EP0915737A2 - Verschlussvorrichtung, trennvorrichtung sowie aufnahmebehälter für eine aufnahmeeinrichtung - Google Patents
Verschlussvorrichtung, trennvorrichtung sowie aufnahmebehälter für eine aufnahmeeinrichtungInfo
- Publication number
- EP0915737A2 EP0915737A2 EP97932645A EP97932645A EP0915737A2 EP 0915737 A2 EP0915737 A2 EP 0915737A2 EP 97932645 A EP97932645 A EP 97932645A EP 97932645 A EP97932645 A EP 97932645A EP 0915737 A2 EP0915737 A2 EP 0915737A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- sealing
- receptacle
- separating device
- holding
- support body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
- B01L3/50825—Closing or opening means, corks, bungs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5021—Test tubes specially adapted for centrifugation purposes
- B01L3/50215—Test tubes specially adapted for centrifugation purposes using a float to separate phases
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S220/00—Receptacles
- Y10S220/916—Container including axially opposed removable closures
Definitions
- the invention relates to a closure device according to the preamble of claim 1, a separating device according to the preamble of claim 20, a receptacle according to the preamble of claim 44, a receiving device according to the preamble of claim 56 and a method for separating a mixture according to the preamble of claim 64.
- a receiving device for a mixture of at least two media which has a test tube-like receiving container which is closed in an open end area with a closure device and in which a separating device for separating the different media of the mixture the separation is used.
- the separating device is provided in the central region with a passage opening through which the mixture enters the remaining interior of the receptacle - can be introduced.
- a height corresponding to the usual remaining amount of the other medium is in the direction of the closed end is provided with a conical widening end dia, with which the separating device runs onto the end stop, which penetrates through the opening.
- a separating device which is formed by a sealing disk and is formed by a gel, is arranged inside.
- this gel flask due to its specific weight, which is higher than the specific weight of the medium with the lower specific weight and lower than the specific weight of the medium with higher specific weight, due to the centrifugal forces acting on it, between the two different separate media. In this position, one medium can thus be separated from the other medium of the mixture.
- the disadvantage here is that, due to the gel separator, the storage time is in many cases not sufficient for the normal period of use.
- the present invention has for its object to provide a closure device, a separating device and a receptacle and an associated receiving device and a method for separating several media of a mixture, which can be quickly adapted to different mixtures and a long storage life and high operational reliability even when used by inexperienced personnel.
- a sufficient pre-tensioning of the sealing body in the opening can be achieved by the further development according to claims 3 and 4.
- the configuration according to claim 5 also makes it possible to remove materials from the interior of the receptacle through the sealing body without loss of sealing.
- a good contact of the sealing body and a drip from the outlet can be avoided by the development according to claim 6.
- Adequate tightness can also be achieved by developing the sealing body according to claim 7, since it also uses materials which have sufficient dimensional stability at the high centrifugal forces to ensure the tightness.
- the embodiment according to claim 14 enables a roll-off protection in a simple manner, which prevents the receptacle from rolling away if it has a cylindrical outer shape.
- a sufficient prestressing force of the sealing body in the receptacle can be achieved by claims 18 and 19, the accessibility to the interior of the receptacle being maintained by the latter configuration despite good support of the sealing body.
- the object of the invention is also achieved independently by the configuration of the separating device according to the characterizing part of claim 20.
- the two parts can each be optimally configured according to their function.
- the density and the associated specific weight make it easy to adjust to the different applications.
- a good seal between the separated media is achieved, which also enables longer storage.
- the advantageous development according to claim 32 prevents the separating device with its axis of rotation from adopting a position perpendicular to the longitudinal central axis of the receptacle in any operating state, especially during centrifuging, even with centrifugal forces acting differently.
- the embodiment variant according to claim 33 enables the production of a passage gap for one of the two media in a simple manner during the centrifuging process.
- the object of the invention is also achieved by the receptacle according to claim 44.
- This configuration enables a reinforced base area which, even if such a receptacle is accidentally dropped, prevents it from bursting with a high degree of certainty.
- this receptacle can be manufactured easily and inexpensively with relatively simple injection molding tools, even in tools with multiple nests. Furthermore, this reinforced area can simultaneously be used for securely anchoring the holding element.
- a secure positioning of the separating device in the receptacle until the start of centrifugation, even during the introduction and removal of media into or from the receptacle, can be achieved by the embodiment variants according to claims 51 to 55.
- the object of the invention is also achieved by a receiving device according to claim 56.
- the object of the invention is also achieved independently of this by a method for separating media according to the features specified in claim 64.
- the separating device On the basis of the selection of the density or the specific weight of the separating device, the latter floats on the specifically heavier or denser medium and, after the centrifugal forces have been removed, completely seals the two media which have already been separated from one another.
- the specifically lighter medium can only pass through during the centrifuging process due to the deformation of the sealing device in the region of the separating device and the inner surface of the receptacle.
- Fig. 1 a receiving device designed according to the invention, e.g. for blood, in side view, cut and simplified, schematic representation;
- FIG. 2 shows the receiving device according to FIG. 1, in a view from below according to an arrow II in FIG. 1;
- FIG. 3 shows a further possible embodiment of a closure device for the receiving device in a side view, in section and in a simplified, schematic representation
- FIG. 4 shows a possible embodiment of a separating device for the receiving device in a diagrammatically simplified illustration
- Fig. 5 shows a receiving device with an arranged in the interior Separation device during the separation process in side view, cut and simplified, schematic representation
- FIG. 6 shows a possible and possibly independent embodiment of a holding element or a cap in a top view and a simplified schematic representation
- FIG. 7 shows a further and possibly independent embodiment of a separating device in a side view, in section and in a simplified, schematic representation
- FIG. 8 shows a further and possibly independent embodiment of a receiving device with a holding device for the separating device in a side view, in section and in a simplified, schematic representation
- FIG. 9 shows a further and possibly independent embodiment of a holding device for the separating device within the receiving device in a side view, in section and in a simplified, schematic representation
- FIG. 10 shows one of the possible forms of design of the receiving device after the separation process of the mixture has taken place in a side view, in section and in a simplified, schematic representation
- FIG. 11 shows a further and possibly independent embodiment of a separating device with differently configured sealing elements in a side view, in section and in a simplified, schematic representation.
- a receiving device 1 for a mixture 2 of at least two mutually different components or media 3, 4, such as body fluids, tissue parts or tissue cultures, is shown, which is designed such that the in the receiving device 1st Mixture 2 is separable in at least two of its components.
