EP0933133B1 - Centrifugeuse et conduite d'alimentation et/ou d'évacuation d'au moins un fluide d'une unité de séparation d'une centrifugeuse vers un site de connexion fixe - Google Patents

Centrifugeuse et conduite d'alimentation et/ou d'évacuation d'au moins un fluide d'une unité de séparation d'une centrifugeuse vers un site de connexion fixe Download PDF

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Publication number
EP0933133B1
EP0933133B1 EP99101930A EP99101930A EP0933133B1 EP 0933133 B1 EP0933133 B1 EP 0933133B1 EP 99101930 A EP99101930 A EP 99101930A EP 99101930 A EP99101930 A EP 99101930A EP 0933133 B1 EP0933133 B1 EP 0933133B1
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EP
European Patent Office
Prior art keywords
sliding
bush
centrifuge
bearing
sliding bush
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP99101930A
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German (de)
English (en)
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EP0933133A2 (fr
EP0933133A3 (fr
Inventor
Thomas Scherer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius SE and Co KGaA
Original Assignee
Fresenius SE and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius SE and Co KGaA filed Critical Fresenius SE and Co KGaA
Publication of EP0933133A2 publication Critical patent/EP0933133A2/fr
Publication of EP0933133A3 publication Critical patent/EP0933133A3/fr
Application granted granted Critical
Publication of EP0933133B1 publication Critical patent/EP0933133B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0492—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with fluid conveying umbilicus between stationary and rotary centrifuge parts

