EP0958364A4 - IMMUNOTHERAPY AND IMPROVED Vaccines - Google Patents
IMMUNOTHERAPY AND IMPROVED VaccinesInfo
- Publication number
- EP0958364A4 EP0958364A4 EP97912961A EP97912961A EP0958364A4 EP 0958364 A4 EP0958364 A4 EP 0958364A4 EP 97912961 A EP97912961 A EP 97912961A EP 97912961 A EP97912961 A EP 97912961A EP 0958364 A4 EP0958364 A4 EP 0958364A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- immunotherapy
- improved vaccines
- vaccines
- improved
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000009169 immunotherapy Methods 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
- A61K2039/55533—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
- A61K2039/55538—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2861396P | 1996-10-23 | 1996-10-23 | |
US2861P | 1996-10-23 | ||
PCT/US1997/019502 WO1998017799A1 (en) | 1996-10-23 | 1997-10-23 | Immunotherapy and improved vaccines |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0958364A1 EP0958364A1 (en) | 1999-11-24 |
EP0958364A4 true EP0958364A4 (en) | 2001-10-31 |
Family
ID=21844431
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97912961A Withdrawn EP0958364A4 (en) | 1996-10-23 | 1997-10-23 | IMMUNOTHERAPY AND IMPROVED Vaccines |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0958364A4 (ko) |
JP (3) | JP2001507216A (ko) |
KR (4) | KR20070108418A (ko) |
CN (2) | CN1868545A (ko) |
AU (1) | AU729579B2 (ko) |
BR (1) | BR9712852A (ko) |
CA (3) | CA2745736C (ko) |
WO (1) | WO1998017799A1 (ko) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002301344B2 (en) * | 1998-05-06 | 2005-01-13 | Association Francais Contre Les Myopathies | Use of a nuclease inhibitor or interleukin-10 (IL-10) for the preparation of a therapeutic composition for improving transfection of a polynucleotide into a cell and compositions useful in gene therapy |
US6528312B1 (en) | 1998-05-06 | 2003-03-04 | Transgene S.A. | Use of G-actin for improving transfection of a polynucleotide into a cell |
CA2328059A1 (en) * | 1998-05-07 | 1999-11-11 | Akzo Nobel Nv | Use of interleukin-18 as vaccine adjuvant |
US6316420B1 (en) * | 1998-07-28 | 2001-11-13 | Technion Research And Development Foundation Ltd. | DNA cytokine vaccines and use of same for protective immunity against multiple sclerosis |
IL144845A0 (en) * | 1999-03-03 | 2002-06-30 | Univ Pennsylvania | Vaccines and gene therapy compositions and methods of making and using the same |
SK14832001A3 (sk) | 1999-04-23 | 2003-02-04 | Pharmexa A/S | Analóg interleukínu 5, fragment nukleovej kyseliny, vektor, bunka, prípravky a použitie |
HUP0201220A3 (en) * | 1999-05-13 | 2004-07-28 | Wyeth Holdings Corp Madison | Adjuvant combination formulations |
US6943152B1 (en) * | 1999-06-10 | 2005-09-13 | Merial | DNA vaccine-PCV |
WO2001048018A1 (en) * | 1999-12-27 | 2001-07-05 | University Of Manitoba | Genetic vaccines for the production of chicken egg-yolk antibodies against enterotoxigenic escherichia coli and other pathogens |
US6544780B1 (en) | 2000-06-02 | 2003-04-08 | Genphar, Inc. | Adenovirus vector with multiple expression cassettes |
US7754201B2 (en) | 2000-06-02 | 2010-07-13 | GenPhar, Inc | Method of vaccination through serotype rotation |
