EP1272277B1 - Centrifugeuse a flux continu et a entrainement circonferentiel - Google Patents
Centrifugeuse a flux continu et a entrainement circonferentiel Download PDFInfo
- Publication number
- EP1272277B1 EP1272277B1 EP00973959A EP00973959A EP1272277B1 EP 1272277 B1 EP1272277 B1 EP 1272277B1 EP 00973959 A EP00973959 A EP 00973959A EP 00973959 A EP00973959 A EP 00973959A EP 1272277 B1 EP1272277 B1 EP 1272277B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- set forth
- centrifuge
- support arm
- fluid
- rope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
- B04B2005/0492—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with fluid conveying umbilicus between stationary and rotary centrifuge parts
Definitions
- the present invention relates to centrifuge apparati and more particularly to a centrifuge which works in conjunction with a cassette, rotor or other device having fluid retentive chambers and fluid flow tubing fixedly attached to the axis of the device.
- U.S. Pat. No. 5,665,048 that provides a centrifuge for rotating a fluid retentive housing having fluid input and output tubing fixedly connected to a rotation axis of the fluid retentive housing, the centrifuge comprising: a frame; a first rotatable mechanism having a rotation axis, the fluid retentive housing being coaxially mounted thereon for co-rotation therewith; a second rotatable mechanism having a rotation axis, the first and second rotation mechanism being coaxially mounted on the frame; the second rotatable mechanism having an outer circumferential surface engaged with a drive mechanism, the drive mechanism driving the outer circumferential surface such that the second rotatable mechanism rotates at a selected rotational speed X; the first rotatable mechanism being interconnected to the second rotatable mechanism such that the first rotatable mechanism rotates simultaneously with the second rotatable mechanism at a rotational speed of 2X.
- the second rotatable mechanism includes a seat for holding a distal length of the output tubing which extends from the axis of the fluid retentive housing, wherein the distal length of the output tubing held by the seat is rotated around the rotation axis at the same rotational speed as the second rotatable mechanism.
- US5431814 discloses a rotary filtration apparatus for separating a selected material suspended in a fluid, the apparatus comprising a housing having a selected axis of rotation, the housing being rotatably mounted on a rotation device which rotates the housing about the selected axis of rotation of the housing; the housing sealably enclosing and defining a fluid sealed cavity extending radially outwardly from the axis of the housing; a filter mounted within the cavity of the housing such that the cavity is divided into at least a first fluid retentive input chamber and a second fluid retentive output chamber, the input and output chambers being disposed on opposite sides of the filter; a fluid input line sealably communicating with the fluid input chamber for feeding the material suspended in the fluid into the input chamber under a selected pressure; the filter being selectively permeable to the fluid under the selected pressure and selectively impermeable to the selected material under the selected pressure, the fluid being fed into the input chamber flowing through the filter and into the output chamber under the selected pressure; a fluid output line
- US4865081 discloses a multi-lumen tube arrangement for use in a sliding-seal-free centrifuge comprising a plurality of equilength individual tubes which after a twisting about the longitudinal axis of the tube arrangement are each held fixed free of tension at their ends.
- US2832374 discloses a flexible conduit assembly comprising spaced, pierced flange members, a plurality of flexible tubes secured at each end thereof to one of said flanges in register with an opening therein, said tubes being helically disposed about one another.
- US3646972 discloses information transmitting systems including a plurality of tubular members for pneumatically or hydraulically passing data in pulse form; the tubular members being stranded about a core member which may be tubular or in electric cable form, the tubular members being stranded with a reverse lay to allow such members to be displaced to allow convenient tapping of the tubular members or the core member.
- US4018304 discloses a lubrication system for a centrifugal liquid processing apparatus or the like having a bearing subject to operation in a centrifugal force field includes a reservoir wherein a quantity of fluid lubricant to be applied to the bearing is contained, an accumulator for receiving lubricant from the bearing, a first flow path from the reservoir through the bearing to the accumulator, and a second flow path from the accumulator to the reservoir.
- lubricant is forced by the centrifugal force field to flow along the first flow path from the reservoir, through the bearing and into the accumulator under pressure.
- An orifice is provided in the first flow path to control the flow and pressure of the lubricant within the bearing, and check valves are provided to restrict the lubricant to a circulating route through the bearing.