- This separation or separation of the mixture 2 into its constituents or media 3, 4 can, for example, be carried out physically by centrifugation in a conventional manner and starting from the rest position until a radial centrifugal force (rcf) of 1,000 g to 5,000 g, preferably 2,200 g can be carried out, g being the force of gravity and 1 g being a value of 9.81 m / s 2 .
- rcf radial centrifugal force
- the receptacle 1 consists of an approximately cylindrical receptacle 5 with closure devices 8, 9 arranged at both spaced-apart end regions 6, 7 and a separating device 1 1 inserted into an interior space 10 enclosed by the receptacle 5.
- This receptacle 5 can also be used, for example be designed or used as an evacuated blood sampling tube.
- the receptacle 5 can for example be bottle-shaped, vial-shaped, piston-shaped or the like. It can also be formed from a wide variety of materials, such as plastic or glass. Used as a material for the receptacle
- Chosen plastic it can be liquid-tight, in particular watertight and possibly gas-tight and, for example, as polypropylene (PP), polyethylene (PE), high-density polyethylene (PE-HD), acrylonitrile-butadiene-styrene copolymers (ABS) or the like. or a combination of these.
- PP polypropylene
- PE polyethylene
- PE-HD high-density polyethylene
- ABS acrylonitrile-butadiene-styrene copolymers
- the receptacle 5 has a container wall 12 with a wall thickness 13, the container wall 12 extending from the one end region 6 with approximately the same inner dimension 14 to the further end region 7.
- the container wall 12 of the receptacle 5 has an inner surface 15 facing the interior 10 and an outer surface 16 facing away from it, which thus defines an outer circumference 17 for the receptacle 5.
- an inner cross-section 18 which has the most varied cross-sectional shapes, such as circular, elliptical shaped, oval, polygonal, etc., may have set. Due to the inner dimension 14 plus twice the wall thickness 13 of the receptacle 5, an outer dimension 19 with an outer cross section 20 is formed for the latter.
- the shape of the outer cross section 20 can in turn be circular, elliptical, oval, polygonal, etc., but it is also possible to design the shape of the outer cross section 20 differently from the shape of the inner cross section 18.
- the inner dimension 14 and the outer dimension 19 of the receptacle 5, starting from an end region 6 to the further end region 7 distanced from this, is preferably designed to have a minimally decreasing shape, for example, the receptacle 5 when it is is made of plastic material in an injection molding process, can be easily removed from the injection mold.
- the receptacle 5 Centrally to the inner dimension 14 or the inner cross section 18, the receptacle 5 has a longitudinal central axis 21 which extends from the end region 6 to the end region 7.
- the end region 6 has an open end face 22 which can be closed by the closure device 8, which can be opened as required.
- the closure device 8 consists of a cap 23 comprising the open end face 22 and a sealing device 24 held therein, such as a sealing plug 25 made of a pierceable, highly elastic and self-sealing material, such as pharmaceutical rubber, silicone rubber or bromobutyl rubber.
- This cap 23 is arranged concentrically to the longitudinal central axis 21 and is formed by a cap jacket 26 in the form of a ring.
- the sealing device 24 Between the cap 23 and the sealing device 24 there are means for coupling, such as coupling parts 27 to 30 of a coupling device 31, consisting in the cap 23 of extensions 32, 33, optionally a retaining ring 34, which are arranged at least over the inner circumference, and in the sealing pre- direction 24 is provided from an extension 35 projecting at least in regions over its outer circumference.
- the sealing device 24 is formed by the sealing plug 25 and has a circumferential cylindrical sealing surface 36 which is arranged approximately concentrically to the longitudinal central axis 21 and which, in its sealing position in the section of the end region 6, on the inner surface 15 of the receptacle 5 Facility is coming.
- the surface quality of the inner surface 15 of the receptacle 5 is to be designed as a sealing surface in this section.
- the sealing device 24 has an approximately aligned perpendicular to the longitudinal center axis 21, further sealing surface 37, which, in cooperation with the sealing surface 36 abutting the inner surface 15, seals or seals off the interior 10 of the receptacle 5 on its open end face 22 from the external environment.
- the arrangement of the extension 33 between the projection 35 projecting beyond the sealing surface 36 and the end face 22 of the receptacle 5 prevents the attachment 35 from sticking or strongly adhering directly to the end face 22.
- the sealing device 24 can preferably have a recess 38 on the side facing the retaining ring 34, which has approximately the same cross-sectional area as an opening 39, the size of this opening 39 being designed such that unimpeded passage and subsequent piercing through the sealing device 24 is possible.
- the projection 35 forming the coupling part 29, which projects flange-like over the sealing surface 36 of the sealing device 24 at least in partial areas of the circumference, is held between the extensions 32 and 33, which are arranged in two planes spaced apart from one another in the direction of the longitudinal central axis 21 and arranged perpendicular to the latter and are designed, for example, as projections or locking projections that run around at least in some areas or also in the form of a ring.
- the retaining ring 34 has a larger outer diameter than an inner dimension that forms between the extensions 32 in a direction perpendicular to the longitudinal central axis 21.
- the diameter of the opening 39 of the retaining ring 34 is smaller than a largest outer dimension of the extension 35 in a plane perpendicular to the longitudinal central axis 21.
- This outer dimension of the sealing device 24 is, however, dimensioned such that it is at least twice the wall thickness 13 of the receptacle 5 larger than the inner dimension 14 of the inner cross section 18 and thus of the interior 10.
- the coupling part 28th forms, has an inner opening width which corresponds essentially to the inner dimension 14 of the receptacle 5, there is a very good retention of the neck 35 in the cap 23 and a good seal between the interior 10 of the receptacle 5 and the receiving device 1st surrounding atmosphere sphere.
- the tightness of the closure device 8 for the open end face 22 of the receiving device 1 is further improved if an outer diameter of the sealing device 24 in the area of its sealing surface 36 in the relaxed state outside the receiving container 5 is larger than the inner dimension 14 of the receiving container 5.
- a longitudinal or vertical extension of the extension 35 of the sealing device 24, viewed in the direction of the longitudinal central axis 21, is greater than a distance between a groove-shaped recess between the two extensions 32, 33 and, if appropriate, less a thickness of the retaining ring 34. Due to the previously described dimensional differences between the groove-shaped recess and the length dimensions of the extension 35 or the thickness of the retaining ring 34, the extension 35 is pretensioned between the two extensions 32, 33. At the same time, this causes the sealing device to be compressed and preloaded 24 with respect to the cap 23. This may also result in a firm fit of the retaining ring 34 and also a snug fit of the two end faces of the extension 35 in the region of the two extensions 32, 33.
