EP1272277B1 - Am umfang angetriebene durchflusszentrifuge - Google Patents

Am umfang angetriebene durchflusszentrifuge Download PDF

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Publication number
EP1272277B1
EP1272277B1 EP00973959A EP00973959A EP1272277B1 EP 1272277 B1 EP1272277 B1 EP 1272277B1 EP 00973959 A EP00973959 A EP 00973959A EP 00973959 A EP00973959 A EP 00973959A EP 1272277 B1 EP1272277 B1 EP 1272277B1
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EP
European Patent Office
Prior art keywords
set forth
centrifuge
support arm
fluid
rope
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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EP00973959A
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English (en)
French (fr)
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EP1272277A1 (de
EP1272277A4 (de
Inventor
William Aitkenhead
Glen Jorgensen
Robert L. Standley
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ZymeQuest Inc
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ZymeQuest Inc
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Priority to EP10172379.9A priority Critical patent/EP2243554A3/de
Publication of EP1272277A1 publication Critical patent/EP1272277A1/de
Publication of EP1272277A4 publication Critical patent/EP1272277A4/de
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0492—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with fluid conveying umbilicus between stationary and rotary centrifuge parts

Definitions

  • the present invention relates to centrifuge apparati and more particularly to a centrifuge which works in conjunction with a cassette, rotor or other device having fluid retentive chambers and fluid flow tubing fixedly attached to the axis of the device.
  • U.S. Pat. No. 5,665,048 that provides a centrifuge for rotating a fluid retentive housing having fluid input and output tubing fixedly connected to a rotation axis of the fluid retentive housing, the centrifuge comprising: a frame; a first rotatable mechanism having a rotation axis, the fluid retentive housing being coaxially mounted thereon for co-rotation therewith; a second rotatable mechanism having a rotation axis, the first and second rotation mechanism being coaxially mounted on the frame; the second rotatable mechanism having an outer circumferential surface engaged with a drive mechanism, the drive mechanism driving the outer circumferential surface such that the second rotatable mechanism rotates at a selected rotational speed X; the first rotatable mechanism being interconnected to the second rotatable mechanism such that the first rotatable mechanism rotates simultaneously with the second rotatable mechanism at a rotational speed of 2X.
  • the second rotatable mechanism includes a seat for holding a distal length of the output tubing which extends from the axis of the fluid retentive housing, wherein the distal length of the output tubing held by the seat is rotated around the rotation axis at the same rotational speed as the second rotatable mechanism.
  • US5431814 discloses a rotary filtration apparatus for separating a selected material suspended in a fluid, the apparatus comprising a housing having a selected axis of rotation, the housing being rotatably mounted on a rotation device which rotates the housing about the selected axis of rotation of the housing; the housing sealably enclosing and defining a fluid sealed cavity extending radially outwardly from the axis of the housing; a filter mounted within the cavity of the housing such that the cavity is divided into at least a first fluid retentive input chamber and a second fluid retentive output chamber, the input and output chambers being disposed on opposite sides of the filter; a fluid input line sealably communicating with the fluid input chamber for feeding the material suspended in the fluid into the input chamber under a selected pressure; the filter being selectively permeable to the fluid under the selected pressure and selectively impermeable to the selected material under the selected pressure, the fluid being fed into the input chamber flowing through the filter and into the output chamber under the selected pressure; a fluid output line
  • US4865081 discloses a multi-lumen tube arrangement for use in a sliding-seal-free centrifuge comprising a plurality of equilength individual tubes which after a twisting about the longitudinal axis of the tube arrangement are each held fixed free of tension at their ends.
  • US2832374 discloses a flexible conduit assembly comprising spaced, pierced flange members, a plurality of flexible tubes secured at each end thereof to one of said flanges in register with an opening therein, said tubes being helically disposed about one another.