- US4163519 discloses a 2:1 compensating rotor is used in a continuous-flow centrifuge system, thereby allowing the dynamic loading and unloading of biological suspensions and processing solutions in a "closed” fashion without resort to rotary seals. Improved high speed performance is obtained by utilization of an inherently symmetrical load sharing epicyclic reverted gear train. The effective lifetime of the component gears is increased due to the load sharing feature of the symmetrical epicyclic reverted gear train.
- US4221322 discloses a 2:1 compensating rotor is used in a continuous-flow centrifuge system, thereby allowing the dynamic loading and unloading of biological suspensions and processing solutions in a "closed” fashion without resort to rotary seals. Improved performance is obtained by relieving the mechanical stresses associated with the 2:1 relative motion between rotary components. In zones of high flexural and torsional stress low-friction bearing mounted tube constraint fittings are utilized to minimize tubing loop wear and risk of rupture.
- a tube guide insert is utilized to separate and constrain the discrete fluid-carrying tubes, thereby minimizing abrasion induced by the relative motion between the discrete tubes, as well as minimizing abrasion induced by the relative motion between the discrete tubes and the inner walls of the tube guide assembly.
- US4425112 discloses a flow-through centrifuge free of rotating seals.
- the centrifuge includes a frame having three spaced apart horizontal plates which carry a central bowl, a countershaft and a tube-supporting hollow shaft.
- a motor is arranged to drive the frame at an angular velocity of omega.
- the countershaft is driven by a stationary pulley on the motor and drives the bowl at an angular velocity of 2 omega.
- the motion of the countershaft is also transferred to the tube-supporting hollow shaft by a pulley coupling having a ratio which effects rotation of the hollow shaft, with respect to the frame, at an angular velocity of - omega.
- US4459169 discloses a rotatable processing bowl assembly adapted for mounting in a centrifuge includes an umbilical tubing system formed of a plurality of individual flexible tubes each of which communicates with the processing bowl.
- Each tube has an exterior wall and includes a first portion extending adjacently from the bowl and a second portion which is spaced from the bowl.
- the exterior walls of the tubes are bonded together along their first portions so that the joined exterior walls collectively define the outer periphery of the tubing system along the first portions of the tubes.
- the tubes are also wound to form a predetermined helical pattern along their first portions. This arrangement enhances the tubing system's durability and resistance to fatigue along the bonded together first portions, particularly at higher rotational speeds, and permits direct, facile connection of the free and unattached second portions with external apparatus.
- a centrifuge for rotating a fluid retentive housing as defined in either of claims 12 or 24.
- a multi-lumen rope comprising a plurality of elongated tubes as defined in claim 1.
- FIG. 1 shows a centrifuge apparatus 10, the basic construction of which may be substantially the same as that described in U. S. Pat. No. 5,665,048 .
- the support includes the support arm 50 as well as its guide members 52 and 54.
- This apparatus includes a bag set 20.
- This may also be referred to as aself-contained fluid retentive centrifuge cassette or rotor which is mounted on an inner-rotatable chuck 60.
- the bag set 20, as illustrated in FIGS. 1 and 3 has fluid input and output 70 coaxially and fixedly attached to the axis 40 of the cassette 20. As shown, the cassette is mounted on the chuck 60 such that it's rotation axis is coaxial along common axis 40.
- FIG. 1 actually shows the cutaway section indicating the chuck 60 and a further cutaway section showing a gear 91, part of the aforementioned gear train.
- FIGS. 2 and 3 illustrate the support arm 50.
- the support arm 50 at its central section 56 is fixedly attached to an inner-periphery of the pulley 90.
- the support arm 50 rotates with the Hub 90.
- the support arm 50 is of elongated shape and extends on either side of the centrifuge apparatus 10, as illustrated in FIG. 1 .
- the support arm 50 has an elongated channel 58 which receives the support tube 80.
- the support tube 80 is actually supported in the channel 58 by means of a pair of bearings 82 illustrated in FIGS. 3 and 4 .
- Each of these bearings is accommodated in a corresponding recess 84 at opposite ends of the support arm, as illustrated in FIG. 2 .
- FIG. 1 shows all of these various components in their final assembled state.
- the fluid tubing 70 is shown being guided by a C-shaped guide member 52 into one end of the support tube 80.
- the fluid tubing length 72 extends out of the support tube and into the S-shaped tubing guide 54, as also illustrated in FIG. 1 .
