EP2243554A2 - Tuyau à lumières multiples pour centrifugeuse a flux continu - Google Patents
Tuyau à lumières multiples pour centrifugeuse a flux continu Download PDFInfo
- Publication number
- EP2243554A2 EP2243554A2 EP10172379A EP10172379A EP2243554A2 EP 2243554 A2 EP2243554 A2 EP 2243554A2 EP 10172379 A EP10172379 A EP 10172379A EP 10172379 A EP10172379 A EP 10172379A EP 2243554 A2 EP2243554 A2 EP 2243554A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- rope
- fluid
- lumen
- set forth
- tubing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
- B04B2005/0492—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with fluid conveying umbilicus between stationary and rotary centrifuge parts
Definitions
- the present invention relates to centrifuge apparati and more particularly to a centrifuge which works in conjunction with a cassette, rotor or other device having fluid retentive chambers and fluid flow tubing fixedly attached to the axis of the device.
- U.S. Pat. No. 5,665,048 that provides a centrifuge for rotating a fluid retentive housing having fluid input and output tubing fixedly connected to a rotation axis of the fluid retentive housing, the centrifuge comprising: a frame; a first rotatable mechanism having a rotation axis, the fluid retentive housing being coaxially mounted thereon for co-rotation therewith; a second rotatable mechanism having a rotation axis, the first and second rotation mechanism being coaxially mounted on the frame; the second rotatable mechanism having an outer circumferential surface engaged with a drive mechanism, the drive mechanism driving the outer circumferential surface such that the second rotatable mechanism rotates at a selected rotational speed X; the first rotatable mechanism being interconnected to the second rotatable mechanism such that the first rotatable mechanism rotates simultaneously with the second rotatable mechanism at a rotational speed of 2X.
- the second rotatable mechanism includes a seat for holding a distal length of the output tubing which extends from the axis of the fluid retentive housing, wherein the distal length of the output tubing held by the seat is rotated around the rotation axis at the same rotational speed as the second rotatable mechanism.
- a centrifuge for rotating a fluid retentive housing such that one or more selected materials suspended in a fluid retained within the housing centrifuged upon rotation of the housing.
- the centrifuge includes a first rotatable mechanism having a rotation access with the fluid retentive housing being coaxially mounted on the first rotatable mechanism for co-rotation therewith.
- a second rotatable mechanism having a rotation axis with the first and second rotatable mechanisms being coaxially interconnected for co-rotation around a common axis.
- Fluid tubing connected to the axis of the fluid retentive housing has a distal length that extends axially outwardly from the fluid retentive housing.
- the improvement comprises a support arm mounted to the second rotatable mechanism, a support tube for receiving therethrough at least part of the distal length of the fluid tubing, and a bearing member for rotatably supporting the support tube in said support arm whereby upon rotation of the first and second rotation mechanisms, the fluid tubing is free to either rotate with or rotate relative to the support tube so as to minimize friction between the fluid tubing and the support therefor.
- a multi-lumen rope comprising a plurality of elongated tubes for delivering one or more fluids between a first fluid containing mechanism and a fluid receiving rotatably driven rotor.
- One end of the rope is attached to the center of the driven rotor and the other end of the rope is attached to the first fluid retaining mechanism.
- the first fluid retaining mechanism is mounted on an opposing side of the rotor such that the point of attachment of the other end of the rope is substantially coaxial with an axis of the rotor.
- the aforementioned elongated tubes may comprise at least one tube disposed of in a spiral wrap.
- This may be either a single strand or a multi-strand wrap and may be either in a counterclockwise or clockwise direction. And also, in a single strand or a multi-strand, at one end the spiral wrap may be clockwise while at the other end counterclockwise and also optionally have a straight section therebetween.
- FIG. 1 shows a centrifuge apparatus 10, the basic construction of which may be substantially the same as that described in U.S. Pat. No. 5,665,048 .
- the support includes the support arm 50 as well as its guide members 52 and 54.
- This apparatus includes a bag set 20.
- This may also be referred to as a self-contained fluid retentive centrifuge cassette or rotor which is mounted on an inner-rotatable chuck 60.