US7092633B2 (en) | 2000-11-14 | 2006-08-15 | University Of Texas System Board Of Regents | System and method for configuring optical circuits |
JP2002221520A (ja) * | 2001-01-29 | 2002-08-09 | Sumitomo Chem Co Ltd | 免疫型の予測方法 |
ATE430807T1 (de) * | 2001-03-27 | 2009-05-15 | Univ Saskatchewan | Verfahren zur kultivierung von circovirus |
KR20030012199A (ko) * | 2001-07-31 | 2003-02-12 | (주)지노첵 | 사이토카인 유전자를 유효성분으로 포함하는 dna 백신 |
EP1465928B1 (en) | 2002-01-17 | 2009-09-30 | Polymun Scientific Immunbiologische Forschung GmbH | Anti-idiotypic antibody inducing hiv-1 neutralizing antibodies |
GB0223696D0 (en) * | 2002-10-14 | 2002-11-20 | Ml Lab Plc | Improved immunotherapy |
CN1756845A (zh) | 2002-11-12 | 2006-04-05 | A·B·德塞罗斯 | 腺病毒载体疫苗 |
US8663622B2 (en) | 2002-12-16 | 2014-03-04 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Recombinant vaccine viruses expressing IL-15 and methods using the same |
US20040146486A1 (en) * | 2003-01-24 | 2004-07-29 | Juan Sun | Hybrid vector system for use as a vaccine |
WO2004069272A2 (en) * | 2003-02-05 | 2004-08-19 | Movecare Ltd | Adjuvant combination for use in the immunization of a mamal comprising il2 and il12 |
NZ570709A (en) * | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
CA2544946A1 (en) | 2003-11-24 | 2005-03-06 | Sidney Kimmel Cancer Center | Mucin antigen vaccine |
US8828957B2 (en) | 2003-12-11 | 2014-09-09 | Microvax, Llc | Methods for generating immunity to antigen |
TWI379839B (en) | 2003-12-17 | 2012-12-21 | Wyeth Llc | Aβ immunogenic peptide carrier conjugates and methods of producing same |
WO2005058940A2 (en) | 2003-12-17 | 2005-06-30 | Wyeth | Immunogenic peptide carrier conjugates and methods of producing same |
GB0410220D0 (en) | 2004-05-07 | 2004-06-09 | Kirkham Lea Ann | Mutant pneumolysin proteins |
TW200613554A (en) | 2004-06-17 | 2006-05-01 | Wyeth Corp | Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV |
CN101228272A (zh) * | 2005-04-20 | 2008-07-23 | 生物载体株式会社 | 用于治疗阿尔茨海默病的具有较高安全性的经鼻腔内给药基因疫苗 |
DK2041270T3 (da) | 2006-07-13 | 2014-01-27 | Wyeth Llc | Fremstilling af glycoproteiner |
EP2395077A1 (en) | 2006-11-03 | 2011-12-14 | Wyeth LLC | Glycolysis-inhibiting substances in cell culture |
WO2008109410A1 (en) | 2007-03-02 | 2008-09-12 | Wyeth | Use of copper and glutamate in cell culture for production of polypeptides |
EP2265715B1 (en) | 2008-04-04 | 2016-12-28 | The Trustees Of The University Of Pennsylvania | Vaccines and immunotherapeutics using il-28 and compositions and methods of using the same |
WO2010051820A1 (en) * | 2008-11-10 | 2010-05-14 | Aarhus Universitet | Multiplexed cytokine vaccination |
WO2010126766A1 (en) | 2009-04-30 | 2010-11-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inducible interleukin-12 |
US20130197612A1 (en) * | 2010-02-26 | 2013-08-01 | Jack W. Lasersohn | Electromagnetic Radiation Therapy |
CN102370979B (zh) * | 2011-10-10 | 2013-05-01 | 中国人民解放军第四军医大学 | 一种针对人TNF-α分子的自体疫苗的构建方法 |
EP2875041A2 (en) | 2012-07-19 | 2015-05-27 | Zoetis LLC | Bovine influenza c virus compositions |
WO2014018724A1 (en) | 2012-07-27 | 2014-01-30 | Zoetis Llc | Tick toxin compositions |