- the fluid tubing is in the form of a multi-lumen rope, embodiments of which will be described hereinafter, the elements of the rope furthest from the access of rotation exert large forces against the supporting surface and consequently produce large frictional forces impeding the twists required to make the slip rope function. It has been found that the following perimeters are desirable for proper operation of a multi-lumen skip rope;
- Parameters 1 and 2 are generally met by selecting relatively small diameter, high durometer thermoplastic tubing. Gluing methods and fixtures were used so that an assembly of at least 9 lumens could be well fabricated with very uniform tubing lay and therefore stiffness and strength. This assembly is of a spiral wrapped construction to improve uniformity.
- FIG. 5A shows a single strand 100A counterclockwise wrap while FIG. 5B shows a multi-strand 100B counterclockwise wrap.
- FIG. 5C shows a single strand 100C clockwise wrap, while FIG. 5D shows a multi-strand 100D clockwise wrap.
- portions of the skip rope progress through curved supports from the access of rotation from the periphery where the rope is guided through very smooth, Teflon, hard coated aluminum parts. Please refer to FIG. 3 and guide members 52 and 54. That in these areas, the co-efficient of friction between the skip rope and the guides is preferably less than 0.2.
- the portion of the skip rope at the maximum radius from the center of rotation is a straight section of various lengths. This section can be very important to the overall torque needed to twist the rope. Indeed the weight of the skip rope assembly (plus fluids if it is filled) is increased by the G-field which may be a multiplier of 1,000 or more.
- this section of skip rope is supported by the aforementioned support tube 80. This is preferably a stiff tube of either metal of structural plastic. The stiff tube is itself supported by the aforementioned low friction bearings 82 allowing full rotation about its own axis. This reduces the torque needed to drive this region of the skip rope assembly to very nearly zero.
- This structure of the support tube and bearings provides an advantageous support for the length of fluid tubing or lumen between the guides 52 and 54. Because the support tube is free to rotate, upon rotation of the members such as 60 and 90 in FIG. 1 , in other words first and second rotation mechanisms, the fluid tubing is free to either rotate with or rotate relative to the support tube.
- FIG.5B Another characteristic of the present invention relates to the construction of the multilumen rope itself, as illustrated, for example, in FIG.5B .
- This may be comprised of a plurality of at least eight lumens 100B about a center lumen 102B.
- the center lumen 102B is straight while the other peripheral lumens wrap, such as illustrated in FIG.5B .
- the center lumen 102B may be an expresser tube while the lumens100B may be processing tubes.
- the tube 102B may be an input tubing and tubings 100B may be output tubings.
- the input and output tubings may be also reversed.
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- Centrifugal Separators (AREA)
- Prostheses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Claims (26)
- Combinaison d'un mécanisme de retenue de fluide à fil multi-lumière, d'un rotor (20), d'un bras de support (50), d'un tube-support (80) et d'un élément de palier (82) composé d'une pluralité de tubes allongés (100B ; 102B), le fil multi-lumière pouvant distribuer un ou plusieurs fluides entre un premier mécanisme de retenue de fluide et un rotor récepteur de fluide entraîné en rotation (20), une extrémité du fil étant fixée au centre du rotor entraîné (20) et l'autre extrémité étant fixée au premier mécanisme de retenue de fluide, le premier mécanisme de retenue de fluide étant installé sur un côté opposé du rotor (20) de telle sorte que le point de fixation de l'autre extrémité du fil est essentiellement coaxial à un axe (40) du rotor (20), caractérisée en ce que ledit bras de support (50) peut entrer en rotation avec le rotor (20), ledit tube-support (80) peut loger à l'intérieur au moins une partie de la longueur distale des tubes allongés (100B ; 102B), et dans laquelle est fourni un élément de guide (52 ; 54) en forme de C ou de S fixé solidement à un côté dudit bras de support (50), et ledit élément de palier (82) soutient en rotation ledit tube-support (80) dans ledit bras de support (50).
- Combinaison selon la revendication 1, dans laquelle ledit bras de support (50) dispose d'un canal permettant de loger ledit tube-support (80), et de renfoncements opposés permettant de loger une paire de paliers comprenant ledit élément de palier.
- Combinaison selon la revendication 1 ou 2, comprenant en outre un autre élément de guide fixé solidement à l'autre extrémité dudit bras de support.
- Combinaison selon la revendication 1, dans laquelle lesdits tubes allongés (100B ; 102B) comprennent au moins un tube enroulé en hélice.
- Combinaison selon la revendication 4, dans laquelle ladite pluralité de tubes comprend un tube d'expression central et une pluralité de tubes de traitement périphériques.