- cap jacket 26 is designed as a cylinder frustum jacket or a truncated cone jacket, which ensures that the cap jacket 26 overlaps in the region of the upper end face 22.
- guide extensions 40, 41 are arranged in the area of the open end face 22 of the receptacle 5, which protrude beyond the outer circumference 17 of the cylindrical receptacle 5.
- any other number of guide extensions 40, 41 is possible, these interacting with guide webs 42, 43 arranged on an inner surface of the cap 23 facing the receiving container 5 and projecting over its surface in the direction of the longitudinal central axis 21.
- the number and, for example, the uniform, angularly offset division of the guide webs 42, 43 over the circumference depends on the number of guide extensions 40, 41 arranged on the receptacle 5.
- These guide extensions 40, 41 cooperate with the guide webs 42, 43 arranged on the inside of the cap shell 26, which makes it possible for the cap 23 to be pushed in the direction of the longitudinal central axis 21 of the receptacle 5 in the direction of the open end face 22 of the same and a corresponding turning clockwise, the guide webs 42, 43 run onto the guide extensions 40, 41 and that due to the combined rotary and longitudinal movement due to the guidance of the guide webs 42, 43 along the Guide extensions 40, 41, the sealing device 24 can be inserted or inserted with its sealing surface 36 into the interior 10 of the receptacle.
- the receiving device 1 has, at the end region 7 facing away from the end region 6, the further closure device 9, which is formed by a pierceable sealing body 44 made of a puncturable, highly elastic and self-sealing material, in particular a rubber, pharmaceutical rubber, silicone rubber or bromobutyl rubber and a holding element 45 for holding the sealing body 44 on the receptacle 5.
- the holding element 45 has, on the one hand, means for coupling, such as one or more coupling parts 46 of a coupling device 47 between the holding element 45 and the receiving container 5, and on the other hand, means for holding, such as one or more holding parts 48 of a hook device 49, the sealing body 44 in a sealing Position in an opening 50 which tapers towards the interior and is formed opposite the sealing body 44.
- the surface quality of the opening 50 is to be designed as a sealing surface.
- the sealing body 44 is conical, in particular in the form of a truncated cone with a cone angle 51, and has an end face 52 with a diameter 53 facing the holding element 45 and an end face 54 facing away from the interior 10 of the receptacle 5 and having a smaller diameter 55 than the diameter 53 on.
- the receptacle 5 has the opening 50 described above, which is configured opposite the cone angle 51 of the sealing body 44, in its end region 7, into which the sealing body 44 can be used for closing or sealing the interior 10 from the outside atmosphere and by means of the holding element 45 is held securely in this sealing position.
- the opening 50 on the side of the receptacle 5 facing away from the interior 10 has a diameter 56 and a diameter 57 in the region of the interior 10. The is preferred
- Diameter 55 of the end face 54 of the sealing body 44 is larger than the smallest diameter 57 of the opening 50 receiving the sealing body 44. Furthermore, the largest diameter 53 of the sealing body 44 is larger than the largest diameter 56 of the opening 50 also receiving the sealing body 44 - Ensures that the end face 54 of the sealing body 44 facing the interior 10 does not protrude beyond an inner bottom surface 58 of the receptacle 5 into its interior 10 and, on the other hand, that another end face 59 in the end region 7 of the receptacle holder 5 does not come into contact with a surface of the holding element 45 facing the interior space 10, as a result of which a distance 60 is formed between the end face 59 and the inner surface of the holding element 45.
- This distance 60 is used to ensure that, if manufacturing inaccuracies occur between the opening 50 of the receptacle 5 and an outer sealing surface 61 of the pierceable sealing body 44, the sealing surface 61 is secured and sealed in the opening 50.
- a slight preload of the sealing body 44 can also be achieved in cooperation with the holding element 45 in the direction of the interior 10.
- This sealing contact of the sealing body 44, in particular the sealing surface 61 in the opening 50, causes the holding means of the holding element 45 already described above, which protrude from the outside into a central central region of the holding element 45 such that they are the largest when placed on the receptacle 5
- Diameter 53 of the sealing body 44 protrudes in the direction of the central region, that is to say in the direction of the longitudinal central axis 21 in the radial direction.
- the holding device 49 can be formed from individual holding parts 48 distributed over the circumference and / or by an end wall 62 of the holding element 45 with an opening 63 arranged in the central region thereof.
- This opening 63 has an opening width 64 which is at least smaller than the largest diameter 53 of the sealing body 44. This ensures that the sealing body 44 is held securely with respect to the receptacle 5 in its inserted position.
- the holding element 45 is designed like a cap and has the means for coupling with the receptacle 5 already described above.
- the coupling parts 46 forming these can be formed, for example, by holding, latching or snap arms which are designed to be resilient, deformable in the radial direction of the holding element 45. It can also be seen that the coupling parts 46 of the coupling device 47 protrude in the position on the receptacle 5 over the outer dimension 19 or over the outer circumference 17 of the receptacle 5 in the direction of the longitudinal central axis 21 thereof.
- a maximum outer dimension 65 of the holding element 45 can be the same and / or slightly larger than the maximum outer dimension 19 of the maximum outer cross section 20 of the receiving container 5.
- the receptacle 5 has in its end region 7 a groove 66 which is approximately opposite to the coupling part 46 and which is formed, for example, all around the entire outer circumference 17 and / or by groove parts 67 distributed over the circumference in segments.
- the arrangement and design of the groove 66 or the individual groove parts 67 or recesses, depressions, etc. depend on the design of the holding element 45.
- the coupling device 47 may be formed by receiving bores which are arranged distributed over the circumference and are preferably conically tapering inwards and which cooperate with individual, cone-shaped coupling parts 46 on the holding element 45 which are configured in opposite directions.
- the coupling device 47 between the holding element 45 and the receiving container 5 such that, for example, projecting coupling parts are arranged on the receiving container 5 over its outer circumference, which cooperate with a groove-shaped arrangement or groove parts of the holding element 45. This in turn also ensures the formation of the coupling device 47 between the holding element 45 and the receptacle 5.