US20160008449A1 (en) | 2013-03-15 | 2016-01-14 | Zoetis Services Llc | CROSS-PROTECTION OF BOVINES AGAINST B. trehalosi INFECTION BY A MULTI-VALENT VACCINE |
AU2014229561B2 (en) | 2013-03-15 | 2018-06-07 | Keith Alan Charlton | Self-assembling synthetic proteins |
EA034110B1 (ru) * | 2013-03-15 | 2019-12-27 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Противораковые вакцины и способы лечения с их применением |
ES2933623T3 (es) | 2015-08-14 | 2023-02-10 | Zoetis Services Llc | Composiciones de Mycoplasma Bovis |
WO2017123201A1 (en) | 2016-01-11 | 2017-07-20 | Zoetis Services Llc | Novel cross protective vaccine compositions for porcine epidemic diarrhea virus |
GB201703529D0 (en) | 2017-03-06 | 2017-04-19 | Cambridge Entpr Ltd | Vaccine composition |
CN110996975A (zh) | 2017-04-13 | 2020-04-10 | 森迪生物科学公司 | 组合癌症免疫疗法 |
US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
TW202035685A (zh) | 2018-10-17 | 2020-10-01 | 美商聖堤生物科技股份有限公司 | 組合癌症免疫療法 |
EP3897691A4 (en) * | 2018-12-21 | 2022-08-31 | The Regents of the University of California | IL-10 VACCINES AND THEIR USES |
CN110170049B (zh) * | 2019-06-01 | 2023-07-04 | 山西农业大学 | 一种用于鸡球虫病活疫苗的细胞因子基因佐剂 |
WO2023177655A1 (en) | 2022-03-14 | 2023-09-21 | Generation Bio Co. | Heterologous prime boost vaccine compositions and methods of use |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1984001575A1 (en) * | 1982-10-11 | 1984-04-26 | Nat Biolog Standards Board | Polypeptides useful in vaccination against enteroviruses |
WO1996011279A2 (en) * | 1994-10-03 | 1996-04-18 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Enhanced immune response by introduction of cytokine gene and/or costimulatory molecule b7 gene in a recombinant virus expressing system |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0275300B1 (en) * | 1986-08-01 | 1996-01-03 | Commonwealth Scientific And Industrial Research Organisation | Recombinant vaccine |
US5457038A (en) * | 1988-11-10 | 1995-10-10 | Genetics Institute, Inc. | Natural killer stimulatory factor |
US5238823A (en) * | 1990-08-22 | 1993-08-24 | Veterinary Infectious Disease Organization | Interleukin-2-leukotoxin gene fusions and uses thereof |
IL112820A0 (en) * | 1994-03-07 | 1995-05-26 | Merck & Co Inc | Coordinate in vivo gene expression |
-
1997
- 1997-10-23 AU AU50022/97A patent/AU729579B2/en not_active Expired
- 1997-10-23 BR BR9712852-0A patent/BR9712852A/pt not_active Application Discontinuation
- 1997-10-23 CN CNA2006100718690A patent/CN1868545A/zh active Pending
- 1997-10-23 CA CA2745736A patent/CA2745736C/en not_active Expired - Lifetime
- 1997-10-23 EP EP97912961A patent/EP0958364A4/en not_active Withdrawn
- 1997-10-23 JP JP51971498A patent/JP2001507216A/ja not_active Ceased
- 1997-10-23 KR KR1020077024846A patent/KR20070108418A/ko not_active Application Discontinuation
- 1997-10-23 CN CNB97180897XA patent/CN1257976C/zh not_active Expired - Lifetime
- 1997-10-23 CA CA002269074A patent/CA2269074A1/en not_active Abandoned
- 1997-10-23 KR KR1019997003507A patent/KR100780158B1/ko not_active IP Right Cessation
- 1997-10-23 KR KR1020057008602A patent/KR20050053796A/ko not_active Application Discontinuation