  • US3646972 discloses information transmitting systems including a plurality of tubular members for pneumatically or hydraulically passing data in pulse form; the tubular members being stranded about a core member which may be tubular or in electric cable form, the tubular members being stranded with a reverse lay to allow such members to be displaced to allow convenient tapping of the tubular members or the core member.
  • US4018304 discloses a lubrication system for a centrifugal liquid processing apparatus or the like having a bearing subject to operation in a centrifugal force field includes a reservoir wherein a quantity of fluid lubricant to be applied to the bearing is contained, an accumulator for receiving lubricant from the bearing, a first flow path from the reservoir through the bearing to the accumulator, and a second flow path from the accumulator to the reservoir.
  • lubricant is forced by the centrifugal force field to flow along the first flow path from the reservoir, through the bearing and into the accumulator under pressure.
  • An orifice is provided in the first flow path to control the flow and pressure of the lubricant within the bearing, and check valves are provided to restrict the lubricant to a circulating route through the bearing.
  • US4163519 discloses a 2:1 compensating rotor is used in a continuous-flow centrifuge system, thereby allowing the dynamic loading and unloading of biological suspensions and processing solutions in a "closed” fashion without resort to rotary seals. Improved high speed performance is obtained by utilization of an inherently symmetrical load sharing epicyclic reverted gear train. The effective lifetime of the component gears is increased due to the load sharing feature of the symmetrical epicyclic reverted gear train.
  • US4221322 discloses a 2:1 compensating rotor is used in a continuous-flow centrifuge system, thereby allowing the dynamic loading and unloading of biological suspensions and processing solutions in a "closed” fashion without resort to rotary seals. Improved performance is obtained by relieving the mechanical stresses associated with the 2:1 relative motion between rotary components. In zones of high flexural and torsional stress low-friction bearing mounted tube constraint fittings are utilized to minimize tubing loop wear and risk of rupture.
  • a tube guide insert is utilized to separate and constrain the discrete fluid-carrying tubes, thereby minimizing abrasion induced by the relative motion between the discrete tubes, as well as minimizing abrasion induced by the relative motion between the discrete tubes and the inner walls of the tube guide assembly.
  • US4425112 discloses a flow-through centrifuge free of rotating seals.
  • the centrifuge includes a frame having three spaced apart horizontal plates which carry a central bowl, a countershaft and a tube-supporting hollow shaft.
  • a motor is arranged to drive the frame at an angular velocity of omega.
  • the countershaft is driven by a stationary pulley on the motor and drives the bowl at an angular velocity of 2 omega.
  • the motion of the countershaft is also transferred to the tube-supporting hollow shaft by a pulley coupling having a ratio which effects rotation of the hollow shaft, with respect to the frame, at an angular velocity of - omega.
  • US4459169 discloses a rotatable processing bowl assembly adapted for mounting in a centrifuge includes an umbilical tubing system formed of a plurality of individual flexible tubes each of which communicates with the processing bowl.
  • Each tube has an exterior wall and includes a first portion extending adjacently from the bowl and a second portion which is spaced from the bowl.
  • the exterior walls of the tubes are bonded together along their first portions so that the joined exterior walls collectively define the outer periphery of the tubing system along the first portions of the tubes.
  • the tubes are also wound to form a predetermined helical pattern along their first portions. This arrangement enhances the tubing system's durability and resistance to fatigue along the bonded together first portions, particularly at higher rotational speeds, and permits direct, facile connection of the free and unattached second portions with external apparatus.
  • a centrifuge for rotating a fluid retentive housing as defined in either of claims 12 or 24.
  • a multi-lumen rope comprising a plurality of elongated tubes as defined in claim 1.
  • FIG. 1 shows a centrifuge apparatus 10, the basic construction of which may be substantially the same as that described in U. S. Pat. No. 5,665,048 .
  • the support includes the support arm 50 as well as its guide members 52 and 54.