- the receptacle 5 in its end region 7, in which the opening 50 for inserting the sealing body 44 or for filling or filling the interior 10 is arranged has a wall thickness 13 of the container wall 12 has a greater wall thickness, as a result of which the opening 50 or the coupling device 47 can be formed in this end region 7. Furthermore, it is advantageous if the coupling device 47 is arranged on the outer circumference 17 of the receptacle 5 in a position covering the opening 50, as a result of which the end region 7 can be designed with a favorable strength, due to the greater wall thickness in this section.
- the separating device 11 which is formed from a sealing device 68, in the present exemplary embodiment from a sealing element 69 made of a first material and a support body 70 made of a second, different material.
- the sealing element 69 of the sealing device 68 is arranged in a recess 72, preferably arranged in a ring in a side wall 71 of the support body 70, and in this case projects beyond the side wall 71 of the support body 70, preferably circumferentially over its circumferential direction.
- the material for the sealing element 69 is resiliently deformable and is formed, for example, by a silicone rubber, pharmaceutical rubber, bromobutyl rubber, rubber, a gel or an elastomeric plastic.
- a silicone rubber for example an O-ring or flange ring or a circumferential sealing lip, a thin-walled web or a thin-walled lamella as sealing element 69, for example in grooves and / or clamping areas or the like. can be used.
- the second material of the support body 70 is liquid-tight and has a higher density and / or hardness than the first material of the sealing element 69, and by means of a plastic, optionally provided with additives or fillers, such as e.g. a thermoset, a crystal clear polystyrene and the like.
- the support body 70 should have a gas permeability which almost prevents the passage of gases at least in a period of 72 hours. It can furthermore prove to be advantageous if the total weight of the support body 70 and / or the separating device 11 can be changed, which makes it possible, for example, to apply the separating device 11 and / or the supporting body 70 to different media 3, 4 separating mixture 2 exactly match.
- the gas permeability of the sealing element 69 is at least equal to or greater than that of the support body 70.
- the separating device 11 consists of at least one sealing element 69 made of a first material and the support body 70 made of a different second material.
- the specific weight or the density of the second material of the support body must on the one hand be smaller than the higher specific weight or the density of one of the the separating device 1 1 to be separated medium 3, 4 and on the other hand be greater than the lighter specific weight or the density of one of the medium 3, 4 to be separated by the separating device. It has proven to be advantageous if, for example, the density of the Support body 70 between 1.03 g / cm 3 and 1.06 g / cm 3 , preferably 1.05 g / cm 3 .
- At least partial areas or the entire inner surface 15 of the interior 10 is provided with a coating 73, in order, for example, the sliding movement of the separating device 1 1 support during the separation process and / or a chemical and / or physical Influencing the mixture 2 or the like.
- a coating 73 in order, for example, the sliding movement of the separating device 1 1 support during the separation process and / or a chemical and / or physical Influencing the mixture 2 or the like.
- at least the surface 15 located between the separating device 11 and the opposite end region 6, 7 can be provided with this coating 73, which, for example, comes into contact with the mixture 2 from the surface 15 is designed to be detachable or detachable and, for example, can simultaneously be used to fix the separating device 11.
- the interior 10 can be evacuated or reduced to an air pressure that is lower than the external air pressure in the case of closure devices 8, 9 that are attached on both sides, before the use of the receiving device 1, that is to say before it is filled, in order to make it easier to suck in the mixture 2 to be filled into the To facilitate interior 10.
- the separating device 11 is arranged close to one of the two closure devices 8, 9, in particular adjacent to one of these two.
- FIG. 3 shows a partial area of the receiving device 1 on an enlarged scale, the same reference numerals as in FIGS. 1 and 2 being used for the same parts.
- This embodiment of the closure device 9 shown here consisting of the holding element 45 and the pierceable sealing body 44, differs from the previously described embodiments, these different embodiments of course forming independent solutions and being able to be combined as desired with other described embodiments in other figures.
- the end region 7 of the receptacle 5 in turn has the opening 50 which tapers conically in the direction of the interior 10 and into which the sealing body 44 is inserted for the sealing position therein.
- the sealing body 44 is formed by a multi-layer component made of materials that are in particular different from one another, such as layers 74 to 76.
- the two layers 74, 76 spaced apart from one another can be formed from a softer material that is more suitable for the seal, and the layer 75 can be formed from a material that is harder for this purpose and serve, for example, as a base layer.
- the end face 52 of the sealing body 44 facing the holding element 45 can be formed with a concave depression 77, which is shown in simplified form, or to be arranged therein.
- the further end face 54 of the sealing body 44 opposite the end face 52 can be made completely concave.
- the combination of the concave depression 77 or the completely concave front end 54 allows the piercing thickness of the sealing body 44 to be adapted to different circumstances, such as a needle diameter.
- the holding element 45 is in turn cap-shaped and in its end wall 62 facing the sealing body 44 again has the opening 63 described above, in order to ensure that the sealing body 44 pierces.
- the holding device 49 between the holding element 45 and the sealing body 44 can take place according to one of the described embodiments.
- a circumferential collar 78 extending in the direction of the receptacle 5 is arranged in its outer edge region and connected to it.
- This collar 78 can, for example, form part of the coupling device 47, in particular a coupling part 46, and can be made expandable and elastically resettable by the selected material of the holding element 45.
- the latter In its end region of the collar 78 facing away from the end wall 62, the latter can be equipped with a collar-like coupling element 79 which projects inwards in the circumferential direction at least over a partial region of the collar 78.
- the coupling element 79 as well as the collar 78 continuously on the holding element 45 so that the coupling force between the receptacle 5 and the holding element 45 and subsequently the sealing force between the sealing body 44 and the opening 50 of the To control receptacle 5.
- the coupling element 79 of the coupling device 47 can in turn engage in the previously described groove 66 of the receptacle 5, wherein the groove 66, as already described above, can again be arranged all around or possibly only in some areas.
- the sealing body 44 can be fastened to the holding element 45, to be adhesively bonded or to be produced or connected to it by a molding process or by a two-component injection molding.
- the sealing body 44 and the holding element 45 can also be formed from one component, that is to say in one piece, and preferably consist of a highly elastic and self-sealing material, in particular of a rubber, pharmaceutical rubber, silicone rubber or bromobutyl rubber.
- the holding element 45 In order to avoid a rolling movement of the entire receiving device 1 in its assembled state, it is possible, as is indicated schematically in dashed lines on the holding element 45, to arrange at least one stop rib 80 on the holding element 45 or on one of its coupling parts 46 of the coupling device 47 - NEN, which is protruding over the outer circumference 17 of the receiving container 5.