Definitions

  • the invention relates to a centrifuge, in particular a sliding seal-free one Flow centrifuge for centrifuging biological fluids and a line for supplying and / or discharging at least one fluid from the Separation unit of such a centrifuge to a stationary Junction.
  • Centrifuges are known in which the biological fluid flows through is centrifuged. The fluid is rotating over a line Centrifuge chamber supplied or removed from the chamber. Because of the Relative movement of the centrifuge chamber and the fixed connection point of the Management, however, turns out to be problematic. To a Avoid twisting the wire, find with conventional Flow centrifuges at the connection points rotating seals Use. Such flow centrifuges allow a high one Speed, but it is disadvantageous that the rotary couplings cause abrasion, Leaks and thus injuries and contamination from in the Components containing fluid can lead.
  • a flow seal free flow seal centrifuge is known from DE-A-32 42 541 known.
  • the line is run by a stationary connection point in a loop around the centrifuge chamber led around.
  • the line is connected to a rotating frame that rotates at half the speed of the centrifuge chamber.
  • Such Flow centrifuge is also known for example from DE-A-42 20 232.
  • the line In the case of the flow-through centrifuges without mechanical seals, the line is relatively large exposed to mechanical stresses with increasing speed solid rising.
  • the line forms under the influence of centrifugal forces an outward sweeping loop, which at the fixed junction and the connection to the separation unit high alternating bending loads occur.
  • the steep entry and exit angle at the connection points leads for additional friction between the connection adapters and the Line, which in turn leads to increased abrasion.
  • the Alternating bending loads and abrasion are the factors that Lifetime of the line or the maximum speed of the centrifuge restrict.
  • Flow seal-free flow centrifuges are known, for which Support the pipe bearing.
  • WO95 / 17261 describes a flow centrifuge, the centrifuge tube with a Roller bearing is supported.
  • the roller bearing which consists of an inner and outer Bearing shell with the rolling elements is part of the line.
  • the roller bearing offers the advantage of low bearing friction, which is disadvantageous however, the complex production and thus the relatively high price. This is particularly disadvantageous in that the centrifuge line is a disposable item, which is discarded after use.
  • EP-A-0 112 990 describes a flow centrifuge, the Centrifuge tube between the fixed connection point and the connection the separation unit is supported with two plain bearings.
  • the plain bearings each have an inner and an outer bearing shell with a cylindrical Tread, which are part of the centrifuge tube, which is why the Hose is relatively expensive to manufacture.
  • the sliding surface is large which creates high abrasion and heat. Furthermore shows the Bearing arrangement does not have sufficient axial support to prevent it from sliding out prevents the socket from the sleeve.
  • WO 93/12887 describes a centrifuge with two on its centrifuge line Slide bushings are seated.
  • the sliding bushes rotate in the bearing shells of the frame.
  • Slide bushes and bearing shells each have two inclined to each other Sliding surfaces, the sliding bush snapping into the bearing shell is inserted.
  • With the V-shaped sliding surfaces the sliding bushes are on the Bearing cups secured in the axial and radial directions.
  • the disadvantage is that the snap-in fixing of the sliding bush in the bearing shell with a relatively large bearing friction when rotating the bushing in the Bearing shell is connected.
  • the invention has for its object to provide a centrifuge whose Line for supplying and / or discharging at least one fluid is exposed to relatively low mechanical stress and can still be manufactured simply and inexpensively as a disposable item. This object is achieved with those specified in claim 1 Features.
  • Another object of the invention is to provide a conduit for feeding and / or removing at least one fluid from or to the separation unit to provide a centrifuge that is simple and inexpensive to use Manufacturing and operating the centrifuge at high speeds Relatively low mechanical stresses on the line allowed. This object is achieved with those specified in claim 8 Features.
  • the bearing shell preferably opened to allow easy insertion of the socket guarantee.
  • the bearing arrangement advantageously has one Snap on, with a longitudinal, slot-shaped opening of the Bearing shell is slightly narrower than the diameter of the bush. But other conventional insertion mechanisms are also conceivable and of the invention includes.
  • the sliding bush can be used as a separate component, preferably as Injection molded part, be formed, which is pushed onto the line and with the Cable is connected in a rotationally fixed manner, for example welded or glued.
  • the sliding bush can also be made in one piece with the line.
  • the sliding bush and the bearing shell each have a cylindrical section on, which connects to their sliding surface.
  • the cylindrical sections of Slide bushes and bearing shells do not represent a running surface, they only serve the additional centering or adjustment of the line. Through the The internal stress of the line becomes the sliding surface of the sliding bush on the sliding surface pressed the bearing shell, the cylindrical sections of the sliding bush and Bearing shell are not loaded.
  • the sliding surfaces are advantageously of this type designed that only a very small circular contact surface is created.
  • a line for supplying and / or discharging at least one fluid in this context is not just a hose with one or more Lumens, but also an arrangement of several single-lumen tubes Roger that.
  • the sliding bushing consists of a material which has a lower hardness than the material from which the bearing shell is made. This has the advantage that the fatigue strength of the non-replaceable bearing shell is ensured. In contrast, the wear of the sliding bush is not disadvantageous as this is part of the line intended for single use is.
  • the sliding bush is preferably made of plastic, preferably polyacetal plastic (POM) or Teflon, i.e. a material with a lower Abrasion resistance, while the bearing shell is preferably made of metal, in particular Steel, i.e. a material with a higher abrasion resistance.
  • Advantageous are especially materials with a low coefficient of friction.
  • the sliding surface of the bearing shell and the sliding bush are preferably machined in such a way that the lowest possible friction losses occur.
  • the bearing shell is advantageously slotted at one point.
  • the cylindrical portion of the sliding bush is inserted, and the sliding surface of the sliding bush is then on the sliding surface of the bearing shell hung up.
  • the sliding bush is thus centered in the bearing shell.
  • the slide bearing for supporting the line is purpose-wise on the side rotating rotating frame of the centrifuge arranged the separation unit carries, so that the line laterally in an arc around the Separation unit can be guided to the fixed connection point. If the plain bearing is approximately at the level at which the separation unit is arranged, i.e. in the area of the lower third of that of the Separation unit to the fixed line running line is the line is adequately supported. More plain bearings are then available Support of the line is no longer required.
  • Fig. 1 shows a schematic diagram of a flow centrifuge free of mechanical seals for centrifuging a biological fluid, in particular blood, which corresponds in structure and function to the centrifuge described in DE 32 42 541 A1.
  • the flow centrifuge has a rotating frame 1 with a lower 1a and an upper support plate 1b and two side parts 1c, 1d.
  • the rotating frame 1 is rotatably mounted on a stationary frame 2 about a vertical axis 3 and is driven by a drive unit (not shown in FIG. 1) at a speed n 1 .
  • a separation unit 4 in the form of a cylindrical chamber is rotatably mounted about the axis of rotation of the frame.
  • the separation unit can be attached to the top or bottom of the support plate.
  • a flexible Line 6 in which one or more hoses for feeding and discharging the blood or the blood components in the centrifuge chamber 4 or from the Chamber are summarized around the centrifuge chamber 4 and connected to the bottom of the chamber. A twisting of the line is avoided in that the line 6 at half the speed as the Centrifuge chamber is guided around this.
  • Line 6 is part of a disposable, which in addition to Centrifuge chamber 4 still bags for collecting the by centrifugation separated blood components can include.
  • the disposable is in the Centrifuge inserted and discarded after use.
  • Such Hose arrangements are part of the prior art, so that here no further explanation is necessary.
  • a comprehensive collection bag Disposable is for example in DE-A-28 45 364 and DE-A-28 45 399 described.
  • the bearing has a sliding bush sitting on the hose line and one Bearing shell, which is attached to the rotating frame 1.
  • Fig. 2 shows the section that one or more hoses 6a, 6b comprehensive hose line 6, on which the sliding bush 9 sits.
  • From Polyacetal plastic (POM) or Teflon existing sliding bush 9 has one cylindrical section 10, which in a forming the sliding surface conical section 11 merges. At its the conical section opposite end is the cylindrical portion 10 of the slide bush 9 provided with a circumferential approach 12.
  • the sliding bush 9 is fixed to the Hose line 6 glued or welded, which is characterized by its axial Hole extends.
  • the bearing shell 13 has a stepped bore with a cylindrical Section 14 and a conical section 15 which is the same Has conicity as the conical section 11 of the sliding bush 9. At a The bearing shell 13 is slotted. The width of the opening 16 is so dimensioned that the cylindrical portion 10 of the sliding bush 9 laterally in the Bearing shell 13 can be pressed and snapped into the bearing shell is set. The length of the cylindrical portion 10 of the slide bush 9 is slightly larger than the height of the bearing shell 13.
  • FIG. 5 shows the sliding bush 9 of the line 6 inserted in the bearing shell 13.
  • the cylindrical portion 10 is in the lateral opening 16 of the bearing shell 13 inserted, and the conical Section 11 of the sliding bush is on the conical sliding surface 15 of the Bearing shell.
  • the bearing shell is in this way on the rotating frame attached that the sliding surface 15 is above.
  • the sliding bush 9 is in the Bearing shell 13 fixed in the axial and radial directions, the circumferential Approach 12 of the sliding bush slipping out of the bearing shell prevented.
  • FIG. 6 shows the sliding bush 9 'inserted into the bearing shell 13 another embodiment.
  • the sliding surfaces the bearing shell and the sliding bush formed such that there is sliding bush and touch the bearing shell only along a circular line 17. So that's it Minimal contact area.

