB9220735D0 (en) * 1992-10-02 1992-11-18 British Tech Group Heterocyclic amines
JPH06293640A (ja) * 1993-02-15 1994-10-21 Shin Nippon Yakuhin Kk 肝疾患治療剤および１，３−ベンゾキサチオール誘導体
JPH06239856A (ja) * 1993-02-15 1994-08-30 Shin Nippon Yakuhin Kk １，３−ベンゾオキサチオール−２−チオン誘導体
JPH07173120A (ja) * 1993-10-08 1995-07-11 Banyu Pharmaceut Co Ltd 置換芳香族カルボン酸誘導体
AP648A (en) * 1995-01-10 1998-05-25 Smithkline Beecham Farm S P A Indole derivatives useful in the treatment of osteoporosis.
AU4547896A (en) * 1995-02-03 1996-08-21 Banyu Pharmaceutical Co., Ltd. 4-oxo-2-butenoic acid derivatives
AU7505196A (en) * 1995-11-07 1997-05-29 Banyu Pharmaceutical Co., Ltd. Cyclic amic acid derivatives
BR9611555A (pt) * 1995-12-06 1999-03-02 Astra Pharma Prod Compostos formulação farmacêutica utilização de um composto processo para tratamento de uma doença obstrutiva reversível das vias aéreas e para preparação do composto
CA2245586A1 (fr) 1996-02-06 1997-08-14 Japan Tobacco Inc. Composes chimiques et utilisation pharmaceutique
FR2746098B1 (fr) * 1996-03-14 1998-04-30 Composes propynyl biaromatiques
MY118876A (en) * 1996-03-29 2005-02-28 Tanabe Seiyaku Co Butadiene derivatives and process for preparing thereof
DE69730837T2 (de) 1996-07-09 2005-09-29 Nikem Research S.R.L., Baranzate Di Bollate Indolderivate zur behandlung von osteoporose
US6005000A (en) * 1996-08-22 1999-12-21 Oxis International, Inc. 5,5-Disubstituted-3, 4-dihydroxy-2(5H)-furanones and methods of use therefor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027989A1 (fr) * 1993-05-21 1994-12-08 Glaxo Group Limited Derives de carbazole a activite d'inhibition de 17,20-lyase
EP0721943A1 (fr) * 1993-09-30 1996-07-17 Yamanouchi Pharmaceutical Co. Ltd. Derive d'azole et composition pharmaceutique le contenant

Also Published As

Publication number Publication date
CN1251577A (zh) 2000-04-26
EP0974584B1 (fr) 2003-01-15
DE69810760D1 (de) 2003-02-20
CA2281598A1 (fr) 1998-08-27
AU6229698A (en) 1998-09-09
EP0974584A1 (fr) 2000-01-26
DE69810760T2 (de) 2003-11-20
WO1998037070A1 (fr) 1998-08-27
ATE231128T1 (de) 2003-02-15
US6420375B1 (en) 2002-07-16

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