EP2243554A2 - Tuyau à lumières multiples pour centrifugeuse a flux continu - Google Patents

Tuyau à lumières multiples pour centrifugeuse a flux continu Download PDF

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Publication number
EP2243554A2
EP2243554A2 EP10172379A EP10172379A EP2243554A2 EP 2243554 A2 EP2243554 A2 EP 2243554A2 EP 10172379 A EP10172379 A EP 10172379A EP 10172379 A EP10172379 A EP 10172379A EP 2243554 A2 EP2243554 A2 EP 2243554A2
Authority
EP
European Patent Office
Prior art keywords
rope
fluid
lumen
set forth
tubing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10172379A
Other languages
German (de)
English (en)
Other versions
EP2243554A3 (fr
Inventor
William Aitkenhead
Glen Jorgensen
Robert L. Standley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ZymeQuest Inc
Original Assignee
ZymeQuest Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ZymeQuest Inc filed Critical ZymeQuest Inc
Publication of EP2243554A2 publication Critical patent/EP2243554A2/fr
Publication of EP2243554A3 publication Critical patent/EP2243554A3/fr
Withdrawn legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0492—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with fluid conveying umbilicus between stationary and rotary centrifuge parts

Definitions

  • the present invention relates to centrifuge apparati and more particularly to a centrifuge which works in conjunction with a cassette, rotor or other device having fluid retentive chambers and fluid flow tubing fixedly attached to the axis of the device.
  • U.S. Pat. No. 5,665,048 that provides a centrifuge for rotating a fluid retentive housing having fluid input and output tubing fixedly connected to a rotation axis of the fluid retentive housing, the centrifuge comprising: a frame; a first rotatable mechanism having a rotation axis, the fluid retentive housing being coaxially mounted thereon for co-rotation therewith; a second rotatable mechanism having a rotation axis, the first and second rotation mechanism being coaxially mounted on the frame; the second rotatable mechanism having an outer circumferential surface engaged with a drive mechanism, the drive mechanism driving the outer circumferential surface such that the second rotatable mechanism rotates at a selected rotational speed X; the first rotatable mechanism being interconnected to the second rotatable mechanism such that the first rotatable mechanism rotates simultaneously with the second rotatable mechanism at a rotational speed of 2X.
  • the second rotatable mechanism includes a seat for holding a distal length of the output tubing which extends from the axis of the fluid retentive housing, wherein the distal length of the output tubing held by the seat is rotated around the rotation axis at the same rotational speed as the second rotatable mechanism.
  • a centrifuge for rotating a fluid retentive housing such that one or more selected materials suspended in a fluid retained within the housing centrifuged upon rotation of the housing.
  • the centrifuge includes a first rotatable mechanism having a rotation access with the fluid retentive housing being coaxially mounted on the first rotatable mechanism for co-rotation therewith.
  • a second rotatable mechanism having a rotation axis with the first and second rotatable mechanisms being coaxially interconnected for co-rotation around a common axis.
  • Fluid tubing connected to the axis of the fluid retentive housing has a distal length that extends axially outwardly from the fluid retentive housing.
  • the improvement comprises a support arm mounted to the second rotatable mechanism, a support tube for receiving therethrough at least part of the distal length of the fluid tubing, and a bearing member for rotatably supporting the support tube in said support arm whereby upon rotation of the first and second rotation mechanisms, the fluid tubing is free to either rotate with or rotate relative to the support tube so as to minimize friction between the fluid tubing and the support therefor.
  • a multi-lumen rope comprising a plurality of elongated tubes for delivering one or more fluids between a first fluid containing mechanism and a fluid receiving rotatably driven rotor.
  • One end of the rope is attached to the center of the driven rotor and the other end of the rope is attached to the first fluid retaining mechanism.
  • the first fluid retaining mechanism is mounted on an opposing side of the rotor such that the point of attachment of the other end of the rope is substantially coaxial with an axis of the rotor.
  • the aforementioned elongated tubes may comprise at least one tube disposed of in a spiral wrap.
  • This may be either a single strand or a multi-strand wrap and may be either in a counterclockwise or clockwise direction. And also, in a single strand or a multi-strand, at one end the spiral wrap may be clockwise while at the other end counterclockwise and also optionally have a straight section therebetween.
  • FIG. 1 shows a centrifuge apparatus 10, the basic construction of which may be substantially the same as that described in U.S. Pat. No. 5,665,048 .
  • the support includes the support arm 50 as well as its guide members 52 and 54.
  • This apparatus includes a bag set 20.
  • This may also be referred to as a self-contained fluid retentive centrifuge cassette or rotor which is mounted on an inner-rotatable chuck 60.
  • the bag set 20, as illustrated in FIGS. 1 and 3 has fluid input and output 70 coaxially and fixedly attached to the axis 40 of the cassette 20. As shown, the cassette is mounted on the chuck 60 such that it's rotation axis is coaxial along common axis 40.
  • FIG. 1 actually shows the cutaway section indicating the chuck 60 and a further cutaway section showing a gear 91, part of the aforementioned gear train.
  • FIGS. 2 and 3 illustrate the support arm 50.
  • the support arm 50 at its central section 56 is fixedly attached to an inner-peripnery of the pulley 90.
  • the support arm 50 rotates with the Hub 90.
  • the support arm 50 is of elongated shape and extends on either side of the centrifuge apparatus 10, as illustrated in FIG. 1 .
  • the support arm 50 has an elongated channel 58 which receives the support tube 80.
  • the support tube 80 is actually supported in the channel 58 by means of a pair of bearings 82 illustrated in FIGS. 3 and 4 .
  • Each of these bearings is accommodated in a corresponding recess 84 at opposite ends of the support arm, as illustrated in FIG. 2 .
  • FIG. 1 shows all of these various components in their final assembled state.
  • the fluid tubing 70 is shown being guided by a C-shaped guide member 52 into one end of the support tube 80.
  • the fluid tubing length 72 extends out of the support tube and into the S-shaped tubing guide 54, as also illustrated in FIG. 1 .
  • the fluid tubing is in the form of a multi-lumen rope, embodiments of which will be described hereinafter, the elements of the rope furthest from the access of rotation exert large forces against the supporting surface and consequently produce large frictional forces impeding the twists required to make the slip rope function. It has been found that the following perimeters are desirable for proper operation of a multi-lumen skip rope;
  • Parameters 1 and 2 are generally met by selecting relatively small diameter, high durometer thermoplastic tubing. Gluing methods and fixtures were used so that an assembly of at least 9 lumens could be well fabricated with very uniform tubing lay and therefore stiffness and strength. This assembly is of a spiral wrapped construction to improve uniformity.
  • FIG. 5A shows a single strand 100A counterclockwise wrap while FIG. 5B shows a multi-strand 100B counterclockwise wrap.
  • FIG. 5C shows a single strand 100C clockwise wrap, while FIG. 5D shows a multi-strand 100D clockwise wrap.
  • portions of the skip rope progress through curved supports from the access of rotation from the periphery where the rope is guided through very smooth, Teflon, hard coated aluminum parts. Please refer to FIG. 3 and guide members 52 and 54. That in these areas, the co-efficient of friction between the skip rope and the guides is preferably less than 0.2.
  • the portion of the skip rope at the maximum radius from the center of rotation is a straight section of various lengths. This section can be very important to the overall torque needed to twist the rope. Indeed the weight of the skip rope assembly (plus fluids if it is filled) is increased by the G-field which may be a multiplier of 1,000 or more.
  • this section of skip rope is supported by the aforementioned support tube 80. This is preferably a stiff tube of either metal of structural plastic. The stiff tube is itself supported by the aforementioned low friction bearings 82 allowing full rotation about its own axis. This reduces the torque needed to drive this region of the skip rope assembly to very nearly zero.
  • This structure of the support tube and bearings provides an advantageous support for the length of fluid tubing or lumen between the guides 52 and 54. Because the support tube is free to rotate, upon rotation of the members such as 60 and 90 in FIG. 1 , in other words first and second rotation mechanisms, the fluid tubing is free to either rotate with or rotate relative to the support tube.
  • FIG. 5B Another characteristic of the present invention relates to the construction of the multi-lumen rope itself, as illustrated, for example, in FIG. 5B .
  • This may be comprised of a plurality of at least eight lumens 100B about a center lumen 102B.
  • the center lumen 102B is straight while the other peripheral lumens wrap, such as illustrated in FIG. 5B .
  • the center lumen 102B may be an expresser tube while the lumens 100B may be processing tubes.
  • the tube 102B may be an input tubing and tubings 100B may be output tubings.
  • the input and output tubings may be also reversed.