- 1997-10-23 KR KR1020047021499A patent/KR100629835B1/ko not_active IP Right Cessation
- 1997-10-23 CA CA2751712A patent/CA2751712C/en not_active Expired - Lifetime
- 1997-10-23 WO PCT/US1997/019502 patent/WO1998017799A1/en not_active Application Discontinuation
-
2008
- 2008-02-27 JP JP2008045969A patent/JP2008194046A/ja active Pending
-
2009
- 2009-07-13 JP JP2009164572A patent/JP2009232860A/ja active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1984001575A1 (en) * | 1982-10-11 | 1984-04-26 | Nat Biolog Standards Board | Polypeptides useful in vaccination against enteroviruses |
WO1996011279A2 (en) * | 1994-10-03 | 1996-04-18 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Enhanced immune response by introduction of cytokine gene and/or costimulatory molecule b7 gene in a recombinant virus expressing system |
Non-Patent Citations (7)
Title |
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BRONTE V ET AL: "IL-2 ENHANCES THE FUNCTION OF RECOMBINANT POXVIRUS-BASED VACCINES IN THE TREATMENT OF ESTABLISHED PULMONARY METASTASES", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 154, no. 10, 15 May 1995 (1995-05-15), pages 5282 - 5292, XP002030630, ISSN: 0022-1767 * |
CHOW YEN-HUNG ET AL: "Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2.", JOURNAL OF VIROLOGY, vol. 71, no. 1, 1997, pages 169 - 178, XP002176596, ISSN: 0022-538X * |
GREENBERGER MJ ET AL.,: "Il-12 gene therapy protects mice in lethal Klebsiella pneumonia", J IMMUNOL., vol. 157, no. 7, 1 October 1997 (1997-10-01), XP001015488 * |
IRVINE K R ET AL: "CYTOKINE ENHANCEMENT OF DNA IMMUNIZATION LEADS TO EFFECTIVE TREATMENT OF ESTABLISHED PULMONARY METASTASES", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 156, 1996, pages 238 - 245, XP002030631, ISSN: 0022-1767 * |
LIEU FRANCIS H L ET AL: "Transmissibility of murine stem cell virus-based retroviral vectors carrying both interleukin-12 cDNAs and a third gene: Implications for immune gene therapy.", CANCER GENE THERAPY, vol. 4, no. 3, 1997, pages 167 - 175, XP001019756, ISSN: 0929-1903 * |
See also references of WO9817799A1 * |
XIANG Z ET AL: "MANIPULATION OF THE IMMUNE RESP0NSE TO A PLASMID-ENCODED VIRAL ANTIGEN BY COINOCULATION WITH PLASMIDS EXPRESSING CYTOKINES", IMMUNITY, CELL PRESS, US, vol. 2, no. 2, 1 February 1995 (1995-02-01), pages 129 - 135, XP000670098, ISSN: 1074-7613 * |
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JP2009232860A (ja) | 2009-10-15 |
CA2751712A1 (en) | 1998-04-30 |
AU729579B2 (en) | 2001-02-01 |
KR20050008860A (ko) | 2005-01-21 |
BR9712852A (pt) | 1999-11-16 |
CA2745736C (en) | 2016-11-22 |
JP2008194046A (ja) | 2008-08-28 |
CA2269074A1 (en) | 1998-04-30 |
KR20070108418A (ko) | 2007-11-09 |
WO1998017799A1 (en) | 1998-04-30 |
CN1868545A (zh) | 2006-11-29 |
EP0958364A1 (en) | 1999-11-24 |
KR20050053796A (ko) | 2005-06-08 |
CA2745736A1 (en) | 1998-04-30 |
CA2751712C (en) | 2016-11-22 |
KR100629835B1 (ko) | 2006-09-29 |
CN1242045A (zh) | 2000-01-19 |
JP2001507216A (ja) | 2001-06-05 |
KR100780158B1 (ko) | 2007-11-27 |
KR20000052710A (ko) | 2000-08-25 |
AU5002297A (en) | 1998-05-15 |
CN1257976C (zh) | 2006-05-31 |
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