EP0933133A2 - Centrifugeuse et conduite d'alimentation et/ou d'évacuation d'au moins un fluide d'une unité de séparation d'une centrifugeuse vers un site de connexion fixe - Google Patents

Centrifugeuse et conduite d'alimentation et/ou d'évacuation d'au moins un fluide d'une unité de séparation d'une centrifugeuse vers un site de connexion fixe Download PDF

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Publication number
EP0933133A2
EP0933133A2 EP99101930A EP99101930A EP0933133A2 EP 0933133 A2 EP0933133 A2 EP 0933133A2 EP 99101930 A EP99101930 A EP 99101930A EP 99101930 A EP99101930 A EP 99101930A EP 0933133 A2 EP0933133 A2 EP 0933133A2
Authority
EP
European Patent Office
Prior art keywords
line
bearing shell
centrifuge
sliding
sliding bush
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP99101930A
Other languages
German (de)
English (en)
Other versions
EP0933133A3 (fr
EP0933133B1 (fr
Inventor
Thomas Scherer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius SE and Co KGaA
Original Assignee
Fresenius SE and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius SE and Co KGaA filed Critical Fresenius SE and Co KGaA
Publication of EP0933133A2 publication Critical patent/EP0933133A2/fr
Publication of EP0933133A3 publication Critical patent/EP0933133A3/fr
Application granted granted Critical
Publication of EP0933133B1 publication Critical patent/EP0933133B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0492—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with fluid conveying umbilicus between stationary and rotary centrifuge parts