- the bag set 20, as illustrated in FIGS. 1 and 3 has fluid input and output 70 coaxially and fixedly attached to the axis 40 of the cassette 20. As shown, the cassette is mounted on the chuck 60 such that it's rotation axis is coaxial along common axis 40.
- FIG. 1 actually shows the cutaway section indicating the chuck 60 and a further cutaway section showing a gear 91, part of the aforementioned gear train.
- FIGS. 2 and 3 illustrate the support arm 50.
- the support arm 50 at its central section 56 is fixedly attached to an inner-peripnery of the pulley 90.
- the support arm 50 rotates with the Hub 90.
- the support arm 50 is of elongated shape and extends on either side of the centrifuge apparatus 10, as illustrated in FIG. 1 .
- the support arm 50 has an elongated channel 58 which receives the support tube 80.
- the support tube 80 is actually supported in the channel 58 by means of a pair of bearings 82 illustrated in FIGS. 3 and 4 .
- Each of these bearings is accommodated in a corresponding recess 84 at opposite ends of the support arm, as illustrated in FIG. 2 .
- FIG. 1 shows all of these various components in their final assembled state.
- the fluid tubing 70 is shown being guided by a C-shaped guide member 52 into one end of the support tube 80.
- the fluid tubing length 72 extends out of the support tube and into the S-shaped tubing guide 54, as also illustrated in FIG. 1 .
- the fluid tubing is in the form of a multi-lumen rope, embodiments of which will be described hereinafter, the elements of the rope furthest from the access of rotation exert large forces against the supporting surface and consequently produce large frictional forces impeding the twists required to make the slip rope function. It has been found that the following perimeters are desirable for proper operation of a multi-lumen skip rope;
- Parameters 1 and 2 are generally met by selecting relatively small diameter, high durometer thermoplastic tubing. Gluing methods and fixtures were used so that an assembly of at least 9 lumens could be well fabricated with very uniform tubing lay and therefore stiffness and strength. This assembly is of a spiral wrapped construction to improve uniformity.
- FIG. 5A shows a single strand 100A counterclockwise wrap while FIG. 5B shows a multi-strand 100B counterclockwise wrap.
- FIG. 5C shows a single strand 100C clockwise wrap, while FIG. 5D shows a multi-strand 100D clockwise wrap.
- portions of the skip rope progress through curved supports from the access of rotation from the periphery where the rope is guided through very smooth, Teflon, hard coated aluminum parts. Please refer to FIG. 3 and guide members 52 and 54. That in these areas, the co-efficient of friction between the skip rope and the guides is preferably less than 0.2.
- the portion of the skip rope at the maximum radius from the center of rotation is a straight section of various lengths. This section can be very important to the overall torque needed to twist the rope. Indeed the weight of the skip rope assembly (plus fluids if it is filled) is increased by the G-field which may be a multiplier of 1,000 or more.
- this section of skip rope is supported by the aforementioned support tube 80. This is preferably a stiff tube of either metal of structural plastic. The stiff tube is itself supported by the aforementioned low friction bearings 82 allowing full rotation about its own axis. This reduces the torque needed to drive this region of the skip rope assembly to very nearly zero.
- This structure of the support tube and bearings provides an advantageous support for the length of fluid tubing or lumen between the guides 52 and 54. Because the support tube is free to rotate, upon rotation of the members such as 60 and 90 in FIG. 1 , in other words first and second rotation mechanisms, the fluid tubing is free to either rotate with or rotate relative to the support tube.
- FIG. 5B Another characteristic of the present invention relates to the construction of the multi-lumen rope itself, as illustrated, for example, in FIG. 5B .
- This may be comprised of a plurality of at least eight lumens 100B about a center lumen 102B.
- the center lumen 102B is straight while the other peripheral lumens wrap, such as illustrated in FIG. 5B .
- the center lumen 102B may be an expresser tube while the lumens 100B may be processing tubes.
- the tube 102B may be an input tubing and tubings 100B may be output tubings.
- the input and output tubings may be also reversed.