- Combinaison selon la revendication 4 ou 5, dans laquelle ladite hélice est enroulée dans le sens inverse des aiguilles d'une montre.
- Combinaison selon la revendication 4 ou 5, dans laquelle ladite hélice est enroulée dans le sens des aiguilles d'une montre.
- Combinaison selon la revendication 4 ou 5, dans laquelle une extrémité du fil est tordue à droite et l'autre extrémité du fil est tordue à gauche.
- Combinaison selon la revendication 8, dans laquelle une section du fil au milieu n'est pas tordue.
- Combinaison selon l'une quelconque des revendications 4 à 9, dans laquelle le fil est installé de telle sorte que les deux extrémités se tordent jusqu'à un niveau de rigidité en torsion maximal.
- Combinaison selon les revendications 4 à 10, dans laquelle le fil est installé de telle sorte que les deux extrémités se déroulent pour créer des restrictions de débit de fluide minimales dans les tubes.
- Centrifugeuse (10) permettant de faire tourner une enceinte de retenue de fluide (20) de telle sorte qu'une ou plusieurs matières sélectionnées mises en suspension dans un fluide retenu dans l'enceinte sont centrifugées lorsque l'enceinte est en rotation, ladite centrifugeuse (10) comprenant : un premier mécanisme rotatif (60) muni d'un axe de rotation, l'enceinte de retenue de fluide (20) étant installée de manière coaxiale sur le premier mécanisme rotatif afin de permettre une co-rotation avec celui-ci ; un deuxième mécanisme rotatif (90) muni d'un axe de rotation, les premier et deuxième mécanismes rotatifs étant interconnectés de manière coaxiale afin de permettre une co-rotation autour d'un axe commun (40) ; des tubes de fluide (70) connectés à l'axe (40) de l'enceinte de retenue de fluide (20) et présentant une longueur distale (72) s'étendant dans une direction axiale vers l'extérieur de l'enceinte de retenue de fluide ; caractérisée par un bras de support (50) installé sur le deuxième mécanisme rotatif (90), un tube-support (80) permettant de loger à l'intérieur au moins une partie de la longueur distale (72) desdits tubes de fluide (70), un élément de guide en forme de C ou de S (52 ; 54) fixé solidement à un côté dudit bras de support (50) et un élément de palier (82) permettant de soutenir en rotation ledit tube-support (80) dans ledit bras de support, dans laquelle, lors de la rotation desdits premier et deuxième mécanismes rotatifs, lesdits tubes de fluide (70) sont libres soit d'entrer en rotation avec ledit tube-support (80), soit d'entrer en rotation par rapport à celui-ci.
- Centrifugeuse (10) selon la revendication 12, dans laquelle ledit bras de support (50) s'étend des deux côtés desdits premier et deuxième mécanismes rotatifs.
- Centrifugeuse (10) selon la revendication 12, dans laquelle ledit bras de support (50) comprend un canal longitudinal permettant de loger ledit tube-support (80).
- Centrifugeuse (10) selon la revendication 14, dans laquelle ledit bras de support (50) comprend également des renfoncements disposés de manière opposée et permettant de loger ledit élément de palier.
- Centrifugeuse (10) selon la revendication 15, dans laquelle ledit élément de palier (82) se compose d'une paire de paliers disposés de manière opposée, logés dans lesdits renfoncements dudit bras de support (50) et permettant de soutenir des extrémités opposées dudit tube-support (80).
- Centrifugeuse (10) selon la revendication 16, dans laquelle ledit élément de guide en forme de C (52) est un élément de guide d'introduction.
- Centrifugeuse (10) selon la revendication 17, comprenant un élément de guide de sortie en forme de S (54) fixé solidement à une extrémité opposée dudit bras de support.
- Centrifugeuse (10) selon la revendication 12, dans laquelle ledit élément de guide en forme de C (52) est un élément de guide d'introduction.
- Centrifugeuse (10) selon la revendication 12, comprenant un élément de guide de sortie en forme de S (54) fixé solidement à une extrémité opposée dudit bras de support.
- Centrifugeuse (10) selon la revendication 12, dans laquelle lesdits tubes de fluide se composent de tubes en uréthane à coefficient de dureté élevé.
- Centrifugeuse (10) selon la revendication 12, comprenant en outre un autre élément de guide en forme de C ou de S (52 ; 54) au niveau d'une extrémité opposée dudit bras de support.