Landscapes

  • Centrifugal Separators (AREA)

Claims (11)

  1. Centrifugeuse avec un cadre rotatif (1), qui est monté rotatif sur un châssis (2), une unité de séparation (4) montée rotative sur le châssis (2) et pouvant être entraínée dans le même sens de rotation que le cadre rotatif à une vitesse de rotation deux fois plus élevée, une conduite (6) d'alimentation et /ou d'évacuation d'au moins un fluide, qui contourne l'unité de séparation (4) à partir d'un point de raccordement (5) fixe, et est raccordée à l'unité de séparation (4), sur un côté de ladite unité de séparation opposé au point de raccordement fixe, et au moins un palier (7) pour supporter la conduite (6) et qui présente une douille de glissement (9) située sur la conduite et un coussinet de palier (13), ledit coussinet de palier (13) étant fixé sur le cadre rotatif (1) et le coussinet de palier (13) et la douille de glissement (9) présentant chacun une surface de glissement (11, 15) s'élargissant radialement, de telle sorte que la douille de glissement (9) est soutenue dans le coussinet de palier (13), dans le sens de l'axe longitudinal de la douille de glissement (9) et dans le sens transversal à son axe longitudinal, caractérisée en ce que la douille de glissement (9) présente un tronçon cylindrique (10) faisant suite à sa surface s'évasant radialement (11), et en ce que le coussinet de palier (13) présente un tronçon cylindrique (14) faisant suite à sa surface de glissement (15) s'évasant radialement.
  2. Centrifugeuse selon la revendication 1, caractérisée en ce que la douille de glissement (9) est réalisée en un matériau de dureté plus faible que le matériau en lequel est réalisé le coussinet de palier (13).
  3. Centrifugeuse selon la revendication 1, caractérisée en ce que la douille de glissement (9) est en matière plastique, de préférence en polyacétal ou en téflon.
  4. Centrifugeuse selon l'une quelconque des revendications 1 à 3, caractérisée en ce que le coussinet de palier (13) est en métal, de préférence en acier.
  5. Centrifugeuse selon l'une quelconque des revendications 1 à 4, caractérisée en ce que les surfaces de glissement (11, 15) s'élargissant radialement de la douille de glissement (9) et du coussinet de palier (13) sont coniques.
  6. Centrifugeuse selon l'une quelconque des revendications 1 à 5, caractérisée en ce que le coussinet de palier (13) est fendu sur un côté pour y introduire la douille de glissement (9).
  7. Centrifugeuse selon l'une quelconque des revendications 1 à 6, caractérisée en ce que le tronçon cylindrique (10) de la douille de glissement (9) est muni d'un embout périphérique (12).
  8. Conduite d'alimentation et/ou d'évacuation d'au moins un fluide d'une unité de séparation, montée rotative sur un cadre rotatif montée rotatif sur un châssis, l'unité de séparation étant entraínée dans le même sens de rotation que le cadre rotatif, à une vitesse de rotation deux fois plus élevée, au moins une douille de glissement (9) étant située sur la conduite, ladite douille présentant une surface de glissement (11) s'élargissant radialement, de telle sorte qu'elle peut être insérée dans un coussinet de palier et être soutenue dans la direction de son axe longitudinal et dans le sens transversal à son axe longitudinal dans ledit coussinet, caractérisée en ce que la douille de glissement (9) présente un tronçon cylindrique (10) auquel fait suite la surface de glissement (11) s'évasant radialement.
  9. Conduite selon la revendication 8, caractérisée en ce que la douille de glissement (9) en matière plastique, de préférence en polyacétal ou en téflon.
  10. Conduite selon la revendication 8, caractérisée en ce que la surface de glissement (11) de la douille de glissement (9) s'élargissant radialement est conique.
  11. Conduite selon la revendication 10, caractérisée en ce que le tronçon cylindrique (10) de la douille de glissement (9) est muni d'un embout périphérique (12).
EP99101930A 1998-01-30 1999-01-29 Centrifugeuse et conduite d'alimentation et/ou d'évacuation d'au moins un fluide d'une unité de séparation d'une centrifugeuse vers un site de connexion fixe Expired - Lifetime EP0933133B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19803534 1998-01-30
DE19803534A DE19803534C2 (de) 1998-01-30 1998-01-30 Zentrifuge und Leitung zum Zuführen und/oder Abführen mindestens eines Fluids von der Separationseinheit einer Zentrifuge zu einer ortsfesten Anschlußstelle