Landscapes
- Centrifugal Separators (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Prostheses (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16232099P | 1999-10-28 | 1999-10-28 | |
EP00973959A EP1272277B1 (fr) | 1999-10-28 | 2000-10-27 | Centrifugeuse a flux continu et a entrainement circonferentiel |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00973959.0 Division | 2000-10-27 | ||
EP00973959A Division EP1272277B1 (fr) | 1999-10-28 | 2000-10-27 | Centrifugeuse a flux continu et a entrainement circonferentiel |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2243554A2 true EP2243554A2 (fr) | 2010-10-27 |
EP2243554A3 EP2243554A3 (fr) | 2014-01-15 |
Family
ID=22585131
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00973959A Expired - Lifetime EP1272277B1 (fr) | 1999-10-28 | 2000-10-27 | Centrifugeuse a flux continu et a entrainement circonferentiel |
EP10172379.9A Withdrawn EP2243554A3 (fr) | 1999-10-28 | 2000-10-27 | Tuyau à lumières multiples pour centrifugeuse a flux continu |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00973959A Expired - Lifetime EP1272277B1 (fr) | 1999-10-28 | 2000-10-27 | Centrifugeuse a flux continu et a entrainement circonferentiel |
Country Status (7)
Country | Link |
---|---|
EP (2) | EP1272277B1 (fr) |
JP (2) | JP5147154B2 (fr) |
AT (1) | ATE477057T1 (fr) |
DE (1) | DE60044823D1 (fr) |
ES (1) | ES2349888T3 (fr) |
HK (1) | HK1053804A1 (fr) |
WO (1) | WO2001030505A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109759247A (zh) * | 2019-03-20 | 2019-05-17 | 尹康康 | 一种台式离心机 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7001322B2 (en) * | 2000-10-04 | 2006-02-21 | Zymequest, Inc. | Multiple processing chamber set and use thereof |
DE10129769A1 (de) * | 2001-06-20 | 2003-01-09 | Fresenius Hemocare Gmbh | Schlauchanordnung und Verfahren zu ihrer Herstellung |
US7651457B2 (en) * | 2003-08-04 | 2010-01-26 | Zymequest, Inc. | Expandable processing and expression chamber |
WO2007014222A2 (fr) * | 2005-07-26 | 2007-02-01 | Zymequest, Inc. | Dispositif de traitement du sang et systemes et methodes associes |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3586413A (en) | 1969-03-25 | 1971-06-22 | Dale A Adams | Apparatus for providing energy communication between a moving and a stationary terminal |
US4216770A (en) | 1979-02-09 | 1980-08-12 | Baxter Travenol Laboratories, Inc. | Sickle cell therapeutic treatment |
US4389206A (en) | 1980-10-09 | 1983-06-21 | Baxter Travenol Laboratories, Inc. | Centrifugal processing apparatus and rotatable processing bowl apparatus |
US4419089A (en) | 1977-07-19 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Blood cell separator |
US5665048A (en) | 1995-12-22 | 1997-09-09 | Jorgensen; Glen | Circumferentially driven continuous flow centrifuge |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2832374A (en) * | 1955-03-10 | 1958-04-29 | Breeze Corp | Flexible tube assemblies |
US3646972A (en) * | 1970-02-27 | 1972-03-07 | Kabel Metallwerke Ghh | Multitubing system |
US4018304A (en) | 1975-10-08 | 1977-04-19 | Baxter Travenol Laboratories, Inc. | Lubrication system for a centrifugal liquid processing system |
US4425112A (en) * | 1976-02-25 | 1984-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Flow-through centrifuge |
US4221322A (en) | 1977-10-31 | 1980-09-09 | Union Carbide Corporation | Tube guide insert and constraint fittings for compensating rotor |
US4163519A (en) * | 1977-11-01 | 1979-08-07 | Union Carbide Corporation | Compensating rotor |