  • This apparatus includes a bag set 20.
  • This may also be referred to as aself-contained fluid retentive centrifuge cassette or rotor which is mounted on an inner-rotatable chuck 60.
  • the bag set 20, as illustrated in FIGS. 1 and 3 has fluid input and output 70 coaxially and fixedly attached to the axis 40 of the cassette 20. As shown, the cassette is mounted on the chuck 60 such that it's rotation axis is coaxial along common axis 40.
  • FIG. 1 actually shows the cutaway section indicating the chuck 60 and a further cutaway section showing a gear 91, part of the aforementioned gear train.
  • FIGS. 2 and 3 illustrate the support arm 50.
  • the support arm 50 at its central section 56 is fixedly attached to an inner-periphery of the pulley 90.
  • the support arm 50 rotates with the Hub 90.
  • the support arm 50 is of elongated shape and extends on either side of the centrifuge apparatus 10, as illustrated in FIG. 1 .
  • the support arm 50 has an elongated channel 58 which receives the support tube 80.
  • the support tube 80 is actually supported in the channel 58 by means of a pair of bearings 82 illustrated in FIGS. 3 and 4 .
  • Each of these bearings is accommodated in a corresponding recess 84 at opposite ends of the support arm, as illustrated in FIG. 2 .
  • FIG. 1 shows all of these various components in their final assembled state.
  • the fluid tubing 70 is shown being guided by a C-shaped guide member 52 into one end of the support tube 80.
  • the fluid tubing length 72 extends out of the support tube and into the S-shaped tubing guide 54, as also illustrated in FIG. 1 .
  • the fluid tubing is in the form of a multi-lumen rope, embodiments of which will be described hereinafter, the elements of the rope furthest from the access of rotation exert large forces against the supporting surface and consequently produce large frictional forces impeding the twists required to make the slip rope function. It has been found that the following perimeters are desirable for proper operation of a multi-lumen skip rope;
  • Parameters 1 and 2 are generally met by selecting relatively small diameter, high durometer thermoplastic tubing. Gluing methods and fixtures were used so that an assembly of at least 9 lumens could be well fabricated with very uniform tubing lay and therefore stiffness and strength. This assembly is of a spiral wrapped construction to improve uniformity.
  • FIG. 5A shows a single strand 100A counterclockwise wrap while FIG. 5B shows a multi-strand 100B counterclockwise wrap.
  • FIG. 5C shows a single strand 100C clockwise wrap, while FIG. 5D shows a multi-strand 100D clockwise wrap.
  • portions of the skip rope progress through curved supports from the access of rotation from the periphery where the rope is guided through very smooth, Teflon, hard coated aluminum parts. Please refer to FIG. 3 and guide members 52 and 54. That in these areas, the co-efficient of friction between the skip rope and the guides is preferably less than 0.2.
  • the portion of the skip rope at the maximum radius from the center of rotation is a straight section of various lengths. This section can be very important to the overall torque needed to twist the rope. Indeed the weight of the skip rope assembly (plus fluids if it is filled) is increased by the G-field which may be a multiplier of 1,000 or more.
  • this section of skip rope is supported by the aforementioned support tube 80. This is preferably a stiff tube of either metal of structural plastic. The stiff tube is itself supported by the aforementioned low friction bearings 82 allowing full rotation about its own axis. This reduces the torque needed to drive this region of the skip rope assembly to very nearly zero.
  • This structure of the support tube and bearings provides an advantageous support for the length of fluid tubing or lumen between the guides 52 and 54. Because the support tube is free to rotate, upon rotation of the members such as 60 and 90 in FIG. 1 , in other words first and second rotation mechanisms, the fluid tubing is free to either rotate with or rotate relative to the support tube.
  • FIG.5B Another characteristic of the present invention relates to the construction of the multilumen rope itself, as illustrated, for example, in FIG.5B .
  • This may be comprised of a plurality of at least eight lumens 100B about a center lumen 102B.
  • the center lumen 102B is straight while the other peripheral lumens wrap, such as illustrated in FIG.5B .
  • the center lumen 102B may be an expresser tube while the lumens100B may be processing tubes.
  • the tube 102B may be an input tubing and tubings 100B may be output tubings.
  • the input and output tubings may be also reversed.