Publications (3)

Publication Number Publication Date
EP0933133A2 EP0933133A2 (fr) 1999-08-04
EP0933133A3 EP0933133A3 (fr) 2000-06-21
EP0933133B1 true EP0933133B1 (fr) 2002-05-08

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EP99101930A Expired - Lifetime EP0933133B1 (fr) 1998-01-30 1999-01-29 Centrifugeuse et conduite d'alimentation et/ou d'évacuation d'au moins un fluide d'une unité de séparation d'une centrifugeuse vers un site de connexion fixe

Country Status (5)

Country Link
US (1) US6273849B1 (fr)
EP (1) EP0933133B1 (fr)
JP (1) JP4354563B2 (fr)
DE (2) DE19803534C2 (fr)
ES (1) ES2177149T3 (fr)

Cited By (1)

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DE102022114273A1 (de) 2022-06-07 2023-12-07 Fresenius Medical Care Deutschland Gmbh Beschichtung von Hohlfasermembranen in der Medizintechnik

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EP1043071A1 (fr) * 1999-04-09 2000-10-11 Jean-Denis Rochat Appareil de cetrifugation de liquide et utillisation de cet appareil
EP1272277B1 (fr) * 1999-10-28 2010-08-11 Velico Medical, Inc. Centrifugeuse a flux continu et a entrainement circonferentiel
US7008366B1 (en) * 2000-10-27 2006-03-07 Zymequest, Inc. Circumferentially driven continuous flow centrifuge
EP1458488B1 (fr) 2000-11-02 2011-12-21 CaridianBCT, Inc. Dispositifs, systemes et procedes de separation de fluides
DE10129769A1 (de) 2001-06-20 2003-01-09 Fresenius Hemocare Gmbh Schlauchanordnung und Verfahren zu ihrer Herstellung
DE10142744C1 (de) * 2001-08-31 2003-05-22 Fresenius Hemocare Gmbh Zentrifuge
US7211037B2 (en) 2002-03-04 2007-05-01 Therakos, Inc. Apparatus for the continuous separation of biological fluids into components and method of using same
US7479123B2 (en) 2002-03-04 2009-01-20 Therakos, Inc. Method for collecting a desired blood component and performing a photopheresis treatment
WO2006069737A1 (fr) 2004-12-27 2006-07-06 Fresenius Medical Care Deutschland Gmbh Reacteur et unite de reacteur comportant des fibres creuses
WO2008002004A1 (fr) * 2006-06-30 2008-01-03 Medikan Inc. Centrifugeuse et procédé de centrifugation
KR100772970B1 (ko) 2006-06-30 2007-11-02 메디칸(주) 원심분리기 및 원심분리방법

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Publication number Priority date Publication date Assignee Title
DE102022114273A1 (de) 2022-06-07 2023-12-07 Fresenius Medical Care Deutschland Gmbh Beschichtung von Hohlfasermembranen in der Medizintechnik
WO2023237523A1 (fr) 2022-06-07 2023-12-14 Fresenius Medical Care Deutschland Gmbh Revêtement pour membranes à fibres creuses en ingénierie médicale

Also Published As

Publication number Publication date
US6273849B1 (en) 2001-08-14
EP0933133A2 (fr) 1999-08-04
ES2177149T3 (es) 2002-12-01
JP4354563B2 (ja) 2009-10-28
JPH11262684A (ja) 1999-09-28
DE59901371D1 (de) 2002-06-13
DE19803534C2 (de) 1999-11-11
EP0933133A3 (fr) 2000-06-21
DE19803534A1 (de) 1999-08-12

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