- Centrifugeuse (10) selon la revendication 12, dans laquelle ladite paire d'éléments de guide est composée d'éléments lisses en aluminium à revêtement dur en téflon.
- Centrifugeuse (10) selon la revendication 12, comprenant en outre : un châssis ; le premier mécanisme rotatif (60) étant muni d'un axe de rotation (40) et d'un premier diamètre ; le deuxième mécanisme rotatif (90) étant muni d'un axe de rotation et d'un deuxième diamètre plus important que le premier diamètre ; les premier et deuxième mécanismes rotatifs étant installés de manière coaxiale sur le châssis ; le deuxième mécanisme rotatif (90) disposant d'une surface circulaire externe (91) en engagement avec un mécanisme d'entraînement, le mécanisme d'entraînement entraînant la surface circulaire externe de telle sorte que le deuxième mécanisme rotatif (90) tourne à une vitesse de rotation sélectionnée X ; le premier mécanisme rotatif (60) étant interconnecté au deuxième mécanisme rotatif (90) de telle sorte que le premier mécanisme rotatif tourne en même temps que le deuxième mécanisme rotatif à une vitesse de rotation de 2X.
- Centrifugeuse (10) selon la revendication 24, dans laquelle ledit bras de support (50) dispose d'un canal permettant de loger ledit tube-support (80), et de renfoncements opposés permettant de loger une paire de paliers comprenant ledit élément de palier.
- Centrifugeuse (10) selon la revendication 25, comprenant en outre un autre élément de guide en forme de S (54) fixé solidement à l'autre extrémité dudit bras de support.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10172379.9A EP2243554A3 (fr) | 1999-10-28 | 2000-10-27 | Tuyau à lumières multiples pour centrifugeuse a flux continu |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16232099P | 1999-10-28 | 1999-10-28 | |
US162320P | 1999-10-28 | ||
PCT/US2000/029705 WO2001030505A1 (fr) | 1999-10-28 | 2000-10-27 | Centrifugeuse a flux continu et a entrainement circonferentiel |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10172379.9A Division EP2243554A3 (fr) | 1999-10-28 | 2000-10-27 | Tuyau à lumières multiples pour centrifugeuse a flux continu |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1272277A1 EP1272277A1 (fr) | 2003-01-08 |
EP1272277A4 EP1272277A4 (fr) | 2005-06-15 |
EP1272277B1 true EP1272277B1 (fr) | 2010-08-11 |
Family
ID=22585131
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00973959A Expired - Lifetime EP1272277B1 (fr) | 1999-10-28 | 2000-10-27 | Centrifugeuse a flux continu et a entrainement circonferentiel |
EP10172379.9A Withdrawn EP2243554A3 (fr) | 1999-10-28 | 2000-10-27 | Tuyau à lumières multiples pour centrifugeuse a flux continu |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10172379.9A Withdrawn EP2243554A3 (fr) | 1999-10-28 | 2000-10-27 | Tuyau à lumières multiples pour centrifugeuse a flux continu |
Country Status (7)
Country | Link |
---|---|
EP (2) | EP1272277B1 (fr) |
JP (2) | JP5147154B2 (fr) |
AT (1) | ATE477057T1 (fr) |
DE (1) | DE60044823D1 (fr) |
ES (1) | ES2349888T3 (fr) |
HK (1) | HK1053804A1 (fr) |
WO (1) | WO2001030505A1 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7001322B2 (en) * | 2000-10-04 | 2006-02-21 | Zymequest, Inc. | Multiple processing chamber set and use thereof |
DE10129769A1 (de) * | 2001-06-20 | 2003-01-09 | Fresenius Hemocare Gmbh | Schlauchanordnung und Verfahren zu ihrer Herstellung |
US7651457B2 (en) * | 2003-08-04 | 2010-01-26 | Zymequest, Inc. | Expandable processing and expression chamber |
WO2007014222A2 (fr) * | 2005-07-26 | 2007-02-01 | Zymequest, Inc. | Dispositif de traitement du sang et systemes et methodes associes |
CN109759247B (zh) * | 2019-03-20 | 2021-04-02 | 梁山新翔新材料有限公司 | 一种台式离心机 |
Family Cites Families (20)