- the arrangement of one or more stop ribs 80 thus reliably prevents a receiving device 1 which is in use from falling from a storage surface, for example onto the floor after it has been filled, as a result of which unwanted vibrations or undesired mixing of the mixture 2 filled in the interior 10 and breaking or loosening of one of the locking devices 8, 9 is reliably avoided.
- FIG. 4 shows the separating device 11 in an enlarged, diagrammatically simplified illustration, as has already been described in FIG. 1, the same reference numerals being used for the same parts.
- the separating device 11 consists of the sealing device 68 arranged on the supporting body 70, which in this exemplary embodiment is again formed by the sealing element 69.
- the sealing element 69 is arranged in the region of the peripheral side wall 71 and projects beyond it in a direction facing away from a central longitudinal axis 81 of the support body 70.
- the supporting body 70 preferably has end faces 82, 83 which are oriented perpendicularly to the central longitudinal axis 81 and are spaced apart from one another and which, in cooperation with the side wall 71, define the spatial shape of the supporting body 70.
- the support body 70 has a round cross-sectional shape with an outer dimension 84, seen in the direction of the central longitudinal axis 81.
- the two end faces 82, 83 are, as already described above, viewed in the direction of the central longitudinal axis 81, spaced apart from one another at an overall height 85, the mean of the recess 72 for the sealing element 69 preferably being centered on the overall height 85, that is at intervals 86, 87 of the two end faces 82, 83 is arranged.
- the support body 70 with its Sealing elements 69 can have all possible cross sections for the use of the same, this cross section having to correspond to the cross section of the inner surface 15 of the receiving device 1 in order to achieve the desired application.
- a diagonal corner dimension 88 for the support body 70 can be determined, which must in any case be larger than the inner dimension 14 or the inner cross section 18 of the receptacle 5 Tilting the support body 70 to avoid a transverse plane to the central longitudinal axis 81 secured. This is particularly important during and after the physical separation process of the two media 3, 4 of the mixture 2, since otherwise the media 3, 4 of the mixture 2 which are separated from one another are not separated from one another in a sealed manner by the separation device 11 after the separation process has ended .
- This corner dimension 88 is determined between an intersection 89 of the lower end surface 82 here with the side wall 71 and a further intersection 90 diametrically opposite the intersection 89 between the end surface 83 opposite the lower end surface 82 and the side wall 7 1, which is preferably centered on the central longitudinal axis 81 the side wall 71 is aligned parallel to the overall height 85, the two end faces 82, 83 each being arranged in the plane of the circumferential side edges of the side wall 71 in a plane perpendicular to the overall height 85.
- This diagonal corner dimension 88 in, for example, a round support body 70 can be determined or calculated using the Pythagorean theorem from the root of the sum of the squares of the outer dimension 84 and the height 85 running perpendicular to it.
- This diagonal corner dimension 88 must in any case be larger than the inner dimension 14 in the inner cross section 18 of the interior 10 of the receptacle container 5, which is perpendicular to the longitudinal central axis 81, and this means that the separating device 11 is inclined, that is to say an angular orientation the central longitudinal axis 81 of the support body 70 with respect to the longitudinal central axis 21 of the receptacle 5 is possible, but a complete tilting and thus a sealless state between the sealing device 68 and the inner surface 15 of the receptacle 5 is avoided.
- the separating device 11 consisting of the support body 70 and the sealing device 68 arranged thereon with the sealing element 69, corresponds to the previously described embodiment.
- the receptacle 5 has the inner dimension 14 perpendicular to its longitudinal center axis 21, the separating device 11 with the sealing element 69 arranged thereon being pressed against the inner surface 15 due to the centrifugal forces which occur. Furthermore, due to the different materials of the supporting body 70 described above for the sealing element 69, only a deformation of the sealing element 69 occurs, as is also indicated schematically.
- the support body 70 is shown in its rest position in broken lines in the left part of the separating device 11.
- This gap 92 formed between the sealing element 69 and the inner surface 15 serves during the physical separation process to make those components of the mixture 2 with a lower specific weight or density, such as the medium 3, of those components of the mixture with a higher one to separate the specific weight or higher density, such as, for example, the medium 4, from each other and thus to allow the physically lighter portion of the mixture 2 to pass through the gap 92.
- the sealing element 69 After the physical separation process has ended and with it associated withdrawal of the centrifugal forces acting on the sealing element 69, the sealing element 69 in turn assumes, on account of its elastically resettable properties, an all-round sealing contact on the inner surface 15 of the receiving container 5, but between the two media 3, 4. It is essential that the maximum deformation path 91 of the sealing device 68, in particular of the sealing element 69 in the direction perpendicular to the central longitudinal axis 1 of the sealing element 69 in the area projecting beyond the support body 11 is greater than a dimensional difference of the sealing element 69 in the direction perpendicular to the longitudinal central axis 21 in relaxed rest position and in the inserted into the interior 10 of the receptacle 5, biased position.
- FIG. 6 shows a further possible and possibly independent embodiment of the holding element 45 in a view and on an enlarged scale, the same reference numerals as in FIGS. 1 to 5 being used for the same parts.
- the embodiment described here in particular the end wall 62, can also be used in the cap 23 of the closure device 8 and can be arranged instead of the extensions 32. This may also make it possible to dispense with the retaining ring 34, as a result of which the attachment 35 comes to rest directly on the inside of the cap 23 facing the interior 10.
- the holding element 45 in turn has the holding device 49 for the pierceable sealing body 44 for the sealing abutment thereof in the opening 50 of the receptacle 5.
- the holding device 49 can be designed as a circular ring with the opening 63 arranged in its center or central area, which is connected via webs 96 to the coupling device 47 arranged in the area of the maximum outer dimension 65.
- openings 97 are arranged between the webs 96, as seen in the radial direction, and extend in the circumferential direction between the individual webs 96.
- the angular division of the individual webs 96 or openings 97 can be symmetrical to each other.
- the opening 63 in the center of the holding element 45 serves to ensure unimpeded piercing through the sealing body 44 into the interior 10 of the receiving device 1.
- FIG. 7 shows a further and possibly independent embodiment of a separating device 11 with a part of the receiving device 1, again using the same reference numerals as in FIGS. 1 to 6 for the same parts.
- the separating device 1 1 shown here consists of the support body 70 and the sealing device 68 arranged thereon, which in the present exemplary embodiment is formed from two sealing elements 69 which are spaced apart from one another in the direction of the central longitudinal axis 81 of the supporting body 70.
- the support body 70 in turn has the outer dimension 84, the center longitudinal axis 8 1 being arranged in the center thereof.