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  • Centrifugal Separators (AREA)
  • Prostheses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (26)

  1. Kombination aus einem Multi-Lumen-Seil, einem Fluidhaltemechanismus, einem Rotor (20), einem Stützarm (50), einem Stützrohr (80) und einem Lagerelement (82), wobei das Multi-Lumen-Seil eine Vielzahl von länglichen Rohren (100B; 102B) umfasst, die für die Zufuhr eines oder mehrerer Fluide zwischen einem ersten Fluidhaltemechanismus und einem drehbar angetriebenen, Fluid empfangenden Rotor (20) geeignet ist, wobei ein Ende des Seils an der Mitte des angetriebenen Rotors (20) und das andere Ende des Seils an dem ersten Fluidhaltemechanismus angebracht ist, der erste Fluidhaltemechanismus an einer gegenüberliegenden Seite des Rotors (20) befestigt ist, so dass der Befestigungspunkt des anderen Endes des Seils im Wesentlichen koaxial zu der Achse (40) des Rotors (20) verläuft, dadurch gekennzeichnet dass der Stützarm (50) mit dem Rotor (20) drehbar ist, das Stützrohr (80) mindestens einen Teil der distalen Länge der länglichen Rohre (100B; 102B) dort hindurch empfangen kann, und wobei ein Führungselement bereitgestellt ist, das ein C-förmiges oder S-förmiges Führungselement (52; 54) ist, das an einer Seite des Stützarms (50) befestigt ist, und das Lagerelement (82) das Stützrohr (80) in dem Stützarm (50) drehbar stützt.
  2. Kombination nach Anspruch 1, wobei der Stützarm (50) einen Kanal für den Empfang des Stützrohrs (80) sowie gegenüberliegende Vertiefungen für den Empfang eines Paars Lager, die das Lagerelement umfassen, aufweist.
  3. Kombination nach Anspruch 1 oder 2, die des Weiteren ein anderes Führungselement umfasst, das an dem anderen Ende des Stützarms befestigt ist.
  4. Kombination nach Anspruch 1, wobei die länglichen Rohre (100B; 102B) mindestens ein Rohr umfassen, das als spiralförmige Umwicklung angeordnet ist.
  5. Kombination nach Anspruch 4, wobei die Vielzahl der Rohre ein zentrales Ausdrückrohr und eine Vielzahl von umfänglichen Verarbeitungsrohren umfasst.
  6. Kombination nach Anspruch 4 oder 5, wobei die spiralförmige Umwicklung gegen den Uhrzeigersinn angeordnet ist.
  7. Kombination nach Anspruch 4 oder 5, wobei die spiralförmige Umwicklung im Uhrzeigersinn angeordnet ist.
  8. Kombination nach Anspruch 4 oder 5, wobei ein Ende des Seils einen Rechtsdrall und das andere Ende des Seils einen Linksdrall aufweist.
  9. Kombination nach Anspruch 8, wobei ein Abschnitt des Seils in der Mitte keinen Drall aufweist.
  10. Kombination nach Anspruch 4 bis 9, wobei das Seil so installiert ist, dass beide Enden verdrallt sind, um eine maximale Torsionssteifigkeit zu ergeben.
  11. Kombination nach Anspruch 4 bis 10, wobei das Seil so installiert ist, dass beide Enden nicht verdrallt sind, um in den Rohren eine minimale Einschränkung der Fluidströmung zu erzeugen.
  12. Zentrifuge (10) zum Rotieren eines Fluid enthaltenden Gehäuses (20), so dass ein oder mehrere ausgewählte Materialien, die in einem Fluid suspendiert sind, das in dem Gehäuse enthalten ist, bei Rotation des Gehäuses zentrifugiert werden, wobei die Zentrifuge (10) Folgendes umfasst: einen ersten rotierbaren Mechanismus (60), der eine Rotationsachse aufweist, wobei das Fluid enthaltende Gehäuse (20) an dem ersten rotierbaren Mechanismus koaxial angebracht ist, um zusammen mit diesem zu rotieren; einen zweiten rotierbaren Mechanismus (90), der eine Rotationsachse aufweist, wobei der erste und zweite rotierbare Mechanismus koaxial miteinander verbunden sind, um zusammen um eine gemeinsame Achse (40) zu rotieren; eine Fluidleitung (70), die mit der Achse (40) des Fluid enthaltenden Gehäuses (20) verbunden ist und eine distale Länge (72) aufweist, die sich axial auswärts von