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  • Centrifugal Separators (AREA)
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  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP10172379.9A 1999-10-28 2000-10-27 Tuyau à lumières multiples pour centrifugeuse a flux continu Withdrawn EP2243554A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16232099P 1999-10-28 1999-10-28
EP00973959A EP1272277B1 (fr) 1999-10-28 2000-10-27 Centrifugeuse a flux continu et a entrainement circonferentiel

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP00973959A Division EP1272277B1 (fr) 1999-10-28 2000-10-27 Centrifugeuse a flux continu et a entrainement circonferentiel
EP00973959.0 Division 2000-10-27

Publications (2)

Publication Number Publication Date
EP2243554A2 true EP2243554A2 (fr) 2010-10-27
EP2243554A3 EP2243554A3 (fr) 2014-01-15

Family

ID=22585131

Family Applications (2)

Application Number Title Priority Date Filing Date
EP10172379.9A Withdrawn EP2243554A3 (fr) 1999-10-28 2000-10-27 Tuyau à lumières multiples pour centrifugeuse a flux continu
EP00973959A Expired - Lifetime EP1272277B1 (fr) 1999-10-28 2000-10-27 Centrifugeuse a flux continu et a entrainement circonferentiel

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP00973959A Expired - Lifetime EP1272277B1 (fr) 1999-10-28 2000-10-27 Centrifugeuse a flux continu et a entrainement circonferentiel

Country Status (7)