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US2832374A (en) * | 1955-03-10 | 1958-04-29 | Breeze Corp | Flexible tube assemblies |
US3586413A (en) | 1969-03-25 | 1971-06-22 | Dale A Adams | Apparatus for providing energy communication between a moving and a stationary terminal |
US3646972A (en) * | 1970-02-27 | 1972-03-07 | Kabel Metallwerke Ghh | Multitubing system |
US4018304A (en) | 1975-10-08 | 1977-04-19 | Baxter Travenol Laboratories, Inc. | Lubrication system for a centrifugal liquid processing system |
US4425112A (en) * | 1976-02-25 | 1984-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Flow-through centrifuge |
US4419089A (en) | 1977-07-19 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Blood cell separator |
US4221322A (en) | 1977-10-31 | 1980-09-09 | Union Carbide Corporation | Tube guide insert and constraint fittings for compensating rotor |
US4163519A (en) * | 1977-11-01 | 1979-08-07 | Union Carbide Corporation | Compensating rotor |
US4287061A (en) * | 1978-10-26 | 1981-09-01 | National Research Development Corporation | Rotating coil centrifuge |
US4216770A (en) | 1979-02-09 | 1980-08-12 | Baxter Travenol Laboratories, Inc. | Sickle cell therapeutic treatment |
JPS5680247U (fr) * | 1979-11-27 | 1981-06-29 | ||
US4389206A (en) * | 1980-10-09 | 1983-06-21 | Baxter Travenol Laboratories, Inc. | Centrifugal processing apparatus and rotatable processing bowl apparatus |
US4372484A (en) * | 1981-02-04 | 1983-02-08 | Gambro Ab | Device for the separation of a liquid, especially whole blood |
US4459169A (en) * | 1981-03-16 | 1984-07-10 | Baxter Travenol Laboratories, Inc. | Rotatable bowl assembly for centrifugal processing apparatus having a bonded and prewound umbilical system |
JPS61245855A (ja) * | 1985-04-22 | 1986-11-01 | Green Cross Corp:The | 連続式血液分離装置 |
DE3632241A1 (de) * | 1986-09-23 | 1988-06-09 | Fresenius Ag | Mehrlumige schlauchanordnung sowie verfahren zu ihrer herstellung |
JPH0790184B2 (ja) * | 1987-07-27 | 1995-10-04 | 株式会社ミドリ十字 | 遠心分離容器組立体 |
US5431814A (en) | 1993-10-22 | 1995-07-11 | Jorgensen; Glen | Centrifugal filter apparatus and method |
US5665048A (en) * | 1995-12-22 | 1997-09-09 | Jorgensen; Glen | Circumferentially driven continuous flow centrifuge |
DE19803534C2 (de) * | 1998-01-30 | 1999-11-11 | Fresenius Ag | Zentrifuge und Leitung zum Zuführen und/oder Abführen mindestens eines Fluids von der Separationseinheit einer Zentrifuge zu einer ortsfesten Anschlußstelle |
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2000
- 2000-10-27 EP EP00973959A patent/EP1272277B1/fr not_active Expired - Lifetime
- 2000-10-27 JP JP2001532909A patent/JP5147154B2/ja not_active Expired - Fee Related
- 2000-10-27 DE DE60044823T patent/DE60044823D1/de not_active Expired - Lifetime
- 2000-10-27 WO PCT/US2000/029705 patent/WO2001030505A1/fr active Application Filing
- 2000-10-27 EP EP10172379.9A patent/EP2243554A3/fr not_active Withdrawn
- 2000-10-27 ES ES00973959T patent/ES2349888T3/es not_active Expired - Lifetime
- 2000-10-27 AT AT00973959T patent/ATE477057T1/de not_active IP Right Cessation
-
2003
- 2003-07-02 HK HK03104730.4A patent/HK1053804A1/zh unknown
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2010
- 2010-07-21 JP JP2010164388A patent/JP2010284651A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP2243554A2 (fr) | 2010-10-27 |
ES2349888T3 (es) | 2011-01-12 |
JP2003514645A (ja) | 2003-04-22 |
ATE477057T1 (de) | 2010-08-15 |
EP1272277A4 (fr) | 2005-06-15 |
EP1272277A1 (fr) | 2003-01-08 |
JP2010284651A (ja) | 2010-12-24 |
WO2001030505A1 (fr) | 2001-05-03 |
HK1053804A1 (zh) | 2003-11-07 |
EP2243554A3 (fr) | 2014-01-15 |
JP5147154B2 (ja) | 2013-02-20 |
DE60044823D1 (de) | 2010-09-23 |
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