Definitions

  • the invention relates to a centrifuge, in particular a sliding seal-free one Flow centrifuge for centrifuging biological fluids and a line for supplying and / or discharging at least one fluid from the Separation unit of such a centrifuge to a stationary Junction.
  • Centrifuges are known in which the biological fluid flows through is centrifuged. The fluid is rotating over a line Centrifuge chamber supplied or removed from the chamber. Because of the Relative movement of the centrifuge chamber and the fixed connection point of the Management, however, turns out to be problematic. To a Avoid twisting the wire, find with conventional Flow centrifuges at the connection points rotating seals Use. Such flow centrifuges allow a high one Speed, but it is disadvantageous that the rotary couplings cause abrasion, Leaks and thus injuries and contamination from in the Components containing fluid can lead.
  • a flow seal free flow seal centrifuge is known from DE-A-32 42 541 known.
  • the line is run by a stationary connection point in a loop around the centrifuge chamber led around.
  • the line is connected to a rotating frame that rotates at half the speed of the centrifuge chamber.
  • Such Flow centrifuge is also known for example from DE-A-42 20 232.
  • the line is relatively large for flow seals without mechanical seals exposed to mechanical stresses with increasing speed solid rising.
  • the line forms under the influence of centrifugal forces an outward sweeping loop, which at the fixed junction and the connection to the separation unit high alternating bending loads occur.
  • the steep entry and exit angle at the connection points leads for additional friction between the connection adapters and the Line, which in turn leads to increased abrasion.
  • the Alternating bending loads and abrasion are the factors that Lifetime of the line or the maximum speed of the centrifuge restrict.
  • Flow seal-free flow seal seals are known, for which Support the pipe bearing.
  • WO95 / 17261 describes a flow centrifuge, the centrifuge tube with a Roller bearing is supported.
  • the roller bearing which consists of an inner and outer Bearing shell with the rolling elements is part of the line.
  • the roller bearing offers the advantage of low bearing friction, which is disadvantageous however, the complex production and thus the relatively high price. This is particularly disadvantageous in that the centrifuge line is a disposable item, which is discarded after use.
  • EP-A-0 112 990 describes a flow centrifuge, the Centrifuge tube between the fixed connection point and the connection the separation unit is supported with two plain bearings.
  • the plain bearings each have an inner and an outer bearing shell with a cylindrical Tread, which are part of the centrifuge tube, which is why the Hose is relatively expensive to manufacture.
  • the sliding surface is large which creates high abrasion and heat. Furthermore shows the Bearing arrangement does not have sufficient axial support to prevent it from sliding out prevents the socket from the sleeve.
  • the invention has for its object to provide a centrifuge whose Line for supplying and / or discharging at least one fluid is exposed to relatively low mechanical stress and can still be manufactured simply and inexpensively as a disposable item. This object is achieved with those specified in claim 1 Characteristics.
  • Another object of the invention is to provide a conduit for feeding and / or removing at least one fluid from or to the separation unit to provide a centrifuge that is simple and inexpensive to use Manufacturing and operating the centrifuge at high speeds Relatively low mechanical stresses on the line allowed. This object is achieved with those specified in claim 8 Characteristics.
  • the bearing shell preferably opened to allow easy insertion of the socket guarantee.
  • the bearing arrangement advantageously has one Snap on, with a longitudinal, slot-shaped opening of the Bearing shell is slightly narrower than the diameter of the bush. But other conventional insertion mechanisms are also conceivable and of the invention includes.
  • the sliding bush can be used as a separate component, preferably as Injection molded part, be formed, which is pushed onto the line and with the Cable is connected in a rotationally fixed manner, for example welded or glued.
  • the sliding bush can also be made in one piece with the line.
  • Under a line for supplying and / or discharging at least one fluid is not just a hose with one or several lumens, but also an arrangement of several single-lumen Hoses understood.
  • the sliding bush consists of a Material that has a lower hardness than the material from which the Bearing shell exists. This has the advantage that the fatigue strength is not replaceable bearing shell is ensured. Wear of the sliding bush is however not disadvantageous insofar as this is part of the one-off Use certain wire is.
  • the sliding bush is preferably made of plastic, preferably of Polyacetal plastic (POM) or Teflon, i.e. a material with a lower abrasion resistance, while the bearing shell is preferably made of metal, especially steel, i.e. a material with a higher abrasion resistance consists. Materials with a low profile are particularly advantageous Coefficient of friction.
  • the sliding surfaces of the bearing shell and sliding bush are preferably processed in such a way that the lowest possible friction losses occur.
  • the sliding bush and the Bearing shell each have a cylindrical section, which is on their Sliding surface connects.
  • the cylindrical sections of the sliding bush and Bearing cups are not a running surface, but only serve as an additional one Centering or adjusting the line. Due to the internal tension of the The sliding surface of the sliding bush is on the sliding surface of the Bearing shell pressed, the cylindrical sections of the sliding bush and Bearing shell are not loaded.
  • the sliding surfaces are advantageous designed such that only a very small circular contact surface arises.
  • the bearing shell is advantageously slotted on one side.
  • the cylindrical section of the sliding bush is inserted, and the sliding surface of the sliding bush is then on the sliding surface of the Bearing shell.
  • the sliding bush is thus centered in the bearing shell.
  • the slide bearing for supporting the line is expediently on the side the rotating rotating frame of the centrifuge, which the Separation unit carries so that the line laterally in an arc around the Separation unit can be guided to the fixed connection point. If the plain bearing is approximately at the level at which the separation unit is arranged, i.e. in the area of the lower third of that of the Separation unit to the fixed line running line is the line is adequately supported. More plain bearings are then available Support of the line is no longer required.
  • Fig. 1 shows a schematic diagram of a flow centrifuge free of mechanical seals for centrifuging a biological fluid, in particular blood, which corresponds in structure and function to the centrifuge described in DE 32 42 541 A1.
  • the flow centrifuge has a rotating frame 1 with a lower la and an upper support plate 1b and two side parts 1c, 1d.
  • the rotating frame 1 is rotatably mounted on a stationary frame 2 about a vertical axis 3 and is driven by a drive unit (not shown in FIG. 1) at a speed n 1 .
  • a separation unit 4 in the form of a cylindrical chamber is rotatably mounted on the upper support plate 1b of the rotating frame 1 about the axis of rotation of the frame.
  • the separation unit can be attached to the top or bottom of the support plate.
  • a flexible Line 6 in which one or more hoses for feeding and discharging the blood or the blood components in the centrifuge chamber 4 or from the Chamber are summarized around the centrifuge chamber 4 and connected to the bottom of the chamber. A twisting of the line is avoided in that the line 6 at half the speed as the Centrifuge chamber is guided around this.
  • Line 6 is part of a disposable, which in addition to Centrifuge chamber 4 still bags for collecting the by centrifugation separated blood components can include.
  • the disposable is in the Centrifuge inserted and discarded after use.
  • Such Hose arrangements are part of the prior art, so that here no further explanation is necessary.
  • a comprehensive collection bag Disposable is for example in DE-A-28 45 364 and DE-A-28 45 399 described.
  • the bearing has a sliding bush sitting on the hose line and one Bearing shell, which is attached to the rotating frame 1.
  • Fig. 2 shows the section that one or more hoses 6a, 6b comprehensive hose line 6, on which the sliding bush 9 sits.
  • From Polyacetal plastic (POM) or Teflon existing sliding bush 9 has one cylindrical section 10, which in a forming the sliding surface conical section 11 merges. At its the conical section opposite end is the cylindrical portion 10 of the slide bush 9 provided with a circumferential approach 12.
  • the sliding bush 9 is fixed to the Hose line 6 glued or welded, which is characterized by its axial Hole extends.
  • the bearing shell 13 has a stepped bore with a cylindrical Section 14 and a conical section 15 which is the same Has conicity as the conical section 11 of the sliding bush 9. At a The bearing shell 13 is slotted. The width of the opening 16 is so dimensioned that the cylindrical portion 10 of the sliding bush 9 laterally in the Bearing shell 13 can be pressed and snapped into the bearing shell is set. The length of the cylindrical portion 10 of the slide bush 9 is slightly larger than the height of the bearing shell 13.
  • FIG. 5 shows the sliding bush 9 of the line 6 inserted in the bearing shell 13.
  • the cylindrical portion 10 is in the lateral opening 16 of the bearing shell 13 inserted, and the conical Section 11 of the sliding bush is on the conical sliding surface 15 of the Bearing shell.
  • the bearing shell is in this way on the rotating frame attached that the sliding surface 15 is above.
  • the sliding bush 9 is in the Bearing shell 13 fixed in the axial and radial directions, the circumferential Approach 12 of the sliding bush slipping out of the bearing shell prevented.
  • FIG. 6 shows the sliding bush 9 'inserted into the bearing shell 13 another embodiment.
  • the sliding surfaces the bearing shell and the sliding bush formed such that there is sliding bush and touch the bearing shell only along a circular line 17. So that's it Minimal contact area.