- This outer dimension 84 is delimited by the preferably all-round side wall 7 1, on which the two sealing elements 69 are also arranged.
- These sealing elements 69 can in turn be inserted into the recesses 72 of the support body 70, the sealing elements 69 having an overhang 98 all around the side wall 71 aligned parallel to the central longitudinal axis 81, which preferably has a uniform value.
- the longitudinal extent of the support body 70 is further limited by the two end faces 82, 83 oriented perpendicular to the central longitudinal axis 81, as a result of which the overall height 85 is formed between them.
- an average of the recesses from the end faces 82, 83 is arranged at an edge distance 99, 100, as a result of which a distance 101 is formed between the two sealing elements 69.
- This at least double arrangement of the sealing elements 69 at a distance 101 from one another in the direction of the central longitudinal axis 81 reliably prevents the entire separating device 11 from tipping over during the physical separating process.
- the separating device 11 has a maximum cross-sectional dimension 102 in the area of the sealing elements 69 in a plane arranged perpendicular to the central longitudinal axis 81, which is derived from the 84 measurement of the support body 70 and the double projection 98 of the sealing element 69 over the support body 70.
- This cross-sectional dimension 102 in the relaxed position and not inserted into the interior 10 is at least the same or to a certain extent larger than the inner dimension 14 in a plane of the receptacle 5 that is also oriented perpendicular to the longitudinal central axis 21. Due to the preferably slight differences in diameter, one takes place sealing contact of the sealing elements 69 on the inner surface 15 of the receptacle 5.
- sealing elements 69 for the sealing device 68 as desired, but it is also possible independently of this. Lich is to design the cross-sectional shape of the individual sealing elements 69 differently over the round embodiment shown here.
- the sealing elements 69 can, for example, also be formed by sealing lips, sealing beads and sealing lugs in the most varied of embodiments.
- at least one sealing element of the sealing device 68 it would be possible for at least one sealing element of the sealing device 68 to be arranged eccentrically to the central longitudinal axis 81, which is aligned parallel to the height 85.
- two or more sealing elements 69 of the sealing device 68 to be arranged eccentrically with respect to the central longitudinal axis 81 of the supporting body 70. It can prove to be advantageous if, for example, a center of gravity of the support body 70 is arranged in an end region assigned to the medium 3, 4 of the mixture 2 with the higher specific weight or the higher density.
- FIG. 8 shows a possible and possibly independent embodiment of a further development of the separating device 11 and the closing device 8 for the receiving device 1 on an enlarged scale and in a schematically simplified representation, the same reference numerals for the same parts as in FIG. 1 to 7 are used.
- the same reference numerals for the same parts as in FIG. 1 to 7 are used.
- any previously described embodiment can be used.
- a holding device 103 is arranged in the area between the end face 83 of the support body 70 and the sealing face 37 of the sealing device 24 facing it, in order to hold the separating device 11 during the assembly process, during the entire storage period of the receiving device 1 and during the filling process of the To hold the interior 10 with the mixture 2 until the start of the centrifuging process in this position.
- a holding device 103 consists of at least one approximately spherical holding extension 104 in the area of the central longitudinal axis 81 of the support body 70 and at least one holding receptacle 105 of opposite design in the center area of the longitudinal central axis 21 of the sealing device 24.
- the shape of the holding device 103 or its Parts are only shown here by way of example, although of course any other form of training is possible.
- the holding extension 104 can also be arranged on the sealing device 24 and the holding receptacle 105 on the support body 70. It is essential that the holding extension 104 is held in the holding receptacle 105 with a certain holding force which is sufficient to hold the separating device 11 securely in position with respect to the closing device 8 until the centrifuging process begins. When a certain centrifugal force is reached, the holding device 103 must release the separating device 11, which means that due to its own weight and the centrifugal force possibly acting on it, it is moved in the direction of an arrow 106 from the closing device 8 in the direction of the further closing device 9.
- the holding extension 104 preferably projects beyond that end face 83 on which it is arranged, molded, etc.
- the holding device 103 between the separating device 11 and the receiving container 5 and to hold it, for example, by means of an extension 107 projecting beyond the inner surface 15 of the receiving container 5 in the direction of the longitudinal central axis 21.
- This extension 107 can be designed in a wide variety of ways, for example by means of individual extensions 107 distributed over the circumference or by a collar-shaped protruding in the direction of the longitudinal central axis 21 and running all around
- Extension 107 may be formed.
- the necessary holding force can be influenced and controlled either by the number of the individual extensions 107 and, if appropriate, by their length of the projection in the direction of the longitudinal central axis 21, and can thus be matched to the different operating conditions.
- a combination of the previously described holding device 103 between the separating device 11 and the sealing device 24 and between the separating device 11 and the receptacle 5 is also possible.
- FIG. 9 shows a further possible and possibly independent design of the holding device 103 between the separating device 11 and the
- Receiving container 5 in the area of the closure device 8 of the receiving device 1 is shown on an enlarged scale and in a schematically simplified manner, again the same reference numerals as in FIGS. 1 to 8 are used for the same parts.
- the receptacle 5 has in its end region 6, in which the sealing device 24 of the closure device 8 is inserted, starting from the open end face 22 of the receptacle 5 in
- Direction of the longitudinal central axis 21 over a length 108 has an internal dimension 109 which is larger than the internal dimension 14 in a plane running perpendicular to the longitudinal central axis 21. Due to the dimensional difference between the two inner dimensions 14 and 109 and the larger outer cross-sectional dimension 102 of the separating device 11 compared to the inner dimension 14, during the assembly process, the entire storage period up to the start of the centrifuging process, a supporting system of one of the Sealing elements 69 of the separating device 11 on a shoulder-shaped attachment 110 forming the holding device 103 in the region of the inner surface 15 of the receptacle 5.
- This collar-shaped or shoulder-shaped attachment 110 is formed by the previously described dimensional difference of the two inner dimensions 14 and 109 from one another .
- This approach 1 10 can be formed, for example, by reducing the wall thickness 13 in the region of the end face 22 or by increasing the same following the length 108.
- the sealing surface 36 of the sealing device 24 nevertheless comes in a secured sealing contact on the inner surface 15 of the receptacle 5 in its end region 6. It is advantageous if the dimensional difference between the inner dimensions 14 and 109 is between 0.1 mm and 4.0 mm, preferably 1.0 mm. Furthermore, a dimension of the extension 107 or extension 110 projecting over the inner surface 15 can be between 0.01 mm and 2.0 mm, preferably 0.5 mm.