Country Link
EP (2) EP2243554A3 (fr)
JP (2) JP5147154B2 (fr)
AT (1) ATE477057T1 (fr)
DE (1) DE60044823D1 (fr)
ES (1) ES2349888T3 (fr)
HK (1) HK1053804A1 (fr)
WO (1) WO2001030505A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109759247A (zh) * 2019-03-20 2019-05-17 尹康康 一种台式离心机

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7001322B2 (en) * 2000-10-04 2006-02-21 Zymequest, Inc. Multiple processing chamber set and use thereof
DE10129769A1 (de) * 2001-06-20 2003-01-09 Fresenius Hemocare Gmbh Schlauchanordnung und Verfahren zu ihrer Herstellung
US7651457B2 (en) 2003-08-04 2010-01-26 Zymequest, Inc. Expandable processing and expression chamber
JP2009506801A (ja) * 2005-07-26 2009-02-19 ザイムクエスト インコーポレイティッド 血液処理装置ならびに関連するシステムおよび方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3586413A (en) 1969-03-25 1971-06-22 Dale A Adams Apparatus for providing energy communication between a moving and a stationary terminal
US4216770A (en) 1979-02-09 1980-08-12 Baxter Travenol Laboratories, Inc. Sickle cell therapeutic treatment
US4389206A (en) 1980-10-09 1983-06-21 Baxter Travenol Laboratories, Inc. Centrifugal processing apparatus and rotatable processing bowl apparatus
US4419089A (en) 1977-07-19 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Blood cell separator
US5665048A (en) 1995-12-22 1997-09-09 Jorgensen; Glen Circumferentially driven continuous flow centrifuge

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US2832374A (en) * 1955-03-10 1958-04-29 Breeze Corp Flexible tube assemblies
US3646972A (en) * 1970-02-27 1972-03-07 Kabel Metallwerke Ghh Multitubing system
US4018304A (en) 1975-10-08 1977-04-19 Baxter Travenol Laboratories, Inc. Lubrication system for a centrifugal liquid processing system
US4425112A (en) 1976-02-25 1984-01-10 The United States Of America As Represented By The Department Of Health And Human Services Flow-through centrifuge
US4221322A (en) 1977-10-31 1980-09-09 Union Carbide Corporation Tube guide insert and constraint fittings for compensating rotor
US4163519A (en) * 1977-11-01 1979-08-07 Union Carbide Corporation Compensating rotor
US4287061A (en) * 1978-10-26 1981-09-01 National Research Development Corporation Rotating coil centrifuge
JPS5680247U (fr) * 1979-11-27 1981-06-29
US4372484A (en) * 1981-02-04 1983-02-08 Gambro Ab Device for the separation of a liquid, especially whole blood
US4459169A (en) * 1981-03-16 1984-07-10 Baxter Travenol Laboratories, Inc. Rotatable bowl assembly for centrifugal processing apparatus having a bonded and prewound umbilical system
JPS61245855A (ja) * 1985-04-22 1986-11-01 Green Cross Corp:The 連続式血液分離装置
DE3632241A1 (de) * 1986-09-23 1988-06-09 Fresenius Ag Mehrlumige schlauchanordnung sowie verfahren zu ihrer herstellung
JPH0790184B2 (ja) * 1987-07-27 1995-10-04 株式会社ミドリ十字 遠心分離容器組立体
US5431814A (en) * 1993-10-22 1995-07-11 Jorgensen; Glen Centrifugal filter apparatus and method
DE19803534C2 (de) * 1998-01-30 1999-11-11 Fresenius Ag Zentrifuge und Leitung zum Zuführen und/oder Abführen mindestens eines Fluids von der Separationseinheit einer Zentrifuge zu einer ortsfesten Anschlußstelle

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3586413A (en) 1969-03-25 1971-06-22 Dale A Adams Apparatus for providing energy communication between a moving and a stationary terminal
USRE29738E (en) 1969-03-25 1978-08-22 Apparatus for providing energy communication between a moving and a stationary terminal
US4419089A (en) 1977-07-19 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Blood cell separator
US4216770A (en) 1979-02-09 1980-08-12 Baxter Travenol Laboratories, Inc. Sickle cell therapeutic treatment
US4389206A (en) 1980-10-09 1983-06-21 Baxter Travenol Laboratories, Inc. Centrifugal processing apparatus and rotatable processing bowl apparatus
US5665048A (en) 1995-12-22 1997-09-09 Jorgensen; Glen Circumferentially driven continuous flow centrifuge

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109759247A (zh) * 2019-03-20 2019-05-17 尹康康 一种台式离心机

Also Published As

Publication number Publication date
ATE477057T1 (de) 2010-08-15
JP5147154B2 (ja) 2013-02-20
EP1272277A1 (fr) 2003-01-08
EP1272277A4 (fr) 2005-06-15
ES2349888T3 (es) 2011-01-12
JP2010284651A (ja) 2010-12-24
EP2243554A3 (fr) 2014-01-15
JP2003514645A (ja) 2003-04-22
DE60044823D1 (de) 2010-09-23
EP1272277B1 (fr) 2010-08-11
WO2001030505A1 (fr) 2001-05-03
HK1053804A1 (zh) 2003-11-07

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