Landscapes

  • Centrifugal Separators (AREA)
EP99101930A 1998-01-30 1999-01-29 Centrifugeuse et conduite d'alimentation et/ou d'évacuation d'au moins un fluide d'une unité de séparation d'une centrifugeuse vers un site de connexion fixe Expired - Lifetime EP0933133B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19803534 1998-01-30
DE19803534A DE19803534C2 (de) 1998-01-30 1998-01-30 Zentrifuge und Leitung zum Zuführen und/oder Abführen mindestens eines Fluids von der Separationseinheit einer Zentrifuge zu einer ortsfesten Anschlußstelle

Publications (3)

Publication Number Publication Date
EP0933133A2 true EP0933133A2 (fr) 1999-08-04
EP0933133A3 EP0933133A3 (fr) 2000-06-21
EP0933133B1 EP0933133B1 (fr) 2002-05-08

Family

ID=7856094

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99101930A Expired - Lifetime EP0933133B1 (fr) 1998-01-30 1999-01-29 Centrifugeuse et conduite d'alimentation et/ou d'évacuation d'au moins un fluide d'une unité de séparation d'une centrifugeuse vers un site de connexion fixe

Country Status (5)

Country Link
US (1) US6273849B1 (fr)
EP (1) EP0933133B1 (fr)
JP (1) JP4354563B2 (fr)
DE (2) DE19803534C2 (fr)
ES (1) ES2177149T3 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1043071A1 (fr) * 1999-04-09 2000-10-11 Jean-Denis Rochat Appareil de cetrifugation de liquide et utillisation de cet appareil
US7008366B1 (en) * 2000-10-27 2006-03-07 Zymequest, Inc. Circumferentially driven continuous flow centrifuge
WO2001030505A1 (fr) * 1999-10-28 2001-05-03 Zymequest, Inc. Centrifugeuse a flux continu et a entrainement circonferentiel
ATE537907T1 (de) 2000-11-02 2012-01-15 Caridianbct Inc Vorrichtungen, systeme und verfahren zur fluidtrennung
DE10129769A1 (de) 2001-06-20 2003-01-09 Fresenius Hemocare Gmbh Schlauchanordnung und Verfahren zu ihrer Herstellung
DE10142744C1 (de) * 2001-08-31 2003-05-22 Fresenius Hemocare Gmbh Zentrifuge
US7479123B2 (en) 2002-03-04 2009-01-20 Therakos, Inc. Method for collecting a desired blood component and performing a photopheresis treatment
US7211037B2 (en) 2002-03-04 2007-05-01 Therakos, Inc. Apparatus for the continuous separation of biological fluids into components and method of using same
JP5038149B2 (ja) 2004-12-27 2012-10-03 フレゼニウス メディカル ケアー ドイチュラント ゲゼルシャフト ミット ベシュレンクテル ハフツング リアクタユニット及びそのリアクタユニットを備えたリアクタ
WO2008002004A1 (fr) * 2006-06-30 2008-01-03 Medikan Inc. Centrifugeuse et procédé de centrifugation
KR100772970B1 (ko) 2006-06-30 2007-11-02 메디칸(주) 원심분리기 및 원심분리방법
DE102022114273A1 (de) 2022-06-07 2023-12-07 Fresenius Medical Care Deutschland Gmbh Beschichtung von Hohlfasermembranen in der Medizintechnik