- FIG. 10 shows one of the possible configurations of the receiving device 1 after the two media 3, 4 of the mixture 2 have been separated, the same reference numerals being used for the same parts as in FIGS. 1 to 9.
- the receiving device 1 consisting of the receiving container 5, the two closure devices 8, 9 arranged in its end regions 6, 7 and the separating device 11 arranged in the interior 10, is shown in the operating state in which the mixture 2 is in its two media 3, 4 is already spatially separated from one another.
- Mixture 2 for example blood, is thus divided into a serum medium 3 and a plasma medium 4.
- the centrifuging process of the entire receiving device 1 usually takes place in a preferably vertical position of the longitudinal central axis 21, with the closing device 8 preferably being arranged at the upper end of the receiving container 5 and the closing device 9 at the lower end of the receiving container 5.
- the interior 1 of the receptacle 5 in the ready-to-use version is evacuated to a pressure kept below the atmospheric air pressure, the separating device 11 also being in the vicinity or adjacent to one of the closure devices 8, 9, as in FIG present embodiment on the closure device 8 is arranged.
- the interior 10 is filled here in the area of the pierceable sealing body 44 of the closure device 9.
- the receiving device 1 is shown there after the filling process and immediately before the centrifuging process.
- the separating device 11 is located between the two separated media 3, 4 of the mixture 2, the specifically lighter medium 3 being physically separated from the specifically heavier medium 4 during the centrifuging process, as is the case with this has already been described in FIG. 5 for only one sealing element. Due to the dead weight of the separating device 11 and the previously described selected specific weight or the density of the same, it sinks into the medium 3 and then floats on the specifically heavier medium 4.
- a deeper sinking of the separating device 11 into the medium 4 is not possible due to the previously described physical properties, as a result of which the separating device 11 after the end of the 2nd, centrifuging process and the reshaping of the sealing device 68 again with its sealing elements 69 sealing against the inner one Surface 15 of the receptacle. 5 comes to rest and thus a renewed mixing of the two media 3, 4 of the mixture 2 is reliably avoided. Following this, it is possible, for example, to remove the specifically lighter medium 3 from the interior 10 of the receptacle 5 by opening it. NEN of the closure device 8 and possibly the heavier medium 4 by opening the closure device 9 also from the interior 10 separately.
- the separating device 1 Due to the design of the separating device 1 1, it is possible, for example, to separate volumes of the mixture 2 filled differently into the interior 10 without having to pay attention to an exact filling quantity or filling height into the receiving container 5 when filling it.
- the separation process of the two media 3, 4 must continue until it is ensured that the separating device 11 is arranged between the two media 3, 4 and floats on the physically heavier medium 4.
- the holding device 103 e.g. can also be formed by a coating 11 1 applied to the inner surface 15 of the receptacle 5, which hold the separating device 11 in the vicinity of one of the closure devices 8, 9 until the centrifuging process begins.
- the coating 1 1 1 in such a way that it serves as a holding device 103 during the entire storage period of the receiving device 1 until the filling process and only loses its holding effect for the separating device 1 1 immediately at the start of the centrifuging process and e.g. also subsequently serves as a lubricant for the separating device 11 during its movement, since it is softened or dissolved or rinsed off by the liquid introduced into the receptacle 5.
- the coating 1 1 1 can be applied to the entire surface of the inner surface 15 or only to certain areas thereof.
- FIG. 1 1 shows a further and possibly independent embodiment of a separating device 1 1 with a part of the receiving container 5 forming the receiving device 1, the same reference numerals being used for the same parts as in FIGS. 1 to 10.
- the sealing device 68 In order to be able to represent a variety of different training options for the sealing device 68 and to avoid several representations, these were shown in a common figure, but in different positions.
- the separating device 11 shown here consists of the support body 70 and the sealing device 68 arranged thereon, which is formed from at least one sealing element 69 which is preferably arranged centrally to the central longitudinal axis 81 of the support body 70.
- the support body 70 in turn has the outer dimension 84, the central longitudinal axis 1 being arranged in the center thereof. This outer dimension 84 is delimited by the preferably all-round side wall 7 1, on which the different sealing elements 69 can also be arranged.
- sealing elements 69 can either in turn be inserted into differently shaped recesses 72 of the supporting body 70 or held on the supporting body 70, the sealing elements 69 having a projection 98 all around the side wall 71 aligned parallel to the central longitudinal axis 1, which preferably has a uniform value.
- the support body 70 is further limited in its longitudinal extent by the two end faces 82, 83 oriented perpendicular to the central longitudinal axis 81, as a result of which the overall height 85 is formed between them.
- a possible multiple arrangement of the sealing elements 69 on the support body 70 in the direction of the central longitudinal axis 81 reliably prevents the entire separating device 11 from tipping over during the physical separating process.
- the separating device 11 has a maximum cross-sectional dimension 102 in the area of the sealing elements 69 in a plane arranged perpendicular to the central longitudinal axis 81, which is derived from the outer dimension 84 of the support body 70 and the double projection 98 of the Sealing element 69 assembled over the support body 70.
- This cross-sectional dimension 102 is in the relaxed position and not inserted into the interior 10 at least the same or to a certain extent larger than the inner dimension 14 in a plane of the receptacle 5 that is also oriented perpendicularly to the longitudinal central axis 21. Due to the preferably slight diameter differences this results in a sealing contact of the sealing elements 69 on the inner surface 15 of the receptacle 5.
- the sealing element 69 shown in the upper left region of the support body 70 has an approximately circular base body with an extension 1 12 arranged thereon, projecting in the direction facing away from the central longitudinal axis 1, which has a thickness 1 13 on that facing away from the central longitudinal axis 81 Direction is preferably continuously decreasing.
- the preferably voluminous basic body of the sealing element 69 can be inserted into the groove-shaped recess 72 in the support body 70.
- a multiple arrangement of the sealing element 69 is also possible to form the sealing device 68.
- the sealing element 69 which consists of an approximately cylindrical base body 114 and at least one, but preferably a plurality of extensions 1 12, which on the side of the separating device facing away from the central longitudinal axis 81. protruding 1 1, is formed.
- the extensions 1 12 can in turn also be formed with a relatively small thickness 1 13 in the direction parallel to the central longitudinal axis 81 and can be formed by thin webs, lamellae, sealing lips or the like that run all around.