dem Fluid enthaltenden Gehäuse erstreckt; gekennzeichnet durch einen Stützarm (50), der an dem zweiten rotierbaren Mechanismus (90) angebracht ist, ein Stützrohr (80) für den Empfang mindestens eines Teils der distalen Länge (72) der Fluidleitung (70) dort hindurch, ein Führungselement, wobei das Führungselement ein C-förmiges oder S-förmiges Führungselement (52; 54) ist, das an einer Seite des Stützarms (50) befestigt ist, und ein Lagerelement (82), das das Stützrohr (80) in dem Stützarm drehbar stützt, wobei die Fluidleitung (70) bei Drehung des ersten und zweiten Rotationsmechanismus entweder mit oder im Verhältnis zu dem Stützrohr (80) frei rotieren kann.
  13. Zentrifuge (10) nach Anspruch 12, wobei sich der Stützarm (50) zu beiden Seiten des ersten und zweiten rotierbaren Mechanismus erstreckt.
  14. Zentrifuge (10) nach Anspruch 12, wobei der Stützarm (50) einen Längskanal für den Empfang des Stützrohrs (80) umfasst.
  15. Zentrifuge (10) nach Anspruch 14, wobei der Stützarm (50) ebenfalls gegenüberliegend angeordnete Vertiefungen für den Empfang des Lagerelements umfasst.
  16. Zentrifuge (10) nach Anspruch 15, wobei das Lagerelement (82) ein Paar gegenüberliegend angeordnete Lager umfasst, die in den Vertiefungen des Stützarms (50) aufgenommen werden, um gegenüberliegende Enden des Stützrohrs (80) zu stützen.
  17. Zentrifuge (10) nach Anspruch 16, wobei das C-förmige Führungselement (52) ein Eingangsführungselement ist.
  18. Zentrifuge (10) nach Anspruch 17, die ein S-förmiges Ausgangsführungselement (54) umfasst, das an einem gegenüberliegenden Ende des Stützarms befestigt ist.
  19. Zentrifuge (10) nach Anspruch 12, wobei das C-förmige Führungselement (52) ein Eingangsführungselement ist.
  20. Zentrifuge (10) nach Anspruch 12, die ein S-förmiges Ausgangsführungselement (54) umfasst, das an einem gegenüberliegenden Ende des Stützarms befestigt ist.
  21. Zentrifuge (10) nach Anspruch 12, wobei die Fluidleitung eine Urethanleitung mit einem hohen Härtegrad umfasst.
  22. Zentrifuge (10) nach Anspruch 12, die des Weiteren ein anderes C-förmiges oder S-förmiges Führungselement (52; 54) an einem gegenüberliegenden Ende des Stützarms umfasst.
  23. Zentrifuge (10) nach Anspruch 12, wobei das Paar Führungselemente jeweils ein glattes hartbeschichtetes Teflon-Aluminiumelement ist.
  24. Zentrifuge (10) nach Anspruch 12, die des Weiteren Folgendes umfasst: einen Rahmen, wobei der erste rotierbare Mechanismus (60) eine Rotationsachse (40) und einen ersten Durchmesser aufweist, der zweite rotierbare Mechanismus (90) eine Rotationsachse und einen zweiten Durchmesser aufweist, der größer als der erste Durchmesser ist, der erste und zweite rotierbare Mechanismus koaxial an dem Rahmen angebracht sind, der zweite rotierbare Mechanismus (90) eine äußere Umfangsfläche (91) aufweist, die in einen Antriebsmechanismus eingreift, wobei der Antriebsmechanismus die äußere Umfangsfläche so antreibt, dass sich der zweite rotierbare Mechanismus (90) mit einer ausgewählten Drehzahl X dreht, wobei der erste rotierbare Mechanismus (60) so mit dem zweiten rotierbaren Mechanismus (90) verbunden ist, dass sich der erste rotierbare Mechanismus gleichzeitig mit dem zweiten rotierbaren Mechanismus mit einer Drehzahl 2X dreht.
  25. Zentrifuge (10) nach Anspruch 24, wobei der Stützarm (50) Folgendes aufweist: einen Kanal für den Empfang des Stützrohrs (80) und gegenüberliegende Vertiefungen für den Empfang eines Paars Lager, die das Lagerelement umfassen.
  26. Zentrifuge (10) nach Anspruch 25, die des Weiteren ein anderes S-förmiges Führungselement (54) umfasst, das an dem anderen Ende des Stützarms befestigt ist.
EP00973959A 1999-10-28 2000-10-27 Am umfang angetriebene durchflusszentrifuge Expired - Lifetime EP1272277B1 (de)