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4114802A (en) * 1977-08-29 1978-09-19 Baxter Travenol Laboratories, Inc. Centrifugal apparatus with biaxial connector
US4439178A (en) * 1982-12-30 1984-03-27 International Business Machines Corporation Sealless centrifuge processing channel and tube system
WO1993012887A1 (fr) * 1991-12-23 1993-07-08 Baxter International Inc. Systeme de traitement centrifuge a tiroir d'acces direct

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US4113173A (en) * 1975-03-27 1978-09-12 Baxter Travenol Laboratories, Inc. Centrifugal liquid processing apparatus
US4120448A (en) * 1977-06-08 1978-10-17 Baxter Travenol Laboratories, Inc. Centrifugal liquid processing apparatus with automatically positioned collection port
US4164318A (en) * 1977-10-12 1979-08-14 Baxter Travenol Laboratories, Inc. Centrifugal processing apparatus with reduced-load tubing
US4185629A (en) * 1977-10-18 1980-01-29 Baxter Travenol Laboratories, Inc. Method and apparatus for processing blood
US4146172A (en) * 1977-10-18 1979-03-27 Baxter Travenol Laboratories, Inc. Centrifugal liquid processing system
US4109852A (en) * 1977-10-21 1978-08-29 Baxter Travenol Laboratories, Inc. Centrifugal strain relief sheath for processing apparatus
US4221322A (en) * 1977-10-31 1980-09-09 Union Carbide Corporation Tube guide insert and constraint fittings for compensating rotor
DE3242541A1 (de) * 1982-11-18 1984-05-24 Fresenius AG, 6380 Bad Homburg Zentrifuge
JPS61245855A (ja) * 1985-04-22 1986-11-01 Green Cross Corp:The 連続式血液分離装置
IT1251147B (it) * 1991-08-05 1995-05-04 Ivo Panzani Tubo multilume per separatore centrifugo particolarmente per sangue
DE4220232A1 (de) * 1992-06-20 1993-12-23 Fresenius Ag Zentrifuge
US5514069A (en) * 1993-12-22 1996-05-07 Baxter International Inc. Stress-bearing umbilicus for a compact centrifuge
US5704887A (en) * 1995-06-07 1998-01-06 Baxter International Inc. Easy load umbilicus holder for a centrifuge
US5989177A (en) * 1997-04-11 1999-11-23 Baxter International Inc. Umbilicus gimbal with bearing retainer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4114802A (en) * 1977-08-29 1978-09-19 Baxter Travenol Laboratories, Inc. Centrifugal apparatus with biaxial connector
US4439178A (en) * 1982-12-30 1984-03-27 International Business Machines Corporation Sealless centrifuge processing channel and tube system
WO1993012887A1 (fr) * 1991-12-23 1993-07-08 Baxter International Inc. Systeme de traitement centrifuge a tiroir d'acces direct

Also Published As

Publication number Publication date
JP4354563B2 (ja) 2009-10-28
ES2177149T3 (es) 2002-12-01
DE19803534C2 (de) 1999-11-11
US6273849B1 (en) 2001-08-14
JPH11262684A (ja) 1999-09-28
DE19803534A1 (de) 1999-08-12
EP0933133A3 (fr) 2000-06-21
DE59901371D1 (de) 2002-06-13
EP0933133B1 (fr) 2002-05-08

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