US4287061A (en) * | 1978-10-26 | 1981-09-01 | National Research Development Corporation | Rotating coil centrifuge |
JPS5680247U (fr) * | 1979-11-27 | 1981-06-29 | ||
US4372484A (en) * | 1981-02-04 | 1983-02-08 | Gambro Ab | Device for the separation of a liquid, especially whole blood |
US4459169A (en) * | 1981-03-16 | 1984-07-10 | Baxter Travenol Laboratories, Inc. | Rotatable bowl assembly for centrifugal processing apparatus having a bonded and prewound umbilical system |
JPS61245855A (ja) * | 1985-04-22 | 1986-11-01 | Green Cross Corp:The | 連続式血液分離装置 |
DE3632241A1 (de) * | 1986-09-23 | 1988-06-09 | Fresenius Ag | Mehrlumige schlauchanordnung sowie verfahren zu ihrer herstellung |
JPH0790184B2 (ja) * | 1987-07-27 | 1995-10-04 | 株式会社ミドリ十字 | 遠心分離容器組立体 |
US5431814A (en) | 1993-10-22 | 1995-07-11 | Jorgensen; Glen | Centrifugal filter apparatus and method |
DE19803534C2 (de) * | 1998-01-30 | 1999-11-11 | Fresenius Ag | Zentrifuge und Leitung zum Zuführen und/oder Abführen mindestens eines Fluids von der Separationseinheit einer Zentrifuge zu einer ortsfesten Anschlußstelle |
-
2000
- 2000-10-27 EP EP00973959A patent/EP1272277B1/fr not_active Expired - Lifetime
- 2000-10-27 JP JP2001532909A patent/JP5147154B2/ja not_active Expired - Fee Related
- 2000-10-27 DE DE60044823T patent/DE60044823D1/de not_active Expired - Lifetime
- 2000-10-27 WO PCT/US2000/029705 patent/WO2001030505A1/fr active Application Filing
- 2000-10-27 EP EP10172379.9A patent/EP2243554A3/fr not_active Withdrawn
- 2000-10-27 ES ES00973959T patent/ES2349888T3/es not_active Expired - Lifetime
- 2000-10-27 AT AT00973959T patent/ATE477057T1/de not_active IP Right Cessation
-
2003
- 2003-07-02 HK HK03104730.4A patent/HK1053804A1/zh unknown
-
2010
- 2010-07-21 JP JP2010164388A patent/JP2010284651A/ja not_active Withdrawn
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3586413A (en) | 1969-03-25 | 1971-06-22 | Dale A Adams | Apparatus for providing energy communication between a moving and a stationary terminal |
USRE29738E (en) | 1969-03-25 | 1978-08-22 | Apparatus for providing energy communication between a moving and a stationary terminal | |
US4419089A (en) | 1977-07-19 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Blood cell separator |
US4216770A (en) | 1979-02-09 | 1980-08-12 | Baxter Travenol Laboratories, Inc. | Sickle cell therapeutic treatment |
US4389206A (en) | 1980-10-09 | 1983-06-21 | Baxter Travenol Laboratories, Inc. | Centrifugal processing apparatus and rotatable processing bowl apparatus |
US5665048A (en) | 1995-12-22 | 1997-09-09 | Jorgensen; Glen | Circumferentially driven continuous flow centrifuge |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109759247A (zh) * | 2019-03-20 | 2019-05-17 | 尹康康 | 一种台式离心机 |
Also Published As
Publication number | Publication date |
---|---|
ES2349888T3 (es) | 2011-01-12 |
JP2003514645A (ja) | 2003-04-22 |
ATE477057T1 (de) | 2010-08-15 |
EP1272277A4 (fr) | 2005-06-15 |
EP1272277A1 (fr) | 2003-01-08 |
JP2010284651A (ja) | 2010-12-24 |
WO2001030505A1 (fr) | 2001-05-03 |
HK1053804A1 (zh) | 2003-11-07 |
EP2243554A3 (fr) | 2014-01-15 |
JP5147154B2 (ja) | 2013-02-20 |
EP1272277B1 (fr) | 2010-08-11 |
DE60044823D1 (de) | 2010-09-23 |
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Inventor name: AITKENHEAD, WILLIAM Inventor name: JORGENSEN, GLEN Inventor name: STANDLEY, ROBERT, L. |
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Effective date: 20140716 |