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EP10172379.9A EP2243554A3 (de) 1999-10-28 2000-10-27 Multilumenschlauch für Durchflusszentrifuge

Applications Claiming Priority (3)

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US16232099P 1999-10-28 1999-10-28
US162320P 1999-10-28
PCT/US2000/029705 WO2001030505A1 (en) 1999-10-28 2000-10-27 Circumferentially driven continuous flow centrifuge

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EP1272277A1 EP1272277A1 (de) 2003-01-08
EP1272277A4 EP1272277A4 (de) 2005-06-15
EP1272277B1 true EP1272277B1 (de) 2010-08-11

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EP10172379.9A Withdrawn EP2243554A3 (de) 1999-10-28 2000-10-27 Multilumenschlauch für Durchflusszentrifuge

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EP (2) EP1272277B1 (de)
JP (2) JP5147154B2 (de)
AT (1) ATE477057T1 (de)
DE (1) DE60044823D1 (de)
ES (1) ES2349888T3 (de)
HK (1) HK1053804A1 (de)
WO (1) WO2001030505A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7001322B2 (en) * 2000-10-04 2006-02-21 Zymequest, Inc. Multiple processing chamber set and use thereof
DE10129769A1 (de) 2001-06-20 2003-01-09 Fresenius Hemocare Gmbh Schlauchanordnung und Verfahren zu ihrer Herstellung
US7651457B2 (en) * 2003-08-04 2010-01-26 Zymequest, Inc. Expandable processing and expression chamber
WO2007014222A2 (en) * 2005-07-26 2007-02-01 Zymequest, Inc. Blood processing device and associated systems and methods
CN109759247B (zh) * 2019-03-20 2021-04-02 梁山新翔新材料有限公司 一种台式离心机

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2832374A (en) 1955-03-10 1958-04-29 Breeze Corp Flexible tube assemblies
US3586413A (en) 1969-03-25 1971-06-22 Dale A Adams Apparatus for providing energy communication between a moving and a stationary terminal
US3646972A (en) * 1970-02-27 1972-03-07 Kabel Metallwerke Ghh Multitubing system
US4018304A (en) 1975-10-08 1977-04-19 Baxter Travenol Laboratories, Inc. Lubrication system for a centrifugal liquid processing system
US4425112A (en) * 1976-02-25 1984-01-10 The United States Of America As Represented By The Department Of Health And Human Services Flow-through centrifuge
US4419089A (en) 1977-07-19 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Blood cell separator
US4221322A (en) 1977-10-31 1980-09-09 Union Carbide Corporation Tube guide insert and constraint fittings for compensating rotor
US4163519A (en) * 1977-11-01 1979-08-07 Union Carbide Corporation Compensating rotor
US4287061A (en) * 1978-10-26 1981-09-01 National Research Development Corporation Rotating coil centrifuge
US4216770A (en) 1979-02-09 1980-08-12 Baxter Travenol Laboratories, Inc. Sickle cell therapeutic treatment
JPS5680247U (de) * 1979-11-27 1981-06-29
US4389206A (en) * 1980-10-09 1983-06-21 Baxter Travenol Laboratories, Inc. Centrifugal processing apparatus and rotatable processing bowl apparatus
US4372484A (en) * 1981-02-04 1983-02-08 Gambro Ab Device for the separation of a liquid, especially whole blood
US4459169A (en) * 1981-03-16 1984-07-10 Baxter Travenol Laboratories, Inc. Rotatable bowl assembly for centrifugal processing apparatus having a bonded and prewound umbilical system
JPS61245855A (ja) * 1985-04-22 1986-11-01 Green Cross Corp:The 連続式血液分離装置
DE3632241A1 (de) * 1986-09-23 1988-06-09 Fresenius Ag Mehrlumige schlauchanordnung sowie verfahren zu ihrer herstellung
JPH0790184B2 (ja) * 1987-07-27 1995-10-04 株式会社ミドリ十字 遠心分離容器組立体
US5431814A (en) 1993-10-22 1995-07-11 Jorgensen; Glen Centrifugal filter apparatus and method
US5665048A (en) 1995-12-22 1997-09-09 Jorgensen; Glen Circumferentially driven continuous flow centrifuge
DE19803534C2 (de) * 1998-01-30 1999-11-11 Fresenius Ag Zentrifuge und Leitung zum Zuführen und/oder Abführen mindestens eines Fluids von der Separationseinheit einer Zentrifuge zu einer ortsfesten Anschlußstelle

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EP1272277A1 (de) 2003-01-08
EP1272277A4 (de) 2005-06-15
ATE477057T1 (de) 2010-08-15
JP5147154B2 (ja) 2013-02-20
EP2243554A2 (de) 2010-10-27
ES2349888T3 (es) 2011-01-12
HK1053804A1 (zh) 2003-11-07
DE60044823D1 (de) 2010-09-23
EP2243554A3 (de) 2014-01-15
JP2010284651A (ja) 2010-12-24
JP2003514645A (ja) 2003-04-22
WO2001030505A1 (en) 2001-05-03

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