- At least one extension 115 is arranged on the base body 114 in the region of the side wall 71, which extension extends from the side wall 71 in the direction of the central longitudinal axis 81. Seen over the circumference, this approach 115 can only be configured in regions and offset from one another or can also be continuous. Of course, a multiple arrangement of the projection 115 in the direction of the central longitudinal axis 81 is also possible, this projection 115 in turn being assigned a correspondingly dimensionally designed recess 72 in the support body 70.
- the individual extensions 1 12 have an even smaller thickness 1 13 than the extensions 1 12 described above, which means that the two media 3, 4 to be separated from one another can be sealed even better after the separation process.
- the individual extensions 1 12 are again arranged on a common base body 1 14, the base body 1 14 being held on the surface of the support body 70 on its surface facing the side wall 71 of the support body 70 by means of a schematically indicated adhesive layer 1 16.
- the design and arrangement of the adhesive layer 116 depends on the choice of materials from which the support body 70 or the sealing device 68 is formed, and can of course be chosen freely. However, it is also possible to provide an adhesive or press fit between the sealing element 69 and the supporting body 70 instead of the adhesive layer 116, in order in turn to ensure secure positioning of the sealing element 69 in relation to the supporting body 70. aim.
- the sealing element 69 can be designed similarly to the sealing element 69 described immediately above and in turn can be formed from the base body 114 and the projections 112 arranged on it and projecting onto the side facing away from the central longitudinal axis 81.
- a dimensionally coordinated recess 72 in the support body 70 is assigned to the base body 1 14, in which the base body 1 14 is inserted.
- the support body 70 or the sealing device 68 in a separate manufacturing process and only then to join them to form the common separating device 11.
- the above-described separating device 11 can be produced in a wide variety of ways, it being possible instead of the previously described separate production and subsequent assembly, the separating device 11 in a co-injection molding or in a coextrusion process and any combination to manufacture from the manufacturing processes described above. It is essential that means for holding are arranged between the sealing element 69 and the support body 70, which ensure a mutual fixation of the two components relative to one another.
- a great advantage over previously known recording devices, which are used for separating different media, is also that, due to the weight-based design of the separating device 11, there is a float between the separated 3, 4 media, without the need for an exact filling quantity the media 3, 4 to be separated must be observed before the centrifugation process.
- FIGS. 1; 2; 3; 4, 5; 6; 7; 8th; 9; 10; 1 1 shown form the subject of independent solutions according to the invention.
- the tasks and solutions according to the invention in this regard can be found in the detailed descriptions of these figures.
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Centrifugal Separators (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Basic Packing Technique (AREA)
- Sampling And Sample Adjustment (AREA)
- Load-Engaging Elements For Cranes (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- External Artificial Organs (AREA)
- Surgical Instruments (AREA)
- Noodles (AREA)
- Massaging Devices (AREA)
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Abstract
Description
Claims
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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AT0138696A AT404317B (de) | 1996-08-02 | 1996-08-02 | Verschlussvorrichtung, trennvorrichtung sowie aufnahmebehälter für eine aufnahmeeinrichtung |
AT138696 | 1996-08-02 | ||
AT1386/96 | 1996-08-02 | ||
PCT/AT1997/000180 WO1998005426A2 (de) | 1996-08-02 | 1997-08-01 | Verschlussvorrichtung, trennvorrichtung sowie aufnahmebehälter für eine aufnahmeeinrichtung |
Publications (2)
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EP0915737A2 true EP0915737A2 (de) | 1999-05-19 |
EP0915737B1 EP0915737B1 (de) | 2003-06-04 |
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EP97932645A Expired - Lifetime EP0915737B1 (de) | 1996-08-02 | 1997-08-01 | Aufnahmeeinrichtung |
Country Status (10)
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US (1) | US6277331B1 (de) |
EP (1) | EP0915737B1 (de) |
JP (1) | JP2000515420A (de) |
AT (2) | AT404317B (de) |
AU (1) | AU3613297A (de) |
BR (1) | BR9710904A (de) |
CA (1) | CA2262919A1 (de) |
DE (1) | DE59710234D1 (de) |
IL (1) | IL128281A (de) |
WO (1) | WO1998005426A2 (de) |
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US9694359B2 (en) | 2014-11-13 | 2017-07-04 | Becton, Dickinson And Company | Mechanical separator for a biological fluid |
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- 1996-08-02 AT AT0138696A patent/AT404317B/de not_active IP Right Cessation
-
1997
- 1997-08-01 EP EP97932645A patent/EP0915737B1/de not_active Expired - Lifetime
- 1997-08-01 BR BR9710904-5A patent/BR9710904A/pt unknown
- 1997-08-01 DE DE59710234T patent/DE59710234D1/de not_active Expired - Fee Related
- 1997-08-01 IL IL12828197A patent/IL128281A/en not_active IP Right Cessation
- 1997-08-01 CA CA002262919A patent/CA2262919A1/en not_active Abandoned
- 1997-08-01 AT AT97932645T patent/ATE242057T1/de not_active IP Right Cessation
- 1997-08-01 WO PCT/AT1997/000180 patent/WO1998005426A2/de active IP Right Grant
- 1997-08-01 AU AU36132/97A patent/AU3613297A/en not_active Abandoned
- 1997-08-01 US US09/230,771 patent/US6277331B1/en not_active Expired - Fee Related
- 1997-08-01 JP JP10507382A patent/JP2000515420A/ja not_active Ceased
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8448800B2 (en) | 2004-01-23 | 2013-05-28 | Greiner Bio-One Gmbh | Method for the assembly of a cap with a receptacle |
WO2023092168A1 (de) | 2021-11-29 | 2023-06-01 | Greiner Bio-One Gmbh | Aufnahmeeinrichtung mit septum und verfahren zu dessen herstellung |
Also Published As
Publication number | Publication date |
---|---|
JP2000515420A (ja) | 2000-11-21 |
AT404317B (de) | 1998-10-27 |
IL128281A0 (en) | 1999-11-30 |
DE59710234D1 (de) | 2003-07-10 |
EP0915737B1 (de) | 2003-06-04 |
CA2262919A1 (en) | 1998-02-12 |
IL128281A (en) | 2002-12-01 |
ATA138696A (de) | 1998-03-15 |
ATE242057T1 (de) | 2003-06-15 |
WO1998005426A3 (de) | 1998-05-07 |
BR9710904A (pt) | 2000-01-11 |
WO1998005426A2 (de) | 1998-02-12 |
US6277331B1 (en) | 2001-08-21 |
AU3613297A (en) | 1998-02-25 |
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